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The map label for this gene is emrK [H]

Identifier: 66045017

GI number: 66045017

Start: 2017234

End: 2018391

Strand: Direct

Name: emrK [H]

Synonym: Psyr_1772

Alternate gene names: 66045017

Gene position: 2017234-2018391 (Clockwise)

Preceding gene: 66045016

Following gene: 66045024

Centisome position: 33.1

GC content: 64.25

Gene sequence:

>1158_bases
ATGACCGAATCCAAGACCCCAGATACCGAAGCTCCGCGCAACTCGCCGCCACCGGCACCGTTGACGTCCCCGGTGACCAG
CAAGCCGCGCTCGACCCGCAAGCGTGTCGTGTCTTCCGTGATTTTCGGCGCCGTCGCCCTGGCCGGGGTGCTGGTGGTGC
TGTACGCCTGGCAACTGCCCCCGTTTGCCAGCCCGATCGAGAGCACCGAGAACGCGCAGGTCAAGGGCCAGACCACGCTG
ATCGGGCCGCAACTGAGCGGCTATGTCTACGAGGTGCCGGTGCAGGACTTCCAGTTCGTCAAGGCCGGTGATTTGCTGGT
GCGTCTGGATGACCGTATCTATCGTCAGCGCCTGGATCAGGCCATTGCACAACTGGCTGTGCAGAAGGCCTCGCTGGCCA
ATAATCTGCAACAACGGCGCAGTGCCGAAGCCACCATCGGCCAGCGTCAGGCCGAACTGCAGAACAGCATCGCCCAGAGC
CGCAAGAGCGCCGCCGATCTGCGGCGCAATCAGGCGCTGGTGACCGACGGTTCGGTTTCGAAAAGCGAGCTGGATGTCAC
GCGTGCCGCCGATGCGCAGGCAAACGCCGCCGTTGCCGAAGCCAGGGCAGTCTTGCAGATCGCCCGTGAGGACCTGCAGA
CCGTCATCGTCAACCGTGGCTCACTGGAAGCCTCGGTCGCCAATGCGCAGGCGGCGATCGAGCTGGCGCGCATAGACCTG
GACAACACCCGTATCGTTGCCCCGCGGGACGGGCAGTTGGGGCAGATTGGCGTGCGTCTGGGGGCCTATGTCAATTCGGG
CGCGCAATTGATGGCGCTGGTGCCCGAGCAGCGCTGGATCGTGGCGAACATGAAAGAAACCCAGATGGCCAACGTGCGCC
TGGGCCAGCCGGTGAGCTTTACCGTCGATGCGCTCGATGGCCACGAGATGCATGGCCACGTACAAAGAATTTCGCCCGCT
GCCGGCTCGGAATTCAGTCTGCTGCCCGCCGACAACGCCACCGGCAACTTCGTGAAGATTTCCCAGCGTATCCCGGTACG
CATCGTGGTCGATGCCGATCAGCCCATGCTTGAGCACCTGCGGCCAGGGATGTCGGTGGTCGTGAGCATCGACACCAGCG
CGGACGGCGATGTGCCGCCTGATCCGGCGGTGCGCTGA

Upstream 100 bases:

>100_bases
CCCGGGTCCTGTGGCTGAAAATGACCACTCAACCTCTGGCGCTGGCACCCGTTGCACCTGCTGCTTCGCCCTCCGTATCC
AACTCCGGCGTTAAATCTTC

Downstream 100 bases:

>100_bases
GCCTCTGGATGATCGCTGATTGCTGGACGCGAGCAGGATTCGATCCGATGCAAGTTGACTATCGTGCCGACGCTCCGCGT
CGGCATGCAGTTCATGACGC

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTESKTPDTEAPRNSPPPAPLTSPVTSKPRSTRKRVVSSVIFGAVALAGVLVVLYAWQLPPFASPIESTENAQVKGQTTL
IGPQLSGYVYEVPVQDFQFVKAGDLLVRLDDRIYRQRLDQAIAQLAVQKASLANNLQQRRSAEATIGQRQAELQNSIAQS
RKSAADLRRNQALVTDGSVSKSELDVTRAADAQANAAVAEARAVLQIAREDLQTVIVNRGSLEASVANAQAAIELARIDL
DNTRIVAPRDGQLGQIGVRLGAYVNSGAQLMALVPEQRWIVANMKETQMANVRLGQPVSFTVDALDGHEMHGHVQRISPA
AGSEFSLLPADNATGNFVKISQRIPVRIVVDADQPMLEHLRPGMSVVVSIDTSADGDVPPDPAVR

Sequences:

>Translated_385_residues
MTESKTPDTEAPRNSPPPAPLTSPVTSKPRSTRKRVVSSVIFGAVALAGVLVVLYAWQLPPFASPIESTENAQVKGQTTL
IGPQLSGYVYEVPVQDFQFVKAGDLLVRLDDRIYRQRLDQAIAQLAVQKASLANNLQQRRSAEATIGQRQAELQNSIAQS
RKSAADLRRNQALVTDGSVSKSELDVTRAADAQANAAVAEARAVLQIAREDLQTVIVNRGSLEASVANAQAAIELARIDL
DNTRIVAPRDGQLGQIGVRLGAYVNSGAQLMALVPEQRWIVANMKETQMANVRLGQPVSFTVDALDGHEMHGHVQRISPA
AGSEFSLLPADNATGNFVKISQRIPVRIVVDADQPMLEHLRPGMSVVVSIDTSADGDVPPDPAVR
>Mature_384_residues
TESKTPDTEAPRNSPPPAPLTSPVTSKPRSTRKRVVSSVIFGAVALAGVLVVLYAWQLPPFASPIESTENAQVKGQTTLI
GPQLSGYVYEVPVQDFQFVKAGDLLVRLDDRIYRQRLDQAIAQLAVQKASLANNLQQRRSAEATIGQRQAELQNSIAQSR
KSAADLRRNQALVTDGSVSKSELDVTRAADAQANAAVAEARAVLQIAREDLQTVIVNRGSLEASVANAQAAIELARIDLD
NTRIVAPRDGQLGQIGVRLGAYVNSGAQLMALVPEQRWIVANMKETQMANVRLGQPVSFTVDALDGHEMHGHVQRISPAA
GSEFSLLPADNATGNFVKISQRIPVRIVVDADQPMLEHLRPGMSVVVSIDTSADGDVPPDPAVR

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=355, Percent_Identity=34.3661971830986, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1789041, Length=359, Percent_Identity=34.8189415041783, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1790519, Length=316, Percent_Identity=28.7974683544304, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI87081951, Length=323, Percent_Identity=26.0061919504644, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789637, Length=357, Percent_Identity=26.3305322128852, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790012, Length=282, Percent_Identity=26.5957446808511, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789900, Length=354, Percent_Identity=24.2937853107345, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790024, Length=285, Percent_Identity=25.9649122807018, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41360; Mature: 41229

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESKTPDTEAPRNSPPPAPLTSPVTSKPRSTRKRVVSSVIFGAVALAGVLVVLYAWQLP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFASPIESTENAQVKGQTTLIGPQLSGYVYEVPVQDFQFVKAGDLLVRLDDRIYRQRLDQ
CCCCCCCCCCCCEECCCEEEECCCCCCEEEECCCCCCEEEECCCEEEEEHHHHHHHHHHH
AIAQLAVQKASLANNLQQRRSAEATIGQRQAELQNSIAQSRKSAADLRRNQALVTDGSVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCC
KSELDVTRAADAQANAAVAEARAVLQIAREDLQTVIVNRGSLEASVANAQAAIELARIDL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEEEEC
DNTRIVAPRDGQLGQIGVRLGAYVNSGAQLMALVPEQRWIVANMKETQMANVRLGQPVSF
CCCEEECCCCCCCCHHHHEEHHHHCCCCEEEEECCCCCEEEECCCHHHCCCEECCCCCEE
TVDALDGHEMHGHVQRISPAAGSEFSLLPADNATGNFVKISQRIPVRIVVDADQPMLEHL
EEECCCCCHHHCHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCCEEEEEECCCHHHHHC
RPGMSVVVSIDTSADGDVPPDPAVR
CCCCEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TESKTPDTEAPRNSPPPAPLTSPVTSKPRSTRKRVVSSVIFGAVALAGVLVVLYAWQLP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFASPIESTENAQVKGQTTLIGPQLSGYVYEVPVQDFQFVKAGDLLVRLDDRIYRQRLDQ
CCCCCCCCCCCCEECCCEEEECCCCCCEEEECCCCCCEEEECCCEEEEEHHHHHHHHHHH
AIAQLAVQKASLANNLQQRRSAEATIGQRQAELQNSIAQSRKSAADLRRNQALVTDGSVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCC
KSELDVTRAADAQANAAVAEARAVLQIAREDLQTVIVNRGSLEASVANAQAAIELARIDL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEEEEC
DNTRIVAPRDGQLGQIGVRLGAYVNSGAQLMALVPEQRWIVANMKETQMANVRLGQPVSF
CCCEEECCCCCCCCHHHHEEHHHHCCCCEEEEECCCCCEEEECCCHHHCCCEECCCCCEE
TVDALDGHEMHGHVQRISPAAGSEFSLLPADNATGNFVKISQRIPVRIVVDADQPMLEHL
EEECCCCCHHHCHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCCEEEEEECCCHHHHHC
RPGMSVVVSIDTSADGDVPPDPAVR
CCCCEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]