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The map label for this gene is tmk [H]

Identifier: 66044897

GI number: 66044897

Start: 1857020

End: 1857652

Strand: Direct

Name: tmk [H]

Synonym: Psyr_1652

Alternate gene names: 66044897

Gene position: 1857020-1857652 (Clockwise)

Preceding gene: 66044896

Following gene: 66044898

Centisome position: 30.47

GC content: 64.14

Gene sequence:

>633_bases
GTGACTGGCTTGTTTATCACTCTTGAAGGCCCGGAAGGTGCAGGCAAAAGTACCAACCGTGACTACCTGGCGGCGCAATT
GCGTGCGCAGGGTGTTCAGGTACTGCTGACCCGCGAGCCGGGTGGTACTCCGCTGGCCGAGCGTGTTCGCGAGCTGTTGC
TGGCGCCCAGCGACGAGGCCATGAGCGCTGACACCGAGCTGCTGCTGGTGTTTGCGGCGCGTGCACAGCATTTGGCCGAA
GTCATTCGTCCAGCGCTGGCGCGTGGCGAGGTGGTGCTCTGTGATCGGTTTACCGATGCGACCTACGCCTATCAGGGCGG
CGGCCGCGGCCTGTCCCATCAGCGTATTGCAGCGCTGGAACAGTTCGTTCAAGGCGACCTGCGCCCTGACCTGACGCTGG
TCTTCGACCTGCCGGTGGAGATCGGTCTGTCACGCGCCGCTGCACGCGGTCGGCTGGATCGCTTCGAGCAGGAAGGCAGA
GCTTTCTTCGACGCTGTGCGCAGCACCTATCTGGAACGGGCCAGGGCCGAGCCTGCGCGCTATCGCCTGGTAGACGCCGC
ACAGACTCTGGCCGACGTTCAGGCTTGCCTCGACACCTTGCTGCCTCAGTTGCTGGAGCTGCAACGTGGCTGA

Upstream 100 bases:

>100_bases
CCCGTAACTGACTTGCCCCCTTCGGAAAGCGTGCCTGCGGATACTCCGGATGCGCCGCAGTCCGAGCCGAATGCACAATG
ATGACGATTAAGGATGACCT

Downstream 100 bases:

>100_bases
AGCCTACCCCTGGCAGGCTTCGCTCTGGCAGCAGATGGCCGGTCGCGCCCAGCACGCTCACGCCTATCTGCTGCACGGGC
CGGCGGGTATCGGCAAGCGC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MTGLFITLEGPEGAGKSTNRDYLAAQLRAQGVQVLLTREPGGTPLAERVRELLLAPSDEAMSADTELLLVFAARAQHLAE
VIRPALARGEVVLCDRFTDATYAYQGGGRGLSHQRIAALEQFVQGDLRPDLTLVFDLPVEIGLSRAAARGRLDRFEQEGR
AFFDAVRSTYLERARAEPARYRLVDAAQTLADVQACLDTLLPQLLELQRG

Sequences:

>Translated_210_residues
MTGLFITLEGPEGAGKSTNRDYLAAQLRAQGVQVLLTREPGGTPLAERVRELLLAPSDEAMSADTELLLVFAARAQHLAE
VIRPALARGEVVLCDRFTDATYAYQGGGRGLSHQRIAALEQFVQGDLRPDLTLVFDLPVEIGLSRAAARGRLDRFEQEGR
AFFDAVRSTYLERARAEPARYRLVDAAQTLADVQACLDTLLPQLLELQRG
>Mature_209_residues
TGLFITLEGPEGAGKSTNRDYLAAQLRAQGVQVLLTREPGGTPLAERVRELLLAPSDEAMSADTELLLVFAARAQHLAEV
IRPALARGEVVLCDRFTDATYAYQGGGRGLSHQRIAALEQFVQGDLRPDLTLVFDLPVEIGLSRAAARGRLDRFEQEGRA
FFDAVRSTYLERARAEPARYRLVDAAQTLADVQACLDTLLPQLLELQRG

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=210, Percent_Identity=44.2857142857143, Blast_Score=163, Evalue=8e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23005; Mature: 22873

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGLFITLEGPEGAGKSTNRDYLAAQLRAQGVQVLLTREPGGTPLAERVRELLLAPSDEA
CCEEEEEEECCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHCCCCCHH
MSADTELLLVFAARAQHLAEVIRPALARGEVVLCDRFTDATYAYQGGGRGLSHQRIAALE
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCCCHHHHHHHH
QFVQGDLRPDLTLVFDLPVEIGLSRAAARGRLDRFEQEGRAFFDAVRSTYLERARAEPAR
HHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
YRLVDAAQTLADVQACLDTLLPQLLELQRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TGLFITLEGPEGAGKSTNRDYLAAQLRAQGVQVLLTREPGGTPLAERVRELLLAPSDEA
CEEEEEEECCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHCCCCCHH
MSADTELLLVFAARAQHLAEVIRPALARGEVVLCDRFTDATYAYQGGGRGLSHQRIAALE
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCCCHHHHHHHH
QFVQGDLRPDLTLVFDLPVEIGLSRAAARGRLDRFEQEGRAFFDAVRSTYLERARAEPAR
HHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
YRLVDAAQTLADVQACLDTLLPQLLELQRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA