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The map label for this gene is lysC [H]

Identifier: 66046784

GI number: 66046784

Start: 4233778

End: 4235010

Strand: Reverse

Name: lysC [H]

Synonym: Psyr_3555

Alternate gene names: 66046784

Gene position: 4235010-4233778 (Counterclockwise)

Preceding gene: 66046785

Following gene: 66046783

Centisome position: 69.5

GC content: 59.53

Gene sequence:

>1233_bases
ATGGCTTTAATCGTACAGAAATTTGGCGGCACCTCCGTGGGCTCTGTAGAGCGCATCGAGCAGGTGGCCGACAAGGTCAA
GAAATTCCGTGAGGCGGGTGACGACCTGGTGGTCGTGCTGTCGGCCATGAGCGGTGAAACCAATCGTCTGATCGAGCTGG
CCAGGCAGATCAGTGATCAGCCGGTTCCCCGTGAGCTGGATGTCATTGTCTCCACGGGCGAGCAGGTGACCATCGCGCTG
CTGGCGATGGCCTTGATGAAGCGTGGCGTTCCGGCGGTGTCCTACACCGGCAATCAGGTGCGTATTCTCACCGACAGCGC
GCACAACAAGGCGCGCATTCTGCAGATCGACGACCAGAAGATCCGCTCCGACCTGAAAGCGGGTCGTGTGGTGGTGGTCG
CCGGTTTCCAGGGTGTCGACGAACACGGCAATATCACCACCCTCGGCCGTGGTGGCTCGGACACGACCGGTGTTGCCCTG
GCGGCGGCGCTGAAAGCGGACGAGTGCCAGATCTACACCGACGTCGATGGCGTCTACACCACCGATCCGCGTGTCGTGTC
GCAGGCCCAGCGCCTCGACAAGATCACCTTCGAAGAGATGCTGGAAATGGCCAGCCTCGGTTCCAAGGTGCTGCAGATCC
GTGCGGTCGAATTCGCCGGCAAATACAATGTCCCGCTGCGCGTTCTGCACAGCTTCAAAGAGGGGCCGGGCACCCTTATT
ACAATCGATGAAGAGGAATCCATGGAACAGCCGATCATTTCCGGCATCGCCTTCAACCGCGATGAAGCCAAGCTGACCAT
CCGTGGTGTGCCAGACACCCCCGGCGTGGCGTTCAAGATTCTCGGCCCGATCAGCGCGGCCAATATCGAAGTGGACATGA
TCGTGCAGAACGTCTCGCACGATAACACCACCGATTTCACCTTCACGATCCATCGCAACGATTATCAGGCGGCCTTGCAG
GTGCTCGAAGCCACCGCGCGTGAAATCAGCGCGCGTGAAGTGTCCGGCGATACCAAGATCGCCAAGGTGTCCATCGTCGG
CGTCGGCATGCGCTCGCATGCCGGCGTTGCGAGTCGCATGTTCGAAGCGCTGGCCAAGGAGAGCATCAATATCCAGATGA
TCTCCACATCGGAAATCAAGGTTTCCGTGGTCATCGAAGAGAAATACCTGGAGTTGGCTGTGCGCGCATTGCACACGGCC
TTTGAGCTGGATGCTCCGCGGCAGGGTGAATGA

Upstream 100 bases:

>100_bases
GGTATCTGAGTCGGGTCAGCGGGCCTGCCGCACACCGGCAGGCCGTACCTGGGCTCGAATGTTAATGGGTGCTCTTAACG
GGATTTGAGGCGGCTTTGAG

Downstream 100 bases:

>100_bases
CCCTGTCATCGAAGGGCGCGGCGTGGCCGCGTCTTTCGGGTGCTGCGCAGAAGGGCTTTTGTTTTCTTTGCGTTAGTCGA
TATACAGGTAGTGGTCATGG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MALIVQKFGGTSVGSVERIEQVADKVKKFREAGDDLVVVLSAMSGETNRLIELARQISDQPVPRELDVIVSTGEQVTIAL
LAMALMKRGVPAVSYTGNQVRILTDSAHNKARILQIDDQKIRSDLKAGRVVVVAGFQGVDEHGNITTLGRGGSDTTGVAL
AAALKADECQIYTDVDGVYTTDPRVVSQAQRLDKITFEEMLEMASLGSKVLQIRAVEFAGKYNVPLRVLHSFKEGPGTLI
TIDEEESMEQPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANIEVDMIVQNVSHDNTTDFTFTIHRNDYQAALQ
VLEATAREISAREVSGDTKIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTA
FELDAPRQGE

Sequences:

>Translated_410_residues
MALIVQKFGGTSVGSVERIEQVADKVKKFREAGDDLVVVLSAMSGETNRLIELARQISDQPVPRELDVIVSTGEQVTIAL
LAMALMKRGVPAVSYTGNQVRILTDSAHNKARILQIDDQKIRSDLKAGRVVVVAGFQGVDEHGNITTLGRGGSDTTGVAL
AAALKADECQIYTDVDGVYTTDPRVVSQAQRLDKITFEEMLEMASLGSKVLQIRAVEFAGKYNVPLRVLHSFKEGPGTLI
TIDEEESMEQPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANIEVDMIVQNVSHDNTTDFTFTIHRNDYQAALQ
VLEATAREISAREVSGDTKIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTA
FELDAPRQGE
>Mature_409_residues
ALIVQKFGGTSVGSVERIEQVADKVKKFREAGDDLVVVLSAMSGETNRLIELARQISDQPVPRELDVIVSTGEQVTIALL
AMALMKRGVPAVSYTGNQVRILTDSAHNKARILQIDDQKIRSDLKAGRVVVVAGFQGVDEHGNITTLGRGGSDTTGVALA
AALKADECQIYTDVDGVYTTDPRVVSQAQRLDKITFEEMLEMASLGSKVLQIRAVEFAGKYNVPLRVLHSFKEGPGTLIT
IDEEESMEQPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANIEVDMIVQNVSHDNTTDFTFTIHRNDYQAALQV
LEATAREISAREVSGDTKIAKVSIVGVGMRSHAGVASRMFEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAF
ELDAPRQGE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=472, Percent_Identity=28.8135593220339, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1790455, Length=454, Percent_Identity=28.1938325991189, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1790376, Length=463, Percent_Identity=22.2462203023758, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320893, Length=491, Percent_Identity=26.2729124236253, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44429; Mature: 44298

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVQKFGGTSVGSVERIEQVADKVKKFREAGDDLVVVLSAMSGETNRLIELARQISDQ
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCC
PVPRELDVIVSTGEQVTIALLAMALMKRGVPAVSYTGNQVRILTDSAHNKARILQIDDQK
CCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCCCCEEEEEECHHH
IRSDLKAGRVVVVAGFQGVDEHGNITTLGRGGSDTTGVALAAALKADECQIYTDVDGVYT
HHHHHCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCEEE
TDPRVVSQAQRLDKITFEEMLEMASLGSKVLQIRAVEFAGKYNVPLRVLHSFKEGPGTLI
CCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCEEE
TIDEEESMEQPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANIEVDMIVQNVSH
EECCHHHHCCHHHHCEEECCCCCEEEEECCCCCCCEEEEEECCCCCCCEEEEEEEEECCC
DNTTDFTFTIHRNDYQAALQVLEATAREISAREVSGDTKIAKVSIVGVGMRSHAGVASRM
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCHHHHHH
FEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELDAPRQGE
HHHHHHCCCEEEEEEECCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ALIVQKFGGTSVGSVERIEQVADKVKKFREAGDDLVVVLSAMSGETNRLIELARQISDQ
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCC
PVPRELDVIVSTGEQVTIALLAMALMKRGVPAVSYTGNQVRILTDSAHNKARILQIDDQK
CCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCCCCEEEEEECHHH
IRSDLKAGRVVVVAGFQGVDEHGNITTLGRGGSDTTGVALAAALKADECQIYTDVDGVYT
HHHHHCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCEEE
TDPRVVSQAQRLDKITFEEMLEMASLGSKVLQIRAVEFAGKYNVPLRVLHSFKEGPGTLI
CCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCEEE
TIDEEESMEQPIISGIAFNRDEAKLTIRGVPDTPGVAFKILGPISAANIEVDMIVQNVSH
EECCHHHHCCHHHHCEEECCCCCEEEEECCCCCCCEEEEEECCCCCCCEEEEEEEEECCC
DNTTDFTFTIHRNDYQAALQVLEATAREISAREVSGDTKIAKVSIVGVGMRSHAGVASRM
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCHHHHHH
FEALAKESINIQMISTSEIKVSVVIEEKYLELAVRALHTAFELDAPRQGE
HHHHHHCCCEEEEEEECCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]