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The map label for this gene is cpxR [H]

Identifier: 66046818

GI number: 66046818

Start: 4270692

End: 4271369

Strand: Direct

Name: cpxR [H]

Synonym: Psyr_3589

Alternate gene names: 66046818

Gene position: 4270692-4271369 (Clockwise)

Preceding gene: 66046817

Following gene: 66046819

Centisome position: 70.08

GC content: 64.6

Gene sequence:

>678_bases
ATGAGCGAGCTGTTACTAATTGATGATGATCAGGAGCTGTGCGAGCTGCTGAGCAGTTGGCTGAGCCAGGAAGGCTTTCA
GGTACGCGCCTGTCACGACGGGAACAGCGCGCGCAAGGCATTGGCCGACGCTGCCCCGGCGGCCGTGGTGCTGGACGTGA
TGCTGCCCGATGGCAGTGGTCTGGAATTGCTCAAGCAATTACGCGCCGAACACCCTGACCTGCCGGTGGTCATGCTCTCG
GCACGCGGCGAGCCGCTGGACCGTATTCTGGGTCTGGAGCTGGGCGCTGACGACTACCTGGCAAAGCCCTGCGACCCTCG
CGAACTCACCGCCCGCCTGCGCGCCGTGCTGCGCCGCAGCCATCCGGTGGCGTCGTCCAGCCAGCTCGAACTGGGCGACC
TGACTTTCAGCCCGATGCGCGGCGTGGTCAGTGTCGACGAGAAGGAACTGACCCTCACCGTGTCCGAAAGCCGTTTGCTG
GAAGCGCTGATGCGCCAGCCCGGCGAGCCGTTGGACAAGCAGGAACTGGCGCAACTGGCCCTGGGCCGCAAACTGACCCT
GTACGACCGCAGTCTGGACATGCACGTCAGCAACCTGCGCAAGAAAATCGGCCCGCACGCCGACGGCCGCCCGCGCATCG
TCGCACTGCGCAGCCGCGGCTATTATTATGCTCTTTGA

Upstream 100 bases:

>100_bases
AGGTTATGCCCTGAGCCTGCCCGACCGACTTCTTAACAGCTCTGCTTTCTGATCGAGGCAGAGTCACGCTGCACCCCGGT
AGTGGCCAATTGAGTGAGTC

Downstream 100 bases:

>100_bases
GCAGCTACAAGCTGCAAGCTACAAGCAGAGCGCTTCTGGCTTGAAGCTTGAAGCTGACAACTTGCAGCTGCCCCTTACAC
AAGCTTTACCAAGCGCTGAC

Product: response regulator receiver:transcriptional regulatory protein, C-terminal

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MSELLLIDDDQELCELLSSWLSQEGFQVRACHDGNSARKALADAAPAAVVLDVMLPDGSGLELLKQLRAEHPDLPVVMLS
ARGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRSHPVASSSQLELGDLTFSPMRGVVSVDEKELTLTVSESRLL
EALMRQPGEPLDKQELAQLALGRKLTLYDRSLDMHVSNLRKKIGPHADGRPRIVALRSRGYYYAL

Sequences:

>Translated_225_residues
MSELLLIDDDQELCELLSSWLSQEGFQVRACHDGNSARKALADAAPAAVVLDVMLPDGSGLELLKQLRAEHPDLPVVMLS
ARGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRSHPVASSSQLELGDLTFSPMRGVVSVDEKELTLTVSESRLL
EALMRQPGEPLDKQELAQLALGRKLTLYDRSLDMHVSNLRKKIGPHADGRPRIVALRSRGYYYAL
>Mature_224_residues
SELLLIDDDQELCELLSSWLSQEGFQVRACHDGNSARKALADAAPAAVVLDVMLPDGSGLELLKQLRAEHPDLPVVMLSA
RGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRSHPVASSSQLELGDLTFSPMRGVVSVDEKELTLTVSESRLLE
ALMRQPGEPLDKQELAQLALGRKLTLYDRSLDMHVSNLRKKIGPHADGRPRIVALRSRGYYYAL

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=46.0526315789474, Blast_Score=181, Evalue=3e-47,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=37.5, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1789809, Length=207, Percent_Identity=37.1980676328502, Blast_Score=146, Evalue=9e-37,
Organism=Escherichia coli, GI1790860, Length=201, Percent_Identity=39.3034825870647, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=33.0316742081448, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=33.1818181818182, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=36.0730593607306, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789402, Length=201, Percent_Identity=34.8258706467662, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=33.4782608695652, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=29.6943231441048, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=33.9285714285714, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=29.2372881355932, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=28.0701754385965, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=29.2576419213974, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788550, Length=162, Percent_Identity=26.5432098765432, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1790437, Length=133, Percent_Identity=29.3233082706767, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=32.4074074074074, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24857; Mature: 24726

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELLLIDDDQELCELLSSWLSQEGFQVRACHDGNSARKALADAAPAAVVLDVMLPDGSG
CCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCC
LELLKQLRAEHPDLPVVMLSARGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRS
HHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHC
HPVASSSQLELGDLTFSPMRGVVSVDEKELTLTVSESRLLEALMRQPGEPLDKQELAQLA
CCCCCCCCEEECCCCCCCCCCCEEECCCEEEEEECHHHHHHHHHHCCCCCCCHHHHHHHH
LGRKLTLYDRSLDMHVSNLRKKIGPHADGRPRIVALRSRGYYYAL
HCCEEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEC
>Mature Secondary Structure 
SELLLIDDDQELCELLSSWLSQEGFQVRACHDGNSARKALADAAPAAVVLDVMLPDGSG
CCEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCC
LELLKQLRAEHPDLPVVMLSARGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRS
HHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHC
HPVASSSQLELGDLTFSPMRGVVSVDEKELTLTVSESRLLEALMRQPGEPLDKQELAQLA
CCCCCCCCEEECCCCCCCCCCCEEECCCEEEEEECHHHHHHHHHHCCCCCCCHHHHHHHH
LGRKLTLYDRSLDMHVSNLRKKIGPHADGRPRIVALRSRGYYYAL
HCCEEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]