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The map label for this gene is cyp18 [H]

Identifier: 66044978

GI number: 66044978

Start: 1968052

End: 1968555

Strand: Reverse

Name: cyp18 [H]

Synonym: Psyr_1733

Alternate gene names: 66044978

Gene position: 1968555-1968052 (Counterclockwise)

Preceding gene: 66044981

Following gene: 66044977

Centisome position: 32.3

GC content: 55.16

Gene sequence:

>504_bases
ATGCCTAATGTAAAGCTGACTACCAACCACGGCGACATCGTGCTGCAACTGAACGAAGAAAAAGCGCCGCTGACCGTTGC
CAACTTCATCGAATACGTTAAAGCCGGCCACTACGAAAACACGGTTTTCCACCGTGTGATCGGCAATTTCATGGTTCAGG
GCGGCGGTTTCGAGCCTGGCATGAAAGAAAAGAAAGACAAGCGCCCGAGCATCCAGAACGAAGCCGACAACGGTCTGCCG
AACAAGAAGTACAGCGTCGCCATGGCCCGTACCATGGAACCGCATTCGGCCTCTGCGCAGTTCTTCATCAACGTCGCTGA
CAACGCCTTTCTGAACCACAGCGCCAAGACCGTTCAGGGCTGGGGTTACGCTGTGTTCGGTGAAGTGATCGAAGGCACCG
ACGTGGTCGACAAGATCAAAGGCGTGGCGACTTCCAGCAAGGCCGGCCATCAGGACGTCCCGGTAGAAGACGTGATCATC
GAGAAAGCCGAGATCGTTGAGTGA

Upstream 100 bases:

>100_bases
TAAAAGCTGCAAAAGCGCTGAAAAATGTAACCTCGTCTGTAAACTGCGCGTCAGGGTCATAATCCGCCCATTCATGCATG
ACTAGAGAGCGACTTCCCAA

Downstream 100 bases:

>100_bases
TACTGCTGATCTCCGATCTGCATCTTGAACAGGAGCGCCCGGACATTACCCGGGCGTTTCTGGATCTGCTCGCAGGACGC
GCTCGCGAAGCCGAGTCGCT

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MPNVKLTTNHGDIVLQLNEEKAPLTVANFIEYVKAGHYENTVFHRVIGNFMVQGGGFEPGMKEKKDKRPSIQNEADNGLP
NKKYSVAMARTMEPHSASAQFFINVADNAFLNHSAKTVQGWGYAVFGEVIEGTDVVDKIKGVATSSKAGHQDVPVEDVII
EKAEIVE

Sequences:

>Translated_167_residues
MPNVKLTTNHGDIVLQLNEEKAPLTVANFIEYVKAGHYENTVFHRVIGNFMVQGGGFEPGMKEKKDKRPSIQNEADNGLP
NKKYSVAMARTMEPHSASAQFFINVADNAFLNHSAKTVQGWGYAVFGEVIEGTDVVDKIKGVATSSKAGHQDVPVEDVII
EKAEIVE
>Mature_166_residues
PNVKLTTNHGDIVLQLNEEKAPLTVANFIEYVKAGHYENTVFHRVIGNFMVQGGGFEPGMKEKKDKRPSIQNEADNGLPN
KKYSVAMARTMEPHSASAQFFINVADNAFLNHSAKTVQGWGYAVFGEVIEGTDVVDKIKGVATSSKAGHQDVPVEDVIIE
KAEIVE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=165, Percent_Identity=34.5454545454545, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI22547212, Length=171, Percent_Identity=30.4093567251462, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI7657473, Length=171, Percent_Identity=30.4093567251462, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4758950, Length=165, Percent_Identity=33.9393939393939, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI22547215, Length=171, Percent_Identity=30.4093567251462, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI24308049, Length=157, Percent_Identity=31.8471337579618, Blast_Score=64, Evalue=5e-11,
Organism=Escherichia coli, GI1786736, Length=164, Percent_Identity=62.8048780487805, Blast_Score=218, Evalue=1e-58,
Organism=Escherichia coli, GI1789763, Length=165, Percent_Identity=52.7272727272727, Blast_Score=176, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17532641, Length=165, Percent_Identity=30.9090909090909, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=157, Percent_Identity=31.2101910828025, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17539496, Length=168, Percent_Identity=30.3571428571429, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320510, Length=169, Percent_Identity=34.3195266272189, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922376, Length=165, Percent_Identity=30.9090909090909, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17986117, Length=165, Percent_Identity=31.5151515151515, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922912, Length=168, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18300; Mature: 18169

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNVKLTTNHGDIVLQLNEEKAPLTVANFIEYVKAGHYENTVFHRVIGNFMVQGGGFEPG
CCCCEEEECCCCEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCCC
MKEKKDKRPSIQNEADNGLPNKKYSVAMARTMEPHSASAQFFINVADNAFLNHSAKTVQG
CCCHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCCEECCCCCEECC
WGYAVFGEVIEGTDVVDKIKGVATSSKAGHQDVPVEDVIIEKAEIVE
CCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
PNVKLTTNHGDIVLQLNEEKAPLTVANFIEYVKAGHYENTVFHRVIGNFMVQGGGFEPG
CCCEEEECCCCEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCCC
MKEKKDKRPSIQNEADNGLPNKKYSVAMARTMEPHSASAQFFINVADNAFLNHSAKTVQG
CCCHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCCEECCCCCEECC
WGYAVFGEVIEGTDVVDKIKGVATSSKAGHQDVPVEDVIIEKAEIVE
CCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]