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The map label for this gene is fkpA [H]

Identifier: 66044839

GI number: 66044839

Start: 1793324

End: 1794094

Strand: Direct

Name: fkpA [H]

Synonym: Psyr_1594

Alternate gene names: 66044839

Gene position: 1793324-1794094 (Clockwise)

Preceding gene: 66044838

Following gene: 66044840

Centisome position: 29.43

GC content: 56.94

Gene sequence:

>771_bases
ATGAAACAGCATCGGTTGGCAGCGGCGATTGCCCTGGTCGGTCTGGTACTCGCAGGTTGTGACAAGCAAGCCAGCACCGT
AGAGCTGAAAACCCCAGCACAAAAAGCGTCTTATGGCATCGGTCTGAACATGGGCAAAAGCCTGGCTCAGGAAGGTATGG
ATGATCTGGATTCCAAGGCTGTAGCCCTGGGTATCGAAGATGCTGTTGGCAAGAAAGATCAGAAACTCAAGGACGAAGAG
CTGGTTGAAGCCTTCTCCGCGCTGCAAAAGCGTTCCGAAGAGCGTCTGGCGAAGATGAGCGAAGAGGCTTCTGCCGCTGG
CAAGAAATTCCTCGAAGAGAACGGTAAGAAGGACGGCGTGGTCACCACCGCTTCCGGCCTGCAGTATCAGATCATCAAGA
AAGCCGATGGCGCTCAGCCCAAGCCTACCGATGTTGTGACTGTTCACTACGAAGGCAAGCTGATCGACGGCAAGGTCTTC
GACAGTTCCGTTGAGCGCGGCAGCCCGATCGACCTGCCGGTTGGCGGTGTGATTCCGGGTTGGGTCGAAGGTCTGCAACT
GATGCACGTCGGCGAGAAGATCAAACTCTTCATCCCGAGTGATCTGGCTTACGGCGCACAGAGCCCGAGCCCGGCGATCC
CTGCCAACTCGGTACTGGTGTTCGATCTTGAACTGCTGGGTATCAAGGACCCTGCAGCGGCACCGACTCCTGGTGCTGAT
GCCGACGAAGAAGAGGCAGCTCCTGCCGCTTCGGCTCCGGCCAAGAAGTAA

Upstream 100 bases:

>100_bases
GCGTTTTCTCCCTCTCATGCCGGTAGCCATTGATCGCGGCGGCCTGATAAGCTCGCGGCTTTACTCGTTTGCCCTTTTGG
CGCATGAACAAGGAATTAGC

Downstream 100 bases:

>100_bases
CACACCACCTGGCTACAGAAAACGCCCTGTCTCGACAGGGCGTTTTTGTGTCCGGCTTATTTCCCGAACGCTTGGCCATT
CGGGCAGTCCCACTATCATG

Product: FKBP-type peptidyl-prolyl isomerase, N-terminal:peptidylprolyl isomerase, FKBP-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MKQHRLAAAIALVGLVLAGCDKQASTVELKTPAQKASYGIGLNMGKSLAQEGMDDLDSKAVALGIEDAVGKKDQKLKDEE
LVEAFSALQKRSEERLAKMSEEASAAGKKFLEENGKKDGVVTTASGLQYQIIKKADGAQPKPTDVVTVHYEGKLIDGKVF
DSSVERGSPIDLPVGGVIPGWVEGLQLMHVGEKIKLFIPSDLAYGAQSPSPAIPANSVLVFDLELLGIKDPAAAPTPGAD
ADEEEAAPAASAPAKK

Sequences:

>Translated_256_residues
MKQHRLAAAIALVGLVLAGCDKQASTVELKTPAQKASYGIGLNMGKSLAQEGMDDLDSKAVALGIEDAVGKKDQKLKDEE
LVEAFSALQKRSEERLAKMSEEASAAGKKFLEENGKKDGVVTTASGLQYQIIKKADGAQPKPTDVVTVHYEGKLIDGKVF
DSSVERGSPIDLPVGGVIPGWVEGLQLMHVGEKIKLFIPSDLAYGAQSPSPAIPANSVLVFDLELLGIKDPAAAPTPGAD
ADEEEAAPAASAPAKK
>Mature_256_residues
MKQHRLAAAIALVGLVLAGCDKQASTVELKTPAQKASYGIGLNMGKSLAQEGMDDLDSKAVALGIEDAVGKKDQKLKDEE
LVEAFSALQKRSEERLAKMSEEASAAGKKFLEENGKKDGVVTTASGLQYQIIKKADGAQPKPTDVVTVHYEGKLIDGKVF
DSSVERGSPIDLPVGGVIPGWVEGLQLMHVGEKIKLFIPSDLAYGAQSPSPAIPANSVLVFDLELLGIKDPAAAPTPGAD
ADEEEAAPAASAPAKK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=119, Percent_Identity=43.6974789915966, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI17149844, Length=119, Percent_Identity=43.6974789915966, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI17149842, Length=119, Percent_Identity=43.6974789915966, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI17149836, Length=104, Percent_Identity=46.1538461538462, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI4503725, Length=104, Percent_Identity=46.1538461538462, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI224809329, Length=104, Percent_Identity=40.3846153846154, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI224809327, Length=104, Percent_Identity=40.3846153846154, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4758384, Length=104, Percent_Identity=40.3846153846154, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=40.1869158878505, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI224809331, Length=104, Percent_Identity=40.3846153846154, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI7706131, Length=87, Percent_Identity=41.3793103448276, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4503729, Length=108, Percent_Identity=39.8148148148148, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI192448443, Length=91, Percent_Identity=37.3626373626374, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI33469985, Length=91, Percent_Identity=39.5604395604396, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4503727, Length=202, Percent_Identity=31.6831683168317, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI87082390, Length=204, Percent_Identity=46.078431372549, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789745, Length=230, Percent_Identity=41.304347826087, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71993519, Length=107, Percent_Identity=45.7943925233645, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17540882, Length=106, Percent_Identity=42.4528301886792, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17561782, Length=115, Percent_Identity=40, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324194, Length=101, Percent_Identity=50.4950495049505, Blast_Score=89, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320727, Length=94, Percent_Identity=54.2553191489362, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323566, Length=97, Percent_Identity=43.298969072165, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323482, Length=86, Percent_Identity=44.1860465116279, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24583150, Length=120, Percent_Identity=35.8333333333333, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=43.9252336448598, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI281363946, Length=121, Percent_Identity=41.3223140495868, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17352457, Length=121, Percent_Identity=41.3223140495868, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356629, Length=89, Percent_Identity=49.438202247191, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 26770; Mature: 26770

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQHRLAAAIALVGLVLAGCDKQASTVELKTPAQKASYGIGLNMGKSLAQEGMDDLDSKA
CCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHCCCCCHHHHHHHHHCHHHHCCCE
VALGIEDAVGKKDQKLKDEELVEAFSALQKRSEERLAKMSEEASAAGKKFLEENGKKDGV
EEEECHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
VTTASGLQYQIIKKADGAQPKPTDVVTVHYEGKLIDGKVFDSSVERGSPIDLPVGGVIPG
EEECCCCEEEEEECCCCCCCCCCCEEEEEECCEEECCHHCCCHHCCCCCCCCCCCCCCHH
WVEGLQLMHVGEKIKLFIPSDLAYGAQSPSPAIPANSVLVFDLELLGIKDPAAAPTPGAD
HHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCC
ADEEEAAPAASAPAKK
CCHHHCCCCCCCCCCC
>Mature Secondary Structure
MKQHRLAAAIALVGLVLAGCDKQASTVELKTPAQKASYGIGLNMGKSLAQEGMDDLDSKA
CCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHCCCCCHHHHHHHHHCHHHHCCCE
VALGIEDAVGKKDQKLKDEELVEAFSALQKRSEERLAKMSEEASAAGKKFLEENGKKDGV
EEEECHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
VTTASGLQYQIIKKADGAQPKPTDVVTVHYEGKLIDGKVFDSSVERGSPIDLPVGGVIPG
EEECCCCEEEEEECCCCCCCCCCCEEEEEECCEEECCHHCCCHHCCCCCCCCCCCCCCHH
WVEGLQLMHVGEKIKLFIPSDLAYGAQSPSPAIPANSVLVFDLELLGIKDPAAAPTPGAD
HHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCC
ADEEEAAPAASAPAKK
CCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]