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The map label for this gene is yitJ [H]

Identifier: 66044228

GI number: 66044228

Start: 1107343

End: 1108275

Strand: Direct

Name: yitJ [H]

Synonym: Psyr_0975

Alternate gene names: 66044228

Gene position: 1107343-1108275 (Clockwise)

Preceding gene: 66044225

Following gene: 66044231

Centisome position: 18.17

GC content: 62.06

Gene sequence:

>933_bases
ATGAGTTTTTTTCATATACATATAAGCAGATCACATATGACGCAAGGTACAACTGTAATTCTCGATGGCGGCATGGGCCG
TGAACTGCAGCGTCGCGGAGCCCCGTTCCGCCAGCCTGAATGGTCGGCTCTGGCATTGAGTGAAGCACCGGAAGCGGTGA
GTGCGGTACACGCCGCTTATATCGAAAGTGGTGCTCAGGTCATCACCAGTAACAGCTACGCCGTCGTGCCGTTTCATATT
GGCGAAGAGCGTTTTGCCCGTGAAGGTCAGGCATTGGCAGCGCTGGCCGGGCAACTGGCGCGCGAGTCGGCCGATGCTTC
TGGCGGACGCGCCCGGGTAGCGGGCTCCATTCCGCCGCTGTTCGGTTCCTATCGCCCTGATCTGTACAAGCCGGAGCAGG
CTACTGATGTTCTGAAACCACTGGTTGCCGGGCTGTCGCCGTATGTCGACCTGTGGCTGGCCGAAACCCAGAGCTGCATT
CTCGAAGCGCAGACCATCCGCGCCGGGCTGCCCAATGACGGCAAACCGTTCTGGCTGTCGTTCACCCTGCAGGATGAGGA
CACTGACGAGGTCCCGCGGCTGCGCTCAGGTGAGCCGGTCGCCGACGCCGCCAGGGCCGCCGCCGCAATGGGTGTCGCCA
CGCTGCTGTTCAACTGCAGTCAGCCAGAGGTGATCGGTGGCGCAATCGATGCAGCGCGTGAGGTGTTCACGTCGCTGAAC
GTCGACATTGCCATCGGCGCCTATGCCAACGCCTTCCCGCCGCAACCCAAGGACGCCACCGCCAACGACGGTCTGGATGA
GCTGCGTGAAGACCTTGACCCGCAGGGCTATCAGCAGTGGGCGGCAGACTGGGTCAAGCGCGGCGCCACGCACATTGGCG
GCTGCTGCGGGATTGGCCCCGAGCACATTGCCGTACTGTCCAGAAGCCTCTGA

Upstream 100 bases:

>100_bases
ATGCCCAGCAGAGCGCGATAATTCACAGATATCCCCTGAAAAAGTGTTTGTAGTTTGATGAAAGGGCCGTATTAAATACG
TTATACAAGACTGACTCATA

Downstream 100 bases:

>100_bases
CCGTCACCTGCAATAAACGCAATAAAAAGCCCCGTGGCTGGTAAAGGCTCACGGGGCTTTTTGTTACAGCACAGCAGCGA
CCGGATCAGGCGAAGCTGTG

Product: homocysteine S-methyltransferase

Products: NA

Alternate protein names: Homocysteine S-methyltransferase; S-methylmethionine:homocysteine methyltransferase; 5,10-methylenetetrahydrofolate reductase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSFFHIHISRSHMTQGTTVILDGGMGRELQRRGAPFRQPEWSALALSEAPEAVSAVHAAYIESGAQVITSNSYAVVPFHI
GEERFAREGQALAALAGQLARESADASGGRARVAGSIPPLFGSYRPDLYKPEQATDVLKPLVAGLSPYVDLWLAETQSCI
LEAQTIRAGLPNDGKPFWLSFTLQDEDTDEVPRLRSGEPVADAARAAAAMGVATLLFNCSQPEVIGGAIDAAREVFTSLN
VDIAIGAYANAFPPQPKDATANDGLDELREDLDPQGYQQWAADWVKRGATHIGGCCGIGPEHIAVLSRSL

Sequences:

>Translated_310_residues
MSFFHIHISRSHMTQGTTVILDGGMGRELQRRGAPFRQPEWSALALSEAPEAVSAVHAAYIESGAQVITSNSYAVVPFHI
GEERFAREGQALAALAGQLARESADASGGRARVAGSIPPLFGSYRPDLYKPEQATDVLKPLVAGLSPYVDLWLAETQSCI
LEAQTIRAGLPNDGKPFWLSFTLQDEDTDEVPRLRSGEPVADAARAAAAMGVATLLFNCSQPEVIGGAIDAAREVFTSLN
VDIAIGAYANAFPPQPKDATANDGLDELREDLDPQGYQQWAADWVKRGATHIGGCCGIGPEHIAVLSRSL
>Mature_309_residues
SFFHIHISRSHMTQGTTVILDGGMGRELQRRGAPFRQPEWSALALSEAPEAVSAVHAAYIESGAQVITSNSYAVVPFHIG
EERFAREGQALAALAGQLARESADASGGRARVAGSIPPLFGSYRPDLYKPEQATDVLKPLVAGLSPYVDLWLAETQSCIL
EAQTIRAGLPNDGKPFWLSFTLQDEDTDEVPRLRSGEPVADAARAAAAMGVATLLFNCSQPEVIGGAIDAAREVFTSLNV
DIAIGAYANAFPPQPKDATANDGLDELREDLDPQGYQQWAADWVKRGATHIGGCCGIGPEHIAVLSRSL

Specific function: Catalyzes Methyl Transfer From S-Methylmethionine Or S- Adenosylmethionine (Less Efficient) To Homocysteine, Selenohomocysteine And Less Efficiently Selenocysteine. [C]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Homo sapiens, GI157266337, Length=318, Percent_Identity=25.7861635220126, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1786456, Length=317, Percent_Identity=26.813880126183, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003171
- InterPro:   IPR003726 [H]

Pfam domain/function: PF02219 MTHFR; PF02574 S-methyl_trans [H]

EC number: =2.1.1.10; =1.5.1.20 [H]

Molecular weight: Translated: 33079; Mature: 32948

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFFHIHISRSHMTQGTTVILDGGMGRELQRRGAPFRQPEWSALALSEAPEAVSAVHAAY
CCEEEEEEECCCCCCCCEEEEECCCCHHHHHCCCCCCCCCCCEEEHHCCHHHHHHHHHHH
IESGAQVITSNSYAVVPFHIGEERFAREGQALAALAGQLARESADASGGRARVAGSIPPL
HHCCCEEEECCCEEEEEEECCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCC
FGSYRPDLYKPEQATDVLKPLVAGLSPYVDLWLAETQSCILEAQTIRAGLPNDGKPFWLS
CCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
FTLQDEDTDEVPRLRSGEPVADAARAAAAMGVATLLFNCSQPEVIGGAIDAAREVFTSLN
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
VDIAIGAYANAFPPQPKDATANDGLDELREDLDPQGYQQWAADWVKRGATHIGGCCGIGP
CEEEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCHHCCCCCCCCH
EHIAVLSRSL
HHHHHHHHCC
>Mature Secondary Structure 
SFFHIHISRSHMTQGTTVILDGGMGRELQRRGAPFRQPEWSALALSEAPEAVSAVHAAY
CEEEEEEECCCCCCCCEEEEECCCCHHHHHCCCCCCCCCCCEEEHHCCHHHHHHHHHHH
IESGAQVITSNSYAVVPFHIGEERFAREGQALAALAGQLARESADASGGRARVAGSIPPL
HHCCCEEEECCCEEEEEEECCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCC
FGSYRPDLYKPEQATDVLKPLVAGLSPYVDLWLAETQSCILEAQTIRAGLPNDGKPFWLS
CCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
FTLQDEDTDEVPRLRSGEPVADAARAAAAMGVATLLFNCSQPEVIGGAIDAAREVFTSLN
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
VDIAIGAYANAFPPQPKDATANDGLDELREDLDPQGYQQWAADWVKRGATHIGGCCGIGP
CEEEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCHHCCCCCCCCH
EHIAVLSRSL
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]