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The map label for this gene is purM [H]

Identifier: 66046918

GI number: 66046918

Start: 4375674

End: 4376732

Strand: Direct

Name: purM [H]

Synonym: Psyr_3689

Alternate gene names: 66046918

Gene position: 4375674-4376732 (Clockwise)

Preceding gene: 66046911

Following gene: 66046919

Centisome position: 71.81

GC content: 62.51

Gene sequence:

>1059_bases
ATGAGCAAGCAACCCTCCCTGAGCTATAAAGACGCCGGTGTAGACATCGACGCCGGTGAAGCATTGGTCGAACGCATCAA
GAGCGTCGCCAAGCGCACCAAGCGTCCGGAAGTCATGGGCGGCCTGGGAGGCTTCGGCGCCCTCTGCGAAATCCCGGCCG
GCTACAAGCAACCGGTTCTGGTTTCCGGCACTGACGGCGTGGGCACCAAGCTGCGTCTGGCGCTGAACCTGAACAAGCAC
GACACCATTGGCATCGATCTGGTCGCCATGTGCGTCAATGACCTGGTGGTCTGTGGTGCCGAACCGCTGTTCTTCCTCGA
TTACTACGCCACCGGCAAGCTCAACGTCGACACCGCCGCTCAGGTCGTCACCGGCATCGGCGCCGGCTGCGAACTGGCCG
GTTGCTCGCTGGTGGGTGGTGAAACCGCTGAAATGCCGGGCATGTACGAAGGCGAAGACTACGACCTGGCAGGCTTCTGC
GTCGGCGTGGTGGAAAAGGCCGAGATCATCGACGGCTCGAAAGTCGCTGCCGGTGATGCCCTGCTCGCCCTGCCATCGTC
CGGCCCGCACTCCAACGGCTACTCGCTGATCCGCAAGATCATCGAGGTGGCAGGTGCCGATATCGAAAACATCCAGCTGG
ACGGCAAACCGCTGACCGAACTGCTGATGGCACCGACCCGCATCTACGTGAAGCCGCTGCTCAAGCTGATCAAGGAAACC
GGCGCGGTCAAGGCCATGGCCCACATCACCGGTGGCGGCCTGCTCGACAACATCCCACGCGTACTGCCGCAAGGCGCTCA
GGCTGTGGTCGACGTCGCCAGCTGGCAGCGTCCGGCTGTGTTCGACTGGCTGCAGCAGCAAGGCAACGTTGCGGAAAACG
AGATGCATCGCGTGCTGAACTGCGGCGTTGGCATGGTCATCTGCGTCGCTCAGGAGCACGTCGAAGCGGCCCTGAAAGTA
CTGCGTGACGCAGGCGAGCAGCCTTGGGTGATCGGCCAGATCGCCAGCGCTGCCGAAGGCGCCGCACAAGTAGAGCTGAA
AAACCTCAAGGCGCATTGA

Upstream 100 bases:

>100_bases
CCATGGCCCCAACATTACCACCGCATGACAGCGCGGTGCTGAACGGGCCCTAACGCAGCGGTCGATACCTCCGAATCCCC
CCTAAAGGCCTGGATTTTCT

Downstream 100 bases:

>100_bases
TGCCAGCCATCTGCGAAGTCGTGGTGCTGCTGTCCGGCACCGGCGGCAACCTGCAAGCGATGATCGACAGCTTCAAGGAC
GGGGCCAGCCCCGTCCGCAT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MSKQPSLSYKDAGVDIDAGEALVERIKSVAKRTKRPEVMGGLGGFGALCEIPAGYKQPVLVSGTDGVGTKLRLALNLNKH
DTIGIDLVAMCVNDLVVCGAEPLFFLDYYATGKLNVDTAAQVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFC
VGVVEKAEIIDGSKVAAGDALLALPSSGPHSNGYSLIRKIIEVAGADIENIQLDGKPLTELLMAPTRIYVKPLLKLIKET
GAVKAMAHITGGGLLDNIPRVLPQGAQAVVDVASWQRPAVFDWLQQQGNVAENEMHRVLNCGVGMVICVAQEHVEAALKV
LRDAGEQPWVIGQIASAAEGAAQVELKNLKAH

Sequences:

>Translated_352_residues
MSKQPSLSYKDAGVDIDAGEALVERIKSVAKRTKRPEVMGGLGGFGALCEIPAGYKQPVLVSGTDGVGTKLRLALNLNKH
DTIGIDLVAMCVNDLVVCGAEPLFFLDYYATGKLNVDTAAQVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFC
VGVVEKAEIIDGSKVAAGDALLALPSSGPHSNGYSLIRKIIEVAGADIENIQLDGKPLTELLMAPTRIYVKPLLKLIKET
GAVKAMAHITGGGLLDNIPRVLPQGAQAVVDVASWQRPAVFDWLQQQGNVAENEMHRVLNCGVGMVICVAQEHVEAALKV
LRDAGEQPWVIGQIASAAEGAAQVELKNLKAH
>Mature_351_residues
SKQPSLSYKDAGVDIDAGEALVERIKSVAKRTKRPEVMGGLGGFGALCEIPAGYKQPVLVSGTDGVGTKLRLALNLNKHD
TIGIDLVAMCVNDLVVCGAEPLFFLDYYATGKLNVDTAAQVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFCV
GVVEKAEIIDGSKVAAGDALLALPSSGPHSNGYSLIRKIIEVAGADIENIQLDGKPLTELLMAPTRIYVKPLLKLIKETG
AVKAMAHITGGGLLDNIPRVLPQGAQAVVDVASWQRPAVFDWLQQQGNVAENEMHRVLNCGVGMVICVAQEHVEAALKVL
RDAGEQPWVIGQIASAAEGAAQVELKNLKAH

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=353, Percent_Identity=50.7082152974504, Blast_Score=348, Evalue=3e-96,
Organism=Homo sapiens, GI209869995, Length=353, Percent_Identity=50.7082152974504, Blast_Score=348, Evalue=3e-96,
Organism=Homo sapiens, GI209869993, Length=353, Percent_Identity=50.7082152974504, Blast_Score=348, Evalue=3e-96,
Organism=Escherichia coli, GI1788845, Length=346, Percent_Identity=68.4971098265896, Blast_Score=483, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17567511, Length=347, Percent_Identity=44.6685878962536, Blast_Score=261, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6321203, Length=354, Percent_Identity=46.6101694915254, Blast_Score=304, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24582400, Length=308, Percent_Identity=42.5324675324675, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36923; Mature: 36792

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQPSLSYKDAGVDIDAGEALVERIKSVAKRTKRPEVMGGLGGFGALCEIPAGYKQPVL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHCCCCCCCCCEE
VSGTDGVGTKLRLALNLNKHDTIGIDLVAMCVNDLVVCGAEPLFFLDYYATGKLNVDTAA
EECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHH
QVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFCVGVVEKAEIIDGSKVAAGDA
HHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCE
LLALPSSGPHSNGYSLIRKIIEVAGADIENIQLDGKPLTELLMAPTRIYVKPLLKLIKET
EEEECCCCCCCCCHHHHHHHHHHHCCCHHEEEECCCHHHHHHHCCHHHHHHHHHHHHHHH
GAVKAMAHITGGGLLDNIPRVLPQGAQAVVDVASWQRPAVFDWLQQQGNVAENEMHRVLN
CHHEEHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHH
CGVGMVICVAQEHVEAALKVLRDAGEQPWVIGQIASAAEGAAQVELKNLKAH
CCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEHHHHHHCCCHHEEEHHCCCCC
>Mature Secondary Structure 
SKQPSLSYKDAGVDIDAGEALVERIKSVAKRTKRPEVMGGLGGFGALCEIPAGYKQPVL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHCCCCCCCCCEE
VSGTDGVGTKLRLALNLNKHDTIGIDLVAMCVNDLVVCGAEPLFFLDYYATGKLNVDTAA
EECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHH
QVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFCVGVVEKAEIIDGSKVAAGDA
HHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCE
LLALPSSGPHSNGYSLIRKIIEVAGADIENIQLDGKPLTELLMAPTRIYVKPLLKLIKET
EEEECCCCCCCCCHHHHHHHHHHHCCCHHEEEECCCHHHHHHHCCHHHHHHHHHHHHHHH
GAVKAMAHITGGGLLDNIPRVLPQGAQAVVDVASWQRPAVFDWLQQQGNVAENEMHRVLN
CHHEEHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHH
CGVGMVICVAQEHVEAALKVLRDAGEQPWVIGQIASAAEGAAQVELKNLKAH
CCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEHHHHHHCCCHHEEEHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA