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The map label for this gene is nodT [H]

Identifier: 66045431

GI number: 66045431

Start: 2546254

End: 2547726

Strand: Reverse

Name: nodT [H]

Synonym: Psyr_2191

Alternate gene names: 66045431

Gene position: 2547726-2546254 (Counterclockwise)

Preceding gene: 66045435

Following gene: 66045429

Centisome position: 41.81

GC content: 59.88

Gene sequence:

>1473_bases
ATGCGCCCGATTTGTACTTATGTACTGGTCATGAGCACCGGCCTGCTGTCGGGCTGCGCCGTGGGTCCGGATTACCAGCG
CCCGGATGCGCCCCTGGCTGACCGCTATCTGACTCAGCCACGTGGCGCTGCGAATATTACCGCGCATCCGCCGGTCAGTG
CCGCGTGGTGGGACGGTTTTGATGATCCGTTACTGAGCAGCTTCGTGTCACGCGCACTGGCGCAGAATCTCGATCTCGCT
CAAGCCAGCGCGCAACTGGCTCAGGCACGCGCCGGAGCAGATGCGGCGACCGCCGCCCTGCTCCCGTCGGGCAACATCGA
TGCACAGACGGCTCGCGCTCATCAATCGGTAGAGACTCCACTCGGTCAGGTCCTGAACTCGGCACCTGGCTACGATCGTT
ACGGCAATTCTTATGAAGCCAATCTGACCGCAAGCTGGGAACTGGACGTTTTTGGCGGTTTGAAACGCAGTCGACAGGCT
GCGCTGGCTGAATATCAAGCTTCGCAGGCAGGTGTCGTGGCTGCCAGGCTCGCTGTGGCAGCCCGGACCGCCGATACCTA
CATCAACATCCGTGGTCTGCAAGCCAGGCTGGCGATCACGAACCGACAACTTAAAACCCGGCAAGACCTGCTGGAAAAAG
TCCAGCTCCTCCATGAGCGTGGTCTGTCCCCTGACTATGAAGTTCGTCAGATCGAAGCGGAGCTTTTACAGGTGCAGGCA
ACAGTGCCGATTCTGCAAACAGGTCTCGACGCTGCAATGAACGCGCTTGACGTGATGCTGGGCGTACCGCCTGGCACTCA
TCGGGGCTCCCTGGCTGAAACGGGTCGAATCCCACACGCACCCGAGCTGACGTCGACAGGAACGCCAGCCGATCTCCTCC
GTCGCAGACCTGATCTGATCGTGGCCGAGCGGCGCCTCGCCGCGTCGAACGCGCGTATCGGCGTGGCGATCAGCGAGTAT
TATCCCAAACTCTCACTCAGCGCATTGCTGGGCAGCGCCACAGCCGTGTCGAGCGGCAATCTGTTTACCGGTGGTGCCAG
TCAGTCAGCAGGTATTTTGGGGCTTCGCTGGAGGCTTTTTGATTTCGGCCGGGTGAACGCCCGGATCAGTCAAGCCAAAG
GACAAGAGGCAGAGGCTCTGGCGGCTTATCGACAGTCAGTTTTGCGCGCCACTGAGGACGTTGAAAACGCTTTTTCTTCG
TTGGCCAGTCGCGAAACTCAAGCTGCAATGCTGGGTAAAGGCGAAACTGCACTTGCTTCAGCCCGGCAATCGTCATTCGC
AAGCTATAGCAAAGGTGCCGCCAGCTTGATCGAGGTGCTGCGCGCCGACGAGAAAATGCTGCAGGTCGCTGACGCCAAGG
CGCAGGCCCAGGTCGAATCCGCGCAGGCGGCGGTCGCCGTATTCAAAGCACTGGGTGGTGGTTGGCAAATGCCTCCCACC
ACTTCATCTGACGAGAAGATGCATACACTGTAG

Upstream 100 bases:

>100_bases
TTTGATTAGTCATGTTTCCAGCTTAGCTATGTGAACACTCGTTGACAACAAGTGACCAAATCGTAATATAGTCACGACCT
GATCACCTCAAGGAATTTCC

Downstream 100 bases:

>100_bases
GCGCCACCAAAGAGTGCATCCTTTCAGATCAGGCTTACTCAGCGATAACGTTCAAGCCAGTGAGCGTAAGGTGCAGGCAA
GGTCCAGGCCGATTTTTCAA

Product: RND efflux system, outer membrane lipoprotein, NodT

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MRPICTYVLVMSTGLLSGCAVGPDYQRPDAPLADRYLTQPRGAANITAHPPVSAAWWDGFDDPLLSSFVSRALAQNLDLA
QASAQLAQARAGADAATAALLPSGNIDAQTARAHQSVETPLGQVLNSAPGYDRYGNSYEANLTASWELDVFGGLKRSRQA
ALAEYQASQAGVVAARLAVAARTADTYINIRGLQARLAITNRQLKTRQDLLEKVQLLHERGLSPDYEVRQIEAELLQVQA
TVPILQTGLDAAMNALDVMLGVPPGTHRGSLAETGRIPHAPELTSTGTPADLLRRRPDLIVAERRLAASNARIGVAISEY
YPKLSLSALLGSATAVSSGNLFTGGASQSAGILGLRWRLFDFGRVNARISQAKGQEAEALAAYRQSVLRATEDVENAFSS
LASRETQAAMLGKGETALASARQSSFASYSKGAASLIEVLRADEKMLQVADAKAQAQVESAQAAVAVFKALGGGWQMPPT
TSSDEKMHTL

Sequences:

>Translated_490_residues
MRPICTYVLVMSTGLLSGCAVGPDYQRPDAPLADRYLTQPRGAANITAHPPVSAAWWDGFDDPLLSSFVSRALAQNLDLA
QASAQLAQARAGADAATAALLPSGNIDAQTARAHQSVETPLGQVLNSAPGYDRYGNSYEANLTASWELDVFGGLKRSRQA
ALAEYQASQAGVVAARLAVAARTADTYINIRGLQARLAITNRQLKTRQDLLEKVQLLHERGLSPDYEVRQIEAELLQVQA
TVPILQTGLDAAMNALDVMLGVPPGTHRGSLAETGRIPHAPELTSTGTPADLLRRRPDLIVAERRLAASNARIGVAISEY
YPKLSLSALLGSATAVSSGNLFTGGASQSAGILGLRWRLFDFGRVNARISQAKGQEAEALAAYRQSVLRATEDVENAFSS
LASRETQAAMLGKGETALASARQSSFASYSKGAASLIEVLRADEKMLQVADAKAQAQVESAQAAVAVFKALGGGWQMPPT
TSSDEKMHTL
>Mature_490_residues
MRPICTYVLVMSTGLLSGCAVGPDYQRPDAPLADRYLTQPRGAANITAHPPVSAAWWDGFDDPLLSSFVSRALAQNLDLA
QASAQLAQARAGADAATAALLPSGNIDAQTARAHQSVETPLGQVLNSAPGYDRYGNSYEANLTASWELDVFGGLKRSRQA
ALAEYQASQAGVVAARLAVAARTADTYINIRGLQARLAITNRQLKTRQDLLEKVQLLHERGLSPDYEVRQIEAELLQVQA
TVPILQTGLDAAMNALDVMLGVPPGTHRGSLAETGRIPHAPELTSTGTPADLLRRRPDLIVAERRLAASNARIGVAISEY
YPKLSLSALLGSATAVSSGNLFTGGASQSAGILGLRWRLFDFGRVNARISQAKGQEAEALAAYRQSVLRATEDVENAFSS
LASRETQAAMLGKGETALASARQSSFASYSKGAASLIEVLRADEKMLQVADAKAQAQVESAQAAVAVFKALGGGWQMPPT
TSSDEKMHTL

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=484, Percent_Identity=26.4462809917355, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI2367348, Length=506, Percent_Identity=24.5059288537549, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 51904; Mature: 51904

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPICTYVLVMSTGLLSGCAVGPDYQRPDAPLADRYLTQPRGAANITAHPPVSAAWWDGF
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHCCCC
DDPLLSSFVSRALAQNLDLAQASAQLAQARAGADAATAALLPSGNIDAQTARAHQSVETP
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHEECCCCCCCHHHHHHHHHHHHH
LGQVLNSAPGYDRYGNSYEANLTASWELDVFGGLKRSRQAALAEYQASQAGVVAARLAVA
HHHHHHCCCCCCCCCCCEECCEEEEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARTADTYINIRGLQARLAITNRQLKTRQDLLEKVQLLHERGLSPDYEVRQIEAELLQVQA
HHHHCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
TVPILQTGLDAAMNALDVMLGVPPGTHRGSLAETGRIPHAPELTSTGTPADLLRRRPDLI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCCCCHHHHHCCCCCE
VAERRLAASNARIGVAISEYYPKLSLSALLGSATAVSSGNLFTGGASQSAGILGLRWRLF
EHHHHHHHCCCEEEEEHHHHCCCHHHHHHHCCHHEECCCCEEECCCCCCCCEEEEEEEEE
DFGRVNARISQAKGQEAEALAAYRQSVLRATEDVENAFSSLASRETQAAMLGKGETALAS
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ARQSSFASYSKGAASLIEVLRADEKMLQVADAKAQAQVESAQAAVAVFKALGGGWQMPPT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TSSDEKMHTL
CCCCCCCCCC
>Mature Secondary Structure
MRPICTYVLVMSTGLLSGCAVGPDYQRPDAPLADRYLTQPRGAANITAHPPVSAAWWDGF
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHCCCC
DDPLLSSFVSRALAQNLDLAQASAQLAQARAGADAATAALLPSGNIDAQTARAHQSVETP
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHEECCCCCCCHHHHHHHHHHHHH
LGQVLNSAPGYDRYGNSYEANLTASWELDVFGGLKRSRQAALAEYQASQAGVVAARLAVA
HHHHHHCCCCCCCCCCCEECCEEEEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARTADTYINIRGLQARLAITNRQLKTRQDLLEKVQLLHERGLSPDYEVRQIEAELLQVQA
HHHHCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
TVPILQTGLDAAMNALDVMLGVPPGTHRGSLAETGRIPHAPELTSTGTPADLLRRRPDLI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCCCCHHHHHCCCCCE
VAERRLAASNARIGVAISEYYPKLSLSALLGSATAVSSGNLFTGGASQSAGILGLRWRLF
EHHHHHHHCCCEEEEEHHHHCCCHHHHHHHCCHHEECCCCEEECCCCCCCCEEEEEEEEE
DFGRVNARISQAKGQEAEALAAYRQSVLRATEDVENAFSSLASRETQAAMLGKGETALAS
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ARQSSFASYSKGAASLIEVLRADEKMLQVADAKAQAQVESAQAAVAVFKALGGGWQMPPT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TSSDEKMHTL
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]