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The map label for this gene is hemA [H]

Identifier: 66044201

GI number: 66044201

Start: 1083627

End: 1084904

Strand: Direct

Name: hemA [H]

Synonym: Psyr_0948

Alternate gene names: 66044201

Gene position: 1083627-1084904 (Clockwise)

Preceding gene: 66044193

Following gene: 66044202

Centisome position: 17.78

GC content: 60.72

Gene sequence:

>1278_bases
ATGGCCTTCCTTGCACTCGGTATCAACCATAAGACCGCCTCGGTCGACGTTCGCGAGCGTGTGGCATTTACCCCGGAACA
GCTGGTCGAGGCATTGCAGCAGCTCTGCCAACTGACGCAAAGCCGCGAGGCTGCGATCCTTTCGACCTGCAACCGCAGCG
AGTTGTACATCGAACACGAGCACCTTGGCGCGGACAGTATTCTTGCCTGGCTGGCCAATTATCATCACCTCAGTCTTGAA
GAATTGCGTGCCAGTGCTTACGTGCACGAAGATGACGCTGCCGTGCGGCACATGATGCGTGTCGCCTCGGGGCTCGATTC
GCTGGTGCTCGGCGAGCCGCAGATTCTCGGCCAGATGAAGTCCGCCTACGCGGTTGCCCGCGAAGCCGGCACGGTCGGGC
CGTTGCTTGGTCGACTGTTTCAGGCGACGTTCAGCGCTGCCAAACAGGTACGTACCGACACTGCCATTGGCGAAAACCCG
GTCTCTGTGGCCTTTGCTGCAGTCAGCCTGGCGAAACAGATTTTCAGTGACCTGCAACGCAGCCAGGCCTTGTTGATCGG
TGCAGGCGAGACCATTACTCTGGTCGCCCGGCATCTGCATGATCTGGGCGTCAAGCGTATCGTGGTCGCCAACCGCACGC
TGGAACGCGCCAGCATGCTCGCCGCCGAGTTCGGTGCGCACGCGGTGCTGCTGTCGGACATCCCGGCGGAACTGGTCAAC
AGCGATATCGTGATCAGCTCCACCGCCAGCCAGTTGCCAATTCTGGGCAAGGGCGCCGTGGAAAGTGCGTTGAAGCTGCG
CAAGCACAAACCGATTTTCATGGTCGATATCGCCGTACCGCGGGATATTGAGCCTGAAGTCGGCGAGCTGGACGATGTTT
ACCTGTACAGCGTTGATGACCTGCATGAAGTGGTGGCAGAGAATCTCAAGAGCCGTCAGGGCGCGGCGCTGGCCGCCGAG
CAGCTGGTCAGCGTGGGTGCCGAGGACTTCATGTCGCGCTTGCGCGAACTGGCCGCAGTCGACGTGCTGCGTGCCTATCG
TCAGCAAAGCGAACGGCTGCGTGACGAAGAGCTGAGCAAGGCGCAACGTATGCTGGCCAACGGCAGCAATGCCGAGGACG
TACTGATCCAGCTGGCGCGTGGCCTGACCAACAAATTGCTGCATGCACCCAGCGTGCAGCTCAAGAAGCTGTCTGCCGAA
GGTCGCGTCGATGCGCTGGCCATGGCCCAGGAACTTTTTGCCCTCGGTGAGGGCTCGACGGATAAACCCCCGCAATGA

Upstream 100 bases:

>100_bases
TGCGACGAGCGATTGTAGTGGGACAATAATATGTGGTGGTTGTTCTGAGCTTATCGAAGTAGGACAATTACCGGCTTCAC
GTCACCACCTGCGACCCTGA

Downstream 100 bases:

>100_bases
AAGCTTCACTGCTCAATAAGCTGGATGTGCTCAGCGACCGTTTCGAGGAACTGACCGCGCTGCTCGGCGACGCGGAAGTC
ATCAGCGACCAGACACGCTT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MAFLALGINHKTASVDVRERVAFTPEQLVEALQQLCQLTQSREAAILSTCNRSELYIEHEHLGADSILAWLANYHHLSLE
ELRASAYVHEDDAAVRHMMRVASGLDSLVLGEPQILGQMKSAYAVAREAGTVGPLLGRLFQATFSAAKQVRTDTAIGENP
VSVAFAAVSLAKQIFSDLQRSQALLIGAGETITLVARHLHDLGVKRIVVANRTLERASMLAAEFGAHAVLLSDIPAELVN
SDIVISSTASQLPILGKGAVESALKLRKHKPIFMVDIAVPRDIEPEVGELDDVYLYSVDDLHEVVAENLKSRQGAALAAE
QLVSVGAEDFMSRLRELAAVDVLRAYRQQSERLRDEELSKAQRMLANGSNAEDVLIQLARGLTNKLLHAPSVQLKKLSAE
GRVDALAMAQELFALGEGSTDKPPQ

Sequences:

>Translated_425_residues
MAFLALGINHKTASVDVRERVAFTPEQLVEALQQLCQLTQSREAAILSTCNRSELYIEHEHLGADSILAWLANYHHLSLE
ELRASAYVHEDDAAVRHMMRVASGLDSLVLGEPQILGQMKSAYAVAREAGTVGPLLGRLFQATFSAAKQVRTDTAIGENP
VSVAFAAVSLAKQIFSDLQRSQALLIGAGETITLVARHLHDLGVKRIVVANRTLERASMLAAEFGAHAVLLSDIPAELVN
SDIVISSTASQLPILGKGAVESALKLRKHKPIFMVDIAVPRDIEPEVGELDDVYLYSVDDLHEVVAENLKSRQGAALAAE
QLVSVGAEDFMSRLRELAAVDVLRAYRQQSERLRDEELSKAQRMLANGSNAEDVLIQLARGLTNKLLHAPSVQLKKLSAE
GRVDALAMAQELFALGEGSTDKPPQ
>Mature_424_residues
AFLALGINHKTASVDVRERVAFTPEQLVEALQQLCQLTQSREAAILSTCNRSELYIEHEHLGADSILAWLANYHHLSLEE
LRASAYVHEDDAAVRHMMRVASGLDSLVLGEPQILGQMKSAYAVAREAGTVGPLLGRLFQATFSAAKQVRTDTAIGENPV
SVAFAAVSLAKQIFSDLQRSQALLIGAGETITLVARHLHDLGVKRIVVANRTLERASMLAAEFGAHAVLLSDIPAELVNS
DIVISSTASQLPILGKGAVESALKLRKHKPIFMVDIAVPRDIEPEVGELDDVYLYSVDDLHEVVAENLKSRQGAALAAEQ
LVSVGAEDFMSRLRELAAVDVLRAYRQQSERLRDEELSKAQRMLANGSNAEDVLIQLARGLTNKLLHAPSVQLKKLSAEG
RVDALAMAQELFALGEGSTDKPPQ

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=417, Percent_Identity=50.599520383693, Blast_Score=398, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 46107; Mature: 45976

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFLALGINHKTASVDVRERVAFTPEQLVEALQQLCQLTQSREAAILSTCNRSELYIEHE
CEEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEHH
HLGADSILAWLANYHHLSLEELRASAYVHEDDAAVRHMMRVASGLDSLVLGEPQILGQMK
HCCHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHH
SAYAVAREAGTVGPLLGRLFQATFSAAKQVRTDTAIGENPVSVAFAAVSLAKQIFSDLQR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SQALLIGAGETITLVARHLHDLGVKRIVVANRTLERASMLAAEFGAHAVLLSDIPAELVN
CCEEEEECCCHHHHHHHHHHHHCHHEEHHHHHHHHHHHHHHHHHCCCEEEHHHCCHHHCC
SDIVISSTASQLPILGKGAVESALKLRKHKPIFMVDIAVPRDIEPEVGELDDVYLYSVDD
CCEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEEEHHH
LHEVVAENLKSRQGAALAAEQLVSVGAEDFMSRLRELAAVDVLRAYRQQSERLRDEELSK
HHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQRMLANGSNAEDVLIQLARGLTNKLLHAPSVQLKKLSAEGRVDALAMAQELFALGEGST
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
DKPPQ
CCCCC
>Mature Secondary Structure 
AFLALGINHKTASVDVRERVAFTPEQLVEALQQLCQLTQSREAAILSTCNRSELYIEHE
EEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEHH
HLGADSILAWLANYHHLSLEELRASAYVHEDDAAVRHMMRVASGLDSLVLGEPQILGQMK
HCCHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHH
SAYAVAREAGTVGPLLGRLFQATFSAAKQVRTDTAIGENPVSVAFAAVSLAKQIFSDLQR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SQALLIGAGETITLVARHLHDLGVKRIVVANRTLERASMLAAEFGAHAVLLSDIPAELVN
CCEEEEECCCHHHHHHHHHHHHCHHEEHHHHHHHHHHHHHHHHHCCCEEEHHHCCHHHCC
SDIVISSTASQLPILGKGAVESALKLRKHKPIFMVDIAVPRDIEPEVGELDDVYLYSVDD
CCEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEEEHHH
LHEVVAENLKSRQGAALAAEQLVSVGAEDFMSRLRELAAVDVLRAYRQQSERLRDEELSK
HHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQRMLANGSNAEDVLIQLARGLTNKLLHAPSVQLKKLSAEGRVDALAMAQELFALGEGST
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
DKPPQ
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA