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The map label for this gene is gyaR [H]

Identifier: 66046351

GI number: 66046351

Start: 3742857

End: 3743813

Strand: Direct

Name: gyaR [H]

Synonym: Psyr_3122

Alternate gene names: 66046351

Gene position: 3742857-3743813 (Clockwise)

Preceding gene: 66046350

Following gene: 66046352

Centisome position: 61.42

GC content: 60.92

Gene sequence:

>957_bases
ATGACCCCATTGAAAATCGCGGTACTCGATGACTGGCAAAACGTCGCCAGCACTGTAGTGGACTGGTCCGTGCTCGGCTC
AATGGGCGAGATCAGTTTTCTGCATGACTACCCTGCCGATACATCGACCATGGCGCGGCGCCTGCGAGACTTCGACATCA
TTTGCGTGATGCGCGAGCGAACCCTGTTCGATGCGACATTGCTCAGCCAGCTGCCGGCGCTGAAACTGCTGGTCACCGGC
GGCATGCGCAATGCGGCGATTGATACCGCTGCGGCCAAGCGTCAGGGCATTGTCGTGTGTGGAACAGAAAGCTATAAGCA
TGCGGCACCGGAGCTGACCTGGGCGCTGATCATGGGCATCACCCGCAACCTGGTGGCCGAGGCCAACGCGTTGCGTGCCG
GCAATTGGCAGGTCGGGCTGGGCAGCGATCTGCATGGCAAAACCCTGGGCATTCTCGGCCTGGGCAGTATCGGTAAGTGG
ATCGCCCGCTACGGGCAGGCATTCGGCATGAAGGTCATTGCCTGGAGCCAGAACCTGACGCCAGAGGCTGCTGCCGAGTC
CGGCGTCACCTATGTCAGCAAACAGCAACTGTTCGAACAGGCCGATGTGCTGTCGGTACACCTGGTGCTCAGCGATCGCA
GCCGTGGCCTGGTGGACGCAGAAGCACTGAACTGGATGAAGCCCGGCGCTTATCTGATCAATTCGTCACGCGGCCCGATC
ATCGATCAGGCCGCGCTGATCGAAACACTGCAGCAGCGCAGAATCTCCGGCGCAGCGCTGGACGTCTTCGACATCGAACC
GCTGCCGGCCGACCACCCGTTCCGTACCCTGGACAACGTGCTGGCGACCCCGCACATCGGGTACGTCACCGAGAACAACT
ACCGGACTTTCTACGGGCAGATGATCGAAGACATCCAGGCGTGGCATGCGGGGTCGCCCATTCGGGTGTTTGACTGA

Upstream 100 bases:

>100_bases
GTTCAACACCGCGATTCTGGGCTTTTCGATCAATATCGCCGCCAGCCTGTTCAATTAGCGTTTGCCTTGAAAAACAATCC
CATCAAGAGGCCTTCAGACA

Downstream 100 bases:

>100_bases
CGGGCCCTGCAACATCAGCCTGTAACCTATGGATGCCACGCTGCTCCTGGGCGTTGCGTATCAGCCGCTTTAAAGCCTGA
TCAAGGGCCGCGCTGTCGGC

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MTPLKIAVLDDWQNVASTVVDWSVLGSMGEISFLHDYPADTSTMARRLRDFDIICVMRERTLFDATLLSQLPALKLLVTG
GMRNAAIDTAAAKRQGIVVCGTESYKHAAPELTWALIMGITRNLVAEANALRAGNWQVGLGSDLHGKTLGILGLGSIGKW
IARYGQAFGMKVIAWSQNLTPEAAAESGVTYVSKQQLFEQADVLSVHLVLSDRSRGLVDAEALNWMKPGAYLINSSRGPI
IDQAALIETLQQRRISGAALDVFDIEPLPADHPFRTLDNVLATPHIGYVTENNYRTFYGQMIEDIQAWHAGSPIRVFD

Sequences:

>Translated_318_residues
MTPLKIAVLDDWQNVASTVVDWSVLGSMGEISFLHDYPADTSTMARRLRDFDIICVMRERTLFDATLLSQLPALKLLVTG
GMRNAAIDTAAAKRQGIVVCGTESYKHAAPELTWALIMGITRNLVAEANALRAGNWQVGLGSDLHGKTLGILGLGSIGKW
IARYGQAFGMKVIAWSQNLTPEAAAESGVTYVSKQQLFEQADVLSVHLVLSDRSRGLVDAEALNWMKPGAYLINSSRGPI
IDQAALIETLQQRRISGAALDVFDIEPLPADHPFRTLDNVLATPHIGYVTENNYRTFYGQMIEDIQAWHAGSPIRVFD
>Mature_317_residues
TPLKIAVLDDWQNVASTVVDWSVLGSMGEISFLHDYPADTSTMARRLRDFDIICVMRERTLFDATLLSQLPALKLLVTGG
MRNAAIDTAAAKRQGIVVCGTESYKHAAPELTWALIMGITRNLVAEANALRAGNWQVGLGSDLHGKTLGILGLGSIGKWI
ARYGQAFGMKVIAWSQNLTPEAAAESGVTYVSKQQLFEQADVLSVHLVLSDRSRGLVDAEALNWMKPGAYLINSSRGPII
DQAALIETLQQRRISGAALDVFDIEPLPADHPFRTLDNVLATPHIGYVTENNYRTFYGQMIEDIQAWHAGSPIRVFD

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=239, Percent_Identity=34.3096234309623, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI6912396, Length=241, Percent_Identity=32.3651452282158, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI145580578, Length=236, Percent_Identity=31.7796610169492, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI4557499, Length=236, Percent_Identity=31.7796610169492, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI4557497, Length=237, Percent_Identity=30.379746835443, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI61743967, Length=237, Percent_Identity=30.379746835443, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI145580575, Length=237, Percent_Identity=31.6455696202532, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI87082289, Length=244, Percent_Identity=33.6065573770492, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1789279, Length=267, Percent_Identity=31.8352059925094, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787645, Length=231, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI87081824, Length=143, Percent_Identity=30.0699300699301, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=272, Percent_Identity=33.8235294117647, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=237, Percent_Identity=27.8481012658228, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=234, Percent_Identity=30.7692307692308, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324964, Length=274, Percent_Identity=29.1970802919708, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=263, Percent_Identity=26.9961977186312, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322116, Length=294, Percent_Identity=25.5102040816327, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324980, Length=160, Percent_Identity=30, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921140, Length=276, Percent_Identity=30.7971014492754, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24646446, Length=236, Percent_Identity=31.7796610169492, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24646448, Length=236, Percent_Identity=31.7796610169492, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24646452, Length=236, Percent_Identity=31.7796610169492, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24646450, Length=236, Percent_Identity=31.7796610169492, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI62472511, Length=236, Percent_Identity=31.7796610169492, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574286, Length=242, Percent_Identity=30.9917355371901, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28571528, Length=223, Percent_Identity=33.1838565022422, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI45552429, Length=299, Percent_Identity=26.4214046822742, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24585514, Length=293, Percent_Identity=26.6211604095563, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI28574282, Length=293, Percent_Identity=26.6211604095563, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI45551003, Length=293, Percent_Identity=26.6211604095563, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28574284, Length=293, Percent_Identity=26.6211604095563, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585516, Length=210, Percent_Identity=27.1428571428571, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34836; Mature: 34705

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLKIAVLDDWQNVASTVVDWSVLGSMGEISFLHDYPADTSTMARRLRDFDIICVMRER
CCCEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCEEEEEEECC
TLFDATLLSQLPALKLLVTGGMRNAAIDTAAAKRQGIVVCGTESYKHAAPELTWALIMGI
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCEEEECCCCHHHCCCHHHHHHHHHH
TRNLVAEANALRAGNWQVGLGSDLHGKTLGILGLGSIGKWIARYGQAFGMKVIAWSQNLT
HHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCC
PEAAAESGVTYVSKQQLFEQADVLSVHLVLSDRSRGLVDAEALNWMKPGAYLINSSRGPI
HHHHHHCCCHHHHHHHHHHHHCEEEEEEEEECCCCCCCCHHHHHCCCCCEEEEECCCCCC
IDQAALIETLQQRRISGAALDVFDIEPLPADHPFRTLDNVLATPHIGYVTENNYRTFYGQ
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCEEECCCCHHHHHH
MIEDIQAWHAGSPIRVFD
HHHHHHHHCCCCCEEECC
>Mature Secondary Structure 
TPLKIAVLDDWQNVASTVVDWSVLGSMGEISFLHDYPADTSTMARRLRDFDIICVMRER
CCEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCEEEEEEECC
TLFDATLLSQLPALKLLVTGGMRNAAIDTAAAKRQGIVVCGTESYKHAAPELTWALIMGI
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCEEEECCCCHHHCCCHHHHHHHHHH
TRNLVAEANALRAGNWQVGLGSDLHGKTLGILGLGSIGKWIARYGQAFGMKVIAWSQNLT
HHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCC
PEAAAESGVTYVSKQQLFEQADVLSVHLVLSDRSRGLVDAEALNWMKPGAYLINSSRGPI
HHHHHHCCCHHHHHHHHHHHHCEEEEEEEEECCCCCCCCHHHHHCCCCCEEEEECCCCCC
IDQAALIETLQQRRISGAALDVFDIEPLPADHPFRTLDNVLATPHIGYVTENNYRTFYGQ
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCEEECCCCHHHHHH
MIEDIQAWHAGSPIRVFD
HHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]