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The map label for this gene is pepA [H]

Identifier: 66044342

GI number: 66044342

Start: 1232656

End: 1234146

Strand: Reverse

Name: pepA [H]

Synonym: Psyr_1091

Alternate gene names: 66044342

Gene position: 1234146-1232656 (Counterclockwise)

Preceding gene: 66044345

Following gene: 66044341

Centisome position: 20.25

GC content: 61.77

Gene sequence:

>1491_bases
ATGGAATTGGTTGTTAAAAGCGTAAGCCCAGAAACCTTGAAAACCGCAACGCTGGTGGTCACCGTCGGTGAAAGCCGTGT
ACTGGCCGGTGCTGCCAGAACTGTGGATATTCTCAGCGGCGGAGCCGTTTCGCTGATCCTCAAGCGCGGCGATCTGGCCG
GCAAGGTCGGCCAGAGCCTGCTGTTGCACAATCTGCCCAACATCAAGGCCGAGCGCGTTCTGCTGGTCGGCACCGGCAAG
GAAGACGAGCTGTCGGACCGTCAGTTGAAAAAGATCGTCGGCGCAGCGCTCACCTGCCTCAAGGGCCTGGGCGGCACCGA
TGCAGCGATTGCGCTCGATGACCTGTCGGTGAAAAACCGCGACACCTATGGCATGGCTCGTCTGCTGGTCGAAGCCCTGG
CCGACGGCGAATACGTCTTCGACCGCTTCAAGACCCAGAAAGCCGAAGTTCGTGCCCTGAAGAAAATCACCCTGTTGACC
GACAAGGTCAAGGCGGCCGACGTCGAACGCGCTTCGACTCACGCTCAGGCAATCGCCACTGGCATGGCGCTGACCCGCGA
CCTGGGTAATCTGCCGCCGAACATCTGCCACCCGACCTACCTGGGCGAAGAAGCCAAGGCACTGGGCAAGGCACACAAGA
ACCTGAAAGTGGAAGTCCACGACGAGAAGAAACTGGCCGATCTGGGCATGGGTTCGTTCCTCGCGGTAGCACAGGGCAGC
GCCCAGCCGCCGCGCCTCATCGTCATGAACTACCAGGGTGGCAAAAAAGGCGACCAGCCATTCGTGCTGGTCGGTAAAGG
CATCACCTTCGATACCGGCGGCATCAGCATCAAGCCTGCCTCGGGCATGGACGAGATGAAGTTCGACATGTGCGGCGCAG
CCAGCGTGTTCGGCACCCTGCGTGCGGTGCTCGAATTGAAGCTGCCGATCAATCTGGTGTGCATTCTGGCCTGTGCCGAA
AACATGCCGAGCGGCACTGCGACACGTCCGGGCGACATCGTCACGACCATGAGCGGCCAGACCGTCGAAATCCTCAACAC
CGACGCCGAAGGCCGTCTGGTGCTGTGCGATGCACTGACCTACGCCGAGCGTTTCAAGCCGCAGGCGGTGATCGATATCG
CAACCCTGACCGGCGCCTGCGTCGTTGCACTGGGTGGCCATACCTCCGGCCTGCTGGGCAATAACGACGCGCTGATCAAT
CAGTTGCTCGACGCGGGCAAACAGGCCGATGACCGTGCCTGGCAGCTGCCGTTGTTCGATGAGTACCAGGAGCAGCTCGA
CAGCCCGTTCGCCGACATTGCCAACATCGGTGGCCCGAAAGGCGGCACCATCACCGCGGCCTGCTTCCTGTCGCGCTTCA
CCAAGGCCTACCACTGGGCTCACCTGGACATCGCCGGCACTGCATGGCTGAGCGGCGGCAAGGAAAAAGGCGCCACCGGG
CGTCCGGTTCCGCTGCTGACCCAATACCTGCTCGACCGCGCCGGCGTATAA

Upstream 100 bases:

>100_bases
AACTGCAAGGCTTAGCGCAGGCATCGCCCCTGAAAACACTCGGGCCATGCTGCGTACGACATTCATATTGCGACTCTCAT
CGTCTATTCGGGGACCCCAC

Downstream 100 bases:

>100_bases
AAAGAGACCCTGGCGTATCGACTGCACAGTCGATACGCCTCCGGTTCTGGAACCCACATGACTCAAGTCGACTTCTACAT
CCTGCCCAGCGCCGATCCTG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MELVVKSVSPETLKTATLVVTVGESRVLAGAARTVDILSGGAVSLILKRGDLAGKVGQSLLLHNLPNIKAERVLLVGTGK
EDELSDRQLKKIVGAALTCLKGLGGTDAAIALDDLSVKNRDTYGMARLLVEALADGEYVFDRFKTQKAEVRALKKITLLT
DKVKAADVERASTHAQAIATGMALTRDLGNLPPNICHPTYLGEEAKALGKAHKNLKVEVHDEKKLADLGMGSFLAVAQGS
AQPPRLIVMNYQGGKKGDQPFVLVGKGITFDTGGISIKPASGMDEMKFDMCGAASVFGTLRAVLELKLPINLVCILACAE
NMPSGTATRPGDIVTTMSGQTVEILNTDAEGRLVLCDALTYAERFKPQAVIDIATLTGACVVALGGHTSGLLGNNDALIN
QLLDAGKQADDRAWQLPLFDEYQEQLDSPFADIANIGGPKGGTITAACFLSRFTKAYHWAHLDIAGTAWLSGGKEKGATG
RPVPLLTQYLLDRAGV

Sequences:

>Translated_496_residues
MELVVKSVSPETLKTATLVVTVGESRVLAGAARTVDILSGGAVSLILKRGDLAGKVGQSLLLHNLPNIKAERVLLVGTGK
EDELSDRQLKKIVGAALTCLKGLGGTDAAIALDDLSVKNRDTYGMARLLVEALADGEYVFDRFKTQKAEVRALKKITLLT
DKVKAADVERASTHAQAIATGMALTRDLGNLPPNICHPTYLGEEAKALGKAHKNLKVEVHDEKKLADLGMGSFLAVAQGS
AQPPRLIVMNYQGGKKGDQPFVLVGKGITFDTGGISIKPASGMDEMKFDMCGAASVFGTLRAVLELKLPINLVCILACAE
NMPSGTATRPGDIVTTMSGQTVEILNTDAEGRLVLCDALTYAERFKPQAVIDIATLTGACVVALGGHTSGLLGNNDALIN
QLLDAGKQADDRAWQLPLFDEYQEQLDSPFADIANIGGPKGGTITAACFLSRFTKAYHWAHLDIAGTAWLSGGKEKGATG
RPVPLLTQYLLDRAGV
>Mature_496_residues
MELVVKSVSPETLKTATLVVTVGESRVLAGAARTVDILSGGAVSLILKRGDLAGKVGQSLLLHNLPNIKAERVLLVGTGK
EDELSDRQLKKIVGAALTCLKGLGGTDAAIALDDLSVKNRDTYGMARLLVEALADGEYVFDRFKTQKAEVRALKKITLLT
DKVKAADVERASTHAQAIATGMALTRDLGNLPPNICHPTYLGEEAKALGKAHKNLKVEVHDEKKLADLGMGSFLAVAQGS
AQPPRLIVMNYQGGKKGDQPFVLVGKGITFDTGGISIKPASGMDEMKFDMCGAASVFGTLRAVLELKLPINLVCILACAE
NMPSGTATRPGDIVTTMSGQTVEILNTDAEGRLVLCDALTYAERFKPQAVIDIATLTGACVVALGGHTSGLLGNNDALIN
QLLDAGKQADDRAWQLPLFDEYQEQLDSPFADIANIGGPKGGTITAACFLSRFTKAYHWAHLDIAGTAWLSGGKEKGATG
RPVPLLTQYLLDRAGV

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=510, Percent_Identity=35.8823529411765, Blast_Score=265, Evalue=1e-70,
Organism=Homo sapiens, GI47155554, Length=338, Percent_Identity=33.1360946745562, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI1790710, Length=499, Percent_Identity=55.5110220440882, Blast_Score=547, Evalue=1e-157,
Organism=Escherichia coli, GI87082123, Length=291, Percent_Identity=40.5498281786942, Blast_Score=185, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=341, Percent_Identity=32.8445747800587, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17565172, Length=220, Percent_Identity=32.2727272727273, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI20129969, Length=325, Percent_Identity=36, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24661038, Length=432, Percent_Identity=32.1759259259259, Blast_Score=201, Evalue=7e-52,
Organism=Drosophila melanogaster, GI21355725, Length=434, Percent_Identity=32.4884792626728, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI161077148, Length=486, Percent_Identity=30.8641975308642, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI20130057, Length=486, Percent_Identity=30.8641975308642, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24662227, Length=324, Percent_Identity=35.1851851851852, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI21355645, Length=490, Percent_Identity=28.9795918367347, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24662223, Length=490, Percent_Identity=28.9795918367347, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI19922386, Length=470, Percent_Identity=29.5744680851064, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI20129963, Length=494, Percent_Identity=29.9595141700405, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI221379063, Length=250, Percent_Identity=37.6, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI221379062, Length=250, Percent_Identity=37.6, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI21357381, Length=250, Percent_Identity=37.6, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24646701, Length=346, Percent_Identity=25.4335260115607, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646703, Length=346, Percent_Identity=25.4335260115607, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358201, Length=346, Percent_Identity=25.4335260115607, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52380; Mature: 52380

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELVVKSVSPETLKTATLVVTVGESRVLAGAARTVDILSGGAVSLILKRGDLAGKVGQSL
CCEEEECCCCCCEEEEEEEEEECCCEEECCCHHEEEEECCCEEEEEEECCCCHHHHHHHH
LLHNLPNIKAERVLLVGTGKEDELSDRQLKKIVGAALTCLKGLGGTDAAIALDDLSVKNR
HHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
DTYGMARLLVEALADGEYVFDRFKTQKAEVRALKKITLLTDKVKAADVERASTHAQAIAT
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMALTRDLGNLPPNICHPTYLGEEAKALGKAHKNLKVEVHDEKKLADLGMGSFLAVAQGS
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHCCCCCEEEEECCC
AQPPRLIVMNYQGGKKGDQPFVLVGKGITFDTGGISIKPASGMDEMKFDMCGAASVFGTL
CCCCEEEEEECCCCCCCCCCEEEEECCEEEECCCEEEECCCCCCHHHHHHCCHHHHHHHH
RAVLELKLPINLVCILACAENMPSGTATRPGDIVTTMSGQTVEILNTDAEGRLVLCDALT
HHHHHHCCCHHHEEEEHHHCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEEEHHH
YAERFKPQAVIDIATLTGACVVALGGHTSGLLGNNDALINQLLDAGKQADDRAWQLPLFD
HHHHCCCCCEEEEHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCHH
EYQEQLDSPFADIANIGGPKGGTITAACFLSRFTKAYHWAHLDIAGTAWLSGGKEKGATG
HHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHEEEEEEECCHHHCCCCCCCCCCC
RPVPLLTQYLLDRAGV
CCHHHHHHHHHHHCCC
>Mature Secondary Structure
MELVVKSVSPETLKTATLVVTVGESRVLAGAARTVDILSGGAVSLILKRGDLAGKVGQSL
CCEEEECCCCCCEEEEEEEEEECCCEEECCCHHEEEEECCCEEEEEEECCCCHHHHHHHH
LLHNLPNIKAERVLLVGTGKEDELSDRQLKKIVGAALTCLKGLGGTDAAIALDDLSVKNR
HHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
DTYGMARLLVEALADGEYVFDRFKTQKAEVRALKKITLLTDKVKAADVERASTHAQAIAT
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMALTRDLGNLPPNICHPTYLGEEAKALGKAHKNLKVEVHDEKKLADLGMGSFLAVAQGS
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHCCCCCEEEEECCC
AQPPRLIVMNYQGGKKGDQPFVLVGKGITFDTGGISIKPASGMDEMKFDMCGAASVFGTL
CCCCEEEEEECCCCCCCCCCEEEEECCEEEECCCEEEECCCCCCHHHHHHCCHHHHHHHH
RAVLELKLPINLVCILACAENMPSGTATRPGDIVTTMSGQTVEILNTDAEGRLVLCDALT
HHHHHHCCCHHHEEEEHHHCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEEEHHH
YAERFKPQAVIDIATLTGACVVALGGHTSGLLGNNDALINQLLDAGKQADDRAWQLPLFD
HHHHCCCCCEEEEHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCHH
EYQEQLDSPFADIANIGGPKGGTITAACFLSRFTKAYHWAHLDIAGTAWLSGGKEKGATG
HHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHEEEEEEECCHHHCCCCCCCCCCC
RPVPLLTQYLLDRAGV
CCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]