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The map label for this gene is dnaX [H]

Identifier: 66045069

GI number: 66045069

Start: 2105845

End: 2108055

Strand: Direct

Name: dnaX [H]

Synonym: Psyr_1825

Alternate gene names: 66045069

Gene position: 2105845-2108055 (Clockwise)

Preceding gene: 66045066

Following gene: 66045070

Centisome position: 34.56

GC content: 64.5

Gene sequence:

>2211_bases
ATGAGTTATCAGGTTCTTGCACGTAAATGGCGTCCGCGCTCGTTCCGCGAAATGGTCGGCCAGGCTCATGTGTTGAAGGC
CCTGATCAACGCGCTGGACAGCCAGCGCCTGCACCATGCCTATCTGTTCACCGGCACACGGGGCGTCGGCAAGACGACTA
TCGCGCGGATCATCGCCAAGTGCCTGAACTGTGAAACCGGCATTACTTCGACGCCCTGCGGCACCTGCTCGGTGTGCAAG
GAGATCGACGAGGGCCGGTTCGTCGACCTGATCGAAATCGACGCCGCCAGCCGCACCAAGGTCGAAGACACGCGCGAGCT
GCTGGATAACGTGCAGTACGCGCCCAGTCGCGGTCGCTTCAAGGTCTACCTGATCGACGAAGTGCACATGCTTTCCAGCC
ACTCGTTCAACGCCTTGCTCAAGACGCTTGAAGAGCCGCCGCCCTACGTCAAGTTCATCCTGGCCACCACCGATCCGCAA
AAACTGCCGGCGACCATTCTGTCGCGCTGCCTGCAGTTCTCGTTGAAAAACATGACGCCTGAGCGCGTTGTCGAGCACCT
CACCCACGTGCTGGGCGTCGAGAACGTGCCGTTCGAAGACGACGCGCTGTGGCTGCTCGGGCGCGCCGCCGACGGTTCGA
TGCGTGATGCGATGAGCCTCACCGATCAGGCCATTGCCTTCGGTGAAGGCAAGGTCATGGCTGCCGATGTACGTGCCATG
CTCGGCACGCTGGACCACGGCCAGGTCTTCGATGTACTGACCGCGCTGCTGGAAGGCGATGCCCGCGGGGTGCTGGAGGC
GGTACGCCATCTGGCCGAGCAGGGCCCTGACTGGAATGGCGTGCTCTCGGAAATTCTCAACGTGCTGCACCGTGTGGCGA
TTGCCCAGGCGCTGCCGGAAGGCGTCGACAACGGTCACGGCGATCGTGACCGGGTGCTGGCCCTGGCGCAGGCCCTGCCT
GCCGAAGATGTGCAGTTTTACTACCAGATGGGCTTGATTGGTCGTCGTGACTTGCCACTGGCCCCTGATCCGCGTGGCGG
CTTCGAGATGGTCCTGCTGCGTATGCTGGCGTTTCGTCCTGCCGACAGCGAGGACGCGCCGAGGCAGCCGCTAAAGCCAG
TGGGGATCAGCCAGGCCACGGTTGATTCCCGAAAAGCAGTGGCTGATGCGACACCTGTTGCATCGGCAGCTCCCGCAGTG
TCGAGCGCCCCGGTGATGGCTGCGCCCGACCCGTCCTTCGAAGCGCTGCCGCCTGCAGCGGCGCCGAAGCCGCCCGCCGC
CCGGCCAGAGCCCGCGGTGCAGCCGGAATCGAAGCCAGAGCCACAAGCCGCGCCAGTCGAAGACCTCGACCTGCCGTGGA
ATGAGCCGAAATCCCCGGCTGCCGAACCCGCCGCCGAAACTGCGCCTGATACCGATACCGCTGCCGAGCCAGTCGCCGAG
CCGGTTCTGGAGACCGTTTCCGAGCAGCCTGACCTGACGCCCATGCCGACGCCTGCGCCCGCCAGCCCGGTGCCGGCCGC
ACCCGAGGCCGAGCCTGAGCAGCCGGTTGCCGAGCAGCAGGACGCGCCGGCAATGCTCGAAGCCATCCCGGACTCTGCGT
ATCTGTCCACGCACACCGATTCGATGTCTTCCGACTCCGGGCCGATGGGGCGTGACGACGAACCGCCAGCGGATGATGAT
TACGTCGAGCCGGATATCGACATAGACCCGGCGTCCTACAGCTATCTGGACGAGCTGGCCCACGAAAGTGTCGTCGAGCT
TGAAGCCGTCGAGCCGGAGCCTGCTCCGGCCGCCAAACCGGCCACCGGTCTTGCGGCCGAGTGGCTGGACGTGTTCCCCA
AGCTGCCGATCTCCGGCATGACCGGCAGCATCGCGGCCAACTGCACATTGATCTCGGTCGATGGCGATAACTGGCTGCTG
CACCTGGACCCGGCGCACAGCGCGCTGTTCAACTCGACTCAGCAGCGGCGTCTGAACGATGCGTTGAACCAGTACCATGG
GCGCACGATCAATCTGAGTATCGAGCTGATCAAGCCCGAGCAGGAAACCCCTGCGCAGGCCGCTTCACGGCTGCGTGCCG
AGCGCCAGCGCCAGGCCGAAGCCTCGATCCAGGCCGACCCGTACATCCAGCAGATGCTGCAACAGTTCGGCGCTGTGATC
CGGGAAGACACGATCAAACCCGTTGACGCGCCTGCGGTGCAGGCTCAATAA

Upstream 100 bases:

>100_bases
TTGCACAGCTTAGCCACAATAGAGACGGACACCAGATGCAATTTTGCCCCTGCTCGGCTAGCATTGGCGGTCTTCCGCTT
ACCAGTTGCGACGGTTTTAA

Downstream 100 bases:

>100_bases
CTGAACACAGGGTGCCGCTGGCGCCACGCAAACGAACCATCCATTTTCGAGGAGATATCCCATGATGAAAGGTGGCATGG
CTGGCCTGATGAAGCAGGCG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 736; Mature: 735

Protein sequence:

>736_residues
MSYQVLARKWRPRSFREMVGQAHVLKALINALDSQRLHHAYLFTGTRGVGKTTIARIIAKCLNCETGITSTPCGTCSVCK
EIDEGRFVDLIEIDAASRTKVEDTRELLDNVQYAPSRGRFKVYLIDEVHMLSSHSFNALLKTLEEPPPYVKFILATTDPQ
KLPATILSRCLQFSLKNMTPERVVEHLTHVLGVENVPFEDDALWLLGRAADGSMRDAMSLTDQAIAFGEGKVMAADVRAM
LGTLDHGQVFDVLTALLEGDARGVLEAVRHLAEQGPDWNGVLSEILNVLHRVAIAQALPEGVDNGHGDRDRVLALAQALP
AEDVQFYYQMGLIGRRDLPLAPDPRGGFEMVLLRMLAFRPADSEDAPRQPLKPVGISQATVDSRKAVADATPVASAAPAV
SSAPVMAAPDPSFEALPPAAAPKPPAARPEPAVQPESKPEPQAAPVEDLDLPWNEPKSPAAEPAAETAPDTDTAAEPVAE
PVLETVSEQPDLTPMPTPAPASPVPAAPEAEPEQPVAEQQDAPAMLEAIPDSAYLSTHTDSMSSDSGPMGRDDEPPADDD
YVEPDIDIDPASYSYLDELAHESVVELEAVEPEPAPAAKPATGLAAEWLDVFPKLPISGMTGSIAANCTLISVDGDNWLL
HLDPAHSALFNSTQQRRLNDALNQYHGRTINLSIELIKPEQETPAQAASRLRAERQRQAEASIQADPYIQQMLQQFGAVI
REDTIKPVDAPAVQAQ

Sequences:

>Translated_736_residues
MSYQVLARKWRPRSFREMVGQAHVLKALINALDSQRLHHAYLFTGTRGVGKTTIARIIAKCLNCETGITSTPCGTCSVCK
EIDEGRFVDLIEIDAASRTKVEDTRELLDNVQYAPSRGRFKVYLIDEVHMLSSHSFNALLKTLEEPPPYVKFILATTDPQ
KLPATILSRCLQFSLKNMTPERVVEHLTHVLGVENVPFEDDALWLLGRAADGSMRDAMSLTDQAIAFGEGKVMAADVRAM
LGTLDHGQVFDVLTALLEGDARGVLEAVRHLAEQGPDWNGVLSEILNVLHRVAIAQALPEGVDNGHGDRDRVLALAQALP
AEDVQFYYQMGLIGRRDLPLAPDPRGGFEMVLLRMLAFRPADSEDAPRQPLKPVGISQATVDSRKAVADATPVASAAPAV
SSAPVMAAPDPSFEALPPAAAPKPPAARPEPAVQPESKPEPQAAPVEDLDLPWNEPKSPAAEPAAETAPDTDTAAEPVAE
PVLETVSEQPDLTPMPTPAPASPVPAAPEAEPEQPVAEQQDAPAMLEAIPDSAYLSTHTDSMSSDSGPMGRDDEPPADDD
YVEPDIDIDPASYSYLDELAHESVVELEAVEPEPAPAAKPATGLAAEWLDVFPKLPISGMTGSIAANCTLISVDGDNWLL
HLDPAHSALFNSTQQRRLNDALNQYHGRTINLSIELIKPEQETPAQAASRLRAERQRQAEASIQADPYIQQMLQQFGAVI
REDTIKPVDAPAVQAQ
>Mature_735_residues
SYQVLARKWRPRSFREMVGQAHVLKALINALDSQRLHHAYLFTGTRGVGKTTIARIIAKCLNCETGITSTPCGTCSVCKE
IDEGRFVDLIEIDAASRTKVEDTRELLDNVQYAPSRGRFKVYLIDEVHMLSSHSFNALLKTLEEPPPYVKFILATTDPQK
LPATILSRCLQFSLKNMTPERVVEHLTHVLGVENVPFEDDALWLLGRAADGSMRDAMSLTDQAIAFGEGKVMAADVRAML
GTLDHGQVFDVLTALLEGDARGVLEAVRHLAEQGPDWNGVLSEILNVLHRVAIAQALPEGVDNGHGDRDRVLALAQALPA
EDVQFYYQMGLIGRRDLPLAPDPRGGFEMVLLRMLAFRPADSEDAPRQPLKPVGISQATVDSRKAVADATPVASAAPAVS
SAPVMAAPDPSFEALPPAAAPKPPAARPEPAVQPESKPEPQAAPVEDLDLPWNEPKSPAAEPAAETAPDTDTAAEPVAEP
VLETVSEQPDLTPMPTPAPASPVPAAPEAEPEQPVAEQQDAPAMLEAIPDSAYLSTHTDSMSSDSGPMGRDDEPPADDDY
VEPDIDIDPASYSYLDELAHESVVELEAVEPEPAPAAKPATGLAAEWLDVFPKLPISGMTGSIAANCTLISVDGDNWLLH
LDPAHSALFNSTQQRRLNDALNQYHGRTINLSIELIKPEQETPAQAASRLRAERQRQAEASIQADPYIQQMLQQFGAVIR
EDTIKPVDAPAVQAQ

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=292, Percent_Identity=25, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI194306571, Length=295, Percent_Identity=24.7457627118644, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI194306567, Length=295, Percent_Identity=24.7457627118644, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1786676, Length=379, Percent_Identity=60.9498680738786, Blast_Score=475, Evalue=1e-135,
Organism=Escherichia coli, GI1787119, Length=230, Percent_Identity=25.2173913043478, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1787341, Length=149, Percent_Identity=30.2013422818792, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322528, Length=305, Percent_Identity=21.9672131147541, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI18859927, Length=276, Percent_Identity=23.1884057971014, Blast_Score=70, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 79485; Mature: 79354

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVLARKWRPRSFREMVGQAHVLKALINALDSQRLHHAYLFTGTRGVGKTTIARIIAK
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHH
CLNCETGITSTPCGTCSVCKEIDEGRFVDLIEIDAASRTKVEDTRELLDNVQYAPSRGRF
HHCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCE
KVYLIDEVHMLSSHSFNALLKTLEEPPPYVKFILATTDPQKLPATILSRCLQFSLKNMTP
EEEEECCHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCH
ERVVEHLTHVLGVENVPFEDDALWLLGRAADGSMRDAMSLTDQAIAFGEGKVMAADVRAM
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHH
LGTLDHGQVFDVLTALLEGDARGVLEAVRHLAEQGPDWNGVLSEILNVLHRVAIAQALPE
HHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
GVDNGHGDRDRVLALAQALPAEDVQFYYQMGLIGRRDLPLAPDPRGGFEMVLLRMLAFRP
HCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
ADSEDAPRQPLKPVGISQATVDSRKAVADATPVASAAPAVSSAPVMAAPDPSFEALPPAA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCCCCCCCCCEEECCCCCCCCCCCCC
APKPPAARPEPAVQPESKPEPQAAPVEDLDLPWNEPKSPAAEPAAETAPDTDTAAEPVAE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
PVLETVSEQPDLTPMPTPAPASPVPAAPEAEPEQPVAEQQDAPAMLEAIPDSAYLSTHTD
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHCCCCCEEECCCC
SMSSDSGPMGRDDEPPADDDYVEPDIDIDPASYSYLDELAHESVVELEAVEPEPAPAAKP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
ATGLAAEWLDVFPKLPISGMTGSIAANCTLISVDGDNWLLHLDPAHSALFNSTQQRRLND
CCHHHHHHHHHHCCCCCCCCCCCEEECEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHH
ALNQYHGRTINLSIELIKPEQETPAQAASRLRAERQRQAEASIQADPYIQQMLQQFGAVI
HHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
REDTIKPVDAPAVQAQ
HHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SYQVLARKWRPRSFREMVGQAHVLKALINALDSQRLHHAYLFTGTRGVGKTTIARIIAK
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHH
CLNCETGITSTPCGTCSVCKEIDEGRFVDLIEIDAASRTKVEDTRELLDNVQYAPSRGRF
HHCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCE
KVYLIDEVHMLSSHSFNALLKTLEEPPPYVKFILATTDPQKLPATILSRCLQFSLKNMTP
EEEEECCHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCH
ERVVEHLTHVLGVENVPFEDDALWLLGRAADGSMRDAMSLTDQAIAFGEGKVMAADVRAM
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHH
LGTLDHGQVFDVLTALLEGDARGVLEAVRHLAEQGPDWNGVLSEILNVLHRVAIAQALPE
HHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
GVDNGHGDRDRVLALAQALPAEDVQFYYQMGLIGRRDLPLAPDPRGGFEMVLLRMLAFRP
HCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
ADSEDAPRQPLKPVGISQATVDSRKAVADATPVASAAPAVSSAPVMAAPDPSFEALPPAA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCCCCCCCCCEEECCCCCCCCCCCCC
APKPPAARPEPAVQPESKPEPQAAPVEDLDLPWNEPKSPAAEPAAETAPDTDTAAEPVAE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
PVLETVSEQPDLTPMPTPAPASPVPAAPEAEPEQPVAEQQDAPAMLEAIPDSAYLSTHTD
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHCCCCCEEECCCC
SMSSDSGPMGRDDEPPADDDYVEPDIDIDPASYSYLDELAHESVVELEAVEPEPAPAAKP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
ATGLAAEWLDVFPKLPISGMTGSIAANCTLISVDGDNWLLHLDPAHSALFNSTQQRRLND
CCHHHHHHHHHHCCCCCCCCCCCEEECEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHH
ALNQYHGRTINLSIELIKPEQETPAQAASRLRAERQRQAEASIQADPYIQQMLQQFGAVI
HHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
REDTIKPVDAPAVQAQ
HHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]