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The map label for this gene is fdhA [H]

Identifier: 66045646

GI number: 66045646

Start: 2791166

End: 2792305

Strand: Direct

Name: fdhA [H]

Synonym: Psyr_2410

Alternate gene names: 66045646

Gene position: 2791166-2792305 (Clockwise)

Preceding gene: 66045639

Following gene: 66045647

Centisome position: 45.8

GC content: 61.05

Gene sequence:

>1140_bases
ATGAAAGCCATCGTCTATAGCGGTCCGCGTGACGTCAGTGTCAAAAACGTACCGGATGCGAAGATTCAGAAGCCGACAGA
TGCGCTTGTCCGAGTGACCTCCACGAATATCTGTGGCTCGGACCTGCACATGTACGAAGGCCGCACGTCGTTCGAGACCG
GGCGCATTTTCGGCCATGAGAACCTCGGCCAGGTGATTGAAGTGGGCGCCGGCGTTGACCGCATCAAGGTGGGCGACTGG
GTGTGCCTGCCGTTCAACATTGGCTGCGGCTTTTGCGAAAACTGTGAGAAGGGCCTGACCGGTTATTGCCTGACCGCCAA
CCCTGGCAGCGCTGGCGCGGCCTATGGTTTTGCCGATATGGGCGATCACGAAGGTGGCCAGGCCGAGTTGCTGCGCGTGC
CGTATGCCGACTTCAACTGCCTGCTGTTGCCCGAAGATGCCGCCGAGCGTGAAGAAGATTACGTCATGCTCTCGGACATC
TTTCCTACCGGCTGGCATGCCACCGAGCTGGCCGGGCTGCTGCCTGGCGAAAGCGTTGCCATCTACGGTGCCGGCCCGGT
CGGTCTGATGGCTGCCCACTCGGCAATGATCAAGGGCGCCTCGCAGGTGTTCGTGGTCGACAACCATCCTGATCGTCTGG
CCCTCGCGGCGAAGATGGGCGCGACGCCGATCAACTCGCTGGAGCAGGGCGCGGTGGATCAGATCCTCAATCTGACCGAT
GGCAAAGGCACCGACCGAGGCTGTGAGTGCGTCGGTTATCAGTGCTGCGACCGTCATGGTCACGAGGCCAATCACGTCAC
CATGAACAACCTCGTTGCCTCGACCAAGGCGACTGGCGGAATCGGTGTCGTGGGCGTTTTCGTGCCGCAGGATCCGGGCG
CCAAAAGCGACCTCGCCAAGGAAGGCAAGATGGCCTTCGACTTCGGCTCGTTCTGGTTCAAGGGCCAGCAGATCCGTACC
GGTCAGGCCAACGTCAAGGCTTACAACCGTCGCCTCGCCGAGCTGATCCACCACGGTCGCGCCAAGCCGTCGCAGATCAT
TTCCCATCGCCTGAAGCTTGAAGAGGGCCCTGACGCCTACAAGCACTTCGATGCGCGTGATGAAGGCTGGACCAAGGTAG
TGCTCAAGCCAGGTGCGTGA

Upstream 100 bases:

>100_bases
TGTAAAGGCAATCGCTTTGAACAGGCGCCTTCTGGTTGTGACAGATATTCGGTGAGCCCTAAAAAGCCCTAACGAATTTT
TTACTGAGGAGACTCCGAAC

Downstream 100 bases:

>100_bases
TAGCCGCGTTTGACCAGCCCTTTGGTTGAAAGCCCTTGTCCTATCCGCCACAGGCGATCGGCAAGGGCTTCAGCACTTCA
GTCAGAACTTTTATTCAGCG

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: FALDH; FDH [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MKAIVYSGPRDVSVKNVPDAKIQKPTDALVRVTSTNICGSDLHMYEGRTSFETGRIFGHENLGQVIEVGAGVDRIKVGDW
VCLPFNIGCGFCENCEKGLTGYCLTANPGSAGAAYGFADMGDHEGGQAELLRVPYADFNCLLLPEDAAEREEDYVMLSDI
FPTGWHATELAGLLPGESVAIYGAGPVGLMAAHSAMIKGASQVFVVDNHPDRLALAAKMGATPINSLEQGAVDQILNLTD
GKGTDRGCECVGYQCCDRHGHEANHVTMNNLVASTKATGGIGVVGVFVPQDPGAKSDLAKEGKMAFDFGSFWFKGQQIRT
GQANVKAYNRRLAELIHHGRAKPSQIISHRLKLEEGPDAYKHFDARDEGWTKVVLKPGA

Sequences:

>Translated_379_residues
MKAIVYSGPRDVSVKNVPDAKIQKPTDALVRVTSTNICGSDLHMYEGRTSFETGRIFGHENLGQVIEVGAGVDRIKVGDW
VCLPFNIGCGFCENCEKGLTGYCLTANPGSAGAAYGFADMGDHEGGQAELLRVPYADFNCLLLPEDAAEREEDYVMLSDI
FPTGWHATELAGLLPGESVAIYGAGPVGLMAAHSAMIKGASQVFVVDNHPDRLALAAKMGATPINSLEQGAVDQILNLTD
GKGTDRGCECVGYQCCDRHGHEANHVTMNNLVASTKATGGIGVVGVFVPQDPGAKSDLAKEGKMAFDFGSFWFKGQQIRT
GQANVKAYNRRLAELIHHGRAKPSQIISHRLKLEEGPDAYKHFDARDEGWTKVVLKPGA
>Mature_379_residues
MKAIVYSGPRDVSVKNVPDAKIQKPTDALVRVTSTNICGSDLHMYEGRTSFETGRIFGHENLGQVIEVGAGVDRIKVGDW
VCLPFNIGCGFCENCEKGLTGYCLTANPGSAGAAYGFADMGDHEGGQAELLRVPYADFNCLLLPEDAAEREEDYVMLSDI
FPTGWHATELAGLLPGESVAIYGAGPVGLMAAHSAMIKGASQVFVVDNHPDRLALAAKMGATPINSLEQGAVDQILNLTD
GKGTDRGCECVGYQCCDRHGHEANHVTMNNLVASTKATGGIGVVGVFVPQDPGAKSDLAKEGKMAFDFGSFWFKGQQIRT
GQANVKAYNRRLAELIHHGRAKPSQIISHRLKLEEGPDAYKHFDARDEGWTKVVLKPGA

Specific function: Catalyzes the oxidation of long-chain alcohols but is inactive against ethanol [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=356, Percent_Identity=27.8089887640449, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI4501933, Length=262, Percent_Identity=29.3893129770992, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786825, Length=407, Percent_Identity=36.3636363636364, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1790045, Length=357, Percent_Identity=31.3725490196078, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI87082125, Length=362, Percent_Identity=28.4530386740331, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI226510992, Length=364, Percent_Identity=24.7252747252747, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788073, Length=239, Percent_Identity=29.7071129707113, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1787863, Length=228, Percent_Identity=30.2631578947368, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788407, Length=233, Percent_Identity=31.3304721030043, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081918, Length=248, Percent_Identity=31.0483870967742, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790718, Length=198, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786552, Length=263, Percent_Identity=27.3764258555133, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=384, Percent_Identity=27.0833333333333, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=374, Percent_Identity=26.4705882352941, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=376, Percent_Identity=27.1276595744681, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6319955, Length=376, Percent_Identity=27.1276595744681, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6323099, Length=271, Percent_Identity=33.210332103321, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319258, Length=285, Percent_Identity=27.719298245614, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=376, Percent_Identity=25.2659574468085, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=292, Percent_Identity=25.6849315068493, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17737897, Length=262, Percent_Identity=29.3893129770992, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17137530, Length=262, Percent_Identity=29.0076335877863, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17737895, Length=285, Percent_Identity=27.0175438596491, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221457811, Length=201, Percent_Identity=29.8507462686567, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45550770, Length=201, Percent_Identity=29.8507462686567, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45551930, Length=201, Percent_Identity=29.8507462686567, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR014184
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.2.1.46 [H]

Molecular weight: Translated: 40594; Mature: 40594

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIVYSGPRDVSVKNVPDAKIQKPTDALVRVTSTNICGSDLHMYEGRTSFETGRIFGHE
CCEEEECCCCCCEECCCCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCEEECCC
NLGQVIEVGAGVDRIKVGDWVCLPFNIGCGFCENCEKGLTGYCLTANPGSAGAAYGFADM
CHHHHHHHCCCCCEEEECCEEEEEEECCCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCC
GDHEGGQAELLRVPYADFNCLLLPEDAAEREEDYVMLSDIFPTGWHATELAGLLPGESVA
CCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCEE
IYGAGPVGLMAAHSAMIKGASQVFVVDNHPDRLALAAKMGATPINSLEQGAVDQILNLTD
EEECCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEHHCCCCCCCHHHHHHHHHHHCCCC
GKGTDRGCECVGYQCCDRHGHEANHVTMNNLVASTKATGGIGVVGVFVPQDPGAKSDLAK
CCCCCCCCCEECHHHHHCCCCCCCEEEHHHEEECCCCCCCEEEEEEEECCCCCCHHHHHH
EGKMAFDFGSFWFKGQQIRTGQANVKAYNRRLAELIHHGRAKPSQIISHRLKLEEGPDAY
CCCEEEEECCCEEECCEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHH
KHFDARDEGWTKVVLKPGA
HCCCCCCCCCEEEEECCCC
>Mature Secondary Structure
MKAIVYSGPRDVSVKNVPDAKIQKPTDALVRVTSTNICGSDLHMYEGRTSFETGRIFGHE
CCEEEECCCCCCEECCCCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCEEECCC
NLGQVIEVGAGVDRIKVGDWVCLPFNIGCGFCENCEKGLTGYCLTANPGSAGAAYGFADM
CHHHHHHHCCCCCEEEECCEEEEEEECCCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCC
GDHEGGQAELLRVPYADFNCLLLPEDAAEREEDYVMLSDIFPTGWHATELAGLLPGESVA
CCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCEE
IYGAGPVGLMAAHSAMIKGASQVFVVDNHPDRLALAAKMGATPINSLEQGAVDQILNLTD
EEECCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEHHCCCCCCCHHHHHHHHHHHCCCC
GKGTDRGCECVGYQCCDRHGHEANHVTMNNLVASTKATGGIGVVGVFVPQDPGAKSDLAK
CCCCCCCCCEECHHHHHCCCCCCCEEEHHHEEECCCCCCCEEEEEEEECCCCCCHHHHHH
EGKMAFDFGSFWFKGQQIRTGQANVKAYNRRLAELIHHGRAKPSQIISHRLKLEEGPDAY
CCCEEEEECCCEEECCEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHH
KHFDARDEGWTKVVLKPGA
HCCCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]