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The map label for this gene is purC [H]

Identifier: 66044797

GI number: 66044797

Start: 1744147

End: 1744857

Strand: Direct

Name: purC [H]

Synonym: Psyr_1551

Alternate gene names: 66044797

Gene position: 1744147-1744857 (Clockwise)

Preceding gene: 66044796

Following gene: 66044798

Centisome position: 28.62

GC content: 57.67

Gene sequence:

>711_bases
ATGGAAAAACGTGAAGAACTCTACCGCGGCAAAGCCAAATCGGTTTACAAGACCGACGACGCTGACCGCTTGATCCTGCT
GTTCCGCAACGACACCTCGGCGTTCGACGGCAAGCGCATCGAACAGCTCGACCGTAAAGGCATGGTGAACAACAAGTTCA
ACGCCTTCATCATGCAAAAGCTCGAAGAAGCGGGTATTCCGACCCAGTTCGACAAGCTGCTGGGCGACAACGAGTGCCTG
GTCAAGAAGCTCGACATGATCCCGGTCGAATGCGTTGTGCGTAACTACGCGGCTGGCAGCCTGGTCAAGCGTCTGGGTAT
CGAAGAGGGCACCAGGCTCAATCCGTACACCTTCGAACTGTTCCTCAAGGACGACGCCAAGGGCGACCCGTTCATCAACG
AATCCCACGTTGTGGCGTTCGGCTGGGGCACCGCCGAGCAACTGGCTCGCATGAAAGAGCTGTCGATCAAGGTCAATGAC
GTGCTGACCAAACTGTTCGACGACGCCGGCCTGCTGCTGGTCGACTTCAAACTCGAATTCGGCGTATTCCACGGTGAAAT
CGTCCTCGGCGACGAATTCAGCCCGGACGGCTGCCGCCTCTGGGACAAGGACACCCGCAAGAAAATGGACAAGGACCGCT
TCCGCCAGGGTCTGGGCGACGTCATCGAAGCCTACGAAGAAGTCGCAAACCGTCTGGGCGTGCCGCTGTAA

Upstream 100 bases:

>100_bases
CTCGGGTGCGACCCGGACTGGCTGCAACTGGCCGATCAAGATTCAGGGCTCGACTGGCGACATATCGCCTAGCCCAACTA
CTTAGCAAGCGGAGCCCATC

Downstream 100 bases:

>100_bases
GCGGAAAAAAACACGCAAGCGCTTGATAGCACGAAAAAAAACAGCAGAAGGGCTTCGCCTTCTGCGTTGATGCTGTTATG
ATGCGCGCCGTTGGAGAGAT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MEKREELYRGKAKSVYKTDDADRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEEAGIPTQFDKLLGDNECL
VKKLDMIPVECVVRNYAAGSLVKRLGIEEGTRLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSIKVND
VLTKLFDDAGLLLVDFKLEFGVFHGEIVLGDEFSPDGCRLWDKDTRKKMDKDRFRQGLGDVIEAYEEVANRLGVPL

Sequences:

>Translated_236_residues
MEKREELYRGKAKSVYKTDDADRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEEAGIPTQFDKLLGDNECL
VKKLDMIPVECVVRNYAAGSLVKRLGIEEGTRLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSIKVND
VLTKLFDDAGLLLVDFKLEFGVFHGEIVLGDEFSPDGCRLWDKDTRKKMDKDRFRQGLGDVIEAYEEVANRLGVPL
>Mature_236_residues
MEKREELYRGKAKSVYKTDDADRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEEAGIPTQFDKLLGDNECL
VKKLDMIPVECVVRNYAAGSLVKRLGIEEGTRLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSIKVND
VLTKLFDDAGLLLVDFKLEFGVFHGEIVLGDEFSPDGCRLWDKDTRKKMDKDRFRQGLGDVIEAYEEVANRLGVPL

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=246, Percent_Identity=34.5528455284553, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI5453539, Length=246, Percent_Identity=34.5528455284553, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI119220559, Length=253, Percent_Identity=33.201581027668, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1788820, Length=236, Percent_Identity=74.1525423728814, Blast_Score=357, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17531275, Length=244, Percent_Identity=31.9672131147541, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI18860083, Length=220, Percent_Identity=33.6363636363636, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24583917, Length=218, Percent_Identity=33.0275229357798, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 26937; Mature: 26937

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKREELYRGKAKSVYKTDDADRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQK
CCHHHHHHCCCCCCEEECCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHHH
LEEAGIPTQFDKLLGDNECLVKKLDMIPVECVVRNYAAGSLVKRLGIEEGTRLNPYTFEL
HHHCCCCHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEE
FLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSIKVNDVLTKLFDDAGLLLVDFKLEF
EEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEE
GVFHGEIVLGDEFSPDGCRLWDKDTRKKMDKDRFRQGLGDVIEAYEEVANRLGVPL
CEEECEEEECCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEKREELYRGKAKSVYKTDDADRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQK
CCHHHHHHCCCCCCEEECCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHHH
LEEAGIPTQFDKLLGDNECLVKKLDMIPVECVVRNYAAGSLVKRLGIEEGTRLNPYTFEL
HHHCCCCHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEE
FLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSIKVNDVLTKLFDDAGLLLVDFKLEF
EEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEE
GVFHGEIVLGDEFSPDGCRLWDKDTRKKMDKDRFRQGLGDVIEAYEEVANRLGVPL
CEEECEEEECCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA