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The map label for this gene is aprA [H]

Identifier: 66046392

GI number: 66046392

Start: 3791203

End: 3792633

Strand: Reverse

Name: aprA [H]

Synonym: Psyr_3163

Alternate gene names: 66046392

Gene position: 3792633-3791203 (Counterclockwise)

Preceding gene: 66046393

Following gene: 66046391

Centisome position: 62.24

GC content: 58.14

Gene sequence:

>1431_bases
ATGACGAAAGTCAAAGAAAATGCTGCAATCCAACTTTCCGCTGCTACCAGCACCTCTTTCGACCAGATCAATGCGTTCGC
GCACCAGTATGACCGTGGCGGCAACCTCACGATCAATGGCAAGCCCTCGTATTCAGTCGATCAGGCCGCTGATTATATTC
TTCGCGACGACGCCTCCTGGACGGATCGCGATGGCAACGGCACCATCAACCTCACTTACACGTTCCTGACGGCCAAACCT
GCCGGGTTCGACAATTCGCTGGGGACTTTCAGTGCGTTCAACGCGCAGCAGAAAGCACAGGCAGTATTGTCGATGCAATC
CTGGGCAGACGTTGCCAAGGTCAGCTTCACCCAGGCAGCTTCCGGCGGCGACGGGCATATGACCTTCGGCAACTACAGCA
ACGGCAGTGCAGGCGGGGCAGCTTTTGCCTACCTGCCCAGCGGCAACAGCCGTACTGACGGCCAGTCCTGGTACCTTGTC
GATAACAGCTACAAGGTCAACACCACCCCGGACAATGGCAATTACGGTCGTCAGACCCTGACCCATGAAATCGGCCACAC
CCTTGGCCTGTCTCACCCAGGTGACTACAACGCGGGCGAGGGCAATCCGAGCTACAAGGACGCCACTTACGCAGAAGATA
CCCGTGGCTACAGCGTCATGAGTTACTGGAGTGAGTCCAACACCGACCAGAACTTCGTCAAGGGCGGTGCTCCGTCGTAC
TCTTCGGCACCGTTGCTGGATGACATCACTGCCGTTCAGCAGCTCTATGGCGCGAACATGAGCACCCGTGCCGGTGATAC
GGTCTATGGGTTCAACTCCACTGCCGGGCGCGATTTCTACAGCGCCACCTCCGCCTCGTCCAAGGTGGTGTTCTCGGTGT
GGGATGGCGGGGGCAAGGATACCCTCGACTTCTCAGGCTTCACCCAGAACCAGAAGATCAACCTCAATGCCGCCTCGTTC
TCGGATGTCGGTGGCATGGTGGGCAACGTTTCGATCGCCAAGGGTGTGGTGGTTGAAAACGCGCTGGGCGGTTCGGGCAA
TGACCTGTTGATCGGCAATGCTGCCGCCAACGACCTCAAGGGTGGTGCCGGCAACGACATCATCTACGGTGGTGGCGGCG
CCGACAGCCTGACCGGTGGTGCAGGTGCCGACATCTTCGTGTTTGGCGCCAGCTCTGATTCCAACCGTGCAGGCCAGGAT
ACGATTCGTGATTTCGTCAGCGGTCAGGACAAGATCGACGTGTCGGCCATTTCCACGCTGAGCGCGCTGCAGTTCGTCAA
CGCGTTCAGCGGCCACGCTGGCGAGGCGATCCTCAACTATAACCAGAGCAGCAATCTGGGCAGTCTGGCGATCGACTTCA
CCGGTCAGGGCATTGGCGATTTTCTGGTCGGTACTGTAGGTCAAGCATTGGCTACTGATATCGTGGTTTAA

Upstream 100 bases:

>100_bases
CGATTTCACGCTTCACCAGGCGAGTGACCGGACTCTCTCGCTACAGGGGAGAGTCTTGTCGTACCTGACCTGTCAATCAA
TCAGCAAACAAGGAAGTGTC

Downstream 100 bases:

>100_bases
TCTGTAACAATCATGGACGACCCTGCGGTTGTCCATGATCTGAAAAGTACCCCGCCATGAAGATCACTCACGTTTTTCGA
ATCGTGCCAGCAGCCTTTGC

Product: serralysin

Products: NA

Alternate protein names: AP [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MTKVKENAAIQLSAATSTSFDQINAFAHQYDRGGNLTINGKPSYSVDQAADYILRDDASWTDRDGNGTINLTYTFLTAKP
AGFDNSLGTFSAFNAQQKAQAVLSMQSWADVAKVSFTQAASGGDGHMTFGNYSNGSAGGAAFAYLPSGNSRTDGQSWYLV
DNSYKVNTTPDNGNYGRQTLTHEIGHTLGLSHPGDYNAGEGNPSYKDATYAEDTRGYSVMSYWSESNTDQNFVKGGAPSY
SSAPLLDDITAVQQLYGANMSTRAGDTVYGFNSTAGRDFYSATSASSKVVFSVWDGGGKDTLDFSGFTQNQKINLNAASF
SDVGGMVGNVSIAKGVVVENALGGSGNDLLIGNAAANDLKGGAGNDIIYGGGGADSLTGGAGADIFVFGASSDSNRAGQD
TIRDFVSGQDKIDVSAISTLSALQFVNAFSGHAGEAILNYNQSSNLGSLAIDFTGQGIGDFLVGTVGQALATDIVV

Sequences:

>Translated_476_residues
MTKVKENAAIQLSAATSTSFDQINAFAHQYDRGGNLTINGKPSYSVDQAADYILRDDASWTDRDGNGTINLTYTFLTAKP
AGFDNSLGTFSAFNAQQKAQAVLSMQSWADVAKVSFTQAASGGDGHMTFGNYSNGSAGGAAFAYLPSGNSRTDGQSWYLV
DNSYKVNTTPDNGNYGRQTLTHEIGHTLGLSHPGDYNAGEGNPSYKDATYAEDTRGYSVMSYWSESNTDQNFVKGGAPSY
SSAPLLDDITAVQQLYGANMSTRAGDTVYGFNSTAGRDFYSATSASSKVVFSVWDGGGKDTLDFSGFTQNQKINLNAASF
SDVGGMVGNVSIAKGVVVENALGGSGNDLLIGNAAANDLKGGAGNDIIYGGGGADSLTGGAGADIFVFGASSDSNRAGQD
TIRDFVSGQDKIDVSAISTLSALQFVNAFSGHAGEAILNYNQSSNLGSLAIDFTGQGIGDFLVGTVGQALATDIVV
>Mature_475_residues
TKVKENAAIQLSAATSTSFDQINAFAHQYDRGGNLTINGKPSYSVDQAADYILRDDASWTDRDGNGTINLTYTFLTAKPA
GFDNSLGTFSAFNAQQKAQAVLSMQSWADVAKVSFTQAASGGDGHMTFGNYSNGSAGGAAFAYLPSGNSRTDGQSWYLVD
NSYKVNTTPDNGNYGRQTLTHEIGHTLGLSHPGDYNAGEGNPSYKDATYAEDTRGYSVMSYWSESNTDQNFVKGGAPSYS
SAPLLDDITAVQQLYGANMSTRAGDTVYGFNSTAGRDFYSATSASSKVVFSVWDGGGKDTLDFSGFTQNQKINLNAASFS
DVGGMVGNVSIAKGVVVENALGGSGNDLLIGNAAANDLKGGAGNDIIYGGGGADSLTGGAGADIFVFGASSDSNRAGQDT
IRDFVSGQDKIDVSAISTLSALQFVNAFSGHAGEAILNYNQSSNLGSLAIDFTGQGIGDFLVGTVGQALATDIVV

Specific function: Unknown

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR016294
- InterPro:   IPR013858
- InterPro:   IPR006026
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF08548 Peptidase_M10_C [H]

EC number: NA

Molecular weight: Translated: 49377; Mature: 49246

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: PS00142 ZINC_PROTEASE ; PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVKENAAIQLSAATSTSFDQINAFAHQYDRGGNLTINGKPSYSVDQAADYILRDDASW
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHEEECCCCC
TDRDGNGTINLTYTFLTAKPAGFDNSLGTFSAFNAQQKAQAVLSMQSWADVAKVSFTQAA
CCCCCCCEEEEEEEEEEECCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
SGGDGHMTFGNYSNGSAGGAAFAYLPSGNSRTDGQSWYLVDNSYKVNTTPDNGNYGRQTL
CCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCEEEECCCCCCCCCHHHH
THEIGHTLGLSHPGDYNAGEGNPSYKDATYAEDTRGYSVMSYWSESNTDQNFVKGGAPSY
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHCCCCCCC
SSAPLLDDITAVQQLYGANMSTRAGDTVYGFNSTAGRDFYSATSASSKVVFSVWDGGGKD
CCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHCCCCCEEEEEEECCCCCC
TLDFSGFTQNQKINLNAASFSDVGGMVGNVSIAKGVVVENALGGSGNDLLIGNAAANDLK
CEECCCCCCCCEEEEECCCCHHHCCCCCCEEHHCCEEEECCCCCCCCEEEEECCCCCCCC
GGAGNDIIYGGGGADSLTGGAGADIFVFGASSDSNRAGQDTIRDFVSGQDKIDVSAISTL
CCCCCCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCEEHHHHHHH
SALQFVNAFSGHAGEAILNYNQSSNLGSLAIDFTGQGIGDFLVGTVGQALATDIVV
HHHHHHHHHCCCCCCEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKVKENAAIQLSAATSTSFDQINAFAHQYDRGGNLTINGKPSYSVDQAADYILRDDASW
CCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHEEECCCCC
TDRDGNGTINLTYTFLTAKPAGFDNSLGTFSAFNAQQKAQAVLSMQSWADVAKVSFTQAA
CCCCCCCEEEEEEEEEEECCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
SGGDGHMTFGNYSNGSAGGAAFAYLPSGNSRTDGQSWYLVDNSYKVNTTPDNGNYGRQTL
CCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCEEEECCCCCCCCCHHHH
THEIGHTLGLSHPGDYNAGEGNPSYKDATYAEDTRGYSVMSYWSESNTDQNFVKGGAPSY
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHCCCCCCC
SSAPLLDDITAVQQLYGANMSTRAGDTVYGFNSTAGRDFYSATSASSKVVFSVWDGGGKD
CCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHCCCCCEEEEEEECCCCCC
TLDFSGFTQNQKINLNAASFSDVGGMVGNVSIAKGVVVENALGGSGNDLLIGNAAANDLK
CEECCCCCCCCEEEEECCCCHHHCCCCCCEEHHCCEEEECCCCCCCCEEEEECCCCCCCC
GGAGNDIIYGGGGADSLTGGAGADIFVFGASSDSNRAGQDTIRDFVSGQDKIDVSAISTL
CCCCCCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCEEHHHHHHH
SALQFVNAFSGHAGEAILNYNQSSNLGSLAIDFTGQGIGDFLVGTVGQALATDIVV
HHHHHHHHHCCCCCCEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1427098; 2123832; 10984043; 8253063; 8690704 [H]