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The map label for this gene is nhaA [H]

Identifier: 66043633

GI number: 66043633

Start: 388591

End: 389766

Strand: Reverse

Name: nhaA [H]

Synonym: Psyr_0364

Alternate gene names: 66043633

Gene position: 389766-388591 (Counterclockwise)

Preceding gene: 66043634

Following gene: 66043632

Centisome position: 6.4

GC content: 63.78

Gene sequence:

>1176_bases
ATGACTCAAGTTCCGAACCGGGAAACGCCCAGAGGCATTGCCATCCTCGCCCGCTTCCTCGCCTCCGAATCAGCCGGCGG
CATCGTGTTGATGGTGGCTGCGCTGGCGGCCTTGATCGTTGCCAACTCGCCGCTTTCTGCCGGCTATTTCTCGATCCTGC
ACAGCGTCTGGCTGGGTCTCTCGGTCGAGCTGTGGATCAACGACGGGCTGATGGCGATCTTCTTCCTGATGGTCGGCCTG
GAGATCAAGCGTGAAGTCCTCGCCGGTGGTCTGGCGAGCTGGGGGCAACGTGCCCTGCCCGGCTTTGCGGCGGCCGGCGG
CATGCTGGTGCCGGCGCTGATCTACATCGCGATCAATTGGGGTAATCCGCAGACCCTGAGCGGCTGGGCGATCCCGGCAG
CCACCGACATCGCCTTCGCCCTCGGCGTGCTGTCGCTGCTCGGCAATCGGGTGCCGACCTCGCTGAAGGTCTTTCTGGCC
GCACTTGCGATCCTCGACGATCTGGGCGCCGTGACCATCATCGCCTTCTTTTACAGCGCCGGTCTGAACCTGCCGATGCT
GGCCGCCGCCTTCGTGACACTGGCGGTGCTGATCGTCATGAACCGTTTGAACGTGCGTCGTTTGCTGCCCTATCTGCTGC
TTGGCGCGCTGCTGTGGTTCTTCGTCCTGCAATCGGGCGTACACGCCACGCTGGCCGGTGTCGCCCTGGCGCTGTGCATC
CCGATGGGCAAGCCCGAGGAAGAAGCCCGCTCGCCACTGCTGTTCCTCGAAGAAAAGATGCACTACTGGGTGGCCTTCGC
CGTGGTGCCGATCTTTGGTTTTGCCAACGCTGGCGTTTCGCTGGCTGGCATTACTCTGGGCAATCTGGTCGATCCTGTGC
CGCTGGGCGTTGCGCTGGGGCTGTTCGTGGGCAAGCAGATCGGCGTGTTTCTCGCCGCCGTGCTGGCCATCCGCGCCGGG
CTGGCGGTATTGCCGGAAGGCAGCAACTGGGTGCAACTGTACGGCGTGGCGATGCTGTGCGGCATCGGTTTCACCATGAG
CCTGTTCATCGGCAACCTGGCGTTCCCCGGCTCGCAACACCTGATCGACGAGGTGAAGGTCGGCGTACTGATCGGCTCGG
GGCTGGCCGCAATTGCCGGAATTGTGTTGCTGCGCAGCCGTTTCAGCAGGCCCTGA

Upstream 100 bases:

>100_bases
CCGCGCGCCAGCCGTTGCTGCCTGATCGAGCTTACCGCCACAGGCCAGTAAGCGCCTGTCTGCACACTTTATAAAAACAG
CTTTGCGTTCAAGGACGACC

Downstream 100 bases:

>100_bases
AAAAATATTTTCAAATCACTGCATCCAGACGGGTTTCTCGCGGGTAGTACATTCAGCAGCCACTTCGAGTTGCTGAGCGC
GGTTAAACCTTCTGGAGATT

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 1 [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MTQVPNRETPRGIAILARFLASESAGGIVLMVAALAALIVANSPLSAGYFSILHSVWLGLSVELWINDGLMAIFFLMVGL
EIKREVLAGGLASWGQRALPGFAAAGGMLVPALIYIAINWGNPQTLSGWAIPAATDIAFALGVLSLLGNRVPTSLKVFLA
ALAILDDLGAVTIIAFFYSAGLNLPMLAAAFVTLAVLIVMNRLNVRRLLPYLLLGALLWFFVLQSGVHATLAGVALALCI
PMGKPEEEARSPLLFLEEKMHYWVAFAVVPIFGFANAGVSLAGITLGNLVDPVPLGVALGLFVGKQIGVFLAAVLAIRAG
LAVLPEGSNWVQLYGVAMLCGIGFTMSLFIGNLAFPGSQHLIDEVKVGVLIGSGLAAIAGIVLLRSRFSRP

Sequences:

>Translated_391_residues
MTQVPNRETPRGIAILARFLASESAGGIVLMVAALAALIVANSPLSAGYFSILHSVWLGLSVELWINDGLMAIFFLMVGL
EIKREVLAGGLASWGQRALPGFAAAGGMLVPALIYIAINWGNPQTLSGWAIPAATDIAFALGVLSLLGNRVPTSLKVFLA
ALAILDDLGAVTIIAFFYSAGLNLPMLAAAFVTLAVLIVMNRLNVRRLLPYLLLGALLWFFVLQSGVHATLAGVALALCI
PMGKPEEEARSPLLFLEEKMHYWVAFAVVPIFGFANAGVSLAGITLGNLVDPVPLGVALGLFVGKQIGVFLAAVLAIRAG
LAVLPEGSNWVQLYGVAMLCGIGFTMSLFIGNLAFPGSQHLIDEVKVGVLIGSGLAAIAGIVLLRSRFSRP
>Mature_390_residues
TQVPNRETPRGIAILARFLASESAGGIVLMVAALAALIVANSPLSAGYFSILHSVWLGLSVELWINDGLMAIFFLMVGLE
IKREVLAGGLASWGQRALPGFAAAGGMLVPALIYIAINWGNPQTLSGWAIPAATDIAFALGVLSLLGNRVPTSLKVFLAA
LAILDDLGAVTIIAFFYSAGLNLPMLAAAFVTLAVLIVMNRLNVRRLLPYLLLGALLWFFVLQSGVHATLAGVALALCIP
MGKPEEEARSPLLFLEEKMHYWVAFAVVPIFGFANAGVSLAGITLGNLVDPVPLGVALGLFVGKQIGVFLAAVLAIRAGL
AVLPEGSNWVQLYGVAMLCGIGFTMSLFIGNLAFPGSQHLIDEVKVGVLIGSGLAAIAGIVLLRSRFSRP

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=386, Percent_Identity=51.5544041450777, Blast_Score=324, Evalue=5e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 40979; Mature: 40847

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVPNRETPRGIAILARFLASESAGGIVLMVAALAALIVANSPLSAGYFSILHSVWLGL
CCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
SVELWINDGLMAIFFLMVGLEIKREVLAGGLASWGQRALPGFAAAGGMLVPALIYIAINW
EEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHCCHHHHHHHHHHEEEC
GNPQTLSGWAIPAATDIAFALGVLSLLGNRVPTSLKVFLAALAILDDLGAVTIIAFFYSA
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLNLPMLAAAFVTLAVLIVMNRLNVRRLLPYLLLGALLWFFVLQSGVHATLAGVALALCI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
PMGKPEEEARSPLLFLEEKMHYWVAFAVVPIFGFANAGVSLAGITLGNLVDPVPLGVALG
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHEEHHHCCCCHHHHHHHH
LFVGKQIGVFLAAVLAIRAGLAVLPEGSNWVQLYGVAMLCGIGFTMSLFIGNLAFPGSQH
HHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
LIDEVKVGVLIGSGLAAIAGIVLLRSRFSRP
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQVPNRETPRGIAILARFLASESAGGIVLMVAALAALIVANSPLSAGYFSILHSVWLGL
CCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
SVELWINDGLMAIFFLMVGLEIKREVLAGGLASWGQRALPGFAAAGGMLVPALIYIAINW
EEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHCCHHHHHHHHHHEEEC
GNPQTLSGWAIPAATDIAFALGVLSLLGNRVPTSLKVFLAALAILDDLGAVTIIAFFYSA
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLNLPMLAAAFVTLAVLIVMNRLNVRRLLPYLLLGALLWFFVLQSGVHATLAGVALALCI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
PMGKPEEEARSPLLFLEEKMHYWVAFAVVPIFGFANAGVSLAGITLGNLVDPVPLGVALG
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHEEHHHCCCCHHHHHHHH
LFVGKQIGVFLAAVLAIRAGLAVLPEGSNWVQLYGVAMLCGIGFTMSLFIGNLAFPGSQH
HHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
LIDEVKVGVLIGSGLAAIAGIVLLRSRFSRP
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA