Click here to switch to the map view.

The map label for this gene is aspS [H]

Identifier: 66044654

GI number: 66044654

Start: 1592180

End: 1593955

Strand: Direct

Name: aspS [H]

Synonym: Psyr_1406

Alternate gene names: 66044654

Gene position: 1592180-1593955 (Clockwise)

Preceding gene: 66044653

Following gene: 66044655

Centisome position: 26.13

GC content: 60.53

Gene sequence:

>1776_bases
ATGATGCGCAGCCATTATTGCGGCCAACTGAACGAGAGTCTGGAAGGCCAGGAAATTACCCTTTGCGGATGGGTCCACCG
TCGTCGTGACCACGGGGGCGTTATCTTCCTCGATATCCGCGACCGTGAAGGCATGGCTCAAGTCGTGTTCGACCCTGATC
GGGCCGACAGTTTCGCTGCCGCTGATCGCGTGCGCAGCGAGTACGTGGTCAAGGTCGTGGGCAAGGTTCGTGCTCGTCCG
GCAGGTGCCGTGAATGCGAACATGGCGTCAGGCGCCATCGAGGTTCTGGGTTACGAGCTCGAGGTGTTGAACGAGTCCGA
AACGCCGCCGTTCCCTCTGAATGAGTATTCCGACGTCGGCGAGGAAACACGCCTGCGCTATCGCTTCATCGACCTGCGCC
GTCCGGAAATGGCCGAGAAGCTGCGTCTGCGTTCGCGTATCACTACCAGTATCCGTCGCTATCTGGATGACAACGGCTTC
CTCGACGTCGAGACGCCGATCCTGACCCGCGCCACACCAGAAGGCGCTCGCGACTATCTGGTTCCAAGCCGCACACACCC
GGGCAGCTTCTTCGCCCTGCCGCAATCGCCTCAGCTGTTCAAGCAACTGCTGATGGTCGCCGGCTTCGATCGTTACTACC
AGATCGCCAAGTGCTTCCGCGACGAGGACCTGCGTGCCGACCGTCAGCCGGAATTCACCCAGATCGACATCGAAACCAGC
TTCCTCAATGAAGAGGACATCATCGGTCTGACCGAGAAGATGGTTCGTCAGTTGTTCAAGGAAGTCCTGGACCTGGAGTT
CGGTGATTTCCCGCACATGACCTTTGAAGAGGCCATGCGCCGCTACGGTTCCGACAAACCGGACCTGCGCAACCCGCTGG
AACTGGTGGATGTTGCCGATCAGCTCACCGGCGTGGAATTCAAGGTGTTCAGCGGCCCGGCCAACGACCCCAAGGGGCGC
GTTGCCGCACTGCGTGTACCGGGCGCCGCCAGCATGGCGCGCAGCCAGATCGACGACTACACCAAGTTCGTCAGCATCTA
TGGTGCCAAGGGGCTGGCCTACATCAAGGTCAACGAGCGCGCGAAGGGGCCGGAAGGCTTGCAGTCGCCGATCGTCAAGT
TCATCCCGGAAGACAACCTGAACGTCATCCTCGATCGCGTTGGTGCGGTTGATGGCGACATCGTCTTCTTCGGTGCGGAC
AAGTTCAAGATCGTCAGCGAGGCCCTTGGCGCGCTGCGCATCAAGATCGGTAATGACCTCAAGCTGCACACTTGCGAGTG
GGCACCGATGTGGGTCGTTGACTTCCCGATGTTCGAAGAAAACGACGACGGCAGCTTCACCGCCTTGCACCACCCCTTCA
CGGCACCCAAGTGCACCCCTGAAGAGCTGGAAGCCAACCCGGCGACCGCGCTGTCCCGTGCCTACGACATGGTGCTCAAC
GGCACCGAGCTGGGCGGCGGTTCGATCCGTATCCATCGCAAGGAAATGCAACAGGCGGTCTTCCGTCTGCTGGGCATTGC
CGAAGACGAGCAGCAGGAGAAGTTCGGCTTCCTGCTCGATGCCTTGAAATATGGTGCGCCACCGCACGGTGGTCTGGCTT
TCGGTCTGGACCGTCTGGTAATGCTGATGACCGGCGCGCAATCGATTCGTGAAGTGATCGCGTTCCCGAAAACCCAGAGC
GCGGCCGATGTCATGACCCAGGCGCCTGGCGTTGTCGATGCCAAAGCGTTGCGCGAGCTGCACATCCGTCTGCGCGAGCA
GCCAAAGGCCGAGTGA

Upstream 100 bases:

>100_bases
AGGGCTGGCTTTGGCCTTGTGCCGGTGCCTTGTACCTCTGAGCGCAAGCCAGGAGCGAAATCGCCACCGAATTCGAATTA
CGAGAAGTGAAAACACCATC

Downstream 100 bases:

>100_bases
TGCCGGGCAGGGCGTATCAATGATGCGCCCTGCATTTACCCCTTATTGAGTGAAGCTTTTTGCCCGTCTGTTCAGGGCGA
AAGGTGAAGGTGTTTCAAAA

Product: aspartyl-tRNA synthetase

Products: NA

Alternate protein names: Aspartate--tRNA ligase; AspRS [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MMRSHYCGQLNESLEGQEITLCGWVHRRRDHGGVIFLDIRDREGMAQVVFDPDRADSFAAADRVRSEYVVKVVGKVRARP
AGAVNANMASGAIEVLGYELEVLNESETPPFPLNEYSDVGEETRLRYRFIDLRRPEMAEKLRLRSRITTSIRRYLDDNGF
LDVETPILTRATPEGARDYLVPSRTHPGSFFALPQSPQLFKQLLMVAGFDRYYQIAKCFRDEDLRADRQPEFTQIDIETS
FLNEEDIIGLTEKMVRQLFKEVLDLEFGDFPHMTFEEAMRRYGSDKPDLRNPLELVDVADQLTGVEFKVFSGPANDPKGR
VAALRVPGAASMARSQIDDYTKFVSIYGAKGLAYIKVNERAKGPEGLQSPIVKFIPEDNLNVILDRVGAVDGDIVFFGAD
KFKIVSEALGALRIKIGNDLKLHTCEWAPMWVVDFPMFEENDDGSFTALHHPFTAPKCTPEELEANPATALSRAYDMVLN
GTELGGGSIRIHRKEMQQAVFRLLGIAEDEQQEKFGFLLDALKYGAPPHGGLAFGLDRLVMLMTGAQSIREVIAFPKTQS
AADVMTQAPGVVDAKALRELHIRLREQPKAE

Sequences:

>Translated_591_residues
MMRSHYCGQLNESLEGQEITLCGWVHRRRDHGGVIFLDIRDREGMAQVVFDPDRADSFAAADRVRSEYVVKVVGKVRARP
AGAVNANMASGAIEVLGYELEVLNESETPPFPLNEYSDVGEETRLRYRFIDLRRPEMAEKLRLRSRITTSIRRYLDDNGF
LDVETPILTRATPEGARDYLVPSRTHPGSFFALPQSPQLFKQLLMVAGFDRYYQIAKCFRDEDLRADRQPEFTQIDIETS
FLNEEDIIGLTEKMVRQLFKEVLDLEFGDFPHMTFEEAMRRYGSDKPDLRNPLELVDVADQLTGVEFKVFSGPANDPKGR
VAALRVPGAASMARSQIDDYTKFVSIYGAKGLAYIKVNERAKGPEGLQSPIVKFIPEDNLNVILDRVGAVDGDIVFFGAD
KFKIVSEALGALRIKIGNDLKLHTCEWAPMWVVDFPMFEENDDGSFTALHHPFTAPKCTPEELEANPATALSRAYDMVLN
GTELGGGSIRIHRKEMQQAVFRLLGIAEDEQQEKFGFLLDALKYGAPPHGGLAFGLDRLVMLMTGAQSIREVIAFPKTQS
AADVMTQAPGVVDAKALRELHIRLREQPKAE
>Mature_591_residues
MMRSHYCGQLNESLEGQEITLCGWVHRRRDHGGVIFLDIRDREGMAQVVFDPDRADSFAAADRVRSEYVVKVVGKVRARP
AGAVNANMASGAIEVLGYELEVLNESETPPFPLNEYSDVGEETRLRYRFIDLRRPEMAEKLRLRSRITTSIRRYLDDNGF
LDVETPILTRATPEGARDYLVPSRTHPGSFFALPQSPQLFKQLLMVAGFDRYYQIAKCFRDEDLRADRQPEFTQIDIETS
FLNEEDIIGLTEKMVRQLFKEVLDLEFGDFPHMTFEEAMRRYGSDKPDLRNPLELVDVADQLTGVEFKVFSGPANDPKGR
VAALRVPGAASMARSQIDDYTKFVSIYGAKGLAYIKVNERAKGPEGLQSPIVKFIPEDNLNVILDRVGAVDGDIVFFGAD
KFKIVSEALGALRIKIGNDLKLHTCEWAPMWVVDFPMFEENDDGSFTALHHPFTAPKCTPEELEANPATALSRAYDMVLN
GTELGGGSIRIHRKEMQQAVFRLLGIAEDEQQEKFGFLLDALKYGAPPHGGLAFGLDRLVMLMTGAQSIREVIAFPKTQS
AADVMTQAPGVVDAKALRELHIRLREQPKAE

Specific function: Unknown

COG id: COG0173

COG function: function code J; Aspartyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI40789249, Length=599, Percent_Identity=40.0667779632721, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI5031815, Length=252, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI194272210, Length=252, Percent_Identity=28.5714285714286, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI45439306, Length=238, Percent_Identity=29.8319327731092, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI4758762, Length=265, Percent_Identity=28.3018867924528, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI226491502, Length=265, Percent_Identity=25.6603773584906, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1788173, Length=585, Percent_Identity=63.4188034188034, Blast_Score=787, Evalue=0.0,
Organism=Escherichia coli, GI1789256, Length=309, Percent_Identity=26.537216828479, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790571, Length=316, Percent_Identity=26.5822784810127, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1787161, Length=274, Percent_Identity=27.007299270073, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87082379, Length=173, Percent_Identity=30.635838150289, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI32566633, Length=608, Percent_Identity=36.1842105263158, Blast_Score=345, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI71994340, Length=251, Percent_Identity=28.2868525896414, Blast_Score=105, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17535927, Length=251, Percent_Identity=28.2868525896414, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17535925, Length=252, Percent_Identity=28.968253968254, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17551876, Length=280, Percent_Identity=25.3571428571429, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6325153, Length=648, Percent_Identity=33.7962962962963, Blast_Score=294, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6320242, Length=262, Percent_Identity=24.8091603053435, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323011, Length=248, Percent_Identity=28.6290322580645, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321807, Length=252, Percent_Identity=26.5873015873016, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6324256, Length=154, Percent_Identity=25.974025974026, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24584738, Length=612, Percent_Identity=36.437908496732, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24640851, Length=257, Percent_Identity=26.4591439688716, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24640849, Length=257, Percent_Identity=26.4591439688716, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17136276, Length=264, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR020564
- InterPro:   IPR004524
- InterPro:   IPR018153
- InterPro:   IPR002312
- InterPro:   IPR004115
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02938 GAD; PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.12 [H]

Molecular weight: Translated: 66340; Mature: 66340

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRSHYCGQLNESLEGQEITLCGWVHRRRDHGGVIFLDIRDREGMAQVVFDPDRADSFAA
CCCCCCCCHHHCCCCCCEEEEEEHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCHHHH
ADRVRSEYVVKVVGKVRARPAGAVNANMASGAIEVLGYELEVLNESETPPFPLNEYSDVG
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHEEEEEEECCCCCCCCCCCHHHCCC
EETRLRYRFIDLRRPEMAEKLRLRSRITTSIRRYLDDNGFLDVETPILTRATPEGARDYL
HHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEECCCCCCCCCCC
VPSRTHPGSFFALPQSPQLFKQLLMVAGFDRYYQIAKCFRDEDLRADRQPEFTQIDIETS
CCCCCCCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHH
FLNEEDIIGLTEKMVRQLFKEVLDLEFGDFPHMTFEEAMRRYGSDKPDLRNPLELVDVAD
HCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHH
QLTGVEFKVFSGPANDPKGRVAALRVPGAASMARSQIDDYTKFVSIYGAKGLAYIKVNER
HHCCCEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
AKGPEGLQSPIVKFIPEDNLNVILDRVGAVDGDIVFFGADKFKIVSEALGALRIKIGNDL
CCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCEEEEEECCCE
KLHTCEWAPMWVVDFPMFEENDDGSFTALHHPFTAPKCTPEELEANPATALSRAYDMVLN
EEEEECCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHCC
GTELGGGSIRIHRKEMQQAVFRLLGIAEDEQQEKFGFLLDALKYGAPPHGGLAFGLDRLV
CCCCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
MLMTGAQSIREVIAFPKTQSAADVMTQAPGVVDAKALRELHIRLREQPKAE
HHHHCHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MMRSHYCGQLNESLEGQEITLCGWVHRRRDHGGVIFLDIRDREGMAQVVFDPDRADSFAA
CCCCCCCCHHHCCCCCCEEEEEEHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCHHHH
ADRVRSEYVVKVVGKVRARPAGAVNANMASGAIEVLGYELEVLNESETPPFPLNEYSDVG
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHEEEEEEECCCCCCCCCCCHHHCCC
EETRLRYRFIDLRRPEMAEKLRLRSRITTSIRRYLDDNGFLDVETPILTRATPEGARDYL
HHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEECCCCCCCCCCC
VPSRTHPGSFFALPQSPQLFKQLLMVAGFDRYYQIAKCFRDEDLRADRQPEFTQIDIETS
CCCCCCCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHH
FLNEEDIIGLTEKMVRQLFKEVLDLEFGDFPHMTFEEAMRRYGSDKPDLRNPLELVDVAD
HCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHH
QLTGVEFKVFSGPANDPKGRVAALRVPGAASMARSQIDDYTKFVSIYGAKGLAYIKVNER
HHCCCEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
AKGPEGLQSPIVKFIPEDNLNVILDRVGAVDGDIVFFGADKFKIVSEALGALRIKIGNDL
CCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCEEEEEECCCE
KLHTCEWAPMWVVDFPMFEENDDGSFTALHHPFTAPKCTPEELEANPATALSRAYDMVLN
EEEEECCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHCC
GTELGGGSIRIHRKEMQQAVFRLLGIAEDEQQEKFGFLLDALKYGAPPHGGLAFGLDRLV
CCCCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
MLMTGAQSIREVIAFPKTQSAADVMTQAPGVVDAKALRELHIRLREQPKAE
HHHHCHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA