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The map label for this gene is edd [H]

Identifier: 66044360

GI number: 66044360

Start: 1256079

End: 1257905

Strand: Direct

Name: edd [H]

Synonym: Psyr_1109

Alternate gene names: 66044360

Gene position: 1256079-1257905 (Clockwise)

Preceding gene: 66044344

Following gene: 66044361

Centisome position: 20.61

GC content: 61.08

Gene sequence:

>1827_bases
ATGCATCCCCGCGTCCTTGAAGTAACCGAGCGTCTCATCGCCCGCAGTCGCGATACCCGTCAGCGCTACCTTCAATTGAT
TCGCGGCGCAGCGAGCGATGGCCCGATGCGCGGCAAGCTCCAATGCGCCAACTTTGCCCATGGCGTCGCCGCCTGCGGAC
CGGAAGACAAGCAAAGTCTGCGTCTGATGAACGCCGCCAACGTGGCCATCGTCTCTTCCTACAACGAGATGCTCTCGGCG
CATCAGCCCTACGAACACTTTCCAGCCCAGATCAAACAGGCTTTACGTGACATTGGTTCGGTCGGTCAGTTTGCCGGCGG
TGTGCCGGCCATGTGCGATGGCGTGACCCAGGGTGAGCCGGGCATGGAGCTGGCCATTGCCAGCCGTGAAGTGATTGCCA
TGTCCACGGCGATTGCCTTGTCACACAATATGTTCGACGCCGCCATGATGCTGGGCATCTGCGACAAGATCGTGCCCGGC
CTGATGATGGGCGCCTTGCGGTTCGGTCATCTGCCGACCATTTTCGTGCCCGGCGGGCCGATGGTTTCAGGCCTCTCCAA
CAAGGAAAAAGCCGACGTACGGCAGCGTTATGCGGAAGGCAAGGCCACCCGCGAAGAGTTGCTCGACTCGGAAATGAAGT
CGTATCACGGTCCGGGAACCTGCACCTTCTACGGCACCGCCAACACCAACCAGCTGGTGATGGAAGTCATGGGCATGCAC
CTTCCCGGCGCCTCGTTCGTCAATCCCTATACACCCTTGCGTGATGCGCTGACGGCCGAGGCGGCCCGCCAGGTAACGCG
TATGACCAAGCAAAGTGGCAGCTTCATGCCGATCGGCGAGATCGTCGACGAGCGCTCGCTGGTCAATTCCATCGTTGCAC
TGCACGCGACTGGCGGCTCGACCAACCACACGCTGCACATGCCGGCCATTGCCCAGGCCGCCGGCATTCAGCTGACCTGG
CAGGACATGGCCGATCTGTCGGAAGTGGTACCGACCCTCAGTCACGTCTACCCCAACGGCAAGGCCGATATCAACCACTT
CCAGGCGGCAGGCGGCATGTCGTTCCTGATTCGCGAGCTGCTGGCTGCCGGCCTGCTGCACGAAAACGTCAACACCGTGG
CCGGTTACGGCCTGAGCCGTTACACCAAGGAGCCGTTCCTGGAAGACGGCAAACTGGTCTGGCGTGAAGGGCCGCTCGAA
AGCCTCGATGAAAATATCCTGCGGCCGGTTGCCCGTCCGTTCTCGCCGGAAGGTGGTCTGCGGGTCATGGAAGGCAATCT
GGGCCGTGGCGTGATGAAAGTGTCCGCCGTAGCTCCGGAACATCAGATCGTCGAAGCGCCGGCCAAGGTGTTCCAGGATC
AGAAGGAACTGGCCGATGCCTTCAAGGCGGGTGAGCTGGAGTGCGATTTCGTCGCGGTGATGCGCTTCCAGGGGCCGCGC
TGCAATGGCATGCCCGAGCTGCACAAGATGACGCCGTTTCTGGGGGTCCTTCAGGATCGCGGGTTCAAGGTTGCGCTGGT
CACCGATGGACGCATGTCGGGCGCCTCGGGCAAGATCCCGGCGGCGATTCATGTCTGCCCGGAAGCGTTCGATGGTGGCC
CATTGGCTCTCGTGCGTGATGGCGATGTGATTCGTGTGGATGGTGTAAAAGGCACGTTACAAGTTCTGGTCGAAGCGTCA
GAATTGGCCGCCAGAGAACCGGCCATCAACCAGATCGACAACAGTGTCGGCTGCGGTCGCGAGCTTTTTGGATTCATGCG
CATGGCCTTCAGCTCCGCAGAGCAAGGCGCCAGCGCCTTTACCTCTAGTCTGGAGACGCTTAAGTGA

Upstream 100 bases:

>100_bases
CCAGTTGATCGAGATCAGGGTTTTGCTCCCTGACAGTCACTGCTCGAAAACCGGAGCCGTCTTTACGGGTGACCTTAGAC
GTTAGCCTGGAGTTCATCAC

Downstream 100 bases:

>100_bases
AGTTGGCCCTGGTCGGTGATATAGGCGGTACCAATGCACGTTTTGCCATTTGGGAAAACAGCACGCTGCATTCTGTCCGG
GTATTCCCGACCATTGACTA

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MHPRVLEVTERLIARSRDTRQRYLQLIRGAASDGPMRGKLQCANFAHGVAACGPEDKQSLRLMNAANVAIVSSYNEMLSA
HQPYEHFPAQIKQALRDIGSVGQFAGGVPAMCDGVTQGEPGMELAIASREVIAMSTAIALSHNMFDAAMMLGICDKIVPG
LMMGALRFGHLPTIFVPGGPMVSGLSNKEKADVRQRYAEGKATREELLDSEMKSYHGPGTCTFYGTANTNQLVMEVMGMH
LPGASFVNPYTPLRDALTAEAARQVTRMTKQSGSFMPIGEIVDERSLVNSIVALHATGGSTNHTLHMPAIAQAAGIQLTW
QDMADLSEVVPTLSHVYPNGKADINHFQAAGGMSFLIRELLAAGLLHENVNTVAGYGLSRYTKEPFLEDGKLVWREGPLE
SLDENILRPVARPFSPEGGLRVMEGNLGRGVMKVSAVAPEHQIVEAPAKVFQDQKELADAFKAGELECDFVAVMRFQGPR
CNGMPELHKMTPFLGVLQDRGFKVALVTDGRMSGASGKIPAAIHVCPEAFDGGPLALVRDGDVIRVDGVKGTLQVLVEAS
ELAAREPAINQIDNSVGCGRELFGFMRMAFSSAEQGASAFTSSLETLK

Sequences:

>Translated_608_residues
MHPRVLEVTERLIARSRDTRQRYLQLIRGAASDGPMRGKLQCANFAHGVAACGPEDKQSLRLMNAANVAIVSSYNEMLSA
HQPYEHFPAQIKQALRDIGSVGQFAGGVPAMCDGVTQGEPGMELAIASREVIAMSTAIALSHNMFDAAMMLGICDKIVPG
LMMGALRFGHLPTIFVPGGPMVSGLSNKEKADVRQRYAEGKATREELLDSEMKSYHGPGTCTFYGTANTNQLVMEVMGMH
LPGASFVNPYTPLRDALTAEAARQVTRMTKQSGSFMPIGEIVDERSLVNSIVALHATGGSTNHTLHMPAIAQAAGIQLTW
QDMADLSEVVPTLSHVYPNGKADINHFQAAGGMSFLIRELLAAGLLHENVNTVAGYGLSRYTKEPFLEDGKLVWREGPLE
SLDENILRPVARPFSPEGGLRVMEGNLGRGVMKVSAVAPEHQIVEAPAKVFQDQKELADAFKAGELECDFVAVMRFQGPR
CNGMPELHKMTPFLGVLQDRGFKVALVTDGRMSGASGKIPAAIHVCPEAFDGGPLALVRDGDVIRVDGVKGTLQVLVEAS
ELAAREPAINQIDNSVGCGRELFGFMRMAFSSAEQGASAFTSSLETLK
>Mature_608_residues
MHPRVLEVTERLIARSRDTRQRYLQLIRGAASDGPMRGKLQCANFAHGVAACGPEDKQSLRLMNAANVAIVSSYNEMLSA
HQPYEHFPAQIKQALRDIGSVGQFAGGVPAMCDGVTQGEPGMELAIASREVIAMSTAIALSHNMFDAAMMLGICDKIVPG
LMMGALRFGHLPTIFVPGGPMVSGLSNKEKADVRQRYAEGKATREELLDSEMKSYHGPGTCTFYGTANTNQLVMEVMGMH
LPGASFVNPYTPLRDALTAEAARQVTRMTKQSGSFMPIGEIVDERSLVNSIVALHATGGSTNHTLHMPAIAQAAGIQLTW
QDMADLSEVVPTLSHVYPNGKADINHFQAAGGMSFLIRELLAAGLLHENVNTVAGYGLSRYTKEPFLEDGKLVWREGPLE
SLDENILRPVARPFSPEGGLRVMEGNLGRGVMKVSAVAPEHQIVEAPAKVFQDQKELADAFKAGELECDFVAVMRFQGPR
CNGMPELHKMTPFLGVLQDRGFKVALVTDGRMSGASGKIPAAIHVCPEAFDGGPLALVRDGDVIRVDGVKGTLQVLVEAS
ELAAREPAINQIDNSVGCGRELFGFMRMAFSSAEQGASAFTSSLETLK

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=64.1196013289037, Blast_Score=800, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=540, Percent_Identity=30.3703703703704, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI2367371, Length=495, Percent_Identity=30.1010101010101, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1786464, Length=498, Percent_Identity=28.5140562248996, Blast_Score=138, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6322476, Length=476, Percent_Identity=31.3025210084034, Blast_Score=199, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 65389; Mature: 65389

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPRVLEVTERLIARSRDTRQRYLQLIRGAASDGPMRGKLQCANFAHGVAACGPEDKQSL
CCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCEEHHHHHCCHHCCCCCCHHHH
RLMNAANVAIVSSYNEMLSAHQPYEHFPAQIKQALRDIGSVGQFAGGVPAMCDGVTQGEP
HHHHHCCEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
GMELAIASREVIAMSTAIALSHNMFDAAMMLGICDKIVPGLMMGALRFGHLPTIFVPGGP
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MVSGLSNKEKADVRQRYAEGKATREELLDSEMKSYHGPGTCTFYGTANTNQLVMEVMGMH
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCC
LPGASFVNPYTPLRDALTAEAARQVTRMTKQSGSFMPIGEIVDERSLVNSIVALHATGGS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEECCCC
TNHTLHMPAIAQAAGIQLTWQDMADLSEVVPTLSHVYPNGKADINHFQAAGGMSFLIREL
CCCEEECCHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHH
LAAGLLHENVNTVAGYGLSRYTKEPFLEDGKLVWREGPLESLDENILRPVARPFSPEGGL
HHHHHHHHCCHHHHCCCHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCC
RVMEGNLGRGVMKVSAVAPEHQIVEAPAKVFQDQKELADAFKAGELECDFVAVMRFQGPR
EEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEECCCC
CNGMPELHKMTPFLGVLQDRGFKVALVTDGRMSGASGKIPAAIHVCPEAFDGGPLALVRD
CCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEEEC
GDVIRVDGVKGTLQVLVEASELAAREPAINQIDNSVGCGRELFGFMRMAFSSAEQGASAF
CCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TSSLETLK
HHHHHHCC
>Mature Secondary Structure
MHPRVLEVTERLIARSRDTRQRYLQLIRGAASDGPMRGKLQCANFAHGVAACGPEDKQSL
CCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCEEHHHHHCCHHCCCCCCHHHH
RLMNAANVAIVSSYNEMLSAHQPYEHFPAQIKQALRDIGSVGQFAGGVPAMCDGVTQGEP
HHHHHCCEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
GMELAIASREVIAMSTAIALSHNMFDAAMMLGICDKIVPGLMMGALRFGHLPTIFVPGGP
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MVSGLSNKEKADVRQRYAEGKATREELLDSEMKSYHGPGTCTFYGTANTNQLVMEVMGMH
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCC
LPGASFVNPYTPLRDALTAEAARQVTRMTKQSGSFMPIGEIVDERSLVNSIVALHATGGS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEECCCC
TNHTLHMPAIAQAAGIQLTWQDMADLSEVVPTLSHVYPNGKADINHFQAAGGMSFLIREL
CCCEEECCHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHH
LAAGLLHENVNTVAGYGLSRYTKEPFLEDGKLVWREGPLESLDENILRPVARPFSPEGGL
HHHHHHHHCCHHHHCCCHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCC
RVMEGNLGRGVMKVSAVAPEHQIVEAPAKVFQDQKELADAFKAGELECDFVAVMRFQGPR
EEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEECCCC
CNGMPELHKMTPFLGVLQDRGFKVALVTDGRMSGASGKIPAAIHVCPEAFDGGPLALVRD
CCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEEEC
GDVIRVDGVKGTLQVLVEASELAAREPAINQIDNSVGCGRELFGFMRMAFSSAEQGASAF
CCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TSSLETLK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]