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The map label for this gene is lysA [H]

Identifier: 66043452

GI number: 66043452

Start: 195060

End: 196307

Strand: Direct

Name: lysA [H]

Synonym: Psyr_0182

Alternate gene names: 66043452

Gene position: 195060-196307 (Clockwise)

Preceding gene: 66043451

Following gene: 66043453

Centisome position: 3.2

GC content: 62.58

Gene sequence:

>1248_bases
ATGGACGCCTTCAACTACCGCGACGGTGAGCTGTTCGCGGAAGGGGTAGCATTGTCTGCCATTGCCGAGCGCTTCGGCAC
GCCGACCTATGTCTACTCGCGCGCTCACATCGAAGCGCAATACCGTGCCTACGCCGACGCGCTGAGCGGCATGCCGCATA
TGGTCTGCTTCGCCGTAAAAGCCAACTCCAACCTGGGCGTGCTCAATGTCCTGGCGCGCCTTGGCGCCGGTTTCGACATC
GTCTCGCGTGGCGAGCTGGAGCGTGTGCTGGCGGCGGGTGGCAAAGCCGAAAAGATCGTGTTTTCCGGTGTCGGCAAGAC
CCGCGAAGACATGCGGCGCGCCCTTGAAGTCGGCGTGCACTGCTTTAACGTCGAATCCACCGACGAGCTGGAGCGCCTGC
AGGAAGTGGCTGCCGAACTCAACGTTCGGGCGCCGATATCGCTGCGGGTCAATCCGGATGTGGATGCAGGCACTCACCCC
TACATCTCCACCGGCCTCAAGGAAAACAAGTTCGGTATCGCCATTGCAGCAGCGGAAGACGTTTACATTCGCGCCTCGCA
ACTGCCGAACCTGGAAGTGATCGGGGTCGACTGCCATATCGGCTCGCAACTGACCACGCTCGAACCGTTCATCGATGCGC
TGGATCGCCTGCTGGCCCTGGTCGATCGTCTGGGCGATTGCGGCATTCATCTGCATCACATCGATCTGGGTGGCGGTCTT
GGCGTGCGTTATCGCGACGAAGAGCCTCCGCTGGCGGCCGACTACATCAAGGCCGTGCGCGAGCGTCTGGCCGGTCGCGA
CCTGGGGCTGCTGTTCGAGCCGGGACGCTTCATCGTCGCCAACGCAGGCGCGTTGCTGACCCGTGTCGAATACCTCAAGC
ATACCGAGCACAAGGATTTTGCCATCGTCGATGCGGCGATGAACGATCTGATCCGGCCTGCGCTGTATCAGGCCTGGATG
GATGTCACGGCGGTGCGTCCGCGTGACAGCGAACCTCGTGCGTACGATATCGTCGGGCCGATCTGCGAGACCGGCGACTT
CCTCGCCAAGGGGCGCGAGCTGGCGCTGGCCGAGGGCGATCTGCTGGCCGTTCATTCAGCCGGTGCCTATGGCTTCGTCA
TGAGCTCGAACTACAACACCCGTGGCCGTGCCGCCGAGGTACTGGTCGACGGTTCCCAGGCTTTTGAAGTGCGTCGTCGC
GAAACCGTGGCCGAGCTGTTCGCTGGCGAAAGCCTGCTGCCGGAGTAA

Upstream 100 bases:

>100_bases
AGCTTGTGGCCAGAAAGGCCCGCTGTATCTGCCGGATGACACCAAAACCCCGGACGAACAAGCCAAATCGCAATCGCACA
AGCACCTTTAAGGGACTCCA

Downstream 100 bases:

>100_bases
TCCCCATGCTGCTGCGTTTTACCAAGATGCACGGGCTGGGTAACGACTTCATGGTCCTGGACCTTGTGAGTCAGCACGCG
CATATCTTGCCCAAGCACGC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MDAFNYRDGELFAEGVALSAIAERFGTPTYVYSRAHIEAQYRAYADALSGMPHMVCFAVKANSNLGVLNVLARLGAGFDI
VSRGELERVLAAGGKAEKIVFSGVGKTREDMRRALEVGVHCFNVESTDELERLQEVAAELNVRAPISLRVNPDVDAGTHP
YISTGLKENKFGIAIAAAEDVYIRASQLPNLEVIGVDCHIGSQLTTLEPFIDALDRLLALVDRLGDCGIHLHHIDLGGGL
GVRYRDEEPPLAADYIKAVRERLAGRDLGLLFEPGRFIVANAGALLTRVEYLKHTEHKDFAIVDAAMNDLIRPALYQAWM
DVTAVRPRDSEPRAYDIVGPICETGDFLAKGRELALAEGDLLAVHSAGAYGFVMSSNYNTRGRAAEVLVDGSQAFEVRRR
ETVAELFAGESLLPE

Sequences:

>Translated_415_residues
MDAFNYRDGELFAEGVALSAIAERFGTPTYVYSRAHIEAQYRAYADALSGMPHMVCFAVKANSNLGVLNVLARLGAGFDI
VSRGELERVLAAGGKAEKIVFSGVGKTREDMRRALEVGVHCFNVESTDELERLQEVAAELNVRAPISLRVNPDVDAGTHP
YISTGLKENKFGIAIAAAEDVYIRASQLPNLEVIGVDCHIGSQLTTLEPFIDALDRLLALVDRLGDCGIHLHHIDLGGGL
GVRYRDEEPPLAADYIKAVRERLAGRDLGLLFEPGRFIVANAGALLTRVEYLKHTEHKDFAIVDAAMNDLIRPALYQAWM
DVTAVRPRDSEPRAYDIVGPICETGDFLAKGRELALAEGDLLAVHSAGAYGFVMSSNYNTRGRAAEVLVDGSQAFEVRRR
ETVAELFAGESLLPE
>Mature_415_residues
MDAFNYRDGELFAEGVALSAIAERFGTPTYVYSRAHIEAQYRAYADALSGMPHMVCFAVKANSNLGVLNVLARLGAGFDI
VSRGELERVLAAGGKAEKIVFSGVGKTREDMRRALEVGVHCFNVESTDELERLQEVAAELNVRAPISLRVNPDVDAGTHP
YISTGLKENKFGIAIAAAEDVYIRASQLPNLEVIGVDCHIGSQLTTLEPFIDALDRLLALVDRLGDCGIHLHHIDLGGGL
GVRYRDEEPPLAADYIKAVRERLAGRDLGLLFEPGRFIVANAGALLTRVEYLKHTEHKDFAIVDAAMNDLIRPALYQAWM
DVTAVRPRDSEPRAYDIVGPICETGDFLAKGRELALAEGDLLAVHSAGAYGFVMSSNYNTRGRAAEVLVDGSQAFEVRRR
ETVAELFAGESLLPE

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=378, Percent_Identity=25.1322751322751, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI16506287, Length=378, Percent_Identity=24.6031746031746, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI22538418, Length=354, Percent_Identity=24.5762711864407, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI21361583, Length=354, Percent_Identity=24.5762711864407, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1789203, Length=424, Percent_Identity=34.6698113207547, Blast_Score=179, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17562780, Length=365, Percent_Identity=25.2054794520548, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322664, Length=383, Percent_Identity=23.7597911227154, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24586474, Length=390, Percent_Identity=25.3846153846154, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24586472, Length=334, Percent_Identity=25.1497005988024, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45212; Mature: 45212

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAFNYRDGELFAEGVALSAIAERFGTPTYVYSRAHIEAQYRAYADALSGMPHMVCFAVK
CCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCEEEEEEEE
ANSNLGVLNVLARLGAGFDIVSRGELERVLAAGGKAEKIVFSGVGKTREDMRRALEVGVH
CCCCCHHHHHHHHHCCCCCEECCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCE
CFNVESTDELERLQEVAAELNVRAPISLRVNPDVDAGTHPYISTGLKENKFGIAIAAAED
EECCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHCCCCCCCCEEEEEECCC
VYIRASQLPNLEVIGVDCHIGSQLTTLEPFIDALDRLLALVDRLGDCGIHLHHIDLGGGL
EEEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
GVRYRDEEPPLAADYIKAVRERLAGRDLGLLFEPGRFIVANAGALLTRVEYLKHTEHKDF
CEEECCCCCCHHHHHHHHHHHHHCCCCCCEEECCCEEEEECCCHHHHHHHHHHCCCCCCE
AIVDAAMNDLIRPALYQAWMDVTAVRPRDSEPRAYDIVGPICETGDFLAKGRELALAEGD
EEEHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEECCCCHHCCCHHHHCCCEEEEECCC
LLAVHSAGAYGFVMSSNYNTRGRAAEVLVDGSQAFEVRRRETVAELFAGESLLPE
EEEEECCCCEEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDAFNYRDGELFAEGVALSAIAERFGTPTYVYSRAHIEAQYRAYADALSGMPHMVCFAVK
CCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCEEEEEEEE
ANSNLGVLNVLARLGAGFDIVSRGELERVLAAGGKAEKIVFSGVGKTREDMRRALEVGVH
CCCCCHHHHHHHHHCCCCCEECCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCE
CFNVESTDELERLQEVAAELNVRAPISLRVNPDVDAGTHPYISTGLKENKFGIAIAAAED
EECCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHCCCCCCCCEEEEEECCC
VYIRASQLPNLEVIGVDCHIGSQLTTLEPFIDALDRLLALVDRLGDCGIHLHHIDLGGGL
EEEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
GVRYRDEEPPLAADYIKAVRERLAGRDLGLLFEPGRFIVANAGALLTRVEYLKHTEHKDF
CEEECCCCCCHHHHHHHHHHHHHCCCCCCEEECCCEEEEECCCHHHHHHHHHHCCCCCCE
AIVDAAMNDLIRPALYQAWMDVTAVRPRDSEPRAYDIVGPICETGDFLAKGRELALAEGD
EEEHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEECCCCHHCCCHHHHCCCEEEEECCC
LLAVHSAGAYGFVMSSNYNTRGRAAEVLVDGSQAFEVRRRETVAELFAGESLLPE
EEEEECCCCEEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9618537 [H]