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The map label for this gene is algC [H]

Identifier: 66043489

GI number: 66043489

Start: 232009

End: 233406

Strand: Reverse

Name: algC [H]

Synonym: Psyr_0219

Alternate gene names: 66043489

Gene position: 233406-232009 (Counterclockwise)

Preceding gene: 66043490

Following gene: 66043488

Centisome position: 3.83

GC content: 59.59

Gene sequence:

>1398_bases
ATGAACAGCCCAGCATCCGTGGCACCCAACCTTCCCGAGACTATTTTCCGAGCCTACGACATCCGTGGCGTGGTCGGGGA
CACCCTCAACGCTGAAACGGCTTACTGGATCGGCCGCGCCATCGGCTCCGAAAGCCTGGCGCAGAACGAACCCAACGTCA
GCGTTGGCCGCGACGGTCGCCTTTCCGGTCCTGAACTGGTACAGCAACTGATTCAAGGTCTGCACGACAGCGGCTGCCAC
GTCAGCGATGTAGGCCTGGTGCCAACGCCTGCGCTGTATTACGCAGCCAACGTGCTGGCCGGCAAGACCGGCGTCATGCT
GACCGGCAGCCATAACCCGAAGGACTACAACGGCTTCAAGATCGTCATCGCCGGCGACACCCTCGCCAACGAGCAGATCC
AGGCGCTGCACGAGCGCATCAAGACCAACAACCTGACGTCGCAGAAAGGCAGCATCACCCAGGTCGACATCCTTGAGCGC
TACTTCCAGCAGATCAAGAATGACATCGTCATGGCGCGCAAGCTGAAGGTCGTGGTCGACTGCGGTAACGGCGCGGCAGG
CGTGATCGCTCCGCAACTGATCGAAGCGCTGGGCTGTGAAGTGATTTCCCTGTTCGCGGAAGTGGATGGCAACTTCCCCA
ACCATCACCCGGATCCGGGCAAGCTGGAAAACCTGCAGGACTTGATCGCCAAGGTCAAGGAAACCGGTGCCGACCTGGGC
CTGGCTTTCGACGGTGACGGCGACCGTGTCGGTGTCGTGACCAACGCAGGCAACGTGGTGTACCCGGACCGCCTGTTGAT
GCTGTTCGCGCTGGACGTGCTCAAGCGCAATCCGGGTGCCGACATCATTTTCGACGTCAAATGCACACGCCGCCTGACTC
CGCTGATCAGCGAGCATGGCGGCCGTCCGGTGATGTGGAAAACCGGTCACTCGCTGATCAAGAAAGAAATGAAGAAAAGC
GGTGCGCTGCTGGCAGGCGAAATGAGCGGCCACATCTTCTTCAAGGAACGCTGGTTCGGTTTCGACGACGGTATCTACAG
CGCAGCACGCCTGCTGGAGATCCTCAGCCAGGAGTCGGCCAACGCCGAAGACCTGTTCGAGACCTTCCCGAACGATATTT
CGACGCCTGAAATCAACATCAAGGTGACGGATGTCACCAAGTTCAGCATCATCAAGGCCCTTGAAACGGATGCGCAGTGG
GGCGACGCCAAACTGACCACCATCGACGGTGTCCGTGTGGACTATCCGAAGGGCTGGGGTCTGGTTCGCGCTTCCAATAC
CACGCCGGTACTGGTGCTGCGTTTCGAAGCCGAGACCGAGGCCGAATTGCAGCGTATCAAGGACGTGTTCCACGCAGAAC
TGAAGAAAGTTGCGCCGGACCTCGACCTGCCATTTTGA

Upstream 100 bases:

>100_bases
CACCGACTGGACCGATCCGCTGTTTCAAGATACCGATATCCTTGATATCGACCTTCTCGACGAAAACCAGGACTTCCTGA
GATCGGAGCATAACCTCGCT

Downstream 100 bases:

>100_bases
TTGTTTTTCCTTTTGACTGGAGCCCTGAATGACCCTCGAACGCGATGCCGCCTCTAATGTAGCCAAGGTCCTTTCCGAAG
CGCTGCCTTACATTCGCCGC

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MNSPASVAPNLPETIFRAYDIRGVVGDTLNAETAYWIGRAIGSESLAQNEPNVSVGRDGRLSGPELVQQLIQGLHDSGCH
VSDVGLVPTPALYYAANVLAGKTGVMLTGSHNPKDYNGFKIVIAGDTLANEQIQALHERIKTNNLTSQKGSITQVDILER
YFQQIKNDIVMARKLKVVVDCGNGAAGVIAPQLIEALGCEVISLFAEVDGNFPNHHPDPGKLENLQDLIAKVKETGADLG
LAFDGDGDRVGVVTNAGNVVYPDRLLMLFALDVLKRNPGADIIFDVKCTRRLTPLISEHGGRPVMWKTGHSLIKKEMKKS
GALLAGEMSGHIFFKERWFGFDDGIYSAARLLEILSQESANAEDLFETFPNDISTPEINIKVTDVTKFSIIKALETDAQW
GDAKLTTIDGVRVDYPKGWGLVRASNTTPVLVLRFEAETEAELQRIKDVFHAELKKVAPDLDLPF

Sequences:

>Translated_465_residues
MNSPASVAPNLPETIFRAYDIRGVVGDTLNAETAYWIGRAIGSESLAQNEPNVSVGRDGRLSGPELVQQLIQGLHDSGCH
VSDVGLVPTPALYYAANVLAGKTGVMLTGSHNPKDYNGFKIVIAGDTLANEQIQALHERIKTNNLTSQKGSITQVDILER
YFQQIKNDIVMARKLKVVVDCGNGAAGVIAPQLIEALGCEVISLFAEVDGNFPNHHPDPGKLENLQDLIAKVKETGADLG
LAFDGDGDRVGVVTNAGNVVYPDRLLMLFALDVLKRNPGADIIFDVKCTRRLTPLISEHGGRPVMWKTGHSLIKKEMKKS
GALLAGEMSGHIFFKERWFGFDDGIYSAARLLEILSQESANAEDLFETFPNDISTPEINIKVTDVTKFSIIKALETDAQW
GDAKLTTIDGVRVDYPKGWGLVRASNTTPVLVLRFEAETEAELQRIKDVFHAELKKVAPDLDLPF
>Mature_465_residues
MNSPASVAPNLPETIFRAYDIRGVVGDTLNAETAYWIGRAIGSESLAQNEPNVSVGRDGRLSGPELVQQLIQGLHDSGCH
VSDVGLVPTPALYYAANVLAGKTGVMLTGSHNPKDYNGFKIVIAGDTLANEQIQALHERIKTNNLTSQKGSITQVDILER
YFQQIKNDIVMARKLKVVVDCGNGAAGVIAPQLIEALGCEVISLFAEVDGNFPNHHPDPGKLENLQDLIAKVKETGADLG
LAFDGDGDRVGVVTNAGNVVYPDRLLMLFALDVLKRNPGADIIFDVKCTRRLTPLISEHGGRPVMWKTGHSLIKKEMKKS
GALLAGEMSGHIFFKERWFGFDDGIYSAARLLEILSQESANAEDLFETFPNDISTPEINIKVTDVTKFSIIKALETDAQW
GDAKLTTIDGVRVDYPKGWGLVRASNTTPVLVLRFEAETEAELQRIKDVFHAELKKVAPDLDLPF

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=456, Percent_Identity=33.1140350877193, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1789566, Length=454, Percent_Identity=28.6343612334802, Blast_Score=125, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 50669; Mature: 50669

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSPASVAPNLPETIFRAYDIRGVVGDTLNAETAYWIGRAIGSESLAQNEPNVSVGRDGR
CCCCCCCCCCCHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHCCHHHHCCCCCCCCCCCCC
LSGPELVQQLIQGLHDSGCHVSDVGLVPTPALYYAANVLAGKTGVMLTGSHNPKDYNGFK
CCCHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCEE
IVIAGDTLANEQIQALHERIKTNNLTSQKGSITQVDILERYFQQIKNDIVMARKLKVVVD
EEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEEE
CGNGAAGVIAPQLIEALGCEVISLFAEVDGNFPNHHPDPGKLENLQDLIAKVKETGADLG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEE
LAFDGDGDRVGVVTNAGNVVYPDRLLMLFALDVLKRNPGADIIFDVKCTRRLTPLISEHG
EEECCCCCEEEEEECCCCEECHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCC
GRPVMWKTGHSLIKKEMKKSGALLAGEMSGHIFFKERWFGFDDGIYSAARLLEILSQESA
CCCEEECCCHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCC
NAEDLFETFPNDISTPEINIKVTDVTKFSIIKALETDAQWGDAKLTTIDGVRVDYPKGWG
CHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHCCCCCCCEEEEEECCEEEECCCCCE
LVRASNTTPVLVLRFEAETEAELQRIKDVFHAELKKVAPDLDLPF
EEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNSPASVAPNLPETIFRAYDIRGVVGDTLNAETAYWIGRAIGSESLAQNEPNVSVGRDGR
CCCCCCCCCCCHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHCCHHHHCCCCCCCCCCCCC
LSGPELVQQLIQGLHDSGCHVSDVGLVPTPALYYAANVLAGKTGVMLTGSHNPKDYNGFK
CCCHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCEE
IVIAGDTLANEQIQALHERIKTNNLTSQKGSITQVDILERYFQQIKNDIVMARKLKVVVD
EEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEEE
CGNGAAGVIAPQLIEALGCEVISLFAEVDGNFPNHHPDPGKLENLQDLIAKVKETGADLG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEE
LAFDGDGDRVGVVTNAGNVVYPDRLLMLFALDVLKRNPGADIIFDVKCTRRLTPLISEHG
EEECCCCCEEEEEECCCCEECHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCC
GRPVMWKTGHSLIKKEMKKSGALLAGEMSGHIFFKERWFGFDDGIYSAARLLEILSQESA
CCCEEECCCHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCC
NAEDLFETFPNDISTPEINIKVTDVTKFSIIKALETDAQWGDAKLTTIDGVRVDYPKGWG
CHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHCCCCCCCEEEEEECCEEEECCCCCE
LVRASNTTPVLVLRFEAETEAELQRIKDVFHAELKKVAPDLDLPF
EEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]