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The map label for this gene is lgrC [H]

Identifier: 66045037

GI number: 66045037

Start: 2054260

End: 2058372

Strand: Direct

Name: lgrC [H]

Synonym: Psyr_1793

Alternate gene names: 66045037

Gene position: 2054260-2058372 (Clockwise)

Preceding gene: 66045036

Following gene: 66045038

Centisome position: 33.71

GC content: 64.09

Gene sequence:

>4113_bases
ATGAATGCCTATCAATTGCTGGAGTTGTTCGGTCGCCACGCCGTGGTGCTTGAAGTGGACGGCGAGAAACTGCGCTGCAA
GGCGCCGCGCGGGTTTCTGAATGACGAGATGTTGCAGGCGCTCAAGCAGCACAAGGCAGAACTGATTGCCTTGCTGAGCG
GCACCGACCCCGCCGCGATCCCTCGGCGTGCTGCCGGGCAAACGGCTGTTGCGCTGTCGTTTTCACAACGCCAGCTGTGG
TTTCTCGATCAGATGGAACCGGGCAATGCGTTCTATAACGTGCCCACTGCGGTGCTGCTGAAAGGCGTGCTGGATGTGTC
GGCGCTGGAGCGGGCGCTGAACGAATTGATCATGCGCCATGAAATATTGCGCACCACCTTTGCCAGCGTGGATGGCGAGC
CACGGCAGATCGTGCACCCGGCGATGCCGCTGGTGATGCCAGGTGTCGACCTGCGTGACCTGTCGCCGACGGCGCGCGAA
GCGCACGTCAGGATGGCGGTGGAGCAGCAGGCCAAGGCGCCGTTTGACCTGGCCAGCGGCCCGTTGCTGCGGGCCTCGCT
GCTGCGCCTGGCCGACGAGGAATACCTCTGGCTGTACAGCGTGCACCACATCATCGCCGATGGCTGGTCGATGGGCGTGA
TCCTTCAGGAAGTGACCACAGTGTACGGCGATTTTCTGCGCGGTCAGGCGTCCAGTCTGGCGCCGCTGGCGGTGCAGTAC
GCCGATTACGCCTGCTGGCAGCAACAGCGTCTGGGTGATGAGGCGCTGGCCGGGCAGCTGGACTTCTGGAAGCGCACGCT
GGCCGACGCGCCGCCGCTGCTCGACATGCCTGCCGACCGGCCACGTCCGACCGTGCAGCGCTACGTCGGGGCGACCTTCA
GCTCGACGGTCGACGGCACCACCCTGCGTGCGCTCAACGCGCTGGCCAGACAGACCCAGGGCACGCTGTTCAACGTGTTG
ATCGGCGCGCTGTCGGTCCTGCTCTGGCGCCACAGCGGTCAGCGGGATCTGTGCATCGGTACGCCATTTGCCAACCGCAG
CCGTCCCGAAATCGAGCCGCTGATCGGCCATTTCGTCAACACTCAGGTGATTCGCCAGCGTCTCGATCCGCTGCAGACCT
TTGCCGAGCTGTTGCGCGAAGTGCGCGCCACTCTGCTGGATGTTCACGCGCATCAGGATGTGCCTTTCGACCGCGTGGTG
GAGGCCGTCAACCCGCCGCGCGATACCGCGTATTCGCCTCTGTTTCAGGTGATGATGGTGTTGCAGAACACCCCGGGCAA
CGCCGCACGGATGCCGGGCCTGAGCATGACCCCATACGGCACCGGGAGCGCCACGGCCAAGTTCGACCTGGCGTTCGAAT
GGGTCGAGCGCGACGGTGTGTTGAGCCTGCTGGTGGAATACAACACCGACCTGTTCGACCAGACCAGCATTGAGCGCCTG
AGCGGGCATTATCGTCAGTTGCTGGAACAGGTGGCGCTGAACCCCAAGCAGCCTGTCGGCGCACTGACGCTGATCAGCGA
TGCCGAACGCGAACAGATACTGCATGCGTGGAACAGCCCGGCACCGCTGGCTCAGCCCGTCGACTGCGTGCATCGCCTGA
TCGAGGCTCAGGTCACGCGTCGGCAGGCCGAGTGTGCGGTCATCTTCGAAGGTCGATCGCTGAGCTACAGCCAGCTCAAC
ACTCAGGCCAACCGCCTGGCGCATCACTTGCTCACCCTCGGCGTCGGCCCGGATGTGCGCGTGGCGGTCTGTATCGAGCG
CTCGCTGGAACTGCCCGTGGCCTTGCTGGCGGTGCTCAAGGCCGGGGGCGCCTATGTGCCGCTGGACCCGGATTATCCAT
CGGGACGCCTGCGGCATATTCTCGATGACACGTCCCCCGTGGTGCTGCTTGCCCAAGGGCCGACGCGCAAGATCCTGCGC
GAAGCTTTAGAAGGAGCGGACTGCGAAGTGCCGATCCTCGACGTGCAGGCCGATGCCGTGCTCTGGGCCGAGTGCCCGTC
GGACAATCCGCAGACGCAGCGTGTCGGTGTGAACGCCGACCACCTGGCGTATGTGCTTTACACCTCCGGCACCACGGGGC
TGCCCAAGGGGGCGATGGTCACGCATCGCGGCCTGAGCAACCTGCTGCTCTGGTGTCAGCAGTTCTGCGGCGAATGTGGA
AGCATGTTGCACAAGATCCCATTCGGTTTCGACGCCTCGGCCTGGGAGATCTTCTGGCCGTTGCTTACCGGTGGCAGGCT
GGTCATCGCCCGTCCCGGCGGGCATTTCGAACCCGGTTACCTGGCGCAGGTGGTGCGCGAACAAAGCGTTACCGCGATGG
TGTTCGTGCCAGCCATGTTGCAACTGTTTCTGGAGGTCGAAGAGGTCAGCGCCTGTCACACCCTCAAGGATGTGTTCAGT
GGCGGCGGGGAGCTGTCGCCCGCAGTGGCCAGGCTGTTTCAGCAGCGTCTGCCGCATGCCCGCCTGCACAACGTCTATGG
TCCGACCGAAACCACAGTGATCAGCAGTGTCTGGACGCTACAGCCCGGTGCCGACGTCCCGCCGCGCCAATTGCCCATCG
GACGGCCCATCGCCAACACCCGTTTTTACGTGCTCGACGAGCGTGATGCGCCGGTGCCGGCCGGGGTCACCGGTCAGTTG
CACATTGGTGGTGTCGGCGTTGCACGGGGTTATCTGGGGCTCGACGAGCTGACTGCCGAACGGTTTATCGACAACCCGTT
CGTTGCCGGTGACCGGCTGTACCGCAGCGGCGACCTGGCGCGTTATCGTCCGGACGGTCAGTTGGAGTTTATCGGTCGCA
ACGACTTTCAGGTCAAGTTGCGTGGCATTCGCCTGGAACTGAGTGAAATCGAAGCGCGGCTGGACCTGTTCCCCGGTATT
CGCACCAGTGTGGCATTGATCGTCGGTGATACTGCGCAGAACCAGCGCCTGGTGGCGTGCTGCGTCACCGATAGCCCAGT
GGATGAATCCGCACTGCGTGCGCATCTGGCAACGACCCTGTCCAGCGCCGTCATGCCCAGCGCTTATCTGTGGCTGGACG
CCTTGCCGTTGACGGTCAACGGCAAGGTCGACCGTGCAGCGCTCGCGGCACAGGCCGATCAGGATCTGGCCGACCGGCAG
GTCAATCTCGGCAGCCCCCGTGACCATATCGAGCTGACCCTGTATCAGATCTGGAAAGACCTGCTGCTGGTGCCGCAGAT
CGGCATTCGCGACAACTTCTTCAACGTCGGCGGGACATCGATTGCGGCGATCAAGATGGCCTACGAAATTGGCCGGGCGT
TCAGCGTCGAGGTGCCTGTGCGCGTGATCCTCGGCCACCCGACCATCGAGGCGCTGGGCGGCTGGCTGCGTAGCGGGGCC
AGCCTGGCCGCGGCACAGGACAACCTGATCGAATTCCGGCGCGGCGCCGGGCAACGCAACGTGGTGTGCATTCACCCGGC
GGGCGGCACGGCGTTCTGCTACCTGTCACTGGCCAAGGAACTGCCGGACAGCATCGGTGTGTACGGTGTGCAATCGCCAG
GGTTGAACCCCGGAGAAAGCACCGAGCCGAGCGTCGAAGCCATGGCCGACGCCTATTTGCGGCGGATCGCGGCGTTGACC
TCACAGCCGCTGGTGCTCACCGGACTGTCGTTCGGTGGCCTGGTGGCGTACGAAATGGCCCGCCGCCTGACGGCTGCCGG
CCATCGTCAGGTGACGGTGGTGCTGCTCGATACCCAGGGCTCGGATGACCCGGGGTTTCGGCAACAGATCGGGACCGTGG
ACATGGCGGAGTTTCGCGACAAGCTGGTGCGTTTCAACGGCATGTACCCCGGCATCGAAGACGCGCAGGTCGAGCGGTAT
TTCCATCTTTACAACCACAACCGTCTGGCCATGGCCGCGTACGAGTGCGCGCCGCAAGCCGGGCGCATCGTGCTGATTCA
GGCTCGCGAAGGCTTTACCCGCACGCAGTTGCATGAGCTGCGCAGCTTCTGGCGTCGTCGCGCGGGTAACGGTTACAAGG
CCCGGCTGGTAAATGGCGGGCACTGGGACATGCTGGAAAGCGCCGAGGTGCATCGGGTCTCGCAGACGCTCAGGCAAGAG
CTGCAACGTTTCGACACGCAGGAGGCGCAATGA

Upstream 100 bases:

>100_bases
GCCTGCGTAATGCCGACGAACAACGCCGCGCGCAGGTCGAGGCGTTCGCTTCTGCCGCGGATCAAACGGACGACGCCAGC
GACATGGAGGAGATAGAGAT

Downstream 100 bases:

>100_bases
TGAACCGGCACGAGGAGAATATCGCCCGCAACCCCCAGACCCTGCTGTCGCGTTTTGCCGAGCAGGTACGCCGTGATCCC
CAGGCGCTGGCCGTGGTCGA

Product: amino acid adenylation

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: ATP-dependent valine adenylase; ValA; Valine activase; ATP-dependent D-valine adenylase; D-ValA; D-valine activase; Valine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan/phenylalanine/tyrosine adenylase; Trp/Phe/TyrA; Tryptophan/phenylalanine/tyrosine activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing] [H]

Number of amino acids: Translated: 1370; Mature: 1370

Protein sequence:

>1370_residues
MNAYQLLELFGRHAVVLEVDGEKLRCKAPRGFLNDEMLQALKQHKAELIALLSGTDPAAIPRRAAGQTAVALSFSQRQLW
FLDQMEPGNAFYNVPTAVLLKGVLDVSALERALNELIMRHEILRTTFASVDGEPRQIVHPAMPLVMPGVDLRDLSPTARE
AHVRMAVEQQAKAPFDLASGPLLRASLLRLADEEYLWLYSVHHIIADGWSMGVILQEVTTVYGDFLRGQASSLAPLAVQY
ADYACWQQQRLGDEALAGQLDFWKRTLADAPPLLDMPADRPRPTVQRYVGATFSSTVDGTTLRALNALARQTQGTLFNVL
IGALSVLLWRHSGQRDLCIGTPFANRSRPEIEPLIGHFVNTQVIRQRLDPLQTFAELLREVRATLLDVHAHQDVPFDRVV
EAVNPPRDTAYSPLFQVMMVLQNTPGNAARMPGLSMTPYGTGSATAKFDLAFEWVERDGVLSLLVEYNTDLFDQTSIERL
SGHYRQLLEQVALNPKQPVGALTLISDAEREQILHAWNSPAPLAQPVDCVHRLIEAQVTRRQAECAVIFEGRSLSYSQLN
TQANRLAHHLLTLGVGPDVRVAVCIERSLELPVALLAVLKAGGAYVPLDPDYPSGRLRHILDDTSPVVLLAQGPTRKILR
EALEGADCEVPILDVQADAVLWAECPSDNPQTQRVGVNADHLAYVLYTSGTTGLPKGAMVTHRGLSNLLLWCQQFCGECG
SMLHKIPFGFDASAWEIFWPLLTGGRLVIARPGGHFEPGYLAQVVREQSVTAMVFVPAMLQLFLEVEEVSACHTLKDVFS
GGGELSPAVARLFQQRLPHARLHNVYGPTETTVISSVWTLQPGADVPPRQLPIGRPIANTRFYVLDERDAPVPAGVTGQL
HIGGVGVARGYLGLDELTAERFIDNPFVAGDRLYRSGDLARYRPDGQLEFIGRNDFQVKLRGIRLELSEIEARLDLFPGI
RTSVALIVGDTAQNQRLVACCVTDSPVDESALRAHLATTLSSAVMPSAYLWLDALPLTVNGKVDRAALAAQADQDLADRQ
VNLGSPRDHIELTLYQIWKDLLLVPQIGIRDNFFNVGGTSIAAIKMAYEIGRAFSVEVPVRVILGHPTIEALGGWLRSGA
SLAAAQDNLIEFRRGAGQRNVVCIHPAGGTAFCYLSLAKELPDSIGVYGVQSPGLNPGESTEPSVEAMADAYLRRIAALT
SQPLVLTGLSFGGLVAYEMARRLTAAGHRQVTVVLLDTQGSDDPGFRQQIGTVDMAEFRDKLVRFNGMYPGIEDAQVERY
FHLYNHNRLAMAAYECAPQAGRIVLIQAREGFTRTQLHELRSFWRRRAGNGYKARLVNGGHWDMLESAEVHRVSQTLRQE
LQRFDTQEAQ

Sequences:

>Translated_1370_residues
MNAYQLLELFGRHAVVLEVDGEKLRCKAPRGFLNDEMLQALKQHKAELIALLSGTDPAAIPRRAAGQTAVALSFSQRQLW
FLDQMEPGNAFYNVPTAVLLKGVLDVSALERALNELIMRHEILRTTFASVDGEPRQIVHPAMPLVMPGVDLRDLSPTARE
AHVRMAVEQQAKAPFDLASGPLLRASLLRLADEEYLWLYSVHHIIADGWSMGVILQEVTTVYGDFLRGQASSLAPLAVQY
ADYACWQQQRLGDEALAGQLDFWKRTLADAPPLLDMPADRPRPTVQRYVGATFSSTVDGTTLRALNALARQTQGTLFNVL
IGALSVLLWRHSGQRDLCIGTPFANRSRPEIEPLIGHFVNTQVIRQRLDPLQTFAELLREVRATLLDVHAHQDVPFDRVV
EAVNPPRDTAYSPLFQVMMVLQNTPGNAARMPGLSMTPYGTGSATAKFDLAFEWVERDGVLSLLVEYNTDLFDQTSIERL
SGHYRQLLEQVALNPKQPVGALTLISDAEREQILHAWNSPAPLAQPVDCVHRLIEAQVTRRQAECAVIFEGRSLSYSQLN
TQANRLAHHLLTLGVGPDVRVAVCIERSLELPVALLAVLKAGGAYVPLDPDYPSGRLRHILDDTSPVVLLAQGPTRKILR
EALEGADCEVPILDVQADAVLWAECPSDNPQTQRVGVNADHLAYVLYTSGTTGLPKGAMVTHRGLSNLLLWCQQFCGECG
SMLHKIPFGFDASAWEIFWPLLTGGRLVIARPGGHFEPGYLAQVVREQSVTAMVFVPAMLQLFLEVEEVSACHTLKDVFS
GGGELSPAVARLFQQRLPHARLHNVYGPTETTVISSVWTLQPGADVPPRQLPIGRPIANTRFYVLDERDAPVPAGVTGQL
HIGGVGVARGYLGLDELTAERFIDNPFVAGDRLYRSGDLARYRPDGQLEFIGRNDFQVKLRGIRLELSEIEARLDLFPGI
RTSVALIVGDTAQNQRLVACCVTDSPVDESALRAHLATTLSSAVMPSAYLWLDALPLTVNGKVDRAALAAQADQDLADRQ
VNLGSPRDHIELTLYQIWKDLLLVPQIGIRDNFFNVGGTSIAAIKMAYEIGRAFSVEVPVRVILGHPTIEALGGWLRSGA
SLAAAQDNLIEFRRGAGQRNVVCIHPAGGTAFCYLSLAKELPDSIGVYGVQSPGLNPGESTEPSVEAMADAYLRRIAALT
SQPLVLTGLSFGGLVAYEMARRLTAAGHRQVTVVLLDTQGSDDPGFRQQIGTVDMAEFRDKLVRFNGMYPGIEDAQVERY
FHLYNHNRLAMAAYECAPQAGRIVLIQAREGFTRTQLHELRSFWRRRAGNGYKARLVNGGHWDMLESAEVHRVSQTLRQE
LQRFDTQEAQ
>Mature_1370_residues
MNAYQLLELFGRHAVVLEVDGEKLRCKAPRGFLNDEMLQALKQHKAELIALLSGTDPAAIPRRAAGQTAVALSFSQRQLW
FLDQMEPGNAFYNVPTAVLLKGVLDVSALERALNELIMRHEILRTTFASVDGEPRQIVHPAMPLVMPGVDLRDLSPTARE
AHVRMAVEQQAKAPFDLASGPLLRASLLRLADEEYLWLYSVHHIIADGWSMGVILQEVTTVYGDFLRGQASSLAPLAVQY
ADYACWQQQRLGDEALAGQLDFWKRTLADAPPLLDMPADRPRPTVQRYVGATFSSTVDGTTLRALNALARQTQGTLFNVL
IGALSVLLWRHSGQRDLCIGTPFANRSRPEIEPLIGHFVNTQVIRQRLDPLQTFAELLREVRATLLDVHAHQDVPFDRVV
EAVNPPRDTAYSPLFQVMMVLQNTPGNAARMPGLSMTPYGTGSATAKFDLAFEWVERDGVLSLLVEYNTDLFDQTSIERL
SGHYRQLLEQVALNPKQPVGALTLISDAEREQILHAWNSPAPLAQPVDCVHRLIEAQVTRRQAECAVIFEGRSLSYSQLN
TQANRLAHHLLTLGVGPDVRVAVCIERSLELPVALLAVLKAGGAYVPLDPDYPSGRLRHILDDTSPVVLLAQGPTRKILR
EALEGADCEVPILDVQADAVLWAECPSDNPQTQRVGVNADHLAYVLYTSGTTGLPKGAMVTHRGLSNLLLWCQQFCGECG
SMLHKIPFGFDASAWEIFWPLLTGGRLVIARPGGHFEPGYLAQVVREQSVTAMVFVPAMLQLFLEVEEVSACHTLKDVFS
GGGELSPAVARLFQQRLPHARLHNVYGPTETTVISSVWTLQPGADVPPRQLPIGRPIANTRFYVLDERDAPVPAGVTGQL
HIGGVGVARGYLGLDELTAERFIDNPFVAGDRLYRSGDLARYRPDGQLEFIGRNDFQVKLRGIRLELSEIEARLDLFPGI
RTSVALIVGDTAQNQRLVACCVTDSPVDESALRAHLATTLSSAVMPSAYLWLDALPLTVNGKVDRAALAAQADQDLADRQ
VNLGSPRDHIELTLYQIWKDLLLVPQIGIRDNFFNVGGTSIAAIKMAYEIGRAFSVEVPVRVILGHPTIEALGGWLRSGA
SLAAAQDNLIEFRRGAGQRNVVCIHPAGGTAFCYLSLAKELPDSIGVYGVQSPGLNPGESTEPSVEAMADAYLRRIAALT
SQPLVLTGLSFGGLVAYEMARRLTAAGHRQVTVVLLDTQGSDDPGFRQQIGTVDMAEFRDKLVRFNGMYPGIEDAQVERY
FHLYNHNRLAMAAYECAPQAGRIVLIQAREGFTRTQLHELRSFWRRRAGNGYKARLVNGGHWDMLESAEVHRVSQTLRQE
LQRFDTQEAQ

Specific function: Activates the 7th to 12th amino acids (Val, D-Val, Trp, D-Leu, Xaa and D-Leu) in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 8th (D-Val), the 10th (D- Leu) an

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 6 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=640, Percent_Identity=24.375, Blast_Score=120, Evalue=1e-26,
Organism=Homo sapiens, GI156151445, Length=537, Percent_Identity=21.415270018622, Blast_Score=78, Evalue=6e-14,
Organism=Homo sapiens, GI42544132, Length=376, Percent_Identity=22.8723404255319, Blast_Score=77, Evalue=1e-13,
Organism=Homo sapiens, GI157311624, Length=476, Percent_Identity=22.0588235294118, Blast_Score=68, Evalue=6e-11,
Organism=Homo sapiens, GI157311622, Length=476, Percent_Identity=22.0588235294118, Blast_Score=68, Evalue=6e-11,
Organism=Escherichia coli, GI1786801, Length=1200, Percent_Identity=29, Blast_Score=387, Evalue=1e-108,
Organism=Escherichia coli, GI145693145, Length=504, Percent_Identity=26.3888888888889, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1790505, Length=587, Percent_Identity=24.190800681431, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1788107, Length=545, Percent_Identity=24.0366972477064, Blast_Score=98, Evalue=3e-21,
Organism=Escherichia coli, GI1786810, Length=509, Percent_Identity=24.75442043222, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17550940, Length=1197, Percent_Identity=21.3868003341688, Blast_Score=184, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17556356, Length=1203, Percent_Identity=22.8595178719867, Blast_Score=170, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI71994694, Length=545, Percent_Identity=23.1192660550459, Blast_Score=95, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71994703, Length=545, Percent_Identity=23.1192660550459, Blast_Score=95, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71994690, Length=545, Percent_Identity=23.1192660550459, Blast_Score=95, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI32563687, Length=507, Percent_Identity=23.4714003944773, Blast_Score=92, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71996755, Length=517, Percent_Identity=19.9226305609284, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558820, Length=503, Percent_Identity=22.0675944333996, Blast_Score=74, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI32564420, Length=361, Percent_Identity=24.9307479224377, Blast_Score=73, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32564422, Length=361, Percent_Identity=24.9307479224377, Blast_Score=73, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17531443, Length=511, Percent_Identity=21.1350293542074, Blast_Score=71, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=975, Percent_Identity=24.4102564102564, Blast_Score=240, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6319699, Length=479, Percent_Identity=23.1732776617954, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24648676, Length=606, Percent_Identity=29.042904290429, Blast_Score=203, Evalue=6e-52,
Organism=Drosophila melanogaster, GI19922652, Length=523, Percent_Identity=22.5621414913958, Blast_Score=86, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24581924, Length=523, Percent_Identity=22.9445506692161, Blast_Score=86, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24653035, Length=489, Percent_Identity=21.2678936605317, Blast_Score=81, Evalue=4e-15,
Organism=Drosophila melanogaster, GI18859661, Length=527, Percent_Identity=24.2884250474383, Blast_Score=81, Evalue=6e-15,
Organism=Drosophila melanogaster, GI161076582, Length=496, Percent_Identity=21.3709677419355, Blast_Score=80, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24582852, Length=448, Percent_Identity=23.8839285714286, Blast_Score=74, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21356947, Length=492, Percent_Identity=19.3089430894309, Blast_Score=70, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR023213
- InterPro:   IPR001242
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 150843; Mature: 150843

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAYQLLELFGRHAVVLEVDGEKLRCKAPRGFLNDEMLQALKQHKAELIALLSGTDPAAI
CCHHHHHHHHCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCC
PRRAAGQTAVALSFSQRQLWFLDQMEPGNAFYNVPTAVLLKGVLDVSALERALNELIMRH
CCCCCCCEEEEEEECCCEEEEEECCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
EILRTTFASVDGEPRQIVHPAMPLVMPGVDLRDLSPTAREAHVRMAVEQQAKAPFDLASG
HHHHHHHHHCCCCCHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
PLLRASLLRLADEEYLWLYSVHHIIADGWSMGVILQEVTTVYGDFLRGQASSLAPLAVQY
CHHHHHHHHHCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
ADYACWQQQRLGDEALAGQLDFWKRTLADAPPLLDMPADRPRPTVQRYVGATFSSTVDGT
HHHHHHHHHHCCHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCHHCCCCCH
TLRALNALARQTQGTLFNVLIGALSVLLWRHSGQRDLCIGTPFANRSRPEIEPLIGHFVN
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHH
TQVIRQRLDPLQTFAELLREVRATLLDVHAHQDVPFDRVVEAVNPPRDTAYSPLFQVMMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
LQNTPGNAARMPGLSMTPYGTGSATAKFDLAFEWVERDGVLSLLVEYNTDLFDQTSIERL
HHCCCCCHHCCCCCCCCCCCCCCCCEEEEEEEEEHHCCCCEEEHHHHCCCCCCHHHHHHH
SGHYRQLLEQVALNPKQPVGALTLISDAEREQILHAWNSPAPLAQPVDCVHRLIEAQVTR
HHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
RQAECAVIFEGRSLSYSQLNTQANRLAHHLLTLGVGPDVRVAVCIERSLELPVALLAVLK
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHH
AGGAYVPLDPDYPSGRLRHILDDTSPVVLLAQGPTRKILREALEGADCEVPILDVQADAV
CCCCEECCCCCCCCCHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEEECCCEE
LWAECPSDNPQTQRVGVNADHLAYVLYTSGTTGLPKGAMVTHRGLSNLLLWCQQFCGECG
EEEECCCCCCCCEEECCCCCCEEEEEEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHH
SMLHKIPFGFDASAWEIFWPLLTGGRLVIARPGGHFEPGYLAQVVREQSVTAMVFVPAML
HHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHH
QLFLEVEEVSACHTLKDVFSGGGELSPAVARLFQQRLPHARLHNVYGPTETTVISSVWTL
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHEEE
QPGADVPPRQLPIGRPIANTRFYVLDERDAPVPAGVTGQLHIGGVGVARGYLGLDELTAE
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEECCEEHHHHHCCHHHHHHH
RFIDNPFVAGDRLYRSGDLARYRPDGQLEFIGRNDFQVKLRGIRLELSEIEARLDLFPGI
HHCCCCCCCCCHHCCCCCCCEECCCCCEEEECCCCEEEEEEEEEEEHHHHHHHHHHCCCC
RTSVALIVGDTAQNQRLVACCVTDSPVDESALRAHLATTLSSAVMPSAYLWLDALPLTVN
CCEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCEEEEEC
GKVDRAALAAQADQDLADRQVNLGSPRDHIELTLYQIWKDLLLVPQIGIRDNFFNVGGTS
CCCHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
IAAIKMAYEIGRAFSVEVPVRVILGHPTIEALGGWLRSGASLAAAQDNLIEFRRGAGQRN
HHHHHHHHHHCCEEEECCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
VVCIHPAGGTAFCYLSLAKELPDSIGVYGVQSPGLNPGESTEPSVEAMADAYLRRIAALT
EEEEECCCCCCHHHHHHHHHCCHHHCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
SQPLVLTGLSFGGLVAYEMARRLTAAGHRQVTVVLLDTQGSDDPGFRQQIGTVDMAEFRD
CCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHCCCCHHHHHH
KLVRFNGMYPGIEDAQVERYFHLYNHNRLAMAAYECAPQAGRIVLIQAREGFTRTQLHEL
HHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEHHHCCCCCCCEEEEECCCCCHHHHHHHH
RSFWRRRAGNGYKARLVNGGHWDMLESAEVHRVSQTLRQELQRFDTQEAQ
HHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNAYQLLELFGRHAVVLEVDGEKLRCKAPRGFLNDEMLQALKQHKAELIALLSGTDPAAI
CCHHHHHHHHCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCC
PRRAAGQTAVALSFSQRQLWFLDQMEPGNAFYNVPTAVLLKGVLDVSALERALNELIMRH
CCCCCCCEEEEEEECCCEEEEEECCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
EILRTTFASVDGEPRQIVHPAMPLVMPGVDLRDLSPTAREAHVRMAVEQQAKAPFDLASG
HHHHHHHHHCCCCCHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
PLLRASLLRLADEEYLWLYSVHHIIADGWSMGVILQEVTTVYGDFLRGQASSLAPLAVQY
CHHHHHHHHHCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
ADYACWQQQRLGDEALAGQLDFWKRTLADAPPLLDMPADRPRPTVQRYVGATFSSTVDGT
HHHHHHHHHHCCHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCHHCCCCCH
TLRALNALARQTQGTLFNVLIGALSVLLWRHSGQRDLCIGTPFANRSRPEIEPLIGHFVN
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHH
TQVIRQRLDPLQTFAELLREVRATLLDVHAHQDVPFDRVVEAVNPPRDTAYSPLFQVMMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
LQNTPGNAARMPGLSMTPYGTGSATAKFDLAFEWVERDGVLSLLVEYNTDLFDQTSIERL
HHCCCCCHHCCCCCCCCCCCCCCCCEEEEEEEEEHHCCCCEEEHHHHCCCCCCHHHHHHH
SGHYRQLLEQVALNPKQPVGALTLISDAEREQILHAWNSPAPLAQPVDCVHRLIEAQVTR
HHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
RQAECAVIFEGRSLSYSQLNTQANRLAHHLLTLGVGPDVRVAVCIERSLELPVALLAVLK
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHH
AGGAYVPLDPDYPSGRLRHILDDTSPVVLLAQGPTRKILREALEGADCEVPILDVQADAV
CCCCEECCCCCCCCCHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEEECCCEE
LWAECPSDNPQTQRVGVNADHLAYVLYTSGTTGLPKGAMVTHRGLSNLLLWCQQFCGECG
EEEECCCCCCCCEEECCCCCCEEEEEEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHH
SMLHKIPFGFDASAWEIFWPLLTGGRLVIARPGGHFEPGYLAQVVREQSVTAMVFVPAML
HHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHH
QLFLEVEEVSACHTLKDVFSGGGELSPAVARLFQQRLPHARLHNVYGPTETTVISSVWTL
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHEEE
QPGADVPPRQLPIGRPIANTRFYVLDERDAPVPAGVTGQLHIGGVGVARGYLGLDELTAE
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEECCEEHHHHHCCHHHHHHH
RFIDNPFVAGDRLYRSGDLARYRPDGQLEFIGRNDFQVKLRGIRLELSEIEARLDLFPGI
HHCCCCCCCCCHHCCCCCCCEECCCCCEEEECCCCEEEEEEEEEEEHHHHHHHHHHCCCC
RTSVALIVGDTAQNQRLVACCVTDSPVDESALRAHLATTLSSAVMPSAYLWLDALPLTVN
CCEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCEEEEEC
GKVDRAALAAQADQDLADRQVNLGSPRDHIELTLYQIWKDLLLVPQIGIRDNFFNVGGTS
CCCHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
IAAIKMAYEIGRAFSVEVPVRVILGHPTIEALGGWLRSGASLAAAQDNLIEFRRGAGQRN
HHHHHHHHHHCCEEEECCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
VVCIHPAGGTAFCYLSLAKELPDSIGVYGVQSPGLNPGESTEPSVEAMADAYLRRIAALT
EEEEECCCCCCHHHHHHHHHCCHHHCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
SQPLVLTGLSFGGLVAYEMARRLTAAGHRQVTVVLLDTQGSDDPGFRQQIGTVDMAEFRD
CCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHCCCCHHHHHH
KLVRFNGMYPGIEDAQVERYFHLYNHNRLAMAAYECAPQAGRIVLIQAREGFTRTQLHEL
HHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEHHHCCCCCCCEEEEECCCCCHHHHHHHH
RSFWRRRAGNGYKARLVNGGHWDMLESAEVHRVSQTLRQELQRFDTQEAQ
HHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA