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The map label for this gene is gcvT [H]

Identifier: 66044346

GI number: 66044346

Start: 1237394

End: 1238518

Strand: Reverse

Name: gcvT [H]

Synonym: Psyr_1095

Alternate gene names: 66044346

Gene position: 1238518-1237394 (Counterclockwise)

Preceding gene: 66044347

Following gene: 66044345

Centisome position: 20.32

GC content: 61.07

Gene sequence:

>1125_bases
ATGTCCACAGAATCACTGCTGACCACTCCCCTGCACGCCCTGCACCGCGAACTCGGCGCGAAGATGGTGCCCTTCGCCGG
TTACGACATGCCTGTTCAATACCCGGCGGGCGTAATGAAAGAGCACCTGCACACCCGCGCTCAGGCCGGTCTGTTCGATG
TCTCGCACATGGGCCAGATTCGCCTCACCGGTGCAGACGCCGCCAAGGCGCTGGAAGCCCTGGTGCCGGTAGACATCATT
GACCTGCCGGTCGGCATGCAGCGTTACGCGATGTTCACCGACGAGAACGGCGGCATTCTCGATGACCTGATGGTTGCCAA
TCTCGGTAACGACCAGTTGATGCTGGTGGTCAATGCGGCCTGCAAGGATCAGGACCTGGCGCACTTGTGCAGGCACCTGG
CCGGCCATTGCAAAATCGAACCACTGTTTGAAGAACGCGCCCTGCTCGCGCTGCAAGGGCCTGCCGCTGTAACCGTACTG
GCACGCCTCGCCCCGGAAGTCGCCCAAATGACCTTCATGCAGTTCAACAGCGTCACGCTGCTGGGCGTCAAATGCTATGT
CAGTCGCTCGGGCTATACCGGCGAAGACGGCTATGAAATTTCGGTGCCTGCCGAACAGGCTGAAGCCCTGGCACGCCGCC
TGCTGGAAGAACCTGAAGTGGCGCCTATTGGCCTGGGCGCACGTGATTCGCTGCGACTGGAAGCCGGTTTGTGCCTGTAC
GGCCATGATATGGACACGCAGACCTCGCCGATCGAGGCCAGTCTGCTATGGGCGATTTCCAAAGTGCGTCGCGCCGACGG
TGCGCGTGCAGGCGGCTTCCCGGGAGCCGAGCGCATCTTTGCCCAGCAACAGAGCGGTGTCAGCAAGAAGCGAGTCGGCC
TGCTTCCGCAGGAGCGCACGCCCGTGCGCGAAGGTACCGAGATCGTCGATGAACAGGGCGCGGTTATCGGCACGGTATGC
AGCGGCGGTTTTGGCCCCTCGCTGACTGGCCCGCTGGCAATGGGTTATCTGCATAACGATTACACAACGCTGAATACACC
GGTGTGGGCAATGGTGCGCGGCAAGAAAGTCCCCATGCTCGTTGCAAAAATGCCTTTCGTTGCGCAACGTTACTTCCGCG
GTTAA

Upstream 100 bases:

>100_bases
GAACTATCAGGAAGCGTGACAGCCGCTGCCTGGCACTGCCTGATTGCGCTGCACGCACAGGCAGTGCCACCGGTATGACC
CGCTCAACAAGGAATCGAAC

Downstream 100 bases:

>100_bases
ATAGCGGCGTCAAAAAAACAGCAACACTTCGGTGTTGCTGGGGCACTGTTCCCCTGCAGCGTTTCGTGAGTATTTCAGCC
GCGTGAACAGCCTGTCATAT

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSTESLLTTPLHALHRELGAKMVPFAGYDMPVQYPAGVMKEHLHTRAQAGLFDVSHMGQIRLTGADAAKALEALVPVDII
DLPVGMQRYAMFTDENGGILDDLMVANLGNDQLMLVVNAACKDQDLAHLCRHLAGHCKIEPLFEERALLALQGPAAVTVL
ARLAPEVAQMTFMQFNSVTLLGVKCYVSRSGYTGEDGYEISVPAEQAEALARRLLEEPEVAPIGLGARDSLRLEAGLCLY
GHDMDTQTSPIEASLLWAISKVRRADGARAGGFPGAERIFAQQQSGVSKKRVGLLPQERTPVREGTEIVDEQGAVIGTVC
SGGFGPSLTGPLAMGYLHNDYTTLNTPVWAMVRGKKVPMLVAKMPFVAQRYFRG

Sequences:

>Translated_374_residues
MSTESLLTTPLHALHRELGAKMVPFAGYDMPVQYPAGVMKEHLHTRAQAGLFDVSHMGQIRLTGADAAKALEALVPVDII
DLPVGMQRYAMFTDENGGILDDLMVANLGNDQLMLVVNAACKDQDLAHLCRHLAGHCKIEPLFEERALLALQGPAAVTVL
ARLAPEVAQMTFMQFNSVTLLGVKCYVSRSGYTGEDGYEISVPAEQAEALARRLLEEPEVAPIGLGARDSLRLEAGLCLY
GHDMDTQTSPIEASLLWAISKVRRADGARAGGFPGAERIFAQQQSGVSKKRVGLLPQERTPVREGTEIVDEQGAVIGTVC
SGGFGPSLTGPLAMGYLHNDYTTLNTPVWAMVRGKKVPMLVAKMPFVAQRYFRG
>Mature_373_residues
STESLLTTPLHALHRELGAKMVPFAGYDMPVQYPAGVMKEHLHTRAQAGLFDVSHMGQIRLTGADAAKALEALVPVDIID
LPVGMQRYAMFTDENGGILDDLMVANLGNDQLMLVVNAACKDQDLAHLCRHLAGHCKIEPLFEERALLALQGPAAVTVLA
RLAPEVAQMTFMQFNSVTLLGVKCYVSRSGYTGEDGYEISVPAEQAEALARRLLEEPEVAPIGLGARDSLRLEAGLCLYG
HDMDTQTSPIEASLLWAISKVRRADGARAGGFPGAERIFAQQQSGVSKKRVGLLPQERTPVREGTEIVDEQGAVIGTVCS
GGFGPSLTGPLAMGYLHNDYTTLNTPVWAMVRGKKVPMLVAKMPFVAQRYFRG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=377, Percent_Identity=45.8885941644562, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI257796258, Length=347, Percent_Identity=46.685878962536, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI257796254, Length=371, Percent_Identity=41.7789757412399, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI257796256, Length=322, Percent_Identity=44.7204968944099, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI197927446, Length=324, Percent_Identity=24.6913580246914, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI21361378, Length=324, Percent_Identity=24.6913580246914, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI24797151, Length=339, Percent_Identity=23.598820058997, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI194306651, Length=301, Percent_Identity=24.2524916943522, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1789272, Length=366, Percent_Identity=33.879781420765, Blast_Score=174, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17560118, Length=380, Percent_Identity=41.5789473684211, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI32563613, Length=318, Percent_Identity=24.2138364779874, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320222, Length=387, Percent_Identity=38.5012919896641, Blast_Score=246, Evalue=5e-66,
Organism=Drosophila melanogaster, GI20129441, Length=378, Percent_Identity=42.3280423280423, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI28571104, Length=271, Percent_Identity=23.6162361623616, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40411; Mature: 40280

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTESLLTTPLHALHRELGAKMVPFAGYDMPVQYPAGVMKEHLHTRAQAGLFDVSHMGQI
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCCEE
RLTGADAAKALEALVPVDIIDLPVGMQRYAMFTDENGGILDDLMVANLGNDQLMLVVNAA
EEECCHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCCCHHHHHHHCCCCCEEEEEEECC
CKDQDLAHLCRHLAGHCKIEPLFEERALLALQGPAAVTVLARLAPEVAQMTFMQFNSVTL
CCCCHHHHHHHHHHCCCEECCCHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCEEE
LGVKCYVSRSGYTGEDGYEISVPAEQAEALARRLLEEPEVAPIGLGARDSLRLEAGLCLY
EEEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCEECCCCCCCEEEECCEEEE
GHDMDTQTSPIEASLLWAISKVRRADGARAGGFPGAERIFAQQQSGVSKKRVGLLPQERT
ECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHCCCCCCCCC
PVREGTEIVDEQGAVIGTVCSGGFGPSLTGPLAMGYLHNDYTTLNTPVWAMVRGKKVPML
CCHHCHHHHHCCCCEEEEEECCCCCCCCCCHHHEEEEECCCEECCCCEEEEECCCCCCCH
VAKMPFVAQRYFRG
HHHCCHHHHHHHCC
>Mature Secondary Structure 
STESLLTTPLHALHRELGAKMVPFAGYDMPVQYPAGVMKEHLHTRAQAGLFDVSHMGQI
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCCEE
RLTGADAAKALEALVPVDIIDLPVGMQRYAMFTDENGGILDDLMVANLGNDQLMLVVNAA
EEECCHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCCCHHHHHHHCCCCCEEEEEEECC
CKDQDLAHLCRHLAGHCKIEPLFEERALLALQGPAAVTVLARLAPEVAQMTFMQFNSVTL
CCCCHHHHHHHHHHCCCEECCCHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCEEE
LGVKCYVSRSGYTGEDGYEISVPAEQAEALARRLLEEPEVAPIGLGARDSLRLEAGLCLY
EEEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCEECCCCCCCEEEECCEEEE
GHDMDTQTSPIEASLLWAISKVRRADGARAGGFPGAERIFAQQQSGVSKKRVGLLPQERT
ECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHCCCCCCCCC
PVREGTEIVDEQGAVIGTVCSGGFGPSLTGPLAMGYLHNDYTTLNTPVWAMVRGKKVPML
CCHHCHHHHHCCCCEEEEEECCCCCCCCCCHHHEEEEECCCEECCCCEEEEECCCCCCCH
VAKMPFVAQRYFRG
HHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA