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The map label for this gene is cobW [H]

Identifier: 66046247

GI number: 66046247

Start: 3612306

End: 3613370

Strand: Reverse

Name: cobW [H]

Synonym: Psyr_3016

Alternate gene names: 66046247

Gene position: 3613370-3612306 (Counterclockwise)

Preceding gene: 66046252

Following gene: 66046246

Centisome position: 59.3

GC content: 61.97

Gene sequence:

>1065_bases
ATGAAAACACTGGCCAAGCTTCCCGTCACCATCGTCACCGGCTTCCTCGGCTCGGGCAAGACCACCCTGTTGCGGCACAT
GCTCGACAACGCCGAAGGGCGGCGCATTGCGGTCATCGTCAATGAGTTCGGCGAGCTGGGCATCGACGGAGAAATCCTCA
AGCAGTGCACGATCGGCTGCACCGAAGAAGAAGCCAACGGCCGGGTGTACGAACTGGCCAATGGCTGCCTGTGCTGCACC
GTGCAGGAAGAGTTCTTCCCGGTGATGCGCGAACTGGTCGCGCGCCGTGGTGACCTGGACCATATCCTGATCGAAACCTC
GGGGCTGGCGCTGCCCAAGCCGCTGGTCCAGGCTTTTCAGTGGCCGGAAATCCGCAACGCCTGCACGGTCGATGCGGTGA
TCACGGTGGTCGACAGCCCGGCGGTACTGGCCGGTACCTTCGCTGCCTTCCCGGATCAGGTCGATGCGCAGCGCAAACTC
GATCCCAACCTGGACCACGAGTCGCCCCTGCACGAACTGTTTGCCGATCAACTGGCCAGCGCCGATCTGGTGATCCTCAA
CAAGGCCGACATGATCGACGCCGAAGGTCTGGCGACGGTGCGTGCCGAAGTTGCCGAGGAGCTGCCGCCTGCGGTCAAGG
TGATCGAAGCCAGCAGCGGTCGCCTGCCGATCAGCGTGCTGCTGGGTGTTGGTGCCGAGTCCGAGCTGCACATCGACGCT
CGCAAGACCCACCATGATCACCACGACGATGACGATCATGATGACCACGATCACGACGCGTTCGATTCGATTTCCCTGAA
GCTGCCGCAAGCCGATGAAAAAGTCCTGCTCGATGCACTGAATCAACTGGTGGTGCAACACGGCATTCTGCGTGTGAAGG
GCTTCGCGGCCATTCCCGGCAAGCCGATGCGCCTGCTGATTCAAGGTGTCGGCACGCGTTTCGACAAGCACTTCGACCGC
GCCTGGCGTGCCGATGAAGAGCGTGCCACGCACCTGGTGCTGATTGGTCAGGAGCTGGATGCCGCAGCCCTGCAAGCGCA
ACTCAATGCTGCGATTGCCGGCTGA

Upstream 100 bases:

>100_bases
CTCACTACAACCGGGCGGGGTGATCCGGTGGCGATCCGATCTGCGTGTCATGCATGCGGTTCTCGTCCTGTTTGCCCGCC
GCATTGCCAAAGGGCACCTG

Downstream 100 bases:

>100_bases
CCCATGCATTTACTGAGAACCCAGCCCGGCGGTTTCGTACCTGACGACAATATTGCCGATCTGGGCCAGACGCCGGCCGA
GCTGGTGATTCTCTGCAGCG

Product: cobalamin synthesis protein/P47K:cobalamin synthesis protein/P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MKTLAKLPVTIVTGFLGSGKTTLLRHMLDNAEGRRIAVIVNEFGELGIDGEILKQCTIGCTEEEANGRVYELANGCLCCT
VQEEFFPVMRELVARRGDLDHILIETSGLALPKPLVQAFQWPEIRNACTVDAVITVVDSPAVLAGTFAAFPDQVDAQRKL
DPNLDHESPLHELFADQLASADLVILNKADMIDAEGLATVRAEVAEELPPAVKVIEASSGRLPISVLLGVGAESELHIDA
RKTHHDHHDDDDHDDHDHDAFDSISLKLPQADEKVLLDALNQLVVQHGILRVKGFAAIPGKPMRLLIQGVGTRFDKHFDR
AWRADEERATHLVLIGQELDAAALQAQLNAAIAG

Sequences:

>Translated_354_residues
MKTLAKLPVTIVTGFLGSGKTTLLRHMLDNAEGRRIAVIVNEFGELGIDGEILKQCTIGCTEEEANGRVYELANGCLCCT
VQEEFFPVMRELVARRGDLDHILIETSGLALPKPLVQAFQWPEIRNACTVDAVITVVDSPAVLAGTFAAFPDQVDAQRKL
DPNLDHESPLHELFADQLASADLVILNKADMIDAEGLATVRAEVAEELPPAVKVIEASSGRLPISVLLGVGAESELHIDA
RKTHHDHHDDDDHDDHDHDAFDSISLKLPQADEKVLLDALNQLVVQHGILRVKGFAAIPGKPMRLLIQGVGTRFDKHFDR
AWRADEERATHLVLIGQELDAAALQAQLNAAIAG
>Mature_354_residues
MKTLAKLPVTIVTGFLGSGKTTLLRHMLDNAEGRRIAVIVNEFGELGIDGEILKQCTIGCTEEEANGRVYELANGCLCCT
VQEEFFPVMRELVARRGDLDHILIETSGLALPKPLVQAFQWPEIRNACTVDAVITVVDSPAVLAGTFAAFPDQVDAQRKL
DPNLDHESPLHELFADQLASADLVILNKADMIDAEGLATVRAEVAEELPPAVKVIEASSGRLPISVLLGVGAESELHIDA
RKTHHDHHDDDDHDDHDHDAFDSISLKLPQADEKVLLDALNQLVVQHGILRVKGFAAIPGKPMRLLIQGVGTRFDKHFDR
AWRADEERATHLVLIGQELDAAALQAQLNAAIAG

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=375, Percent_Identity=29.0666666666667, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI126722884, Length=373, Percent_Identity=28.9544235924933, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI148727351, Length=375, Percent_Identity=28.8, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI223941779, Length=363, Percent_Identity=28.6501377410468, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI146231952, Length=375, Percent_Identity=28.8, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI223941776, Length=361, Percent_Identity=27.4238227146814, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI119120938, Length=150, Percent_Identity=40, Blast_Score=105, Evalue=9e-23,
Organism=Escherichia coli, GI87082430, Length=364, Percent_Identity=28.8461538461538, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788499, Length=188, Percent_Identity=32.9787234042553, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324356, Length=372, Percent_Identity=27.4193548387097, Blast_Score=105, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 38521; Mature: 38521

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLAKLPVTIVTGFLGSGKTTLLRHMLDNAEGRRIAVIVNEFGELGIDGEILKQCTIGC
CCCHHHCCHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEEECHHCCCCCHHHHHHHHCCC
TEEEANGRVYELANGCLCCTVQEEFFPVMRELVARRGDLDHILIETSGLALPKPLVQAFQ
CCCCCCCCEEEECCCEEEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHC
WPEIRNACTVDAVITVVDSPAVLAGTFAAFPDQVDAQRKLDPNLDHESPLHELFADQLAS
CCHHCCCHHHHHEEEEECCCHHHHHHHHHCCCCCCHHHCCCCCCCCCCHHHHHHHHHHCC
ADLVILNKADMIDAEGLATVRAEVAEELPPAVKVIEASSGRLPISVLLGVGAESELHIDA
CCEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEH
RKTHHDHHDDDDHDDHDHDAFDSISLKLPQADEKVLLDALNQLVVQHGILRVKGFAAIPG
HHCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCEEEECEECCCC
KPMRLLIQGVGTRFDKHFDRAWRADEERATHLVLIGQELDAAALQAQLNAAIAG
CHHHHHHHHHHHHHHHHHHHHHCCCHHCCEEEEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTLAKLPVTIVTGFLGSGKTTLLRHMLDNAEGRRIAVIVNEFGELGIDGEILKQCTIGC
CCCHHHCCHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEEECHHCCCCCHHHHHHHHCCC
TEEEANGRVYELANGCLCCTVQEEFFPVMRELVARRGDLDHILIETSGLALPKPLVQAFQ
CCCCCCCCEEEECCCEEEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHC
WPEIRNACTVDAVITVVDSPAVLAGTFAAFPDQVDAQRKLDPNLDHESPLHELFADQLAS
CCHHCCCHHHHHEEEEECCCHHHHHHHHHCCCCCCHHHCCCCCCCCCCHHHHHHHHHHCC
ADLVILNKADMIDAEGLATVRAEVAEELPPAVKVIEASSGRLPISVLLGVGAESELHIDA
CCEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEH
RKTHHDHHDDDDHDDHDHDAFDSISLKLPQADEKVLLDALNQLVVQHGILRVKGFAAIPG
HHCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCEEEECEECCCC
KPMRLLIQGVGTRFDKHFDRAWRADEERATHLVLIGQELDAAALQAQLNAAIAG
CHHHHHHHHHHHHHHHHHHHHHCCCHHCCEEEEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]