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The map label for this gene is mtnP [H]

Identifier: 66046509

GI number: 66046509

Start: 3927626

End: 3928366

Strand: Reverse

Name: mtnP [H]

Synonym: Psyr_3280

Alternate gene names: 66046509

Gene position: 3928366-3927626 (Counterclockwise)

Preceding gene: 66046510

Following gene: 66046507

Centisome position: 64.47

GC content: 60.86

Gene sequence:

>741_bases
ATGACTGTTTACGCGATTATTGGCGGTACTGGCCTGACCCAGCTCGAAGGCCTGAACATTCGGCAATCCCTGCCGATGAA
CACGCCTTATGGCGCACCTTCCGGCGAAATCCAGATCGGCGACTATGCCGGTCGCGAAGTGATGTTTCTGGCGCGCCACG
GCCACCCGCACCGCTTGCCGCCGCATCAGGTCAACTACCGGGCCAATATCTGGGCCCTGAAGCAGGCAGGTGCCGAAGCG
ATTCTTGCGGTCAACGCAGTCGGCGGCATTCATCCGGCCATGGGCACCGGTCATTTCTGTGTGCCGCATGATCTGGTCGA
CTACACCAGCGGTCGCCAGCACACATTTTTTGCCGATGACCTGGAAGAGGTCACGCACATCGACTTCAGTTATCCGTACA
GCGAGCCACTGCGTGCCCGGCTGATTGCGGCGCTGGCTACTGAAGGATGCGCGTTCTCTGATCGGGGCGTTTATGCCTGT
ACCCAGGGACCGCGTCTGGAGACCGTTGCCGAAATCATTCGCCTGGAGCGTGATGGTTGCGACATCGTCGGCATGACTGG
CATGCCCGAAGCCGCGCTGGCGCGTGAGCTGGAGCTTGAATACGCCTGCCTGGCGCTGGTGGTCAATCCGGCAGCGGGCA
AGTCGACCACCGTCATTACCATGGCGGAAATCGAACAGGCCTTGCGCGACGGAATGGGCAAGGTGAAAGCCACGCTTGCC
CGGGTTCTGTCAGCGTCCTGA

Upstream 100 bases:

>100_bases
CGGTCTGGCGTCGGCCAGTACCGACTATCGGCAACACCCGCGCTGGCAGGCCGCGCTCCAGGCTCTGCGCGCTGCTCAAC
TGATCGATTAAGGATTTGCG

Downstream 100 bases:

>100_bases
ATTACAGCATGCGCTTGAGGGTATTGTCCTTGCGCACCAGATGGTGCCAGAGCGCAGCGATCACATGCAGACCGATGACA
TAGTAGAAGATCGAGCCCAG

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MTVYAIIGGTGLTQLEGLNIRQSLPMNTPYGAPSGEIQIGDYAGREVMFLARHGHPHRLPPHQVNYRANIWALKQAGAEA
ILAVNAVGGIHPAMGTGHFCVPHDLVDYTSGRQHTFFADDLEEVTHIDFSYPYSEPLRARLIAALATEGCAFSDRGVYAC
TQGPRLETVAEIIRLERDGCDIVGMTGMPEAALARELELEYACLALVVNPAAGKSTTVITMAEIEQALRDGMGKVKATLA
RVLSAS

Sequences:

>Translated_246_residues
MTVYAIIGGTGLTQLEGLNIRQSLPMNTPYGAPSGEIQIGDYAGREVMFLARHGHPHRLPPHQVNYRANIWALKQAGAEA
ILAVNAVGGIHPAMGTGHFCVPHDLVDYTSGRQHTFFADDLEEVTHIDFSYPYSEPLRARLIAALATEGCAFSDRGVYAC
TQGPRLETVAEIIRLERDGCDIVGMTGMPEAALARELELEYACLALVVNPAAGKSTTVITMAEIEQALRDGMGKVKATLA
RVLSAS
>Mature_245_residues
TVYAIIGGTGLTQLEGLNIRQSLPMNTPYGAPSGEIQIGDYAGREVMFLARHGHPHRLPPHQVNYRANIWALKQAGAEAI
LAVNAVGGIHPAMGTGHFCVPHDLVDYTSGRQHTFFADDLEEVTHIDFSYPYSEPLRARLIAALATEGCAFSDRGVYACT
QGPRLETVAEIIRLERDGCDIVGMTGMPEAALARELELEYACLALVVNPAAGKSTTVITMAEIEQALRDGMGKVKATLAR
VLSAS

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=238, Percent_Identity=30.2521008403361, Blast_Score=126, Evalue=2e-29,
Organism=Escherichia coli, GI1788746, Length=200, Percent_Identity=27.5, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71980569, Length=239, Percent_Identity=35.5648535564854, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323045, Length=215, Percent_Identity=33.4883720930233, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI221459247, Length=207, Percent_Identity=35.7487922705314, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI20130079, Length=207, Percent_Identity=34.7826086956522, Blast_Score=128, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 26461; Mature: 26329

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVYAIIGGTGLTQLEGLNIRQSLPMNTPYGAPSGEIQIGDYAGREVMFLARHGHPHRLP
CEEEEEECCCCCCEECCCCCHHCCCCCCCCCCCCCCEEECCCCCCEEEEEEECCCCCCCC
PHQVNYRANIWALKQAGAEAILAVNAVGGIHPAMGTGHFCVPHDLVDYTSGRQHTFFADD
CCCCCEEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCEECCHHHHHCCCCCCEEEEHHH
LEEVTHIDFSYPYSEPLRARLIAALATEGCAFSDRGVYACTQGPRLETVAEIIRLERDGC
HHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCC
DIVGMTGMPEAALARELELEYACLALVVNPAAGKSTTVITMAEIEQALRDGMGKVKATLA
CEEECCCCCHHHHHHHHHHHEEEEEEEECCCCCCCEEEEEHHHHHHHHHHCHHHHHHHHH
RVLSAS
HHHHCC
>Mature Secondary Structure 
TVYAIIGGTGLTQLEGLNIRQSLPMNTPYGAPSGEIQIGDYAGREVMFLARHGHPHRLP
EEEEEECCCCCCEECCCCCHHCCCCCCCCCCCCCCEEECCCCCCEEEEEEECCCCCCCC
PHQVNYRANIWALKQAGAEAILAVNAVGGIHPAMGTGHFCVPHDLVDYTSGRQHTFFADD
CCCCCEEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCEECCHHHHHCCCCCCEEEEHHH
LEEVTHIDFSYPYSEPLRARLIAALATEGCAFSDRGVYACTQGPRLETVAEIIRLERDGC
HHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCC
DIVGMTGMPEAALARELELEYACLALVVNPAAGKSTTVITMAEIEQALRDGMGKVKATLA
CEEECCCCCHHHHHHHHHHHEEEEEEEECCCCCCCEEEEEHHHHHHHHHHCHHHHHHHHH
RVLSAS
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]