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The map label for this gene is wzb [H]

Identifier: 66046453

GI number: 66046453

Start: 3862023

End: 3862475

Strand: Direct

Name: wzb [H]

Synonym: Psyr_3224

Alternate gene names: 66046453

Gene position: 3862023-3862475 (Clockwise)

Preceding gene: 66046452

Following gene: 66046454

Centisome position: 63.38

GC content: 61.59

Gene sequence:

>453_bases
ATGTTCAGTAGTGTGCTGGTGGTGTGCGTGGGCAACGTCTGCCGCAGTCCGATGGCCGTCGCGATGCTGCATCAACGCCT
GAAAGCCACGCAGGTACGTATTCAGTCGGCAGGCATCGCTGCGTTATCGGGTTCGTCGATCGACCCGACAGCACATGCGG
TTCTGCAGTCGCACCGGGTTCAACCTCAGCGGCACGCCGCTCGCCAGATGAGTCGCGAGCTGCTGCGCCAGGCCGACCTG
ATCCTGCTGATGGAGCAGGCGCATTTTTCCGACGTCCTCGACCTTGCCCCCGAAGTGCGCGGCAAAGCCTTTCTGATCGG
TAAATGGCAGGACCCGCTCGACATCACCGACCCTTACCGGCGCCCCGCGTCAGCCTTCGAGCAGACCTACGCGCAGCTCT
CACGCTGCATTGACGACTGGCTTCCCCATTTTCAGTCAGGAGCAACAGGATAA

Upstream 100 bases:

>100_bases
GCGCTCGCCCCACGCCACAAGTTGCAGACGCTGTGCAAAGTGGCAGGCAACGTGATCGGCAACCTGGCCAGGCGCCTGTT
GCCAGCCACCGGCAAAGCTC

Downstream 100 bases:

>100_bases
ATGACCGCCATGAACCATCCTTCCCTGAATTTCCAACCGGACTCCCGGATTGATCTGGCAACAGTCCTGCGCATGCTGTT
CGATCACAAAGCCCTGATCC

Product: low molecular weight phosphotyrosine protein phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 150; Mature: 150

Protein sequence:

>150_residues
MFSSVLVVCVGNVCRSPMAVAMLHQRLKATQVRIQSAGIAALSGSSIDPTAHAVLQSHRVQPQRHAARQMSRELLRQADL
ILLMEQAHFSDVLDLAPEVRGKAFLIGKWQDPLDITDPYRRPASAFEQTYAQLSRCIDDWLPHFQSGATG

Sequences:

>Translated_150_residues
MFSSVLVVCVGNVCRSPMAVAMLHQRLKATQVRIQSAGIAALSGSSIDPTAHAVLQSHRVQPQRHAARQMSRELLRQADL
ILLMEQAHFSDVLDLAPEVRGKAFLIGKWQDPLDITDPYRRPASAFEQTYAQLSRCIDDWLPHFQSGATG
>Mature_150_residues
MFSSVLVVCVGNVCRSPMAVAMLHQRLKATQVRIQSAGIAALSGSSIDPTAHAVLQSHRVQPQRHAARQMSRELLRQADL
ILLMEQAHFSDVLDLAPEVRGKAFLIGKWQDPLDITDPYRRPASAFEQTYAQLSRCIDDWLPHFQSGATG

Specific function: Dephosphorylates wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI6005988, Length=143, Percent_Identity=34.2657342657343, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI4757714, Length=148, Percent_Identity=32.4324324324324, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788375, Length=140, Percent_Identity=45, Blast_Score=131, Evalue=2e-32,
Organism=Escherichia coli, GI87081812, Length=139, Percent_Identity=43.8848920863309, Blast_Score=120, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 16618; Mature: 16618

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSSVLVVCVGNVCRSPMAVAMLHQRLKATQVRIQSAGIAALSGSSIDPTAHAVLQSHRV
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHCC
QPQRHAARQMSRELLRQADLILLMEQAHFSDVLDLAPEVRGKAFLIGKWQDPLDITDPYR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
RPASAFEQTYAQLSRCIDDWLPHFQSGATG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFSSVLVVCVGNVCRSPMAVAMLHQRLKATQVRIQSAGIAALSGSSIDPTAHAVLQSHRV
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHCC
QPQRHAARQMSRELLRQADLILLMEQAHFSDVLDLAPEVRGKAFLIGKWQDPLDITDPYR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
RPASAFEQTYAQLSRCIDDWLPHFQSGATG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]