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The map label for this gene is macA [H]

Identifier: 66045210

GI number: 66045210

Start: 2284475

End: 2285647

Strand: Reverse

Name: macA [H]

Synonym: Psyr_1970

Alternate gene names: 66045210

Gene position: 2285647-2284475 (Counterclockwise)

Preceding gene: 66045212

Following gene: 66045209

Centisome position: 37.51

GC content: 64.45

Gene sequence:

>1173_bases
ATGAAACGCTCTCGACATCCTCGACGCGCCCTCCTGGTGGCGCTGTGCCTGTTCCCGGTCATTGCCGTATGCGCCTGGCA
GATCCTGCCCGACAGCAAAAGCAGCGCCGCAACTGTGACGGTGACCCGCGGCACGATCGAAAACAGCGTCACGGCGTTGG
GTACCCTGCAGCCGCGCAGCTACGTGGACGTGGGCTCGCAGGCCAGCGGGCAGATCATGAAAATCCACGCCCAGGTCGGC
GATCAGGTCAAGGAAGGCGACTTGCTGGTCGAAATCGATCCTTCGACGCAAAAAGCCAAGCTCGACGCCGCACGCTACGC
CATCGACAACCTCAAGGCGCAATTGCAGGAACAGCGTGCGCTGCACGAACTGGCCGAACAGAAGCAGCAGCGCCAGAAGC
GCCTCGCCGCAGGCGGTGCCACGCGGGCCGAGGACGTGCAGGCTGCGGAATCGGAATTTCGCGCCACCCAGGCACGGGTC
GACATGTTCAAGGCGCAGATTCTCGAAGCCCAGGCCGCCCTGCGCAGCGACGAAGCAGCGCTGGGCTACACCCGTATTTT
CGCGCCCATGAGCGGCACAGTGGTGGCCCTCGACGCACGTGAAGGCCAGACGCTGAACGCACAACAACAGACGCCGCTGA
TTCTGCGCATCGCCCGCTTGTCGCCGATGACGGTCTGGGCCGAGGTCTCGGAAGCCGATATCGGCCATGTCAAACCCGGC
ATGACTGCCTATTTCACCACCCTGAGCGGCGGCAACCGGCGCTGGAGCAGCACCGTGCGACAGATCCTGCCAGTACCGCC
CAGGCCGCTGGATCAAGCCAATCAGGGCGGCGGCAGCCCGAGCAGTGCGCGCAAGAACGGCGGTGGCCGGGTGGTGTTGT
ACACCGTGCTGCTGGACGTGGATAACAGCGATCAGGCGCTGATGGCAGAAATGACCGCGCAGATATTTTTCGTCGCCGAT
AAAGCCGAGAACACACTTACCGCGCCACTCGCGGCGTTGCGAAACGGAGCGCAGACCGATCGGCAGACCGCCCAGGTGTT
GTCTGCCAATGGCGAGGTGCAGAACCGTCAGGTACGCACCGGCATCAGCGACCGCCTGCGCGTGCAGGTACTCGACGGCC
TGAATGAAGGTGAGCGCCTGCTGGTGCCCGCCTCTGTCGGCAGCGGGGGCTGA

Upstream 100 bases:

>100_bases
CCGTGATCGACGCTAAATTCCTGCCGGCACGCCTCGTTTAAAGGGCAGCTCTCGTGGCCGTCGTTCATCGACCGACTGAT
CTCCCAGCGCAGGAATCTGC

Downstream 100 bases:

>100_bases
ATGCGCACGCCGCTGATCGACCTGCGAGGCATTCGCAAATCCTACGGCGGAGGCGACAGCCCGCTGGTCAACGTGCTGCG
CGGCATCGATCTGTCGATTC

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKRSRHPRRALLVALCLFPVIAVCAWQILPDSKSSAATVTVTRGTIENSVTALGTLQPRSYVDVGSQASGQIMKIHAQVG
DQVKEGDLLVEIDPSTQKAKLDAARYAIDNLKAQLQEQRALHELAEQKQQRQKRLAAGGATRAEDVQAAESEFRATQARV
DMFKAQILEAQAALRSDEAALGYTRIFAPMSGTVVALDAREGQTLNAQQQTPLILRIARLSPMTVWAEVSEADIGHVKPG
MTAYFTTLSGGNRRWSSTVRQILPVPPRPLDQANQGGGSPSSARKNGGGRVVLYTVLLDVDNSDQALMAEMTAQIFFVAD
KAENTLTAPLAALRNGAQTDRQTAQVLSANGEVQNRQVRTGISDRLRVQVLDGLNEGERLLVPASVGSGG

Sequences:

>Translated_390_residues
MKRSRHPRRALLVALCLFPVIAVCAWQILPDSKSSAATVTVTRGTIENSVTALGTLQPRSYVDVGSQASGQIMKIHAQVG
DQVKEGDLLVEIDPSTQKAKLDAARYAIDNLKAQLQEQRALHELAEQKQQRQKRLAAGGATRAEDVQAAESEFRATQARV
DMFKAQILEAQAALRSDEAALGYTRIFAPMSGTVVALDAREGQTLNAQQQTPLILRIARLSPMTVWAEVSEADIGHVKPG
MTAYFTTLSGGNRRWSSTVRQILPVPPRPLDQANQGGGSPSSARKNGGGRVVLYTVLLDVDNSDQALMAEMTAQIFFVAD
KAENTLTAPLAALRNGAQTDRQTAQVLSANGEVQNRQVRTGISDRLRVQVLDGLNEGERLLVPASVGSGG
>Mature_390_residues
MKRSRHPRRALLVALCLFPVIAVCAWQILPDSKSSAATVTVTRGTIENSVTALGTLQPRSYVDVGSQASGQIMKIHAQVG
DQVKEGDLLVEIDPSTQKAKLDAARYAIDNLKAQLQEQRALHELAEQKQQRQKRLAAGGATRAEDVQAAESEFRATQARV
DMFKAQILEAQAALRSDEAALGYTRIFAPMSGTVVALDAREGQTLNAQQQTPLILRIARLSPMTVWAEVSEADIGHVKPG
MTAYFTTLSGGNRRWSSTVRQILPVPPRPLDQANQGGGSPSSARKNGGGRVVLYTVLLDVDNSDQALMAEMTAQIFFVAD
KAENTLTAPLAALRNGAQTDRQTAQVLSANGEVQNRQVRTGISDRLRVQVLDGLNEGERLLVPASVGSGG

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=382, Percent_Identity=32.7225130890052, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87082036, Length=332, Percent_Identity=26.5060240963855, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41980; Mature: 41980

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRSRHPRRALLVALCLFPVIAVCAWQILPDSKSSAATVTVTRGTIENSVTALGTLQPRS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHEEEECCCCH
YVDVGSQASGQIMKIHAQVGDQVKEGDLLVEIDPSTQKAKLDAARYAIDNLKAQLQEQRA
HHCCCCCCCCCEEEEEEHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
LHELAEQKQQRQKRLAAGGATRAEDVQAAESEFRATQARVDMFKAQILEAQAALRSDEAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LGYTRIFAPMSGTVVALDAREGQTLNAQQQTPLILRIARLSPMTVWAEVSEADIGHVKPG
HCHHEEECCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCC
MTAYFTTLSGGNRRWSSTVRQILPVPPRPLDQANQGGGSPSSARKNGGGRVVLYTVLLDV
CEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEC
DNSDQALMAEMTAQIFFVADKAENTLTAPLAALRNGAQTDRQTAQVLSANGEVQNRQVRT
CCCCHHHHHHHHEEEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHC
GISDRLRVQVLDGLNEGERLLVPASVGSGG
CCCHHEEEEEECCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MKRSRHPRRALLVALCLFPVIAVCAWQILPDSKSSAATVTVTRGTIENSVTALGTLQPRS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHEEEECCCCH
YVDVGSQASGQIMKIHAQVGDQVKEGDLLVEIDPSTQKAKLDAARYAIDNLKAQLQEQRA
HHCCCCCCCCCEEEEEEHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
LHELAEQKQQRQKRLAAGGATRAEDVQAAESEFRATQARVDMFKAQILEAQAALRSDEAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LGYTRIFAPMSGTVVALDAREGQTLNAQQQTPLILRIARLSPMTVWAEVSEADIGHVKPG
HCHHEEECCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCC
MTAYFTTLSGGNRRWSSTVRQILPVPPRPLDQANQGGGSPSSARKNGGGRVVLYTVLLDV
CEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEC
DNSDQALMAEMTAQIFFVADKAENTLTAPLAALRNGAQTDRQTAQVLSANGEVQNRQVRT
CCCCHHHHHHHHEEEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHC
GISDRLRVQVLDGLNEGERLLVPASVGSGG
CCCHHEEEEEECCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]