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The map label for this gene is cueR [H]

Identifier: 66045708

GI number: 66045708

Start: 2866141

End: 2866533

Strand: Reverse

Name: cueR [H]

Synonym: Psyr_2472

Alternate gene names: 66045708

Gene position: 2866533-2866141 (Counterclockwise)

Preceding gene: 66045709

Following gene: 66045707

Centisome position: 47.04

GC content: 58.52

Gene sequence:

>393_bases
ATGAGCAGTCACACCTACAGCATTTCCGAGCTCGCCCGCGAGCTGGACATCACCACCCGCGCCATACGCTTTTACGAAGA
GCAAGGCATGCTCAGCCCTGAACGCAAGGGCCTGGAACGTATCTATACGGCCCGTGACAAAGTCACTCTGAAACTGATCC
TGCGAGGCAAGCGCATCGGTTTTTCCCTGGCCGAGTGCAAGGAACTGATCTCGTTGTACGACCCTGCCGGTGGCAATCAG
AAGCAGTTGCAGACCATGCTGGGCAAGATCGCCGAACGCCGTGATCAGCTGGAGCAGCAGTTGCTGGACATCCAGCAGAT
GCAACTGGAACTGGACACCGCCGAAGAGCGCTGCCGAGCCGCACTCGATAAAACCGCTGCCGCCCCACTCTGA

Upstream 100 bases:

>100_bases
GCGGGGTGCGACCGCTCAAGCTCTGGTATCGCCACTGCAGCTTGACGCATACGTAAAGCAGCCCTTAGCTTTGCGGTTGT
ATACCTCGCCGAGTCATGCC

Downstream 100 bases:

>100_bases
CCCCTTCGCACTGACTACAAAGGCGCCGCCATGTCCCTCCCGCAAAAGGTGAATCTCGTTGAAGTCGGCCCGCGTGACGG
TCTGCAGAATGAATCGCAAC

Product: regulatory protein, MerR

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 130; Mature: 129

Protein sequence:

>130_residues
MSSHTYSISELARELDITTRAIRFYEEQGMLSPERKGLERIYTARDKVTLKLILRGKRIGFSLAECKELISLYDPAGGNQ
KQLQTMLGKIAERRDQLEQQLLDIQQMQLELDTAEERCRAALDKTAAAPL

Sequences:

>Translated_130_residues
MSSHTYSISELARELDITTRAIRFYEEQGMLSPERKGLERIYTARDKVTLKLILRGKRIGFSLAECKELISLYDPAGGNQ
KQLQTMLGKIAERRDQLEQQLLDIQQMQLELDTAEERCRAALDKTAAAPL
>Mature_129_residues
SSHTYSISELARELDITTRAIRFYEEQGMLSPERKGLERIYTARDKVTLKLILRGKRIGFSLAECKELISLYDPAGGNQK
QLQTMLGKIAERRDQLEQQLLDIQQMQLELDTAEERCRAALDKTAAAPL

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=116, Percent_Identity=34.4827586206897, Blast_Score=60, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14842; Mature: 14711

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSHTYSISELARELDITTRAIRFYEEQGMLSPERKGLERIYTARDKVTLKLILRGKRIG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FSLAECKELISLYDPAGGNQKQLQTMLGKIAERRDQLEQQLLDIQQMQLELDTAEERCRA
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALDKTAAAPL
HHHHHCCCCC
>Mature Secondary Structure 
SSHTYSISELARELDITTRAIRFYEEQGMLSPERKGLERIYTARDKVTLKLILRGKRIG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FSLAECKELISLYDPAGGNQKQLQTMLGKIAERRDQLEQQLLDIQQMQLELDTAEERCRA
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALDKTAAAPL
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]