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The map label for this gene is rnd [H]

Identifier: 66044808

GI number: 66044808

Start: 1760015

End: 1761148

Strand: Direct

Name: rnd [H]

Synonym: Psyr_1563

Alternate gene names: 66044808

Gene position: 1760015-1761148 (Clockwise)

Preceding gene: 66044807

Following gene: 66044809

Centisome position: 28.88

GC content: 64.46

Gene sequence:

>1134_bases
GTGGCCATCGATATTCACTGGATTCGCGACGACGACAGCCTCGCCCGGCATTGCGCACAATGGCAGTCACTGCCTTTCGT
GGCGCTCGACACCGAGTTCATGCGGGTCGACACTTTTTATCCGATCGCCGCGCTGCTGCAGATCGGCGACGGGCAGAGCG
CCTGGCTGATTGATCCGTTGCTGATCAACGACTGGCGGCCGCTGTCTGCGTTGCTCGAAAACCCCGACGTCATCAAAGTG
GTGCATGCGTGCAGCGAAGACCTCGAGGTGTTGCTGCGCCTGACCGGCAGCCTGCCGGTTCCGCTGTTCGATACCCAGTT
GGCAGCCGCCTACCTGAACCTCGGTTTTTCCATGGGCTACTCGCGCCTGGTGCAGGAGGTCCTCGACATCGACCTGCCCA
AGGGCGAAACCCGTTCCGACTGGCTGCAACGCCCGTTGTCGGAAACGCAGGTCAGCTACGCTGCCGAAGACGCCGTGCAC
CTGGCCGAGCTATTCACCATCCTGCGCCCGCGCTTGTCCGACGACAAATATGCCTGGCTGCTGGATGACGGTGCCGAACT
GGTCGCCAACCTGCGCCGTGAGGTGGACCCGTACGAGGTGTATCGCGACGCCAAGCTGGCCTGGAAGCTGTCCCGCGCCC
AGCTGGCGGTGCTGCGCGAGTTGTGTGCCTGGCGTGAGCGTGAGGCGCGCGCCCGTAATCTGCCGCGCAACCGTATCGTG
CGTGAGCACTCGCTCTGGCCATTGGCCAAGACCCAGCCGGACAACCTCGGCGCGCTGGCGCGGATCGAGGACATGCACCC
GCGTACGGTCCGTCATGACGGCGAGTTTCTGCTCGAGCTGATCAAGACCGCGAGCGTGCTGCCTCCCGAAGAGTGGCCAC
CTGCGTTGCCCGAGCCATTGCCCATCGATGCGGCCGGGTCGATCAAGCGTCTGCGTGCAATCGGCCAGCAATACGCCGAG
CAACTGGACATGGCGCCGGAGCTGATGCTGCGCAAGAAGACCCTCGAAGCCCTGCTCAAGAGCGGCTACCCCGACGGTCC
TTACCAATTGCCCGACTCGCTGCGTGGCTGGCGTCGCGAGTTGATGGGTCAGGCGCTGCTGGACAGCCTGGCCGCCCCCG
GAGAACCGTCTTGA

Upstream 100 bases:

>100_bases
GTCCGTCATTTGCATGAAGATGCGCCAGACCCGGACGACAGACGCGCGATAATCTCCCATGACGATATATACTGCGCGCC
ATTGTTGAAGGGAGAGCCAT

Downstream 100 bases:

>100_bases
AGCGCATCTGTTCGATTTATCGCAGCCCGAAAAGAAACGAGATGTACCTTTACGTCCTGAAAAGCGACGTTCTCAAGCGT
GTGCCGCCAGAACTGATGGT

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MAIDIHWIRDDDSLARHCAQWQSLPFVALDTEFMRVDTFYPIAALLQIGDGQSAWLIDPLLINDWRPLSALLENPDVIKV
VHACSEDLEVLLRLTGSLPVPLFDTQLAAAYLNLGFSMGYSRLVQEVLDIDLPKGETRSDWLQRPLSETQVSYAAEDAVH
LAELFTILRPRLSDDKYAWLLDDGAELVANLRREVDPYEVYRDAKLAWKLSRAQLAVLRELCAWREREARARNLPRNRIV
REHSLWPLAKTQPDNLGALARIEDMHPRTVRHDGEFLLELIKTASVLPPEEWPPALPEPLPIDAAGSIKRLRAIGQQYAE
QLDMAPELMLRKKTLEALLKSGYPDGPYQLPDSLRGWRRELMGQALLDSLAAPGEPS

Sequences:

>Translated_377_residues
MAIDIHWIRDDDSLARHCAQWQSLPFVALDTEFMRVDTFYPIAALLQIGDGQSAWLIDPLLINDWRPLSALLENPDVIKV
VHACSEDLEVLLRLTGSLPVPLFDTQLAAAYLNLGFSMGYSRLVQEVLDIDLPKGETRSDWLQRPLSETQVSYAAEDAVH
LAELFTILRPRLSDDKYAWLLDDGAELVANLRREVDPYEVYRDAKLAWKLSRAQLAVLRELCAWREREARARNLPRNRIV
REHSLWPLAKTQPDNLGALARIEDMHPRTVRHDGEFLLELIKTASVLPPEEWPPALPEPLPIDAAGSIKRLRAIGQQYAE
QLDMAPELMLRKKTLEALLKSGYPDGPYQLPDSLRGWRRELMGQALLDSLAAPGEPS
>Mature_376_residues
AIDIHWIRDDDSLARHCAQWQSLPFVALDTEFMRVDTFYPIAALLQIGDGQSAWLIDPLLINDWRPLSALLENPDVIKVV
HACSEDLEVLLRLTGSLPVPLFDTQLAAAYLNLGFSMGYSRLVQEVLDIDLPKGETRSDWLQRPLSETQVSYAAEDAVHL
AELFTILRPRLSDDKYAWLLDDGAELVANLRREVDPYEVYRDAKLAWKLSRAQLAVLRELCAWREREARARNLPRNRIVR
EHSLWPLAKTQPDNLGALARIEDMHPRTVRHDGEFLLELIKTASVLPPEEWPPALPEPLPIDAAGSIKRLRAIGQQYAEQ
LDMAPELMLRKKTLEALLKSGYPDGPYQLPDSLRGWRRELMGQALLDSLAAPGEPS

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI50301240, Length=302, Percent_Identity=25.8278145695364, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4505917, Length=302, Percent_Identity=25.8278145695364, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1788105, Length=373, Percent_Identity=38.3378016085791, Blast_Score=229, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17531757, Length=247, Percent_Identity=28.3400809716599, Blast_Score=81, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6324574, Length=297, Percent_Identity=26.2626262626263, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161078302, Length=295, Percent_Identity=25.7627118644068, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42768; Mature: 42636

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIDIHWIRDDDSLARHCAQWQSLPFVALDTEFMRVDTFYPIAALLQIGDGQSAWLIDPL
CEEEEEEECCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEECHH
LINDWRPLSALLENPDVIKVVHACSEDLEVLLRLTGSLPVPLFDTQLAAAYLNLGFSMGY
HHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCH
SRLVQEVLDIDLPKGETRSDWLQRPLSETQVSYAAEDAVHLAELFTILRPRLSDDKYAWL
HHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
LDDGAELVANLRREVDPYEVYRDAKLAWKLSRAQLAVLRELCAWREREARARNLPRNRIV
ECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
REHSLWPLAKTQPDNLGALARIEDMHPRTVRHDGEFLLELIKTASVLPPEEWPPALPEPL
HHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
PIDAAGSIKRLRAIGQQYAEQLDMAPELMLRKKTLEALLKSGYPDGPYQLPDSLRGWRRE
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LMGQALLDSLAAPGEPS
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AIDIHWIRDDDSLARHCAQWQSLPFVALDTEFMRVDTFYPIAALLQIGDGQSAWLIDPL
EEEEEEECCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEECHH
LINDWRPLSALLENPDVIKVVHACSEDLEVLLRLTGSLPVPLFDTQLAAAYLNLGFSMGY
HHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCH
SRLVQEVLDIDLPKGETRSDWLQRPLSETQVSYAAEDAVHLAELFTILRPRLSDDKYAWL
HHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
LDDGAELVANLRREVDPYEVYRDAKLAWKLSRAQLAVLRELCAWREREARARNLPRNRIV
ECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
REHSLWPLAKTQPDNLGALARIEDMHPRTVRHDGEFLLELIKTASVLPPEEWPPALPEPL
HHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
PIDAAGSIKRLRAIGQQYAEQLDMAPELMLRKKTLEALLKSGYPDGPYQLPDSLRGWRRE
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LMGQALLDSLAAPGEPS
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]