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The map label for this gene is ppx [H]

Identifier: 66043564

GI number: 66043564

Start: 313637

End: 315217

Strand: Reverse

Name: ppx [H]

Synonym: Psyr_0294

Alternate gene names: 66043564

Gene position: 315217-313637 (Counterclockwise)

Preceding gene: 66043565

Following gene: 66043561

Centisome position: 5.17

GC content: 60.91

Gene sequence:

>1581_bases
GTGCCTGAACAGCTTCGCGTTGGCGGCAGGCATGGATCGTGGCACGATGGTCCGGTTATCGAACCGGATTTCCTGACCAT
GCCGCACTCAACACCCAAGAATTTTTCACTGATCGCCGCTATCGACCTGGGCTCCAACAGCTTTCATATGGTTGTGGCAA
AAGCCAATCAGGGCGAGATTCGCATTCTTGAGCGCCTGGGCGAGAAGGTGCAGTTGGCCGCTGGCATCGACGAAGAGCGC
CAGCTGACCGAAGAATCCATGCAGCGCGGTCTCGACTGCCTGAAACGTTTCGCCCAGTTGATCAACGGGCTGCCGCCCGG
TGCGGTGCGCATCGTGGGCACCAATGCCCTGCGCGAGGCGCGTAACCGCAACGACTTCATTCACCGCGCCGAAGAAATTC
TCGGCCACCCGGTGGAAGTGATTTCCGGCCGCGAAGAGGCGCGCCTCATTTACCTGGGCGTCTCCCACACGCTGGCCGAC
ACCCCGGGCAAACGTCTGGTCGCCGACATCGGCGGCGGCAGTACCGAATTCATCATCGGCCAGCGCTTCGAGCCGCTGCT
GCGTGAAAGCCTGCAGATGGGCTGCGTGAGTTTTACCCAGCGCTACTTCCGCGACGGCAAGGTGACACCGGCCCGTTACG
CTCAGGCGTACACCGCTGCGCGCCTGGAAATCATGAGCATTGAACACGCGCTGCATCGCCTCAAGTGGGATGAAGCGATC
GGCTCGTCAGGCACCATTCGTGCTATCGGTCTGGCGCTCAAGGCCAATGGTTACGGCGCTGGCGAGGTCAACGCCGAAGG
GCTGGCCTGGCTCAAGCGCAAGCTGTTCAAGCTGGGTGACGTGGACAAGATCGACTTCGATGGCATCAAGCCCGACCGTC
GCGCCATTTTTCCCGCAGGCCTGGCGATTCTGGAAGCCATCTTCGACGCCCTCGAACTCAAGCGCATGGATCACTGCGAA
GGTGCCCTGCGTGAAGGCGTGCTGTACGACCTGATGGGCCGCCATCATCATGAAGACGTACGTGAACGCACACTCAGCTC
GTTGATGGAGCGTTATCACGTCGATCTGGAACAGGCTGCACGCGTCGAAGCGAAGGCGCTGCATGCGCTGGAGCAGGTTG
CCGAGAGCTGGGAATTGCAGCACGAGAGTTATGCCGAACTGCTGAGCTGGGCGGCCAAGGTGCACGAGATCGGCCTGGAC
ATCGCCCACTATCACTACCACAAGCACGGCGCGTACCTGATCGAGCACTCCGACCTGGCCGGCTTCTCACGCGAAGACCA
GCAAATGCTCGCACTGCTGGTGCGCGGTCATCGCCGTAACATTCCCAAGGACAAGTTCGCCGATTTCGGCGCTGAAGGCA
TCAAGCTGATTCGCCTGTGCGTGCTGTTGCGCTTTGCGATTCTGTTTCACCACATTCGCGGCACCCAGGAGATGCCGCGT
GTGACGTTGCGTGCCGACGGCCCGAATCTGGACGCCGAATTCCCGAAAGGCTGGCTGGAAAACAACCAGCTGACTCAGGC
CGACTTCGCCCTGGAAGCGGAGTGGCTGACCCGAGTCGGCATCGTCTTCAGCGTACGCTGA

Upstream 100 bases:

>100_bases
TTCCGCACGCTTTAGCGTGGCAATGCATTTTGGTAACGCTCTGCGTCACATGGCATTGATAGCCATACGCCACGCGCGCG
AGTAATACCGGGTATTTCCG

Downstream 100 bases:

>100_bases
GGACCGGGTTGCTCAGGCGCTCCAGAAGGGTCGCCTGGGCGCTTCGCGGGTTCTGGTTGCCGGTCGGCGTGCTGCGCACG
TAACGCCCGTCCGACTGCAA

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MPEQLRVGGRHGSWHDGPVIEPDFLTMPHSTPKNFSLIAAIDLGSNSFHMVVAKANQGEIRILERLGEKVQLAAGIDEER
QLTEESMQRGLDCLKRFAQLINGLPPGAVRIVGTNALREARNRNDFIHRAEEILGHPVEVISGREEARLIYLGVSHTLAD
TPGKRLVADIGGGSTEFIIGQRFEPLLRESLQMGCVSFTQRYFRDGKVTPARYAQAYTAARLEIMSIEHALHRLKWDEAI
GSSGTIRAIGLALKANGYGAGEVNAEGLAWLKRKLFKLGDVDKIDFDGIKPDRRAIFPAGLAILEAIFDALELKRMDHCE
GALREGVLYDLMGRHHHEDVRERTLSSLMERYHVDLEQAARVEAKALHALEQVAESWELQHESYAELLSWAAKVHEIGLD
IAHYHYHKHGAYLIEHSDLAGFSREDQQMLALLVRGHRRNIPKDKFADFGAEGIKLIRLCVLLRFAILFHHIRGTQEMPR
VTLRADGPNLDAEFPKGWLENNQLTQADFALEAEWLTRVGIVFSVR

Sequences:

>Translated_526_residues
MPEQLRVGGRHGSWHDGPVIEPDFLTMPHSTPKNFSLIAAIDLGSNSFHMVVAKANQGEIRILERLGEKVQLAAGIDEER
QLTEESMQRGLDCLKRFAQLINGLPPGAVRIVGTNALREARNRNDFIHRAEEILGHPVEVISGREEARLIYLGVSHTLAD
TPGKRLVADIGGGSTEFIIGQRFEPLLRESLQMGCVSFTQRYFRDGKVTPARYAQAYTAARLEIMSIEHALHRLKWDEAI
GSSGTIRAIGLALKANGYGAGEVNAEGLAWLKRKLFKLGDVDKIDFDGIKPDRRAIFPAGLAILEAIFDALELKRMDHCE
GALREGVLYDLMGRHHHEDVRERTLSSLMERYHVDLEQAARVEAKALHALEQVAESWELQHESYAELLSWAAKVHEIGLD
IAHYHYHKHGAYLIEHSDLAGFSREDQQMLALLVRGHRRNIPKDKFADFGAEGIKLIRLCVLLRFAILFHHIRGTQEMPR
VTLRADGPNLDAEFPKGWLENNQLTQADFALEAEWLTRVGIVFSVR
>Mature_525_residues
PEQLRVGGRHGSWHDGPVIEPDFLTMPHSTPKNFSLIAAIDLGSNSFHMVVAKANQGEIRILERLGEKVQLAAGIDEERQ
LTEESMQRGLDCLKRFAQLINGLPPGAVRIVGTNALREARNRNDFIHRAEEILGHPVEVISGREEARLIYLGVSHTLADT
PGKRLVADIGGGSTEFIIGQRFEPLLRESLQMGCVSFTQRYFRDGKVTPARYAQAYTAARLEIMSIEHALHRLKWDEAIG
SSGTIRAIGLALKANGYGAGEVNAEGLAWLKRKLFKLGDVDKIDFDGIKPDRRAIFPAGLAILEAIFDALELKRMDHCEG
ALREGVLYDLMGRHHHEDVRERTLSSLMERYHVDLEQAARVEAKALHALEQVAESWELQHESYAELLSWAAKVHEIGLDI
AHYHYHKHGAYLIEHSDLAGFSREDQQMLALLVRGHRRNIPKDKFADFGAEGIKLIRLCVLLRFAILFHHIRGTQEMPRV
TLRADGPNLDAEFPKGWLENNQLTQADFALEAEWLTRVGIVFSVR

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=487, Percent_Identity=42.5051334702259, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI48994966, Length=485, Percent_Identity=39.1752577319588, Blast_Score=333, Evalue=1e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 59137; Mature: 59006

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEQLRVGGRHGSWHDGPVIEPDFLTMPHSTPKNFSLIAAIDLGSNSFHMVVAKANQGEI
CCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEEEEEECCCCEEEEEEECCCCHH
RILERLGEKVQLAAGIDEERQLTEESMQRGLDCLKRFAQLINGLPPGAVRIVGTNALREA
HHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHH
RNRNDFIHRAEEILGHPVEVISGREEARLIYLGVSHTLADTPGKRLVADIGGGSTEFIIG
HCCHHHHHHHHHHHCCCHHHHCCCCCCEEEEEECCHHHCCCCCCEEEEECCCCCEEEEEC
QRFEPLLRESLQMGCVSFTQRYFRDGKVTPARYAQAYTAARLEIMSIEHALHRLKWDEAI
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSSGTIRAIGLALKANGYGAGEVNAEGLAWLKRKLFKLGDVDKIDFDGIKPDRRAIFPAG
CCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
LAILEAIFDALELKRMDHCEGALREGVLYDLMGRHHHEDVRERTLSSLMERYHVDLEQAA
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHH
RVEAKALHALEQVAESWELQHESYAELLSWAAKVHEIGLDIAHYHYHKHGAYLIEHSDLA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHEEECCCEEEEEECCCC
GFSREDQQMLALLVRGHRRNIPKDKFADFGAEGIKLIRLCVLLRFAILFHHIRGTQEMPR
CCCCHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VTLRADGPNLDAEFPKGWLENNQLTQADFALEAEWLTRVGIVFSVR
EEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEC
>Mature Secondary Structure 
PEQLRVGGRHGSWHDGPVIEPDFLTMPHSTPKNFSLIAAIDLGSNSFHMVVAKANQGEI
CCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEEEEEECCCCEEEEEEECCCCHH
RILERLGEKVQLAAGIDEERQLTEESMQRGLDCLKRFAQLINGLPPGAVRIVGTNALREA
HHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHH
RNRNDFIHRAEEILGHPVEVISGREEARLIYLGVSHTLADTPGKRLVADIGGGSTEFIIG
HCCHHHHHHHHHHHCCCHHHHCCCCCCEEEEEECCHHHCCCCCCEEEEECCCCCEEEEEC
QRFEPLLRESLQMGCVSFTQRYFRDGKVTPARYAQAYTAARLEIMSIEHALHRLKWDEAI
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSSGTIRAIGLALKANGYGAGEVNAEGLAWLKRKLFKLGDVDKIDFDGIKPDRRAIFPAG
CCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
LAILEAIFDALELKRMDHCEGALREGVLYDLMGRHHHEDVRERTLSSLMERYHVDLEQAA
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHH
RVEAKALHALEQVAESWELQHESYAELLSWAAKVHEIGLDIAHYHYHKHGAYLIEHSDLA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHEEECCCEEEEEECCCC
GFSREDQQMLALLVRGHRRNIPKDKFADFGAEGIKLIRLCVLLRFAILFHHIRGTQEMPR
CCCCHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VTLRADGPNLDAEFPKGWLENNQLTQADFALEAEWLTRVGIVFSVR
EEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]