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The map label for this gene is copA [H]

Identifier: 66046650

GI number: 66046650

Start: 4084022

End: 4086496

Strand: Direct

Name: copA [H]

Synonym: Psyr_3421

Alternate gene names: 66046650

Gene position: 4084022-4086496 (Clockwise)

Preceding gene: 66046649

Following gene: 66046651

Centisome position: 67.02

GC content: 65.01

Gene sequence:

>2475_bases
GTGGCCAGGCCCTCCTCTCCCGCGCCGCTGCACTGCTACCACTGCGGTTTGCCGGTCCCGGCGGGCAGCCATTTCAACGC
TGTAGTGCTCGGTGCATCCCGACGGCTGTGCTGCCCCGGTTGTCAGGCAGTGACCGAAGCCATCGTTGCGAGCGGTCTGG
ACAACTATTACCGCCATCGCAGTGAAACCTCGGCCAACCCGGAAAGCCTGCCCAGCCAATTGCTCGATGAACTGGCGCTC
TACGACCGCCCCGACGTACAGGCGCCATTCGTGCGCCACGACGGCGACCTCTCAGAGGCCACGCTGCTTGTCGAAGGCAT
CAGTTGCGCGGCCTGCGGCTGGCTGATCGAGCAACGCCTGGGGCGATTACCCGGGGTGACCGAAGCGCGGCTGAACCTGT
CCACTCATCGCCTGCTGGTGCGCTGGAACGCCGACCAGCTTGCCCTCAGCCAATTGCTCAACGAACTGCACGCGATTGGC
TATGTCGCCCATCCATGGCAGGCCGATCGCGCTGCCGAACGCCTGGCGAGTGACAATCGCCTGGCGTTGCGACAACTGGG
CGTCGCCGGCCTGCTGTGGTTTCAGGCCATGATGGCAACCATGGCCACCTGGCCGGAGTTCAATATCGATCTCAGCCCGC
AGATGCACACCATCCTGCGCTGGGTGGCGCTGTTTCTGACCACGCCGATCGTCTTCTACAGTTGCGCACCGTTCTTTCGC
GGTGCCTTGCGCGACCTGCGCAGCCGCCACCTGACAATGGATGTGTCGGTGTCGCTGGCAATAGGCGCGGCCTACGCCGC
AGGGATCTGGACCGCTGTCACCGGCGCTGGCGAACTGTATGTCGATGCCGTCGGCATGTTTGCACTGTTCCTGCTGGCCG
GCCGCTACCTGGAGCGCCGGGCCCGCGAGCGCACGGCGGCAGCCACCGCCCAACTGGTCAACGTGCTGCCCGCCTCATGC
CTGCGCCTCAATGATGACGGCCAGAGCCAGCGCATCATGCTCAGTGAGCTGCACCTGGCTGACCAGGTGCTGGTGCAGCC
AGGTGCAGTGATACCGGCTGATGGCAAAATCCTCGAAGGCCGCTCCAGTGTCGACGAGTCGCTGTTGACCGGCGAATACC
TGCCACAAATGCGCAGTGTAGGCGATGCGGTCACCGCAGGAACGTTGAATGTCGAAAGCCCGCTGACCATCGGCGTGACG
GCGCTGGGTCACGAAACCCGCCTTTCGGCCATTGTCCGACTGCTCGAACGTGCTCAGGCAGAAAAACCCCGACTCGCGCA
GATCGCCGACCGGGCGGCACAGACCTTTCTGCTGTTATCGCTGATCGCAGCTGCGCTGATCGGGGTGATCTGGTGGCAGT
TGGACGCATCGCGCGCGGTCTGGATCGTACTGGCCATGCTCGTCGCCACCTGCCCTTGCGCACTGTCGCTGGCGACGCCG
ACCGCCTTGACTGCGGCGACCGGCACTCTGCACAGACTCGGCCTGCTGCTGACCCGAGGTCACGTGCTCGAAGGCCTCAA
CCAGATCGACACGGTCATCTTCGACAAGACCGGCACCCTGACCGAAGGACGCCTGACGCTGCGCAGCATTCACCCATTGC
GCGAGCTGGACGCCAATCGCTGCCTGGAACTGGCGGCCGCTCTGGAAAACCGCTCCGAGCACCCCATCGCCCGCGTTTTC
GGTCGAGCGCCGAGAGCTGCCGAGGAGGTGCTCAGCACACCGGGGATGGGTCTGCAAGGTCGTGTTGACGGGCATCTGCT
GCGCATCGGCGAGGCGGCTTTCGTCTGTGCGCTGAGCGGCGCTGAAACGCCCTTGCCAACTGAAAGATCCGGCCAATGGC
TGTTGCTGGGCGATGCGCAGGGCCCACTCGCATGGCTGGTGCTGGACGACCGGCTGCGCGAGGATGCAGGCACCCTGTTA
CACGCATGCCGGGCGCGAGGCTGGAAAACGCTGCTGTTGTCCGGTGACAGCTCGCCGATGGTTGGCAGTGTCGCGCAGGC
GCTGGGCATCGACGATGCGCGTGGCGGCATGCGCCCGAACGATAAGCTGGAGGTGCTGCGCCAGCTTCAGGCTCAGGGGC
GCAAGGTGCTGATGATCGGTGACGGGGTGAACGACGTACCGGTCATGGCAGCAGCCGACATCAGTGTGGCGATGGGCTCG
GCCACCGACCTCGCCAAAACCAGCGCTGACGCCGTGCTGCTGTGCAACCGCTTGCCGGTGCTGATCGACGCCCTGAATCT
GGCGCGACGCACGCGGAGGGTCATTATCGAAAACCTGCTCTGGGCCGGTCTGTACAATGGCCTCATGCTGCCCTTCGCGG
CGCTGGGCTGGATCACTCCGGTGTGGGCGGCGATCGGTATGTCGCTCAGTTCACTGACCGTGGTGCTCAACGCCTTGCGC
CTGACCCGCCTGCCGCGTCGTGCCCTTGCCCGCCAACCTGCCCCGGAGGTTTCATGCCCGCGCTTTACATCATGA

Upstream 100 bases:

>100_bases
AGCAGACCTGGCGCCTGTTCGAGGAAGAACAGATTGGCACTGACGACGTGACCCTCGGTGACGAACCCCTGCAAGCCGCG
CAACGCCGGAAAGACTGAAC

Downstream 100 bases:

>100_bases
TCCCCGCCGCTCTGCTGCTGGTGGGCGTGGCGATCTACGTGTTCTTCTGGGCGGTGGACAGCGGCCAGTACGACGACATG
GAAGGCCCTGCGCACAGCAT

Product: copper-translocating P-type ATPase:heavy metal translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 824; Mature: 823

Protein sequence:

>824_residues
MARPSSPAPLHCYHCGLPVPAGSHFNAVVLGASRRLCCPGCQAVTEAIVASGLDNYYRHRSETSANPESLPSQLLDELAL
YDRPDVQAPFVRHDGDLSEATLLVEGISCAACGWLIEQRLGRLPGVTEARLNLSTHRLLVRWNADQLALSQLLNELHAIG
YVAHPWQADRAAERLASDNRLALRQLGVAGLLWFQAMMATMATWPEFNIDLSPQMHTILRWVALFLTTPIVFYSCAPFFR
GALRDLRSRHLTMDVSVSLAIGAAYAAGIWTAVTGAGELYVDAVGMFALFLLAGRYLERRARERTAAATAQLVNVLPASC
LRLNDDGQSQRIMLSELHLADQVLVQPGAVIPADGKILEGRSSVDESLLTGEYLPQMRSVGDAVTAGTLNVESPLTIGVT
ALGHETRLSAIVRLLERAQAEKPRLAQIADRAAQTFLLLSLIAAALIGVIWWQLDASRAVWIVLAMLVATCPCALSLATP
TALTAATGTLHRLGLLLTRGHVLEGLNQIDTVIFDKTGTLTEGRLTLRSIHPLRELDANRCLELAAALENRSEHPIARVF
GRAPRAAEEVLSTPGMGLQGRVDGHLLRIGEAAFVCALSGAETPLPTERSGQWLLLGDAQGPLAWLVLDDRLREDAGTLL
HACRARGWKTLLLSGDSSPMVGSVAQALGIDDARGGMRPNDKLEVLRQLQAQGRKVLMIGDGVNDVPVMAAADISVAMGS
ATDLAKTSADAVLLCNRLPVLIDALNLARRTRRVIIENLLWAGLYNGLMLPFAALGWITPVWAAIGMSLSSLTVVLNALR
LTRLPRRALARQPAPEVSCPRFTS

Sequences:

>Translated_824_residues
MARPSSPAPLHCYHCGLPVPAGSHFNAVVLGASRRLCCPGCQAVTEAIVASGLDNYYRHRSETSANPESLPSQLLDELAL
YDRPDVQAPFVRHDGDLSEATLLVEGISCAACGWLIEQRLGRLPGVTEARLNLSTHRLLVRWNADQLALSQLLNELHAIG
YVAHPWQADRAAERLASDNRLALRQLGVAGLLWFQAMMATMATWPEFNIDLSPQMHTILRWVALFLTTPIVFYSCAPFFR
GALRDLRSRHLTMDVSVSLAIGAAYAAGIWTAVTGAGELYVDAVGMFALFLLAGRYLERRARERTAAATAQLVNVLPASC
LRLNDDGQSQRIMLSELHLADQVLVQPGAVIPADGKILEGRSSVDESLLTGEYLPQMRSVGDAVTAGTLNVESPLTIGVT
ALGHETRLSAIVRLLERAQAEKPRLAQIADRAAQTFLLLSLIAAALIGVIWWQLDASRAVWIVLAMLVATCPCALSLATP
TALTAATGTLHRLGLLLTRGHVLEGLNQIDTVIFDKTGTLTEGRLTLRSIHPLRELDANRCLELAAALENRSEHPIARVF
GRAPRAAEEVLSTPGMGLQGRVDGHLLRIGEAAFVCALSGAETPLPTERSGQWLLLGDAQGPLAWLVLDDRLREDAGTLL
HACRARGWKTLLLSGDSSPMVGSVAQALGIDDARGGMRPNDKLEVLRQLQAQGRKVLMIGDGVNDVPVMAAADISVAMGS
ATDLAKTSADAVLLCNRLPVLIDALNLARRTRRVIIENLLWAGLYNGLMLPFAALGWITPVWAAIGMSLSSLTVVLNALR
LTRLPRRALARQPAPEVSCPRFTS
>Mature_823_residues
ARPSSPAPLHCYHCGLPVPAGSHFNAVVLGASRRLCCPGCQAVTEAIVASGLDNYYRHRSETSANPESLPSQLLDELALY
DRPDVQAPFVRHDGDLSEATLLVEGISCAACGWLIEQRLGRLPGVTEARLNLSTHRLLVRWNADQLALSQLLNELHAIGY
VAHPWQADRAAERLASDNRLALRQLGVAGLLWFQAMMATMATWPEFNIDLSPQMHTILRWVALFLTTPIVFYSCAPFFRG
ALRDLRSRHLTMDVSVSLAIGAAYAAGIWTAVTGAGELYVDAVGMFALFLLAGRYLERRARERTAAATAQLVNVLPASCL
RLNDDGQSQRIMLSELHLADQVLVQPGAVIPADGKILEGRSSVDESLLTGEYLPQMRSVGDAVTAGTLNVESPLTIGVTA
LGHETRLSAIVRLLERAQAEKPRLAQIADRAAQTFLLLSLIAAALIGVIWWQLDASRAVWIVLAMLVATCPCALSLATPT
ALTAATGTLHRLGLLLTRGHVLEGLNQIDTVIFDKTGTLTEGRLTLRSIHPLRELDANRCLELAAALENRSEHPIARVFG
RAPRAAEEVLSTPGMGLQGRVDGHLLRIGEAAFVCALSGAETPLPTERSGQWLLLGDAQGPLAWLVLDDRLREDAGTLLH
ACRARGWKTLLLSGDSSPMVGSVAQALGIDDARGGMRPNDKLEVLRQLQAQGRKVLMIGDGVNDVPVMAAADISVAMGSA
TDLAKTSADAVLLCNRLPVLIDALNLARRTRRVIIENLLWAGLYNGLMLPFAALGWITPVWAAIGMSLSSLTVVLNALRL
TRLPRRALARQPAPEVSCPRFTS

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=829, Percent_Identity=27.7442702050663, Blast_Score=282, Evalue=7e-76,
Organism=Homo sapiens, GI55743073, Length=557, Percent_Identity=29.2639138240575, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI115529486, Length=562, Percent_Identity=26.8683274021352, Blast_Score=202, Evalue=1e-51,
Organism=Escherichia coli, GI1786691, Length=805, Percent_Identity=30.4347826086957, Blast_Score=322, Evalue=6e-89,
Organism=Escherichia coli, GI1789879, Length=726, Percent_Identity=31.404958677686, Blast_Score=255, Evalue=6e-69,
Organism=Escherichia coli, GI1786914, Length=538, Percent_Identity=26.3940520446097, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17556548, Length=637, Percent_Identity=25.2747252747253, Blast_Score=168, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320475, Length=735, Percent_Identity=27.0748299319728, Blast_Score=249, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6319772, Length=670, Percent_Identity=26.4179104477612, Blast_Score=205, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6325221, Length=503, Percent_Identity=23.0616302186879, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221329854, Length=562, Percent_Identity=28.4697508896797, Blast_Score=195, Evalue=9e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR001366
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 88887; Mature: 88756

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARPSSPAPLHCYHCGLPVPAGSHFNAVVLGASRRLCCPGCQAVTEAIVASGLDNYYRHR
CCCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHC
SETSANPESLPSQLLDELALYDRPDVQAPFVRHDGDLSEATLLVEGISCAACGWLIEQRL
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHH
GRLPGVTEARLNLSTHRLLVRWNADQLALSQLLNELHAIGYVAHPWQADRAAERLASDNR
CCCCCCCHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCH
LALRQLGVAGLLWFQAMMATMATWPEFNIDLSPQMHTILRWVALFLTTPIVFYSCAPFFR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GALRDLRSRHLTMDVSVSLAIGAAYAAGIWTAVTGAGELYVDAVGMFALFLLAGRYLERR
HHHHHHHHHCEEEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
ARERTAAATAQLVNVLPASCLRLNDDGQSQRIMLSELHLADQVLVQPGAVIPADGKILEG
HHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCEECC
RSSVDESLLTGEYLPQMRSVGDAVTAGTLNVESPLTIGVTALGHETRLSAIVRLLERAQA
CHHHHHHHHHHHHHHHHHHHCCHHEECEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHC
EKPRLAQIADRAAQTFLLLSLIAAALIGVIWWQLDASRAVWIVLAMLVATCPCALSLATP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEECCCC
TALTAATGTLHRLGLLLTRGHVLEGLNQIDTVIFDKTGTLTEGRLTLRSIHPLRELDANR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHCHHHHHCHHH
CLELAAALENRSEHPIARVFGRAPRAAEEVLSTPGMGLQGRVDGHLLRIGEAAFVCALSG
HHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEEEECC
AETPLPTERSGQWLLLGDAQGPLAWLVLDDRLREDAGTLLHACRARGWKTLLLSGDSSPM
CCCCCCCCCCCCEEEEECCCCCEEEEEECHHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
VGSVAQALGIDDARGGMRPNDKLEVLRQLQAQGRKVLMIGDGVNDVPVMAAADISVAMGS
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEECCHHHCCCC
ATDLAKTSADAVLLCNRLPVLIDALNLARRTRRVIIENLLWAGLYNGLMLPFAALGWITP
CHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWAAIGMSLSSLTVVLNALRLTRLPRRALARQPAPEVSCPRFTS
HHHHHCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARPSSPAPLHCYHCGLPVPAGSHFNAVVLGASRRLCCPGCQAVTEAIVASGLDNYYRHR
CCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHC
SETSANPESLPSQLLDELALYDRPDVQAPFVRHDGDLSEATLLVEGISCAACGWLIEQRL
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHH
GRLPGVTEARLNLSTHRLLVRWNADQLALSQLLNELHAIGYVAHPWQADRAAERLASDNR
CCCCCCCHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCH
LALRQLGVAGLLWFQAMMATMATWPEFNIDLSPQMHTILRWVALFLTTPIVFYSCAPFFR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GALRDLRSRHLTMDVSVSLAIGAAYAAGIWTAVTGAGELYVDAVGMFALFLLAGRYLERR
HHHHHHHHHCEEEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
ARERTAAATAQLVNVLPASCLRLNDDGQSQRIMLSELHLADQVLVQPGAVIPADGKILEG
HHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCEECC
RSSVDESLLTGEYLPQMRSVGDAVTAGTLNVESPLTIGVTALGHETRLSAIVRLLERAQA
CHHHHHHHHHHHHHHHHHHHCCHHEECEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHC
EKPRLAQIADRAAQTFLLLSLIAAALIGVIWWQLDASRAVWIVLAMLVATCPCALSLATP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEECCCC
TALTAATGTLHRLGLLLTRGHVLEGLNQIDTVIFDKTGTLTEGRLTLRSIHPLRELDANR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHCHHHHHCHHH
CLELAAALENRSEHPIARVFGRAPRAAEEVLSTPGMGLQGRVDGHLLRIGEAAFVCALSG
HHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEEEECC
AETPLPTERSGQWLLLGDAQGPLAWLVLDDRLREDAGTLLHACRARGWKTLLLSGDSSPM
CCCCCCCCCCCCEEEEECCCCCEEEEEECHHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
VGSVAQALGIDDARGGMRPNDKLEVLRQLQAQGRKVLMIGDGVNDVPVMAAADISVAMGS
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEECCHHHCCCC
ATDLAKTSADAVLLCNRLPVLIDALNLARRTRRVIIENLLWAGLYNGLMLPFAALGWITP
CHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWAAIGMSLSSLTVVLNALRLTRLPRRALARQPAPEVSCPRFTS
HHHHHCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA