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The map label for this gene is lrp [H]

Identifier: 66043414

GI number: 66043414

Start: 157030

End: 157518

Strand: Reverse

Name: lrp [H]

Synonym: Psyr_0144

Alternate gene names: 66043414

Gene position: 157518-157030 (Counterclockwise)

Preceding gene: 66043415

Following gene: 66043413

Centisome position: 2.58

GC content: 53.99

Gene sequence:

>489_bases
ATGGAAGGCTTGGTCAAACTGGATCGGATTGATATCAATATTTTGGTAGAACTCCAGAAAGACGGGCGCATGACCAACGT
CAGCCTGGCCGATGCCGTCGGACTTTCCGCGAGCCCTTGCCTGCAACGCGTCAAACGCCTGGAGTCGGCAGGTTACATTT
CCAGCTACAAGGCGCACCTTAATCTGGCCAAGATCACCGAATCGGTCACCGTGTTCACGGAAATCTCCCTCAGCGACCAC
AAGCGCGAAGACTTCGCCAAATTCGAAGCCAACATCCGTCACGTCGACGAAGTGCTGGAATGCCACCTGATCAGCGGCGG
CTACGATTACCTGGTGCGCTTCATGACCCGCAGCATTCAGCATTATCAGGAAGTGATCGAAGAGCTGTTGGACAAGAACA
TCGGCATCTCCAAGTACTTCAGCTACATCGTCATCAAATCCCCGGTCATGAAAGACGGCGTGCCGCTGCGCAAACTGTTG
CGCCATTGA

Upstream 100 bases:

>100_bases
TCAACAGCATGGCTGATCTGGTCGCTCAGCATCAGCTGTCTTTACGGCGCTGATTTTGCTAGAAGGTAGGCACCGTGAAT
GGCAATACATGAGGTAGGTA

Downstream 100 bases:

>100_bases
AACACTAGCCAAGAGAGGACGCGGAGCGTCCAGAACGGCATACCCACGCGGAGCATGGGCACGATAGCGTTCGCCCGGAC
ACCTCACGCGCCACCCGTTC

Product: regulatory proteins, AsnC/Lrp

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MEGLVKLDRIDINILVELQKDGRMTNVSLADAVGLSASPCLQRVKRLESAGYISSYKAHLNLAKITESVTVFTEISLSDH
KREDFAKFEANIRHVDEVLECHLISGGYDYLVRFMTRSIQHYQEVIEELLDKNIGISKYFSYIVIKSPVMKDGVPLRKLL
RH

Sequences:

>Translated_162_residues
MEGLVKLDRIDINILVELQKDGRMTNVSLADAVGLSASPCLQRVKRLESAGYISSYKAHLNLAKITESVTVFTEISLSDH
KREDFAKFEANIRHVDEVLECHLISGGYDYLVRFMTRSIQHYQEVIEELLDKNIGISKYFSYIVIKSPVMKDGVPLRKLL
RH
>Mature_162_residues
MEGLVKLDRIDINILVELQKDGRMTNVSLADAVGLSASPCLQRVKRLESAGYISSYKAHLNLAKITESVTVFTEISLSDH
KREDFAKFEANIRHVDEVLECHLISGGYDYLVRFMTRSIQHYQEVIEELLDKNIGISKYFSYIVIKSPVMKDGVPLRKLL
RH

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=140, Percent_Identity=42.8571428571429, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI87081742, Length=131, Percent_Identity=34.3511450381679, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18497; Mature: 18497

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGLVKLDRIDINILVELQKDGRMTNVSLADAVGLSASPCLQRVKRLESAGYISSYKAHL
CCCCCEEEEEEEEEEEEECCCCCEECCHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHH
NLAKITESVTVFTEISLSDHKREDFAKFEANIRHVDEVLECHLISGGYDYLVRFMTRSIQ
HHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HYQEVIEELLDKNIGISKYFSYIVIKSPVMKDGVPLRKLLRH
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHCC
>Mature Secondary Structure
MEGLVKLDRIDINILVELQKDGRMTNVSLADAVGLSASPCLQRVKRLESAGYISSYKAHL
CCCCCEEEEEEEEEEEEECCCCCEECCHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHH
NLAKITESVTVFTEISLSDHKREDFAKFEANIRHVDEVLECHLISGGYDYLVRFMTRSIQ
HHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HYQEVIEELLDKNIGISKYFSYIVIKSPVMKDGVPLRKLLRH
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]