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The map label for this gene is degS [H]

Identifier: 66045181

GI number: 66045181

Start: 2214084

End: 2215268

Strand: Reverse

Name: degS [H]

Synonym: Psyr_1941

Alternate gene names: 66045181

Gene position: 2215268-2214084 (Counterclockwise)

Preceding gene: 66045183

Following gene: 66045180

Centisome position: 36.35

GC content: 63.04

Gene sequence:

>1185_bases
ATGCAAAGTCCTCCCCATGACCCGGCAAGCGCACTGGCCATTCGCAACCAGTATCGCCAGTCGCAAAGCCGCGCCGCACG
TCTTCGTCTGCTGGTCGATACCGGTCAGGAGCTGACTCATCTGCCACCTCAAGCCATGCGCCAGCGCGTGCTGCAACGCG
CGTGCGCATTCGTGGCGATGGACCATGGCCTGCTGCTGGAATGGAGCGCCGACAACGGTGTGCAGACCACCGCCAGCCAT
GGCAGTGCCGAACGCCTCGCCACGCTTGAAACCGCTGCCGACCCGCTGGCCATCGGCCCGCAATGGCTGGACAGGCCCGC
TGCCGATCTGCCGTGCATGCTGCTGTTACCGTTGCGTGGCGCCGATGAAGGCTCTTTTGGCACCCTGCTGCTGGCCAACA
GCGTGGGCATCAATGCACCGGACAACGAGGACATCGAGTCGCTGCAATTGCTGGCGACGTTGCTGGCGGCACACCTGGAA
AACAATCGGCTGCTTGACGCGCTGGTGGTCAGAGAGCAGACCATGTCCGAACTGGTCCGCCAGTTGTTCACCGCTCAGGA
AGACGAACGCAAGCGCATGGCCTACGACCTGCATGATGGTCTGGCTCAGACACTGGCCGGTCTGCACCAGCGATTGCAGG
GCTTTGCCGGTCGCTGTCCGGACCTGCCCGAGCCGCTGGACGCCGATCTGCAGGCCATTCTCAAGCTGGCGCAGCACTGC
GTGGGTGAAGGTCGACAGTTGATCAGTGGCCTGCGTCCTAGCGTGCTCGACGATTTCGGCCTGCTGCAGGCAGTCGACAA
GGACGCCGACCGGTTGCGCGAAGCCGGAGTCGCGGTGCACTGGCGCTCGCGCTCCCTGACCCGCCTGCCCAGCCATCTGG
AAATCGCCCTGTTCCGTATTGCCCAGGAAGGCATCAACAATGTGCTCAAACACGCCAGTGCAGGCCGCGTAGAATTGGCC
CTGGAACTGAGTGAAGAGCACATTTCACTGCTGCTGGAAGACAACGGCAGTGGTTTCATCACCCAGAAACCGTTTAATGG
CAAAGGCGTCCAGAAACTGGGCCTGGTGGCCATGCAAGAGCGCGCCAGCCTGCTCGGCGGGCGCCTGACCTGCGTCAGTC
GGCCCGGGCACGGCACCCGACTGCGCGCCATCGTTCCTTTTACCGCAGACAAGGCAATGACATGA

Upstream 100 bases:

>100_bases
GTGTATGCCGATCGGCAGATGGGCTTCACCTCCTGATACAGTTCTAATAGCCTTACTTCTGTTATGCCCGCGCGGGCATC
AACCCTCGCTGGAGCACCCC

Downstream 100 bases:

>100_bases
CTGACACTGTGCGACTGGTTTTGGCAGACGATCATGAAGTGACGCGTACCGGGTTCGTCTCGCTATTGGCGGGGCATCCG
GAGTTCGAAGTGGTCGGTCA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MQSPPHDPASALAIRNQYRQSQSRAARLRLLVDTGQELTHLPPQAMRQRVLQRACAFVAMDHGLLLEWSADNGVQTTASH
GSAERLATLETAADPLAIGPQWLDRPAADLPCMLLLPLRGADEGSFGTLLLANSVGINAPDNEDIESLQLLATLLAAHLE
NNRLLDALVVREQTMSELVRQLFTAQEDERKRMAYDLHDGLAQTLAGLHQRLQGFAGRCPDLPEPLDADLQAILKLAQHC
VGEGRQLISGLRPSVLDDFGLLQAVDKDADRLREAGVAVHWRSRSLTRLPSHLEIALFRIAQEGINNVLKHASAGRVELA
LELSEEHISLLLEDNGSGFITQKPFNGKGVQKLGLVAMQERASLLGGRLTCVSRPGHGTRLRAIVPFTADKAMT

Sequences:

>Translated_394_residues
MQSPPHDPASALAIRNQYRQSQSRAARLRLLVDTGQELTHLPPQAMRQRVLQRACAFVAMDHGLLLEWSADNGVQTTASH
GSAERLATLETAADPLAIGPQWLDRPAADLPCMLLLPLRGADEGSFGTLLLANSVGINAPDNEDIESLQLLATLLAAHLE
NNRLLDALVVREQTMSELVRQLFTAQEDERKRMAYDLHDGLAQTLAGLHQRLQGFAGRCPDLPEPLDADLQAILKLAQHC
VGEGRQLISGLRPSVLDDFGLLQAVDKDADRLREAGVAVHWRSRSLTRLPSHLEIALFRIAQEGINNVLKHASAGRVELA
LELSEEHISLLLEDNGSGFITQKPFNGKGVQKLGLVAMQERASLLGGRLTCVSRPGHGTRLRAIVPFTADKAMT
>Mature_394_residues
MQSPPHDPASALAIRNQYRQSQSRAARLRLLVDTGQELTHLPPQAMRQRVLQRACAFVAMDHGLLLEWSADNGVQTTASH
GSAERLATLETAADPLAIGPQWLDRPAADLPCMLLLPLRGADEGSFGTLLLANSVGINAPDNEDIESLQLLATLLAAHLE
NNRLLDALVVREQTMSELVRQLFTAQEDERKRMAYDLHDGLAQTLAGLHQRLQGFAGRCPDLPEPLDADLQAILKLAQHC
VGEGRQLISGLRPSVLDDFGLLQAVDKDADRLREAGVAVHWRSRSLTRLPSHLEIALFRIAQEGINNVLKHASAGRVELA
LELSEEHISLLLEDNGSGFITQKPFNGKGVQKLGLVAMQERASLLGGRLTCVSRPGHGTRLRAIVPFTADKAMT

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=233, Percent_Identity=33.0472103004292, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787474, Length=209, Percent_Identity=28.2296650717703, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 42975; Mature: 42975

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSPPHDPASALAIRNQYRQSQSRAARLRLLVDTGQELTHLPPQAMRQRVLQRACAFVAM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHCCCHHHHHHHHHHHHHHHHHC
DHGLLLEWSADNGVQTTASHGSAERLATLETAADPLAIGPQWLDRPAADLPCMLLLPLRG
CCCEEEEECCCCCCEECCCCCCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCEEEEEECCC
ADEGSFGTLLLANSVGINAPDNEDIESLQLLATLLAAHLENNRLLDALVVREQTMSELVR
CCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QLFTAQEDERKRMAYDLHDGLAQTLAGLHQRLQGFAGRCPDLPEPLDADLQAILKLAQHC
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
VGEGRQLISGLRPSVLDDFGLLQAVDKDADRLREAGVAVHWRSRSLTRLPSHLEIALFRI
HHCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCCHHHHHHHHH
AQEGINNVLKHASAGRVELALELSEEHISLLLEDNGSGFITQKPFNGKGVQKLGLVAMQE
HHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHH
RASLLGGRLTCVSRPGHGTRLRAIVPFTADKAMT
HHHHHCCEEEEEECCCCCCEEEEEEEECCCCCCC
>Mature Secondary Structure
MQSPPHDPASALAIRNQYRQSQSRAARLRLLVDTGQELTHLPPQAMRQRVLQRACAFVAM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHCCCHHHHHHHHHHHHHHHHHC
DHGLLLEWSADNGVQTTASHGSAERLATLETAADPLAIGPQWLDRPAADLPCMLLLPLRG
CCCEEEEECCCCCCEECCCCCCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCEEEEEECCC
ADEGSFGTLLLANSVGINAPDNEDIESLQLLATLLAAHLENNRLLDALVVREQTMSELVR
CCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QLFTAQEDERKRMAYDLHDGLAQTLAGLHQRLQGFAGRCPDLPEPLDADLQAILKLAQHC
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
VGEGRQLISGLRPSVLDDFGLLQAVDKDADRLREAGVAVHWRSRSLTRLPSHLEIALFRI
HHCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCCHHHHHHHHH
AQEGINNVLKHASAGRVELALELSEEHISLLLEDNGSGFITQKPFNGKGVQKLGLVAMQE
HHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHH
RASLLGGRLTCVSRPGHGTRLRAIVPFTADKAMT
HHHHHCCEEEEEECCCCCCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]