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The map label for this gene is ghrA [H]

Identifier: 66043417

GI number: 66043417

Start: 159893

End: 160822

Strand: Direct

Name: ghrA [H]

Synonym: Psyr_0147

Alternate gene names: 66043417

Gene position: 159893-160822 (Clockwise)

Preceding gene: 66043412

Following gene: 66043418

Centisome position: 2.62

GC content: 62.26

Gene sequence:

>930_bases
ATGCCCGCCCTGCTCTACAAAGCCGATCCCGCACGTGCCGAACGCTGGCGCGTCCTGTTTGCCGAGCACGCGCCGGACAT
CGAGTGGCGGGTATGGCCGGACATCGGCGACCCGGCCGACATCCACTATCTGGGCGCCTGGCTTGCGCCCGACGATCTGC
AGGAACTGCTGCCCAACCTCAAAGTGCTGTTCGCCCTGTCGGCGGGTGTGGACCAGTTGGACCTGAGCCGTATTCCAAAA
TCGCTGCCGGTGGTGCGTCTGCTGGACCCCGGCATCAGTCACGCGATGTGTGAGTACGCAACCTTTGCCGTGCTGAGCCT
GCACCGGGAAATGCTGCGTTATCGGCAGCAGCAAGTTGAAGGCGTCTGGAAAGCTCACCCGCTGATACCGGCGAACCAAC
GCCGAGTCGGCGTGATGGGGCTGGGGTTGCAGGCGCAGCATATTCTGTCGAGCCTCAAACCGTTCGGTTTCGAGCTGTCG
GGCTGGGCGCGCAGCGAGCATCGAATCGACGCTGTGCAGTGCTATGCCGGAGAAGAGCAACTGGACGCATTTCTGGGGCA
GTGCGACATTTTGCTGTGTGTGCTGCCGCTGACCGGGCAGACCGAAGGCATCCTCAATCGTCGGCTTTTCGAACAATTGC
CCAAGGGCGCCGCGCTGATCAATATGGGCCGTGGCGGGCATCTGGTGGAAGCGGAGCTGATTGAAGCGCTGGACAGCGGT
CAACTCAGCGCTGCAGTGCTGGATGTGCTGCAGCAGGAACCGGCAGCAGCCGACCATCCGTTCTGGACACACCCGAAGAT
CCTGCTGACCCCGCATGTGGCGGCCATGACCCAGCCGGAAAGCGCCTTTCCTGGCCTGCTCGATAACATCCGCCGTTTTG
AGCGTGGTGAAGCGATGCAAGGACAGGTGGATCGCGGCCAGGGTTATTAA

Upstream 100 bases:

>100_bases
CTTTTCGGACATTGGAGCGGCCAGGAAGCAGGCGTTTCGACAGATCATGCTTTGCATTTGCGGCATGATGGGGCTCCTCT
TTCATGCTCAGGAAACGCCC

Downstream 100 bases:

>100_bases
CTGACGATCGCCCCCACGCTCGCACCCCGCGTCATACACAAGTCTGCTTTTGATTCTGGCCGCAGGCCGTAGGAGCGAAC
CGGGCGACGCTTCGCTTGTT

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MPALLYKADPARAERWRVLFAEHAPDIEWRVWPDIGDPADIHYLGAWLAPDDLQELLPNLKVLFALSAGVDQLDLSRIPK
SLPVVRLLDPGISHAMCEYATFAVLSLHREMLRYRQQQVEGVWKAHPLIPANQRRVGVMGLGLQAQHILSSLKPFGFELS
GWARSEHRIDAVQCYAGEEQLDAFLGQCDILLCVLPLTGQTEGILNRRLFEQLPKGAALINMGRGGHLVEAELIEALDSG
QLSAAVLDVLQQEPAAADHPFWTHPKILLTPHVAAMTQPESAFPGLLDNIRRFERGEAMQGQVDRGQGY

Sequences:

>Translated_309_residues
MPALLYKADPARAERWRVLFAEHAPDIEWRVWPDIGDPADIHYLGAWLAPDDLQELLPNLKVLFALSAGVDQLDLSRIPK
SLPVVRLLDPGISHAMCEYATFAVLSLHREMLRYRQQQVEGVWKAHPLIPANQRRVGVMGLGLQAQHILSSLKPFGFELS
GWARSEHRIDAVQCYAGEEQLDAFLGQCDILLCVLPLTGQTEGILNRRLFEQLPKGAALINMGRGGHLVEAELIEALDSG
QLSAAVLDVLQQEPAAADHPFWTHPKILLTPHVAAMTQPESAFPGLLDNIRRFERGEAMQGQVDRGQGY
>Mature_308_residues
PALLYKADPARAERWRVLFAEHAPDIEWRVWPDIGDPADIHYLGAWLAPDDLQELLPNLKVLFALSAGVDQLDLSRIPKS
LPVVRLLDPGISHAMCEYATFAVLSLHREMLRYRQQQVEGVWKAHPLIPANQRRVGVMGLGLQAQHILSSLKPFGFELSG
WARSEHRIDAVQCYAGEEQLDAFLGQCDILLCVLPLTGQTEGILNRRLFEQLPKGAALINMGRGGHLVEAELIEALDSGQ
LSAAVLDVLQQEPAAADHPFWTHPKILLTPHVAAMTQPESAFPGLLDNIRRFERGEAMQGQVDRGQGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=253, Percent_Identity=29.2490118577075, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI23308577, Length=260, Percent_Identity=26.1538461538462, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI87081824, Length=294, Percent_Identity=39.7959183673469, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI87082289, Length=270, Percent_Identity=25.5555555555556, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=245, Percent_Identity=25.3061224489796, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324055, Length=216, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324964, Length=278, Percent_Identity=23.3812949640288, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28571528, Length=224, Percent_Identity=28.125, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI19921140, Length=224, Percent_Identity=25.8928571428571, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24585514, Length=232, Percent_Identity=24.1379310344828, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28574282, Length=232, Percent_Identity=24.1379310344828, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28574284, Length=232, Percent_Identity=24.1379310344828, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45552429, Length=232, Percent_Identity=24.1379310344828, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45551003, Length=232, Percent_Identity=24.1379310344828, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28574286, Length=228, Percent_Identity=23.6842105263158, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585516, Length=252, Percent_Identity=26.1904761904762, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34358; Mature: 34227

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPALLYKADPARAERWRVLFAEHAPDIEWRVWPDIGDPADIHYLGAWLAPDDLQELLPNL
CCCEEECCCCCHHHHHEEEEECCCCCCCEEECCCCCCCCCCCEEEEECCHHHHHHHHHHH
KVLFALSAGVDQLDLSRIPKSLPVVRLLDPGISHAMCEYATFAVLSLHREMLRYRQQQVE
HEEHHHHCCCCHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVWKAHPLIPANQRRVGVMGLGLQAQHILSSLKPFGFELSGWARSEHRIDAVQCYAGEEQ
HHHHCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCCEECCCCCCCCCCCCHHEEECCHHH
LDAFLGQCDILLCVLPLTGQTEGILNRRLFEQLPKGAALINMGRGGHLVEAELIEALDSG
HHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCC
QLSAAVLDVLQQEPAAADHPFWTHPKILLTPHVAAMTQPESAFPGLLDNIRRFERGEAMQ
CHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHCCCCCC
GQVDRGQGY
CCCCCCCCC
>Mature Secondary Structure 
PALLYKADPARAERWRVLFAEHAPDIEWRVWPDIGDPADIHYLGAWLAPDDLQELLPNL
CCEEECCCCCHHHHHEEEEECCCCCCCEEECCCCCCCCCCCEEEEECCHHHHHHHHHHH
KVLFALSAGVDQLDLSRIPKSLPVVRLLDPGISHAMCEYATFAVLSLHREMLRYRQQQVE
HEEHHHHCCCCHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVWKAHPLIPANQRRVGVMGLGLQAQHILSSLKPFGFELSGWARSEHRIDAVQCYAGEEQ
HHHHCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCCEECCCCCCCCCCCCHHEEECCHHH
LDAFLGQCDILLCVLPLTGQTEGILNRRLFEQLPKGAALINMGRGGHLVEAELIEALDSG
HHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCC
QLSAAVLDVLQQEPAAADHPFWTHPKILLTPHVAAMTQPESAFPGLLDNIRRFERGEAMQ
CHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHCCCCCC
GQVDRGQGY
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA