Click here to switch to the map view.

The map label for this gene is folX [H]

Identifier: 66044272

GI number: 66044272

Start: 1151611

End: 1151982

Strand: Reverse

Name: folX [H]

Synonym: Psyr_1019

Alternate gene names: 66044272

Gene position: 1151982-1151611 (Counterclockwise)

Preceding gene: 66044273

Following gene: 66044271

Centisome position: 18.9

GC content: 58.06

Gene sequence:

>372_bases
ATGGCAAGACTCGAACCTGGCACCGCACGCATCCGCGTCAAGGACCTGCGCCTGCGCACGTTCATCGGCATCAACGAGGA
CGAAATCCTCAACAAACAGGACGTGCTGATCAACCTGACGATTCTGTATGCCGCTCAGGAAGCCGTGCGGGATAACGACA
TCGAGCATGCCCTCAACTATCGCACCATCACCAAGGCCATCATCCAGCATGTCGAGGGTAATCGCTTTGCCCTGCTGGAA
CGACTGACCCAGGAAGTGCTGGACCTGGTGATGAGCCACGAGGCGGTAACCTACGCTGAAGTGGAAGTCGACAAGCCGCA
TGCCCTGCGCTTTGCCGAATCCGTATCGATCACGCTCGCCGGTCAACGCTGA

Upstream 100 bases:

>100_bases
AGAATTCGACCATGAATACGTCAGTGATGCTCGGCGCCTTCCGTGACTCGAGCACCACGCGCATGGAGTTTCTGCAATTG
ATCGGACGGAGCAGACAATA

Downstream 100 bases:

>100_bases
AACTCTTATCATGACCTCAACCGTCAACTGAAAAGAGCCCGTCATGACCGAGCAAGAACGCCTCGAACTCGAAGCCGCAG
CCTTCCGCCGACTGGTCGCG

Product: D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase

Products: L-Threo-7,8-Dihydroneopterin Triphosphate. [C]

Alternate protein names: Dihydroneopterin triphosphate 2'-epimerase [H]

Number of amino acids: Translated: 123; Mature: 122

Protein sequence:

>123_residues
MARLEPGTARIRVKDLRLRTFIGINEDEILNKQDVLINLTILYAAQEAVRDNDIEHALNYRTITKAIIQHVEGNRFALLE
RLTQEVLDLVMSHEAVTYAEVEVDKPHALRFAESVSITLAGQR

Sequences:

>Translated_123_residues
MARLEPGTARIRVKDLRLRTFIGINEDEILNKQDVLINLTILYAAQEAVRDNDIEHALNYRTITKAIIQHVEGNRFALLE
RLTQEVLDLVMSHEAVTYAEVEVDKPHALRFAESVSITLAGQR
>Mature_122_residues
ARLEPGTARIRVKDLRLRTFIGINEDEILNKQDVLINLTILYAAQEAVRDNDIEHALNYRTITKAIIQHVEGNRFALLER
LTQEVLDLVMSHEAVTYAEVEVDKPHALRFAESVSITLAGQR

Specific function: Catalyzes the epimerization of carbon 2' of the side chain of dihydroneopterin triphosphate (H2NTP) to form dihydromonapterin triphosphate (H2MTP) [H]

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI1788641, Length=119, Percent_Identity=64.7058823529412, Blast_Score=155, Evalue=1e-39,
Organism=Escherichia coli, GI87082204, Length=107, Percent_Identity=27.1028037383178, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: 5.-.-.- [C]

Molecular weight: Translated: 14021; Mature: 13890

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLEPGTARIRVKDLRLRTFIGINEDEILNKQDVLINLTILYAAQEAVRDNDIEHALNY
CCCCCCCCEEEEEEEEEEEEEECCCHHHHCCCCCEEEEEHHHHHHHHHHCCCCHHHHHHH
RTITKAIIQHVEGNRFALLERLTQEVLDLVMSHEAVTYAEVEVDKPHALRFAESVSITLA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHEEEECEEEEEEE
GQR
CCC
>Mature Secondary Structure 
ARLEPGTARIRVKDLRLRTFIGINEDEILNKQDVLINLTILYAAQEAVRDNDIEHALNY
CCCCCCCEEEEEEEEEEEEEECCCHHHHCCCCCEEEEEHHHHHHHHHHCCCCHHHHHHH
RTITKAIIQHVEGNRFALLERLTQEVLDLVMSHEAVTYAEVEVDKPHALRFAESVSITLA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHEEEECEEEEEEE
GQR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-Erythro-7,8-Dihydroneopterin Triphosphate [C]

Specific reaction: D-Erythro-7,8-Dihydroneopterin Triphosphate = L-Threo-7,8-Dihydroneopterin Triphosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]