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The map label for this gene is comA [H]

Identifier: 66044877

GI number: 66044877

Start: 1835715

End: 1837931

Strand: Direct

Name: comA [H]

Synonym: Psyr_1632

Alternate gene names: 66044877

Gene position: 1835715-1837931 (Clockwise)

Preceding gene: 66044876

Following gene: 66044878

Centisome position: 30.12

GC content: 65.94

Gene sequence:

>2217_bases
ATGCGCACAGGGATGATCGCGCTCGCGCTCGGGCTGCTTGCCCTGCGTTTTCTACCGGCCCTGCCGCCGGCCTGGCTTCT
GCTGCTGATGCCGATACTGGCGTTGATGTTGCTGCCGTTCCGTACCTATCCGCTGGCGTTCTTTCTGCTCGGTTTCACCT
GGGCCTGCGTTTCGGCGCAGTGGGCATTGAGTGACCGCTTGGCGCAGCGTCTCGATGGTCAGACGCTGTGGGTGCAGGGC
AAGGTGGTCGGTTTGCCCAGTGTCGCCGAAGGTGTGGTGCGCTTTGAACTGGAAGATGCCTGGTCACGACGTGCCAGGCT
GCCGGCGCGAATCCGCATGGCGTGGTACGGCGGCCAGCCCGTAAACAGCGGCGAGCGCTGGCGCATGGCGATCAAACTCA
AGCGGCCGGCCGGGCTGGTCAATCCGGATGCTTTCGACTACGAAGCCTGGCTACTGGCGCAGCGCATCGGTGCGACCGGC
ACGGTAGTGGATGGTCAGCTATTGGCACCCGCGCGTGCCGCCTGGCGCGATGCCATTCGTCAGCGCCTGCTGGCGGTCGA
TGCGCAGGGCCGGGAGGGCGGTCTGGCGGCGCTGGTGCTGGGCGATGGCTCAGGGCTGTCGAGCACCGACTGGCAGGTGT
TGCAGGATACTGGCACTGTGCATCTGCTGGTCATTTCCGGCCAGCACATCGGTTTGCTGGCCGGCGTGATCTACGCGCTG
GTCGCAGGCCTGGCGCGCTGGGGGCTGTGGCCACGCTTTTTGCCCTGGCTGCCGTCGGCGTGTGCACTGGCGTTCAGTGC
TGCACTGGGCTACGGACTGCTGGCCGGTTTCGAGGTGCCGGTCCGGCGAGCCTGTGTGATGGTCGCGATGGTGCTGCTGT
GGCGCTTGCGTTTTCGTCACCTGGGCGTGGTCTGGCCTTTGTTGCTGTCCTTCAACGCGGTGCTGATCTTCGAGCCGCTG
GTGACGCTGCAGCCGGGTTTCTGGCTGTCCTTCGCGGCGGTCGGCATTCTGATCCTGATTTTCAGCGGGCGTCTTGGCGC
CTGGAGCTGGTGGCAAAGCTGGACACGGGCGCAATGGCTGATCGCCGTTGGCTTGTTGCCGATCCTGCTGGCGCTGAACC
TGCCGATCAGCCTCAGCGGCCCGTTTGCCAACCTGCTTGCGGTGCCTTGGGTCAGCGTGATTGTCCTGCCGCCGGCATTG
CTCGGAACGCTGTTGCTGCCAGTCCCCGTGGTCGGGGAAGGTCTGCTCTGGCTGGCGGGCGGGGCGCTGCAGGGGCTGTT
CGTATTCCTCGGCGCGGTGGCCGCCGCATTGCCGGCCTGGTTGCCCAGTGCCGTGCCGGTCTGGGCATGGTGGTTGAGTC
TGCTCGGGGCCTTGCTCCTGTTGCTGCCCAAGGGCGTGCCCCTGCGTCCGCTGGGCTGGCCGTTGCTGTTGCTGTGCGTT
TTTCCGCCGCTCGAATCAGTGCCTGAAGGTCAGGTCGATGTGTTGCAACTGGATGTGGGGCAGGGCCTGGCGATTCTCCT
GCGCACCCGCAATCACACACTCCTGTATGACGCAGGTCCACGTTTCGGTGAGTTCGATATCGGTCAGCGCGTGGTCGTGC
CCGCCATGCGCAAGGCGGGTGTCCGCCATCTTGACCTGATGTTGATCAGCCATTCCGACGCAGACCATGCCGGAGGTGCA
GCAGCGGTTCATCAGGCCTTTCCGGTGGCCCGCGTGCTAGGCGGTGAGCTGGCCCGCCTCGCGCCGCAACTCGACGCCCG
ACTGTGCGAGAGCGGTGCACGCTGGGAGTGGGATGGCGTGGTGTTTTCCACGTGGCGCTGGGAGCAGGGGCCTGAAGGCA
ATCCGGCCTCCTGCATCCTCAGCGTCGACGCCAGGGGCGAGCGTCTGCTGCTGGCGGGCGATATCGACGTGCACGCCGAG
CGTGCGGCGATCGACAGCGGGTTCGACCTTCGTGCCCACTGGTTGCAGTCGCCGCATCACGGCAGCCGTACCTCGTCGTC
CAAAGCATTTCTGCGCGCCGTGGCACCGGTTGGCGTGCTGATTTCCCGTGGTCGCAACAACGCGTTCGGTCACCCGCATC
CGTTGGTCATGGCGCGCTATCGAGGCCTGGGCATCGCCAGTTACGACAGTGCCGAGCTGGGCGCGGTCCGTCTGCAACTG
GGGACATTCGGAACGCCACAGGCCGAGCGCGCGCAACGGCGCTTCTGGCGTGATTGA

Upstream 100 bases:

>100_bases
CGCTGGCCGGGACCGGCCGTTCAGATTCTGCAACACACCACCCCTTCCGACATTTCCCCTGTGCGCTGATTCTTGAGGCT
TTCCGCTGCAAGGAACCGTC

Downstream 100 bases:

>100_bases
GTGAATGGATATCGATCTCGGCGTTCGGCACTTGGCGACCCTATGGTAGAGTGGCGCCAATTTTTCGAGGGAGTGATCAC
TGTGTGGGAACTGGTCAAAT

Product: ComEC/Rec2-related protein:DNA internalization-related competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 738; Mature: 738

Protein sequence:

>738_residues
MRTGMIALALGLLALRFLPALPPAWLLLLMPILALMLLPFRTYPLAFFLLGFTWACVSAQWALSDRLAQRLDGQTLWVQG
KVVGLPSVAEGVVRFELEDAWSRRARLPARIRMAWYGGQPVNSGERWRMAIKLKRPAGLVNPDAFDYEAWLLAQRIGATG
TVVDGQLLAPARAAWRDAIRQRLLAVDAQGREGGLAALVLGDGSGLSSTDWQVLQDTGTVHLLVISGQHIGLLAGVIYAL
VAGLARWGLWPRFLPWLPSACALAFSAALGYGLLAGFEVPVRRACVMVAMVLLWRLRFRHLGVVWPLLLSFNAVLIFEPL
VTLQPGFWLSFAAVGILILIFSGRLGAWSWWQSWTRAQWLIAVGLLPILLALNLPISLSGPFANLLAVPWVSVIVLPPAL
LGTLLLPVPVVGEGLLWLAGGALQGLFVFLGAVAAALPAWLPSAVPVWAWWLSLLGALLLLLPKGVPLRPLGWPLLLLCV
FPPLESVPEGQVDVLQLDVGQGLAILLRTRNHTLLYDAGPRFGEFDIGQRVVVPAMRKAGVRHLDLMLISHSDADHAGGA
AAVHQAFPVARVLGGELARLAPQLDARLCESGARWEWDGVVFSTWRWEQGPEGNPASCILSVDARGERLLLAGDIDVHAE
RAAIDSGFDLRAHWLQSPHHGSRTSSSKAFLRAVAPVGVLISRGRNNAFGHPHPLVMARYRGLGIASYDSAELGAVRLQL
GTFGTPQAERAQRRFWRD

Sequences:

>Translated_738_residues
MRTGMIALALGLLALRFLPALPPAWLLLLMPILALMLLPFRTYPLAFFLLGFTWACVSAQWALSDRLAQRLDGQTLWVQG
KVVGLPSVAEGVVRFELEDAWSRRARLPARIRMAWYGGQPVNSGERWRMAIKLKRPAGLVNPDAFDYEAWLLAQRIGATG
TVVDGQLLAPARAAWRDAIRQRLLAVDAQGREGGLAALVLGDGSGLSSTDWQVLQDTGTVHLLVISGQHIGLLAGVIYAL
VAGLARWGLWPRFLPWLPSACALAFSAALGYGLLAGFEVPVRRACVMVAMVLLWRLRFRHLGVVWPLLLSFNAVLIFEPL
VTLQPGFWLSFAAVGILILIFSGRLGAWSWWQSWTRAQWLIAVGLLPILLALNLPISLSGPFANLLAVPWVSVIVLPPAL
LGTLLLPVPVVGEGLLWLAGGALQGLFVFLGAVAAALPAWLPSAVPVWAWWLSLLGALLLLLPKGVPLRPLGWPLLLLCV
FPPLESVPEGQVDVLQLDVGQGLAILLRTRNHTLLYDAGPRFGEFDIGQRVVVPAMRKAGVRHLDLMLISHSDADHAGGA
AAVHQAFPVARVLGGELARLAPQLDARLCESGARWEWDGVVFSTWRWEQGPEGNPASCILSVDARGERLLLAGDIDVHAE
RAAIDSGFDLRAHWLQSPHHGSRTSSSKAFLRAVAPVGVLISRGRNNAFGHPHPLVMARYRGLGIASYDSAELGAVRLQL
GTFGTPQAERAQRRFWRD
>Mature_738_residues
MRTGMIALALGLLALRFLPALPPAWLLLLMPILALMLLPFRTYPLAFFLLGFTWACVSAQWALSDRLAQRLDGQTLWVQG
KVVGLPSVAEGVVRFELEDAWSRRARLPARIRMAWYGGQPVNSGERWRMAIKLKRPAGLVNPDAFDYEAWLLAQRIGATG
TVVDGQLLAPARAAWRDAIRQRLLAVDAQGREGGLAALVLGDGSGLSSTDWQVLQDTGTVHLLVISGQHIGLLAGVIYAL
VAGLARWGLWPRFLPWLPSACALAFSAALGYGLLAGFEVPVRRACVMVAMVLLWRLRFRHLGVVWPLLLSFNAVLIFEPL
VTLQPGFWLSFAAVGILILIFSGRLGAWSWWQSWTRAQWLIAVGLLPILLALNLPISLSGPFANLLAVPWVSVIVLPPAL
LGTLLLPVPVVGEGLLWLAGGALQGLFVFLGAVAAALPAWLPSAVPVWAWWLSLLGALLLLLPKGVPLRPLGWPLLLLCV
FPPLESVPEGQVDVLQLDVGQGLAILLRTRNHTLLYDAGPRFGEFDIGQRVVVPAMRKAGVRHLDLMLISHSDADHAGGA
AAVHQAFPVARVLGGELARLAPQLDARLCESGARWEWDGVVFSTWRWEQGPEGNPASCILSVDARGERLLLAGDIDVHAE
RAAIDSGFDLRAHWLQSPHHGSRTSSSKAFLRAVAPVGVLISRGRNNAFGHPHPLVMARYRGLGIASYDSAELGAVRLQL
GTFGTPQAERAQRRFWRD

Specific function: Essential for natural transformation. Could be a transporter involved in DNA uptake [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis ComEC, H.influenzae REC2, and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=769, Percent_Identity=27.8283485045514, Blast_Score=178, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 80259; Mature: 80259

Theoretical pI: Translated: 10.35; Mature: 10.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTGMIALALGLLALRFLPALPPAWLLLLMPILALMLLPFRTYPLAFFLLGFTWACVSAQ
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
WALSDRLAQRLDGQTLWVQGKVVGLPSVAEGVVRFELEDAWSRRARLPARIRMAWYGGQP
HHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHEEEEHHHHHHHHCCCCEEEEEEEECCCC
VNSGERWRMAIKLKRPAGLVNPDAFDYEAWLLAQRIGATGTVVDGQLLAPARAAWRDAIR
CCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHH
QRLLAVDAQGREGGLAALVLGDGSGLSSTDWQVLQDTGTVHLLVISGQHIGLLAGVIYAL
HHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCEEECCCCEEEEEECCCCHHHHHHHHHHH
VAGLARWGLWPRFLPWLPSACALAFSAALGYGLLAGFEVPVRRACVMVAMVLLWRLRFRH
HHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LGVVWPLLLSFNAVLIFEPLVTLQPGFWLSFAAVGILILIFSGRLGAWSWWQSWTRAQWL
HHHHHHHHHHCCHHEEECCHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IAVGLLPILLALNLPISLSGPFANLLAVPWVSVIVLPPALLGTLLLPVPVVGEGLLWLAG
HHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCHHEECC
GALQGLFVFLGAVAAALPAWLPSAVPVWAWWLSLLGALLLLLPKGVPLRPLGWPLLLLCV
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
FPPLESVPEGQVDVLQLDVGQGLAILLRTRNHTLLYDAGPRFGEFDIGQRVVVPAMRKAG
CCCCCCCCCCCEEEEEEECCCCEEEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHCC
VRHLDLMLISHSDADHAGGAAAVHQAFPVARVLGGELARLAPQLDARLCESGARWEWDGV
CCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCE
VFSTWRWEQGPEGNPASCILSVDARGERLLLAGDIDVHAERAAIDSGFDLRAHWLQSPHH
EEEEEECCCCCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHCCCCCCHHHHHHCCCCC
GSRTSSSKAFLRAVAPVGVLISRGRNNAFGHPHPLVMARYRGLGIASYDSAELGAVRLQL
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEECCCCCCCCEEEEEE
GTFGTPQAERAQRRFWRD
CCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MRTGMIALALGLLALRFLPALPPAWLLLLMPILALMLLPFRTYPLAFFLLGFTWACVSAQ
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
WALSDRLAQRLDGQTLWVQGKVVGLPSVAEGVVRFELEDAWSRRARLPARIRMAWYGGQP
HHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHEEEEHHHHHHHHCCCCEEEEEEEECCCC
VNSGERWRMAIKLKRPAGLVNPDAFDYEAWLLAQRIGATGTVVDGQLLAPARAAWRDAIR
CCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHH
QRLLAVDAQGREGGLAALVLGDGSGLSSTDWQVLQDTGTVHLLVISGQHIGLLAGVIYAL
HHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCEEECCCCEEEEEECCCCHHHHHHHHHHH
VAGLARWGLWPRFLPWLPSACALAFSAALGYGLLAGFEVPVRRACVMVAMVLLWRLRFRH
HHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LGVVWPLLLSFNAVLIFEPLVTLQPGFWLSFAAVGILILIFSGRLGAWSWWQSWTRAQWL
HHHHHHHHHHCCHHEEECCHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IAVGLLPILLALNLPISLSGPFANLLAVPWVSVIVLPPALLGTLLLPVPVVGEGLLWLAG
HHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCHHEECC
GALQGLFVFLGAVAAALPAWLPSAVPVWAWWLSLLGALLLLLPKGVPLRPLGWPLLLLCV
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
FPPLESVPEGQVDVLQLDVGQGLAILLRTRNHTLLYDAGPRFGEFDIGQRVVVPAMRKAG
CCCCCCCCCCCEEEEEEECCCCEEEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHCC
VRHLDLMLISHSDADHAGGAAAVHQAFPVARVLGGELARLAPQLDARLCESGARWEWDGV
CCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCE
VFSTWRWEQGPEGNPASCILSVDARGERLLLAGDIDVHAERAAIDSGFDLRAHWLQSPHH
EEEEEECCCCCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHCCCCCCHHHHHHCCCCC
GSRTSSSKAFLRAVAPVGVLISRGRNNAFGHPHPLVMARYRGLGIASYDSAELGAVRLQL
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEECCCCCCCCEEEEEE
GTFGTPQAERAQRRFWRD
CCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934834; 8830266 [H]