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The map label for this gene is helD [H]

Identifier: 66045747

GI number: 66045747

Start: 2919741

End: 2922134

Strand: Direct

Name: helD [H]

Synonym: Psyr_2511

Alternate gene names: 66045747

Gene position: 2919741-2922134 (Clockwise)

Preceding gene: 66045746

Following gene: 66045749

Centisome position: 47.91

GC content: 60.07

Gene sequence:

>2394_bases
ATGGGGCGCGGCCTTACCGGGCTGCGCTCGCAGCACGCGCCCTCATGGTCGCAGGGGCATGCCGACGGTTATCTGAACGG
CCACATCGAAGGCGTGCGTGAAGGCTATGAAGAGGGTTATCTGGATGGCCAGGAGTCGGGCCGTCAGGTGCTGGTCATCA
GCGATACCCGGCCAGCCCGGCATCGTGGCCCCAAGGTCGACGATCATCTGTTCGATGACTGGCGACTGGCGCTCACACCT
GAACTGAAAAAGCGCATCAAGGCCGATGTCGCCGAAAAACTCCCCGCACATGCCCAGCCCAGCGCAGCGCAGTGGAAGAT
GATCTTCAGCGATACGCCGTCTACCTATGTGATTGCCGGGGCCGGCGCAGGCAAATCCACGTCGCTGGTCCTGCGGATTC
TGTTGCTGCATCACTACCTGGGCTTCGAACTGAACGCCATGACGGTGGTGACCTTCACCCGTGAGTCGCGCAAGGACTTC
ATCAGCAAACTGATCGATGTCATGGCCCTGTGGGGGCATGCGCTGGAGCAAAAGCAGGCGCGCGAGGTGGTACGTACCTT
CCATTCGCGCATTCTGCCGCTGGTGCGCAGCCTGCCGGGGTTTGAGCAGCTGCGCGCGTTCGAGAACCTGAGCAGTCAGT
CTTCCGGCCTGGAAGAGGCGGACAGCAACCCCTTCGACTTGCGGATCAACGATGCGCAGCGCCAGCAACTCAATCTCTGC
TACCGCGATCTGTACGCCGGCAACGAGCGTTTTCGCGAAGTCATGGCGCCGCTGTATCGCCATGCCCTGCAGCTCAAGGA
ACTGGACCGCGATCACCCTGATGTGCAGAAACGGGTCGCCGTGACCGAGCTGTCCTCGAAACGCGATGAGGAGTGGTGCG
ACACCGTTGAAGATCTATGGATTCGCGCGGGAGCCTGGCCTATAAAAGGCATTGAGCCCATGCGCCAAGCTGTTGAAATA
AATGGTTTTCCGTTTTCTTTTCACGGCTATATCGCCGAGCTGGATGCCTGGGTCGTGCTGGGTCTGGACGCCAGTGAGGA
CCAGCAACTCAAGCGGCCGGGCGCCAAGCTGCCGGTGTGGGCAGAGGGCGTGATAAAGCGCACGCTGTTTCAAGCTTTCT
GCAGTAAGCCATTGATATGGTTGGATAACTACCAGTCGGCCAATGAGGTTTTGCAATCGCTGGCAGGGGAAGCCGCCGCG
GGGCCTGGATTCGATTACCGGGTCAAGGGCGAACTCGGTGCGGCACCCTTGCTGGACTGCTTCGTCACGGCCGCCAGCTT
CATCGAGAACCTGGGGCTGGATGTGCCGAGCGCCGTGTCCGAGATGAGTTTTGCCAGCGATGACCCGGACCGCTTCTTCT
TCGAAGCACTCAGCCTGTTCTGGAAAGCCTTTGAAACGCACCTGCTGGCTCAATCGCCGCCGATCATGACCTACAACCGC
ATGTTTGCCTTGTTCGGCGAGACCTCACCCGAGAACCTCAAGCACGTCAGTGACCCGATGCTCAGACCCTTGGCGCATTT
GATGATCGACGAGTTCCAGGACGTCTCGCCGCAGATCGTGTCATGGTTACGCGCCAGCCTGCGCGAAATCAGGCGCCGTG
GTCCGGCGTTGCACACGGGGCGCATCGCTCAGCATTCATCGCTGCTGTGTGTCGGTGACGATTGGCAATCGATCTACGGC
TGGCGCGGCAGCTCGCCGAAGTACTTCATGGAGTTCGCAAAGGAGTTTTCCTCCCCGGCGACCACCAGGGTCATGCTCAG
TGACAACTTCCGCAGTCATCAGCACATCATCGACGCCGCCGAGCACATCGTCCGTGCGGCCCCGGCCATCCCGGGCAAGA
AGGCCCGCGCCAGTGGCCTGCTTCAGGAACTGCTGCCGGTCAAGGTACTGGATCGCGATGAGGACGAGCTTGCCGAGCGG
GTCGCCGAGCATTATCACGATGGCGACTCGATCCTGCTGCTGTACCGCAAGGGCAGCGAGAAGGCGCGCTTCTCGGCGCG
CCTGCAGGCATTGATCGACGCCGATTCGGCAAATGGCGCGCAGAACCGTCGCATCAGAACGCTGACCTACCACAGCTCCA
AGGGCTTGCAGGCGGATGCCGTATTTTTGCTGGGCGATTGTCAGCATCTGACCGTCTCGCCCTACAAGAATCAGGTTTAC
CGCTTGGCAGGGCTGGGTGATACGAATGATCTTCAGCCATTCGATACGGCACAGAAGGATGAAGTCTTGCGTCTGGCCTA
TGTCGCCATTACTCGTTCGGCGCGGCACTGTTATTGGTATATCGATGAAAGCGCCACTTCAGGAGACGCTGTTCAGATGC
CCAAAGCGTCAGACAGGATTGCCCGCGACAAGCCTTTCTTCGAAGACCTGCGTAACAGGGTTCGTGCCGGCTGA

Upstream 100 bases:

>100_bases
CGTGCCTGACGACCTGCCTTCTGCGCTTCCTCATGACCTGGATGTCGACCTTGTACCGCCCCGGCAATTGCCGTTTTTCC
GACGCCTGTTGGCGCGGCTG

Downstream 100 bases:

>100_bases
GGCATTCATGTCAGATAAAACCGGCGATCTGTCGTTGCGTATGAGTGCCGAATAATTCCAGCTCATCCTCGATGGCTTCG
ATGATGCGCTCCACGTCTGC

Product: UvrD/REP helicase

Products: NA

Alternate protein names: 75 kDa helicase [H]

Number of amino acids: Translated: 797; Mature: 796

Protein sequence:

>797_residues
MGRGLTGLRSQHAPSWSQGHADGYLNGHIEGVREGYEEGYLDGQESGRQVLVISDTRPARHRGPKVDDHLFDDWRLALTP
ELKKRIKADVAEKLPAHAQPSAAQWKMIFSDTPSTYVIAGAGAGKSTSLVLRILLLHHYLGFELNAMTVVTFTRESRKDF
ISKLIDVMALWGHALEQKQAREVVRTFHSRILPLVRSLPGFEQLRAFENLSSQSSGLEEADSNPFDLRINDAQRQQLNLC
YRDLYAGNERFREVMAPLYRHALQLKELDRDHPDVQKRVAVTELSSKRDEEWCDTVEDLWIRAGAWPIKGIEPMRQAVEI
NGFPFSFHGYIAELDAWVVLGLDASEDQQLKRPGAKLPVWAEGVIKRTLFQAFCSKPLIWLDNYQSANEVLQSLAGEAAA
GPGFDYRVKGELGAAPLLDCFVTAASFIENLGLDVPSAVSEMSFASDDPDRFFFEALSLFWKAFETHLLAQSPPIMTYNR
MFALFGETSPENLKHVSDPMLRPLAHLMIDEFQDVSPQIVSWLRASLREIRRRGPALHTGRIAQHSSLLCVGDDWQSIYG
WRGSSPKYFMEFAKEFSSPATTRVMLSDNFRSHQHIIDAAEHIVRAAPAIPGKKARASGLLQELLPVKVLDRDEDELAER
VAEHYHDGDSILLLYRKGSEKARFSARLQALIDADSANGAQNRRIRTLTYHSSKGLQADAVFLLGDCQHLTVSPYKNQVY
RLAGLGDTNDLQPFDTAQKDEVLRLAYVAITRSARHCYWYIDESATSGDAVQMPKASDRIARDKPFFEDLRNRVRAG

Sequences:

>Translated_797_residues
MGRGLTGLRSQHAPSWSQGHADGYLNGHIEGVREGYEEGYLDGQESGRQVLVISDTRPARHRGPKVDDHLFDDWRLALTP
ELKKRIKADVAEKLPAHAQPSAAQWKMIFSDTPSTYVIAGAGAGKSTSLVLRILLLHHYLGFELNAMTVVTFTRESRKDF
ISKLIDVMALWGHALEQKQAREVVRTFHSRILPLVRSLPGFEQLRAFENLSSQSSGLEEADSNPFDLRINDAQRQQLNLC
YRDLYAGNERFREVMAPLYRHALQLKELDRDHPDVQKRVAVTELSSKRDEEWCDTVEDLWIRAGAWPIKGIEPMRQAVEI
NGFPFSFHGYIAELDAWVVLGLDASEDQQLKRPGAKLPVWAEGVIKRTLFQAFCSKPLIWLDNYQSANEVLQSLAGEAAA
GPGFDYRVKGELGAAPLLDCFVTAASFIENLGLDVPSAVSEMSFASDDPDRFFFEALSLFWKAFETHLLAQSPPIMTYNR
MFALFGETSPENLKHVSDPMLRPLAHLMIDEFQDVSPQIVSWLRASLREIRRRGPALHTGRIAQHSSLLCVGDDWQSIYG
WRGSSPKYFMEFAKEFSSPATTRVMLSDNFRSHQHIIDAAEHIVRAAPAIPGKKARASGLLQELLPVKVLDRDEDELAER
VAEHYHDGDSILLLYRKGSEKARFSARLQALIDADSANGAQNRRIRTLTYHSSKGLQADAVFLLGDCQHLTVSPYKNQVY
RLAGLGDTNDLQPFDTAQKDEVLRLAYVAITRSARHCYWYIDESATSGDAVQMPKASDRIARDKPFFEDLRNRVRAG
>Mature_796_residues
GRGLTGLRSQHAPSWSQGHADGYLNGHIEGVREGYEEGYLDGQESGRQVLVISDTRPARHRGPKVDDHLFDDWRLALTPE
LKKRIKADVAEKLPAHAQPSAAQWKMIFSDTPSTYVIAGAGAGKSTSLVLRILLLHHYLGFELNAMTVVTFTRESRKDFI
SKLIDVMALWGHALEQKQAREVVRTFHSRILPLVRSLPGFEQLRAFENLSSQSSGLEEADSNPFDLRINDAQRQQLNLCY
RDLYAGNERFREVMAPLYRHALQLKELDRDHPDVQKRVAVTELSSKRDEEWCDTVEDLWIRAGAWPIKGIEPMRQAVEIN
GFPFSFHGYIAELDAWVVLGLDASEDQQLKRPGAKLPVWAEGVIKRTLFQAFCSKPLIWLDNYQSANEVLQSLAGEAAAG
PGFDYRVKGELGAAPLLDCFVTAASFIENLGLDVPSAVSEMSFASDDPDRFFFEALSLFWKAFETHLLAQSPPIMTYNRM
FALFGETSPENLKHVSDPMLRPLAHLMIDEFQDVSPQIVSWLRASLREIRRRGPALHTGRIAQHSSLLCVGDDWQSIYGW
RGSSPKYFMEFAKEFSSPATTRVMLSDNFRSHQHIIDAAEHIVRAAPAIPGKKARASGLLQELLPVKVLDRDEDELAERV
AEHYHDGDSILLLYRKGSEKARFSARLQALIDADSANGAQNRRIRTLTYHSSKGLQADAVFLLGDCQHLTVSPYKNQVYR
LAGLGDTNDLQPFDTAQKDEVLRLAYVAITRSARHCYWYIDESATSGDAVQMPKASDRIARDKPFFEDLRNRVRAG

Specific function: Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase ATP-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787196, Length=287, Percent_Identity=27.1777003484321, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000212
- InterPro:   IPR014016
- InterPro:   IPR022161
- InterPro:   IPR003661 [H]

Pfam domain/function: PF12462 Nucleolin_N; PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 89755; Mature: 89623

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRGLTGLRSQHAPSWSQGHADGYLNGHIEGVREGYEEGYLDGQESGRQVLVISDTRPAR
CCCCCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHH
HRGPKVDDHLFDDWRLALTPELKKRIKADVAEKLPAHAQPSAAQWKMIFSDTPSTYVIAG
HCCCCCCCHHCCCCCEEECHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEECCCCEEEEEE
AGAGKSTSLVLRILLLHHYLGFELNAMTVVTFTRESRKDFISKLIDVMALWGHALEQKQA
CCCCCHHHHHHHHHHHHHHHCCEECEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
REVVRTFHSRILPLVRSLPGFEQLRAFENLSSQSSGLEEADSNPFDLRINDAQRQQLNLC
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHCCCCCCEEEECHHHHHHHHHH
YRDLYAGNERFREVMAPLYRHALQLKELDRDHPDVQKRVAVTELSSKRDEEWCDTVEDLW
HHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
IRAGAWPIKGIEPMRQAVEINGFPFSFHGYIAELDAWVVLGLDASEDQQLKRPGAKLPVW
HHCCCCCCCCHHHHHHHHCCCCCCEEHHHHHHHCCEEEEEECCCCCCHHHHCCCCCCCCH
AEGVIKRTLFQAFCSKPLIWLDNYQSANEVLQSLAGEAAAGPGFDYRVKGELGAAPLLDC
HHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCCCCCCCCEEECCCCCCHHHHHH
FVTAASFIENLGLDVPSAVSEMSFASDDPDRFFFEALSLFWKAFETHLLAQSPPIMTYNR
HHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
MFALFGETSPENLKHVSDPMLRPLAHLMIDEFQDVSPQIVSWLRASLREIRRRGPALHTG
HHHEECCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC
RIAQHSSLLCVGDDWQSIYGWRGSSPKYFMEFAKEFSSPATTRVMLSDNFRSHQHIIDAA
CCCCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHH
EHIVRAAPAIPGKKARASGLLQELLPVKVLDRDEDELAERVAEHYHDGDSILLLYRKGSE
HHHHHHCCCCCCCHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCC
KARFSARLQALIDADSANGAQNRRIRTLTYHSSKGLQADAVFLLGDCQHLTVSPYKNQVY
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEECCCCEEECCHHCCEE
RLAGLGDTNDLQPFDTAQKDEVLRLAYVAITRSARHCYWYIDESATSGDAVQMPKASDRI
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEECCCCHHHH
ARDKPFFEDLRNRVRAG
HCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
GRGLTGLRSQHAPSWSQGHADGYLNGHIEGVREGYEEGYLDGQESGRQVLVISDTRPAR
CCCCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHH
HRGPKVDDHLFDDWRLALTPELKKRIKADVAEKLPAHAQPSAAQWKMIFSDTPSTYVIAG
HCCCCCCCHHCCCCCEEECHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEECCCCEEEEEE
AGAGKSTSLVLRILLLHHYLGFELNAMTVVTFTRESRKDFISKLIDVMALWGHALEQKQA
CCCCCHHHHHHHHHHHHHHHCCEECEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
REVVRTFHSRILPLVRSLPGFEQLRAFENLSSQSSGLEEADSNPFDLRINDAQRQQLNLC
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHCCCCCCEEEECHHHHHHHHHH
YRDLYAGNERFREVMAPLYRHALQLKELDRDHPDVQKRVAVTELSSKRDEEWCDTVEDLW
HHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
IRAGAWPIKGIEPMRQAVEINGFPFSFHGYIAELDAWVVLGLDASEDQQLKRPGAKLPVW
HHCCCCCCCCHHHHHHHHCCCCCCEEHHHHHHHCCEEEEEECCCCCCHHHHCCCCCCCCH
AEGVIKRTLFQAFCSKPLIWLDNYQSANEVLQSLAGEAAAGPGFDYRVKGELGAAPLLDC
HHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCCCCCCCCEEECCCCCCHHHHHH
FVTAASFIENLGLDVPSAVSEMSFASDDPDRFFFEALSLFWKAFETHLLAQSPPIMTYNR
HHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
MFALFGETSPENLKHVSDPMLRPLAHLMIDEFQDVSPQIVSWLRASLREIRRRGPALHTG
HHHEECCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC
RIAQHSSLLCVGDDWQSIYGWRGSSPKYFMEFAKEFSSPATTRVMLSDNFRSHQHIIDAA
CCCCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHH
EHIVRAAPAIPGKKARASGLLQELLPVKVLDRDEDELAERVAEHYHDGDSILLLYRKGSE
HHHHHHCCCCCCCHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCC
KARFSARLQALIDADSANGAQNRRIRTLTYHSSKGLQADAVFLLGDCQHLTVSPYKNQVY
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEECCCCEEECCHHCCEE
RLAGLGDTNDLQPFDTAQKDEVLRLAYVAITRSARHCYWYIDESATSGDAVQMPKASDRI
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEECCCCHHHH
ARDKPFFEDLRNRVRAG
HCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2542273; 8905232; 9278503 [H]