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The map label for this gene is pepP [H]

Identifier: 66043590

GI number: 66043590

Start: 337506

End: 338840

Strand: Direct

Name: pepP [H]

Synonym: Psyr_0321

Alternate gene names: 66043590

Gene position: 337506-338840 (Clockwise)

Preceding gene: 66043589

Following gene: 66043591

Centisome position: 5.54

GC content: 61.8

Gene sequence:

>1335_bases
ATGATTCAGATCCCGAAGTCCGAGTACGCCCGCCGCCGCAAGGCTCTGATGGCTCAGATGGAGCCGGACAGCATTGCCAT
CCTGCCCGCCGCTGCGGTTGCCATTCGCAATCGTGATGTCGAGCACGTCTATCGGCAGGACAGCGACTTTCAGTACCTGA
GCGGCTTTCCCGAGCCCGAAGCGGTGGTGGTGCTGATCCCCGGTCGTGAATACGGTGAGTACGTATTGTTCTGCCGCGAG
CGCAACCCCGAGCGCGAGCTGTGGGAAGGCCTTCGCGCGGGGCAGGAAGGCGCGATCCGCGAGTACGGTGCGGACGACGC
GTTCCCCATCAATGACATCGATGAAATCCTGCCCGGCCTGATCGAAGGCCGGGATCGGGTGTATTCGGCGATGGGCAGCA
ATCCTGAATTCGACCGACACCTGATGGACTGGATCAACGTGATTCGCTCCAAGGCGCACCTCGGTGCCCAGCCGCCCAAG
GAGTTCGTGGCGCTGGACCATCTGTTGCACGACATGCGCCTGTACAAGTCCGCCGCGGAAATCAAAGTCATGCGTTGCGC
GGCGGATATTTCCGCGCGGGCCCATGTGCGGGCGATGCAGGCCTGCCGCGCGGGGTTGCATGAGTTCAGTCTGGAAGCCG
AACTGGACTACGAGTTCCGCAAGGGCGGTTCGAAGATGCCTGCCTATGGCTCGATCGTCGCCTCGGGTCGCAACGGTTGC
ATCCTGCATTACCAGCAGAACGACGCGGTGCTCAGGGACGGTGATCTGGTGTTGATCGACGCGGGCTGCGAAATCGACTG
CTATGCCAGCGACATCACCCGTACCTTCCCGGTGAACGGCAGGTTTTCCCCCGAACAGAAAGCCATCTACGAGCTGGTGC
TCAAGTCCCAGCAGGCGGCCTTCGCGGCCATCGGGCCTGACAAACACTGGAACCAGGCACACGAGGCGACGGTCAAGGTG
ATTACCGCCGGGCTGGTCGAGCTGGGCCTGCTACGCGGCGATGTCCGCGAGCTGATCGAAAGCGAGGCCTACAAGATGTT
TTACATGCACCGTGCCGGGCACTGGCTGGGCATGGATGTGCATGACGTCGGCGAATACAAGGTCGGCGGCGAGTGGCGCG
TACTGGAGGTTGGCATGACGCTGACCGTTGAACCCGGGATTTACATATCCCCCGACAACCTGGACGTCGCGAAGAAATGG
CGAGGTATTGGTGTGCGAATCGAGGATGACGTGGTTGTGACCAGGCAGGGGTGTGAAATTCTGTCCGGCGGCGTGCCCAA
GACCGTCGCCGAGATCGAGGCGCTGATGGCGGCTGCACAGGAACAGGTCGTATGA

Upstream 100 bases:

>100_bases
GCAACCCAAGCCTTCCCTGCACTGATAGCCGATCACTGCGACACCGGCCAGCGCTTGCCACAGCGCGAGCCGGTGGACTC
CATCAGGACGCCCGCTGCCC

Downstream 100 bases:

>100_bases
GCCGCTTCAATATCGCCATCGTCGGCGGCGGATTGGTCGGTGCGAGCCTTGCGCTGTCGCTGCAGGCCGGTGCCAAGGCG
CGCGGCTGGAAAATCGTGCT

Product: peptidase M24:peptidase M24B, X-Pro dipeptidase/aminopeptidase N-terminal

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MIQIPKSEYARRRKALMAQMEPDSIAILPAAAVAIRNRDVEHVYRQDSDFQYLSGFPEPEAVVVLIPGREYGEYVLFCRE
RNPERELWEGLRAGQEGAIREYGADDAFPINDIDEILPGLIEGRDRVYSAMGSNPEFDRHLMDWINVIRSKAHLGAQPPK
EFVALDHLLHDMRLYKSAAEIKVMRCAADISARAHVRAMQACRAGLHEFSLEAELDYEFRKGGSKMPAYGSIVASGRNGC
ILHYQQNDAVLRDGDLVLIDAGCEIDCYASDITRTFPVNGRFSPEQKAIYELVLKSQQAAFAAIGPDKHWNQAHEATVKV
ITAGLVELGLLRGDVRELIESEAYKMFYMHRAGHWLGMDVHDVGEYKVGGEWRVLEVGMTLTVEPGIYISPDNLDVAKKW
RGIGVRIEDDVVVTRQGCEILSGGVPKTVAEIEALMAAAQEQVV

Sequences:

>Translated_444_residues
MIQIPKSEYARRRKALMAQMEPDSIAILPAAAVAIRNRDVEHVYRQDSDFQYLSGFPEPEAVVVLIPGREYGEYVLFCRE
RNPERELWEGLRAGQEGAIREYGADDAFPINDIDEILPGLIEGRDRVYSAMGSNPEFDRHLMDWINVIRSKAHLGAQPPK
EFVALDHLLHDMRLYKSAAEIKVMRCAADISARAHVRAMQACRAGLHEFSLEAELDYEFRKGGSKMPAYGSIVASGRNGC
ILHYQQNDAVLRDGDLVLIDAGCEIDCYASDITRTFPVNGRFSPEQKAIYELVLKSQQAAFAAIGPDKHWNQAHEATVKV
ITAGLVELGLLRGDVRELIESEAYKMFYMHRAGHWLGMDVHDVGEYKVGGEWRVLEVGMTLTVEPGIYISPDNLDVAKKW
RGIGVRIEDDVVVTRQGCEILSGGVPKTVAEIEALMAAAQEQVV
>Mature_444_residues
MIQIPKSEYARRRKALMAQMEPDSIAILPAAAVAIRNRDVEHVYRQDSDFQYLSGFPEPEAVVVLIPGREYGEYVLFCRE
RNPERELWEGLRAGQEGAIREYGADDAFPINDIDEILPGLIEGRDRVYSAMGSNPEFDRHLMDWINVIRSKAHLGAQPPK
EFVALDHLLHDMRLYKSAAEIKVMRCAADISARAHVRAMQACRAGLHEFSLEAELDYEFRKGGSKMPAYGSIVASGRNGC
ILHYQQNDAVLRDGDLVLIDAGCEIDCYASDITRTFPVNGRFSPEQKAIYELVLKSQQAAFAAIGPDKHWNQAHEATVKV
ITAGLVELGLLRGDVRELIESEAYKMFYMHRAGHWLGMDVHDVGEYKVGGEWRVLEVGMTLTVEPGIYISPDNLDVAKKW
RGIGVRIEDDVVVTRQGCEILSGGVPKTVAEIEALMAAAQEQVV

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=453, Percent_Identity=34.878587196468, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI149589008, Length=485, Percent_Identity=32.5773195876289, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI260593665, Length=319, Percent_Identity=37.9310344827586, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI260593663, Length=480, Percent_Identity=30, Blast_Score=177, Evalue=1e-44,
Organism=Escherichia coli, GI1789275, Length=443, Percent_Identity=46.5011286681716, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1788728, Length=262, Percent_Identity=33.206106870229, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1790282, Length=287, Percent_Identity=27.5261324041812, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17508215, Length=468, Percent_Identity=32.6923076923077, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI71989583, Length=370, Percent_Identity=28.6486486486486, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6320922, Length=439, Percent_Identity=29.8405466970387, Blast_Score=200, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6321118, Length=472, Percent_Identity=29.6610169491525, Blast_Score=173, Evalue=5e-44,
Organism=Drosophila melanogaster, GI19920384, Length=424, Percent_Identity=33.7264150943396, Blast_Score=224, Evalue=8e-59,
Organism=Drosophila melanogaster, GI21357079, Length=456, Percent_Identity=32.8947368421053, Blast_Score=205, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49613; Mature: 49613

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQIPKSEYARRRKALMAQMEPDSIAILPAAAVAIRNRDVEHVYRQDSDFQYLSGFPEPE
CCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCHHHHHCCCCCCHHHCCCCCCC
AVVVLIPGREYGEYVLFCRERNPERELWEGLRAGQEGAIREYGADDAFPINDIDEILPGL
EEEEEECCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHCCCCCCCCCCCHHHHHHHH
IEGRDRVYSAMGSNPEFDRHLMDWINVIRSKAHLGAQPPKEFVALDHLLHDMRLYKSAAE
HCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
IKVMRCAADISARAHVRAMQACRAGLHEFSLEAELDYEFRKGGSKMPAYGSIVASGRNGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHCCCCCCCCCCEEEECCCCCE
ILHYQQNDAVLRDGDLVLIDAGCEIDCYASDITRTFPVNGRFSPEQKAIYELVLKSQQAA
EEEEECCCCEEECCCEEEEECCCCEEEECCCCCEECCCCCCCCHHHHHHHHHHHHHCCCE
FAAIGPDKHWNQAHEATVKVITAGLVELGLLRGDVRELIESEAYKMFYMHRAGHWLGMDV
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEECCCH
HDVGEYKVGGEWRVLEVGMTLTVEPGIYISPDNLDVAKKWRGIGVRIEDDVVVTRQGCEI
HHCCCEEECCCEEEEEECEEEEECCCEEECCCCCCHHHHHCCCCEEEECCEEEEECCCHH
LSGGVPKTVAEIEALMAAAQEQVV
HCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIQIPKSEYARRRKALMAQMEPDSIAILPAAAVAIRNRDVEHVYRQDSDFQYLSGFPEPE
CCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCHHHHHCCCCCCHHHCCCCCCC
AVVVLIPGREYGEYVLFCRERNPERELWEGLRAGQEGAIREYGADDAFPINDIDEILPGL
EEEEEECCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHCCCCCCCCCCCHHHHHHHH
IEGRDRVYSAMGSNPEFDRHLMDWINVIRSKAHLGAQPPKEFVALDHLLHDMRLYKSAAE
HCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
IKVMRCAADISARAHVRAMQACRAGLHEFSLEAELDYEFRKGGSKMPAYGSIVASGRNGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHCCCCCCCCCCEEEECCCCCE
ILHYQQNDAVLRDGDLVLIDAGCEIDCYASDITRTFPVNGRFSPEQKAIYELVLKSQQAA
EEEEECCCCEEECCCEEEEECCCCEEEECCCCCEECCCCCCCCHHHHHHHHHHHHHCCCE
FAAIGPDKHWNQAHEATVKVITAGLVELGLLRGDVRELIESEAYKMFYMHRAGHWLGMDV
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEECCCH
HDVGEYKVGGEWRVLEVGMTLTVEPGIYISPDNLDVAKKWRGIGVRIEDDVVVTRQGCEI
HHCCCEEECCCEEEEEECEEEEECCCEEECCCCCCHHHHHCCCCEEEECCEEEEECCCHH
LSGGVPKTVAEIEALMAAAQEQVV
HCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]