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The map label for this gene is nuoC [H]

Identifier: 66046428

GI number: 66046428

Start: 3828879

End: 3830660

Strand: Direct

Name: nuoC [H]

Synonym: Psyr_3199

Alternate gene names: 66046428

Gene position: 3828879-3830660 (Clockwise)

Preceding gene: 66046427

Following gene: 66046429

Centisome position: 62.83

GC content: 59.71

Gene sequence:

>1782_bases
ATGACTGCAGACAACGCTCTGTACATCCCGCCTTACAAGGCTGACGACCAAGATGTCGTCGTTGAACTGAATAACCGTTT
TGGTGCCGAGGCTTTCACTGCCCAGCCGACTCGCACCGGTATGCCCGTGCTGTGGGTCGAGCGCGCCCGACTGTTTGAAA
TTCTGACGTTCCTGCGCAACGTGCCCAAACCCTACTCCATGCTCTATGACCTGCATGGCGTGGACGAGCGGCTGCGCACA
AACCGTCGTGGTCTGCCCGGCGCAGACTTCACCGTGTTCTATCACCTGCTGTCGATCGAGCGAAACAGCGACGTGATGAT
CAAGGTAGCGCTTTCCGAAAGCGACCTGAGCGTACCGACCATCACCAGCATCTGGCCGAACGCCAACTGGTACGAGCGTG
AAGTCTGGGACATGTTCGGTATCGATTTCCCGGGCCACCCGCACCTGAGCCGCATCATGATGCCGCCGACCTGGGAAGGC
CATCCGCTGCGCAAGGACTTCCCTGCCCGTGCGACGGAATTCGACCCGTACAGCCTGACCCTTGCCAAACAGCAACTGGA
AGAGGAAGCCGCACGCTTCCGTCCGGAAGACTGGGGCATGAAACGCTCTGGCGCCAACGAGGACTACATGTTCCTCAACC
TGGGCCCGAACCACCCTTCCGCTCACGGTGCGTTCCGTATCATTCTGCAACTGGACGGTGAAGAAATCGTCGATTGCGTT
CCGGACATCGGCTACCACCACCGTGGTGCCGAGAAGATGGCCGAACGTCAGTCCTGGCACAGCTTCATTCCCTACACCGA
CCGTATCGATTACCTGGGCGGGGTGATGAACAACCTGCCTTATGTGCTCTCGGTCGAGAAGCTGGCAGGCATCAAGGTGC
CGGAAAAGGTCGACGTCATCCGCATCATGATGGCCGAGTTCTTCCGTATCACCAGTCACCTGCTGTTCCTGGGAACCTAC
ATTCAGGACGTGGGCGCCATGACACCGGTGTTCTTCACGTTCACCGACCGCCAGAAAGCCTACACCGTGATCGAAGCCAT
TACCGGCTTCCGTCTGCACCCTGCCTGGTACCGCATCGGCGGGGTCGCTCACGACCTGCCGCGTGGCTGGGAAAAACTGG
TCAAGGACTTCGTCGACTGGCTGCCCAAGCGTCTCGACGAATACACCAAGGCGGCCCTGCAAAACAGTATTCTCAAGGGT
CGTACCATTGGCGTCGCCGCCTACAACACCAAGGAAGCCCTCGAGTGGGGCGTCACCGGTGCAGGCCTGCGCTCCACAGG
TTGCGACTTCGACCTGCGCAAGGCTCGCCCTTACTCGGGCTACGAGAACTTCGAATTCGAAGTGCCACTGGCCGCCAACG
GCGATGCCTATGACCGCTGCATGGTCCGCGTCGAAGAGATGCGCCAGAGCATCAAGATCATCGACCAGTGCATGCGCAAC
ATGCCGGAAGGCCCGTACAAGGCGGATCACCCGCTGACCACGCCGCCGCCGAAAGAGCGCACCCTGCAGCACATCGAAAC
CCTGATCACGCACTTCCTGCAGGTTTCGTGGGGCCCGGTCATGCCGGCCAACGAATCCTTCCAGATGATCGAAGCGACCA
AGGGTATCAACAGCTATTACCTGACGAGCGACGGCGGCACCATGAGCTACCGTACCCGGATCCGCACCCCGAGTTACCCG
CACCTGCAGCAGATCCCTTCGGTGATCAAAGGCAGCATGGTCGCGGACTTGATCGCGTACCTGGGTAGTATCGATTTCGT
TATGGCCGACGTGGACCGCTAA

Upstream 100 bases:

>100_bases
ACCTGCGCAGCCCCGACGAAGTCTGATCCAGCCCGTTCTTCTTATAAAAAAGACAAGAACCGGGGTTGATTCTGTACGTT
GACCGAAGTGATTGAGACCT

Downstream 100 bases:

>100_bases
GCATGAATAGCCCGCTAATCCAGACTGACCGTTTCGCCCTGAGCGAAACCGAGCGCTCGGCCATCGAGCATGAGATGCAT
CACTACGAGGACCCGCGCGC

Product: bifunctional NADH:ubiquinone oxidoreductase subunit C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D [H]

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MTADNALYIPPYKADDQDVVVELNNRFGAEAFTAQPTRTGMPVLWVERARLFEILTFLRNVPKPYSMLYDLHGVDERLRT
NRRGLPGADFTVFYHLLSIERNSDVMIKVALSESDLSVPTITSIWPNANWYEREVWDMFGIDFPGHPHLSRIMMPPTWEG
HPLRKDFPARATEFDPYSLTLAKQQLEEEAARFRPEDWGMKRSGANEDYMFLNLGPNHPSAHGAFRIILQLDGEEIVDCV
PDIGYHHRGAEKMAERQSWHSFIPYTDRIDYLGGVMNNLPYVLSVEKLAGIKVPEKVDVIRIMMAEFFRITSHLLFLGTY
IQDVGAMTPVFFTFTDRQKAYTVIEAITGFRLHPAWYRIGGVAHDLPRGWEKLVKDFVDWLPKRLDEYTKAALQNSILKG
RTIGVAAYNTKEALEWGVTGAGLRSTGCDFDLRKARPYSGYENFEFEVPLAANGDAYDRCMVRVEEMRQSIKIIDQCMRN
MPEGPYKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGGTMSYRTRIRTPSYP
HLQQIPSVIKGSMVADLIAYLGSIDFVMADVDR

Sequences:

>Translated_593_residues
MTADNALYIPPYKADDQDVVVELNNRFGAEAFTAQPTRTGMPVLWVERARLFEILTFLRNVPKPYSMLYDLHGVDERLRT
NRRGLPGADFTVFYHLLSIERNSDVMIKVALSESDLSVPTITSIWPNANWYEREVWDMFGIDFPGHPHLSRIMMPPTWEG
HPLRKDFPARATEFDPYSLTLAKQQLEEEAARFRPEDWGMKRSGANEDYMFLNLGPNHPSAHGAFRIILQLDGEEIVDCV
PDIGYHHRGAEKMAERQSWHSFIPYTDRIDYLGGVMNNLPYVLSVEKLAGIKVPEKVDVIRIMMAEFFRITSHLLFLGTY
IQDVGAMTPVFFTFTDRQKAYTVIEAITGFRLHPAWYRIGGVAHDLPRGWEKLVKDFVDWLPKRLDEYTKAALQNSILKG
RTIGVAAYNTKEALEWGVTGAGLRSTGCDFDLRKARPYSGYENFEFEVPLAANGDAYDRCMVRVEEMRQSIKIIDQCMRN
MPEGPYKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGGTMSYRTRIRTPSYP
HLQQIPSVIKGSMVADLIAYLGSIDFVMADVDR
>Mature_592_residues
TADNALYIPPYKADDQDVVVELNNRFGAEAFTAQPTRTGMPVLWVERARLFEILTFLRNVPKPYSMLYDLHGVDERLRTN
RRGLPGADFTVFYHLLSIERNSDVMIKVALSESDLSVPTITSIWPNANWYEREVWDMFGIDFPGHPHLSRIMMPPTWEGH
PLRKDFPARATEFDPYSLTLAKQQLEEEAARFRPEDWGMKRSGANEDYMFLNLGPNHPSAHGAFRIILQLDGEEIVDCVP
DIGYHHRGAEKMAERQSWHSFIPYTDRIDYLGGVMNNLPYVLSVEKLAGIKVPEKVDVIRIMMAEFFRITSHLLFLGTYI
QDVGAMTPVFFTFTDRQKAYTVIEAITGFRLHPAWYRIGGVAHDLPRGWEKLVKDFVDWLPKRLDEYTKAALQNSILKGR
TIGVAAYNTKEALEWGVTGAGLRSTGCDFDLRKARPYSGYENFEFEVPLAANGDAYDRCMVRVEEMRQSIKIIDQCMRNM
PEGPYKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGGTMSYRTRIRTPSYPH
LQQIPSVIKGSMVADLIAYLGSIDFVMADVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=382, Percent_Identity=40.5759162303665, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI260898743, Length=372, Percent_Identity=40.3225806451613, Blast_Score=302, Evalue=7e-82,
Organism=Homo sapiens, GI4758788, Length=116, Percent_Identity=43.1034482758621, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI145693162, Length=579, Percent_Identity=75.1295336787565, Blast_Score=961, Evalue=0.0,
Organism=Escherichia coli, GI1789076, Length=513, Percent_Identity=26.1208576998051, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1788832, Length=507, Percent_Identity=27.0216962524655, Blast_Score=152, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17568379, Length=427, Percent_Identity=38.8758782201405, Blast_Score=330, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17555284, Length=401, Percent_Identity=40.1496259351621, Blast_Score=330, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI71990788, Length=148, Percent_Identity=33.1081081081081, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI32563621, Length=116, Percent_Identity=35.3448275862069, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI221459469, Length=383, Percent_Identity=40.2088772845953, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24638644, Length=384, Percent_Identity=40.625, Blast_Score=322, Evalue=7e-88,
Organism=Drosophila melanogaster, GI24656494, Length=116, Percent_Identity=39.6551724137931, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR010218
- InterPro:   IPR023062
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR022885
- ProDom:   PD001581 [H]

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 67771; Mature: 67640

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADNALYIPPYKADDQDVVVELNNRFGAEAFTAQPTRTGMPVLWVERARLFEILTFLRN
CCCCCEEEECCCCCCCCCEEEEECCCCCCCCEECCCCCCCCCEEHHHHHHHHHHHHHHHC
VPKPYSMLYDLHGVDERLRTNRRGLPGADFTVFYHLLSIERNSDVMIKVALSESDLSVPT
CCCHHHHHHHHHCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCE
ITSIWPNANWYEREVWDMFGIDFPGHPHLSRIMMPPTWEGHPLRKDFPARATEFDPYSLT
EEECCCCCCCHHHHHHHHHCCCCCCCCCHHEEECCCCCCCCCCCCCCCCCCCCCCCCCHH
LAKQQLEEEAARFRPEDWGMKRSGANEDYMFLNLGPNHPSAHGAFRIILQLDGEEIVDCV
HHHHHHHHHHHHCCCHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHHH
PDIGYHHRGAEKMAERQSWHSFIPYTDRIDYLGGVMNNLPYVLSVEKLAGIKVPEKVDVI
CCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEHHHHHCCCCCCHHHHH
RIMMAEFFRITSHLLFLGTYIQDVGAMTPVFFTFTDRQKAYTVIEAITGFRLHPAWYRIG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCEECHHHHHHC
GVAHDLPRGWEKLVKDFVDWLPKRLDEYTKAALQNSILKGRTIGVAAYNTKEALEWGVTG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHCCCC
AGLRSTGCDFDLRKARPYSGYENFEFEVPLAANGDAYDRCMVRVEEMRQSIKIIDQCMRN
CCCCCCCCCCCHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MPEGPYKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEE
LTSDGGTMSYRTRIRTPSYPHLQQIPSVIKGSMVADLIAYLGSIDFVMADVDR
EECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
>Mature Secondary Structure 
TADNALYIPPYKADDQDVVVELNNRFGAEAFTAQPTRTGMPVLWVERARLFEILTFLRN
CCCCEEEECCCCCCCCCEEEEECCCCCCCCEECCCCCCCCCEEHHHHHHHHHHHHHHHC
VPKPYSMLYDLHGVDERLRTNRRGLPGADFTVFYHLLSIERNSDVMIKVALSESDLSVPT
CCCHHHHHHHHHCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCE
ITSIWPNANWYEREVWDMFGIDFPGHPHLSRIMMPPTWEGHPLRKDFPARATEFDPYSLT
EEECCCCCCCHHHHHHHHHCCCCCCCCCHHEEECCCCCCCCCCCCCCCCCCCCCCCCCHH
LAKQQLEEEAARFRPEDWGMKRSGANEDYMFLNLGPNHPSAHGAFRIILQLDGEEIVDCV
HHHHHHHHHHHHCCCHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHHH
PDIGYHHRGAEKMAERQSWHSFIPYTDRIDYLGGVMNNLPYVLSVEKLAGIKVPEKVDVI
CCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEHHHHHCCCCCCHHHHH
RIMMAEFFRITSHLLFLGTYIQDVGAMTPVFFTFTDRQKAYTVIEAITGFRLHPAWYRIG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCEECHHHHHHC
GVAHDLPRGWEKLVKDFVDWLPKRLDEYTKAALQNSILKGRTIGVAAYNTKEALEWGVTG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHCCCC
AGLRSTGCDFDLRKARPYSGYENFEFEVPLAANGDAYDRCMVRVEEMRQSIKIIDQCMRN
CCCCCCCCCCCHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MPEGPYKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEE
LTSDGGTMSYRTRIRTPSYPHLQQIPSVIKGSMVADLIAYLGSIDFVMADVDR
EECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA