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The map label for this gene is ilvD [H]

Identifier: 66044953

GI number: 66044953

Start: 1932877

End: 1934619

Strand: Reverse

Name: ilvD [H]

Synonym: Psyr_1708

Alternate gene names: 66044953

Gene position: 1934619-1932877 (Counterclockwise)

Preceding gene: 66044959

Following gene: 66044952

Centisome position: 31.75

GC content: 63.05

Gene sequence:

>1743_bases
ATGTCTGACTCCGATAAAAAACCGACCCTCCGTTCTGCCCAGTGGTTTGGCACTGCCGACAAGAATGGCTTCATGTACCG
CAGCTGGATGAAGAATCAGGGTATTGCCGACCACCAGTTTCAGGGCAAGCCGATCATCGGCATCTGCAATACCTGGTCGG
AGTTGACCCCCTGCAACGCGCATTTCCGGCAGATCGCCGAGCATGTCAAACGTGGCGTGATCGAAGCAGGCGGCTGGCCG
GTCGAGTTTCCGGTGTTTTCCAACGGCGAATCCAACCTGCGCCCTACCGCTATGTTCACCCGCAACCTGGCGAGCATGGA
CGTTGAAGAAGCGATTCGCGGCAACCCCATCGATGGCGTCGTGCTGTTGACCGGCTGTGACAAGACCACCCCTGCCCTGT
TGATGGGGGCTGCCAGCTGTGACATCCCCGCCATCGTCGTCACCGGCGGACCGATGCTCAACGGCAAGCATGAAGGCAAG
GACATCGGCGCCGGCACCATCGTCTGGCAGATGCACGAGTCCTACAAGGCCGGGACCATCAGCCTGGATGAATTCCTGTC
CGCCGAAGCAGGCATGTCGCGCTCGGCAGGCACCTGCAACACCATGGGCACGGCCTCGACCATGGCCTGCATGGCCGAAG
CGCTGGGCACTTCGCTGCCGCACAACGCGGCCATTCCGGCGGTGGATTCGCGGCGTTACGTGCTGGCGCACATGTCCGGC
ATGCGCGCCGTCGATATGGTCCGTGAAGACCTGCGCCTGTCGAAGATTCTCACCAAGGCCGCATTCGAAAACGCCATCAG
GGTCAACGCGGCCATCGGTGGCTCGACCAACGCCGTGATTCACCTGAAGGCCATCGCCGGACGCATCGGCGTCGATCTGG
ACCTGGATGACTGGTCACGCATGGGCCGGGGCATGCCGACGATTGTCGACCTGCAACCGTCGGGGCGCTTCCTGATGGAA
GAGTTCTATTACGCCGGCGGCCTGCCCGCCGTGCTGCGCCGTATGAACGAAGCCAGGCTGCTGCCCAACCCGGATGCCTT
GACCGTCAATGGCAAGAGCATCGGCGAAAACACCTGCAACTCACCGATCTATGGTGAAGATCAGGTAATCCGCGCGCTGG
ACAACCCGATCCGCGCCGACGGCGGGATTTGCGTGCTGCGCGGCAACCTCGCGCCGCTGGGTGCCGTGCTCAAGCCCTCG
GCCGCGACGCCGGCGCTGATGCAGCACCGTGGCCGCGCAGTGGTGTTCGAGAATTTCGAGATGTACAAGTCACGGATCAA
CGACCCGGATCTGGACATCGATGCCAACTCGGTCATGGTGCTGAAGAACTGCGGCCCCAAGGGTTATCCGGGCATGGCCG
AGGTCGGCAACATGGGCTTGCCAGCCAAGCTGCTGGCGCAGGGCGTGACTGACATGGTGCGCATTTCCGATGCGCGCATG
AGCGGCACAGCTTACGGCACCGTGGTTCTGCATGTGGCGCCGGAAGCCGCAGCGGGCGGCCCGCTGGCGGTGGTCAAGGA
AGGCGACTGGATCGAGCTGGACTGCGCTGGCGGGCGTCTGCATCTGGACATCCCGGAAGCCGAACTGGCGGCGCGCCTCG
CCGACTGGCAGGCTCCGCCTCAATTGCTGTTGGGTGGCTATCGTCAGCTGTACGTAGACCGGGTGATGCAGGCAGACCAG
GGCTGTGATTTCGACTTCCTGGTCGGTTGCAGAGGTTCCGAAGTGCCCCGCCACTCGCACTGA

Upstream 100 bases:

>100_bases
TAGTAATACTATTTAAACTGACAACTCTTCCAATACGCGTTTTTTAGGCTTACCTTAGCCAGCAGTATCGCCATTAAGTC
TTACAATAAGAGAGCCGATC

Downstream 100 bases:

>100_bases
CCAAAGCGGCGGTTTACCTGACGCAGGCAGCCGCCGCAAGTGTTACGCAATGGTATGATGCCCAGCAATTACCGCCAGGA
CCGACCAGCGTTCCCATGGA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 580; Mature: 579

Protein sequence:

>580_residues
MSDSDKKPTLRSAQWFGTADKNGFMYRSWMKNQGIADHQFQGKPIIGICNTWSELTPCNAHFRQIAEHVKRGVIEAGGWP
VEFPVFSNGESNLRPTAMFTRNLASMDVEEAIRGNPIDGVVLLTGCDKTTPALLMGAASCDIPAIVVTGGPMLNGKHEGK
DIGAGTIVWQMHESYKAGTISLDEFLSAEAGMSRSAGTCNTMGTASTMACMAEALGTSLPHNAAIPAVDSRRYVLAHMSG
MRAVDMVREDLRLSKILTKAAFENAIRVNAAIGGSTNAVIHLKAIAGRIGVDLDLDDWSRMGRGMPTIVDLQPSGRFLME
EFYYAGGLPAVLRRMNEARLLPNPDALTVNGKSIGENTCNSPIYGEDQVIRALDNPIRADGGICVLRGNLAPLGAVLKPS
AATPALMQHRGRAVVFENFEMYKSRINDPDLDIDANSVMVLKNCGPKGYPGMAEVGNMGLPAKLLAQGVTDMVRISDARM
SGTAYGTVVLHVAPEAAAGGPLAVVKEGDWIELDCAGGRLHLDIPEAELAARLADWQAPPQLLLGGYRQLYVDRVMQADQ
GCDFDFLVGCRGSEVPRHSH

Sequences:

>Translated_580_residues
MSDSDKKPTLRSAQWFGTADKNGFMYRSWMKNQGIADHQFQGKPIIGICNTWSELTPCNAHFRQIAEHVKRGVIEAGGWP
VEFPVFSNGESNLRPTAMFTRNLASMDVEEAIRGNPIDGVVLLTGCDKTTPALLMGAASCDIPAIVVTGGPMLNGKHEGK
DIGAGTIVWQMHESYKAGTISLDEFLSAEAGMSRSAGTCNTMGTASTMACMAEALGTSLPHNAAIPAVDSRRYVLAHMSG
MRAVDMVREDLRLSKILTKAAFENAIRVNAAIGGSTNAVIHLKAIAGRIGVDLDLDDWSRMGRGMPTIVDLQPSGRFLME
EFYYAGGLPAVLRRMNEARLLPNPDALTVNGKSIGENTCNSPIYGEDQVIRALDNPIRADGGICVLRGNLAPLGAVLKPS
AATPALMQHRGRAVVFENFEMYKSRINDPDLDIDANSVMVLKNCGPKGYPGMAEVGNMGLPAKLLAQGVTDMVRISDARM
SGTAYGTVVLHVAPEAAAGGPLAVVKEGDWIELDCAGGRLHLDIPEAELAARLADWQAPPQLLLGGYRQLYVDRVMQADQ
GCDFDFLVGCRGSEVPRHSH
>Mature_579_residues
SDSDKKPTLRSAQWFGTADKNGFMYRSWMKNQGIADHQFQGKPIIGICNTWSELTPCNAHFRQIAEHVKRGVIEAGGWPV
EFPVFSNGESNLRPTAMFTRNLASMDVEEAIRGNPIDGVVLLTGCDKTTPALLMGAASCDIPAIVVTGGPMLNGKHEGKD
IGAGTIVWQMHESYKAGTISLDEFLSAEAGMSRSAGTCNTMGTASTMACMAEALGTSLPHNAAIPAVDSRRYVLAHMSGM
RAVDMVREDLRLSKILTKAAFENAIRVNAAIGGSTNAVIHLKAIAGRIGVDLDLDDWSRMGRGMPTIVDLQPSGRFLMEE
FYYAGGLPAVLRRMNEARLLPNPDALTVNGKSIGENTCNSPIYGEDQVIRALDNPIRADGGICVLRGNLAPLGAVLKPSA
ATPALMQHRGRAVVFENFEMYKSRINDPDLDIDANSVMVLKNCGPKGYPGMAEVGNMGLPAKLLAQGVTDMVRISDARMS
GTAYGTVVLHVAPEAAAGGPLAVVKEGDWIELDCAGGRLHLDIPEAELAARLADWQAPPQLLLGGYRQLYVDRVMQADQG
CDFDFLVGCRGSEVPRHSH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=579, Percent_Identity=29.8791018998273, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI2367371, Length=482, Percent_Identity=32.3651452282158, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1788157, Length=513, Percent_Identity=28.8499025341131, Blast_Score=168, Evalue=9e-43,
Organism=Escherichia coli, GI1786464, Length=445, Percent_Identity=32.1348314606742, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322476, Length=572, Percent_Identity=29.5454545454545, Blast_Score=249, Evalue=8e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62262; Mature: 62131

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSDKKPTLRSAQWFGTADKNGFMYRSWMKNQGIADHQFQGKPIIGICNTWSELTPCNA
CCCCCCCCCCCCCCCCCCCCCCCCEEHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHH
HFRQIAEHVKRGVIEAGGWPVEFPVFSNGESNLRPTAMFTRNLASMDVEEAIRGNPIDGV
HHHHHHHHHHHCCEECCCCEEECCEECCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCE
VLLTGCDKTTPALLMGAASCDIPAIVVTGGPMLNGKHEGKDIGAGTIVWQMHESYKAGTI
EEEECCCCCCHHHEEECCCCCCCEEEEECCCEECCCCCCCCCCCCEEEEEECCCCCCCCE
SLDEFLSAEAGMSRSAGTCNTMGTASTMACMAEALGTSLPHNAAIPAVDSRRYVLAHMSG
EHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHCC
MRAVDMVREDLRLSKILTKAAFENAIRVNAAIGGSTNAVIHLKAIAGRIGVDLDLDDWSR
CHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEEECCCCCCEECCHHHHH
MGRGMPTIVDLQPSGRFLMEEFYYAGGLPAVLRRMNEARLLPNPDALTVNGKSIGENTCN
HCCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCC
SPIYGEDQVIRALDNPIRADGGICVLRGNLAPLGAVLKPSAATPALMQHRGRAVVFENFE
CCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCHHCCCCCCCHHHHHCCCCEEEEECHH
MYKSRINDPDLDIDANSVMVLKNCGPKGYPGMAEVGNMGLPAKLLAQGVTDMVRISDARM
HHHHHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
SGTAYGTVVLHVAPEAAAGGPLAVVKEGDWIELDCAGGRLHLDIPEAELAARLADWQAPP
CCCEEEEEEEEECCCCCCCCCEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHCCCCH
QLLLGGYRQLYVDRVMQADQGCDFDFLVGCRGSEVPRHSH
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
SDSDKKPTLRSAQWFGTADKNGFMYRSWMKNQGIADHQFQGKPIIGICNTWSELTPCNA
CCCCCCCCCCCCCCCCCCCCCCCEEHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHH
HFRQIAEHVKRGVIEAGGWPVEFPVFSNGESNLRPTAMFTRNLASMDVEEAIRGNPIDGV
HHHHHHHHHHHCCEECCCCEEECCEECCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCE
VLLTGCDKTTPALLMGAASCDIPAIVVTGGPMLNGKHEGKDIGAGTIVWQMHESYKAGTI
EEEECCCCCCHHHEEECCCCCCCEEEEECCCEECCCCCCCCCCCCEEEEEECCCCCCCCE
SLDEFLSAEAGMSRSAGTCNTMGTASTMACMAEALGTSLPHNAAIPAVDSRRYVLAHMSG
EHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHCC
MRAVDMVREDLRLSKILTKAAFENAIRVNAAIGGSTNAVIHLKAIAGRIGVDLDLDDWSR
CHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEEECCCCCCEECCHHHHH
MGRGMPTIVDLQPSGRFLMEEFYYAGGLPAVLRRMNEARLLPNPDALTVNGKSIGENTCN
HCCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCC
SPIYGEDQVIRALDNPIRADGGICVLRGNLAPLGAVLKPSAATPALMQHRGRAVVFENFE
CCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCHHCCCCCCCHHHHHCCCCEEEEECHH
MYKSRINDPDLDIDANSVMVLKNCGPKGYPGMAEVGNMGLPAKLLAQGVTDMVRISDARM
HHHHHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
SGTAYGTVVLHVAPEAAAGGPLAVVKEGDWIELDCAGGRLHLDIPEAELAARLADWQAPP
CCCEEEEEEEEECCCCCCCCCEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHCCCCH
QLLLGGYRQLYVDRVMQADQGCDFDFLVGCRGSEVPRHSH
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA