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The map label for this gene is moaA [H]

Identifier: 66045564

GI number: 66045564

Start: 2704116

End: 2705114

Strand: Reverse

Name: moaA [H]

Synonym: Psyr_2327

Alternate gene names: 66045564

Gene position: 2705114-2704116 (Counterclockwise)

Preceding gene: 66045565

Following gene: 66045561

Centisome position: 44.39

GC content: 60.36

Gene sequence:

>999_bases
ATGTCAGAACCCGTCCTGATGGACCGCTTTGCACGTAAAGTCGATTATCTGCGCATGTCGGTCACCGACCGCTGTGATTT
TCGCTGCGTGTACTGCATGGCCGAAGAGATGACGTTTCTGCCTCGGCAACAGATTCTGTCGCTGGAGGAGATCCTCCAGG
TGGCCGAGCGCTTCGTGGCACTGGGCACGCGCAAGATTCGTCTGACCGGTGGTGAGCCGCTGGTACGTGCAGGCGTGGTG
GGGCTTTGTGAAAAGATCGCCGCCCTGCCCGGCCTGCGTGAACTGTGCATGACCACCAACGGTTCGCAGCTGGACAAACT
GGCTGCACCGCTGTTCAAGGCCGGCGTCACGCGCCTGAACATCAGCCTGGACAGCCTTGATCCGCAGCGTTTCCGCGAGC
TGACCCGCACAGGCGATCTGCACAAGGTAATTGCCGGCATCGATGCCGCCAACGCCGCCGGTTTTGTGCACACCAAGCTC
AACTGCGTGGTGATGCACGGCCGCAACGATGATGAGATCAACGACCTGCTGGCGTTCGCCATCGATCGCAACCTGGACGT
CTCGTTCATCGAAGAAATGCCGCTGGGCATCATCAGCGAACACAGCCGCGCCGAGTCCTTCTACTCCAGCGATCAGGTGC
GCGAACGCATTGCCGAACGTTACACGCTGGTGCCTTCCACTGACTCGACTCAGGGGCCATCGCGCTACTGGCGTCTGGCC
GAGGCACCGGGAATTCGCATTGGCTTCATTTCCCCGCACAGCCATAACTTCTGCGGCACCTGCAACCGCGTGCGCATGAC
CGTTGAAGGTCGCTTGCTGCTGTGCCTGGGCAACGAGCATTCCGTGGATTTGAAAGCGGTACTGCGCGCCAATCCCGGCC
AGCCGGAAAAGCTCGAAAAAGCCATCATCGACGCCATGCAGCTCAAGCCGTGGAGCCACAACTTCACCCACGACGATGGC
GTGCAGGTGGTGCGCTTCATGAATATGACGGGCGGCTGA

Upstream 100 bases:

>100_bases
ATCAGGCCTGAAATCGGCACACTGCAATTTGGCTGAACCCTTGTAAAGCACTGGCCTCCAAATCCGGTAATACACCCCAC
TTGATTATTTAGAAGGTGAA

Downstream 100 bases:

>100_bases
CCGCCGCCCTGAAGGATGACGCCTCATACGAGGCGTTATTTATTTGCCGGCCTTGCGAAAGAACAAAGTGATCTGCCCGA
CTTCGACACCCAGCTTGGTC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSEPVLMDRFARKVDYLRMSVTDRCDFRCVYCMAEEMTFLPRQQILSLEEILQVAERFVALGTRKIRLTGGEPLVRAGVV
GLCEKIAALPGLRELCMTTNGSQLDKLAAPLFKAGVTRLNISLDSLDPQRFRELTRTGDLHKVIAGIDAANAAGFVHTKL
NCVVMHGRNDDEINDLLAFAIDRNLDVSFIEEMPLGIISEHSRAESFYSSDQVRERIAERYTLVPSTDSTQGPSRYWRLA
EAPGIRIGFISPHSHNFCGTCNRVRMTVEGRLLLCLGNEHSVDLKAVLRANPGQPEKLEKAIIDAMQLKPWSHNFTHDDG
VQVVRFMNMTGG

Sequences:

>Translated_332_residues
MSEPVLMDRFARKVDYLRMSVTDRCDFRCVYCMAEEMTFLPRQQILSLEEILQVAERFVALGTRKIRLTGGEPLVRAGVV
GLCEKIAALPGLRELCMTTNGSQLDKLAAPLFKAGVTRLNISLDSLDPQRFRELTRTGDLHKVIAGIDAANAAGFVHTKL
NCVVMHGRNDDEINDLLAFAIDRNLDVSFIEEMPLGIISEHSRAESFYSSDQVRERIAERYTLVPSTDSTQGPSRYWRLA
EAPGIRIGFISPHSHNFCGTCNRVRMTVEGRLLLCLGNEHSVDLKAVLRANPGQPEKLEKAIIDAMQLKPWSHNFTHDDG
VQVVRFMNMTGG
>Mature_331_residues
SEPVLMDRFARKVDYLRMSVTDRCDFRCVYCMAEEMTFLPRQQILSLEEILQVAERFVALGTRKIRLTGGEPLVRAGVVG
LCEKIAALPGLRELCMTTNGSQLDKLAAPLFKAGVTRLNISLDSLDPQRFRELTRTGDLHKVIAGIDAANAAGFVHTKLN
CVVMHGRNDDEINDLLAFAIDRNLDVSFIEEMPLGIISEHSRAESFYSSDQVRERIAERYTLVPSTDSTQGPSRYWRLAE
APGIRIGFISPHSHNFCGTCNRVRMTVEGRLLLCLGNEHSVDLKAVLRANPGQPEKLEKAIIDAMQLKPWSHNFTHDDGV
QVVRFMNMTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=298, Percent_Identity=41.6107382550336, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI116734668, Length=298, Percent_Identity=41.6107382550336, Blast_Score=209, Evalue=4e-54,
Organism=Escherichia coli, GI1786999, Length=329, Percent_Identity=34.9544072948328, Blast_Score=193, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI32566331, Length=314, Percent_Identity=36.624203821656, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI32566329, Length=314, Percent_Identity=36.624203821656, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17561210, Length=311, Percent_Identity=36.9774919614148, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI28574490, Length=312, Percent_Identity=40.3846153846154, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI28574488, Length=312, Percent_Identity=40.3846153846154, Blast_Score=210, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37162; Mature: 37031

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPVLMDRFARKVDYLRMSVTDRCDFRCVYCMAEEMTFLPRQQILSLEEILQVAERFVA
CCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHCCHHHHHCHHHHHHHHHHHHH
LGTRKIRLTGGEPLVRAGVVGLCEKIAALPGLRELCMTTNGSQLDKLAAPLFKAGVTRLN
HCCEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHCCCEEEE
ISLDSLDPQRFRELTRTGDLHKVIAGIDAANAAGFVHTKLNCVVMHGRNDDEINDLLAFA
EEECCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHH
IDRNLDVSFIEEMPLGIISEHSRAESFYSSDQVRERIAERYTLVPSTDSTQGPSRYWRLA
HCCCCCHHHHHHCCCCHHCCHHHHHHHHCHHHHHHHHHHHEEECCCCCCCCCHHHHEEHH
EAPGIRIGFISPHSHNFCGTCNRVRMTVEGRLLLCLGNEHSVDLKAVLRANPGQPEKLEK
CCCCEEEEEECCCCCCCCCCCCEEEEEECCEEEEEECCCCCCCHHEEEECCCCCHHHHHH
AIIDAMQLKPWSHNFTHDDGVQVVRFMNMTGG
HHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SEPVLMDRFARKVDYLRMSVTDRCDFRCVYCMAEEMTFLPRQQILSLEEILQVAERFVA
CCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHCCHHHHHCHHHHHHHHHHHHH
LGTRKIRLTGGEPLVRAGVVGLCEKIAALPGLRELCMTTNGSQLDKLAAPLFKAGVTRLN
HCCEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHCCCEEEE
ISLDSLDPQRFRELTRTGDLHKVIAGIDAANAAGFVHTKLNCVVMHGRNDDEINDLLAFA
EEECCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHH
IDRNLDVSFIEEMPLGIISEHSRAESFYSSDQVRERIAERYTLVPSTDSTQGPSRYWRLA
HCCCCCHHHHHHCCCCHHCCHHHHHHHHCHHHHHHHHHHHEEECCCCCCCCCHHHHEEHH
EAPGIRIGFISPHSHNFCGTCNRVRMTVEGRLLLCLGNEHSVDLKAVLRANPGQPEKLEK
CCCCEEEEEECCCCCCCCCCCCEEEEEECCEEEEEECCCCCCCHHEEEECCCCCHHHHHH
AIIDAMQLKPWSHNFTHDDGVQVVRFMNMTGG
HHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA