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The map label for this gene is qacF [H]

Identifier: 66045782

GI number: 66045782

Start: 2961089

End: 2961448

Strand: Reverse

Name: qacF [H]

Synonym: Psyr_2546

Alternate gene names: 66045782

Gene position: 2961448-2961089 (Counterclockwise)

Preceding gene: 66045783

Following gene: 66045770

Centisome position: 48.6

GC content: 53.33

Gene sequence:

>360_bases
ATGCCTGAAAAGCGATCTGCCATCATGGTCATAAAAGCTTATTTGTTCCTGCTTGCAGGTATCGTCGCTGAAACAGTAGC
GACCATTGCGCTCAAAGAAAGCAATGGCTTCACCCGCTGGGTTCCGGTCATTGCCTCGATAGCAGGCTATGGCCTTGGGA
TTGTGTGTCTGGGGTATGCACAACGGGACTTGCCCATGTCACTGATCACGTCCATGTGGTCAGGCCTGGGCATTACCCTG
ATCACCGTCATTGCAGCGTTTCGTTATCAGCAGGTGCCCACTTTGATGGCCATTGGCGGTATCAGCCTGATCATCGCGGG
CATCATCCTGGTCAATCTTGCCAAGGAGCAGGCGACCTGA

Upstream 100 bases:

>100_bases
CGACTGGCTGGAGTTTCAATCGACCGGCGCTTACTCGGTGTCCTTGCGCACCCCGTTCAACGGGTTTTACGCCGACCGCA
TCATCTCTCTCCCTTCCTGA

Downstream 100 bases:

>100_bases
CAGCCTGCGCTGTCAGGGTCATCCCCGTTCAGGCGAAGTCAAAAGGTCCTTCGAAGCGGCCTATCGGCACCCAATGGGTG
ATCAGGCCCGTGTCGGCTTT

Product: DMT superfamily multiple drug (quaternary ammonium compounds) efflux pump

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant F [H]

Number of amino acids: Translated: 119; Mature: 118

Protein sequence:

>119_residues
MPEKRSAIMVIKAYLFLLAGIVAETVATIALKESNGFTRWVPVIASIAGYGLGIVCLGYAQRDLPMSLITSMWSGLGITL
ITVIAAFRYQQVPTLMAIGGISLIIAGIILVNLAKEQAT

Sequences:

>Translated_119_residues
MPEKRSAIMVIKAYLFLLAGIVAETVATIALKESNGFTRWVPVIASIAGYGLGIVCLGYAQRDLPMSLITSMWSGLGITL
ITVIAAFRYQQVPTLMAIGGISLIIAGIILVNLAKEQAT
>Mature_118_residues
PEKRSAIMVIKAYLFLLAGIVAETVATIALKESNGFTRWVPVIASIAGYGLGIVCLGYAQRDLPMSLITSMWSGLGITLI
TVIAAFRYQQVPTLMAIGGISLIIAGIILVNLAKEQAT

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 12654; Mature: 12523

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEKRSAIMVIKAYLFLLAGIVAETVATIALKESNGFTRWVPVIASIAGYGLGIVCLGYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
QRDLPMSLITSMWSGLGITLITVIAAFRYQQVPTLMAIGGISLIIAGIILVNLAKEQAT
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PEKRSAIMVIKAYLFLLAGIVAETVATIALKESNGFTRWVPVIASIAGYGLGIVCLGYA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
QRDLPMSLITSMWSGLGITLITVIAAFRYQQVPTLMAIGGISLIIAGIILVNLAKEQAT
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9756755 [H]