Click here to switch to the map view.

The map label for this gene is gabT [H]

Identifier: 66043361

GI number: 66043361

Start: 98488

End: 99768

Strand: Reverse

Name: gabT [H]

Synonym: Psyr_0090

Alternate gene names: 66043361

Gene position: 99768-98488 (Counterclockwise)

Preceding gene: 66043362

Following gene: 66043360

Centisome position: 1.64

GC content: 60.89

Gene sequence:

>1281_bases
ATGAGCAAGACTAACGAATCCCTGATGCAACGCCGCCATGCAGCCGTCCCGCGTGGTGTTGGTCAGATCCACCCGATCTT
CGCTGCTTCGGCGAAGAACGCGACCGTTACCGACGTTGAAGGTCGTGAGTTCATCGACTTCGCCGGCGGTATTGCCGTGC
TGAACACCGGTCACCTGCACCCGAAGATCATCGCCGCCGTGCAAGAACAGCTGACCAAGCTGAGCCACACCTGCTTCCAG
GTACTGGCCTACGAGCCTTACGTCGAGCTGTGCGAAAAAATCAACGCCAAAGTGCCAGGCGATTTCGACAAGAAAACCCT
GCTGGTGACCACCGGTTCCGAAGCAGTGGAAAACGCTGTGAAGATCGCCCGTGCTGCGACGGGTCGTGCGGGCGTTATCG
CCTTCACCGGCGCTTACCACGGCCGCACCATGATGACCCTGGGTCTGACCGGCAAAGTCGTGCCTTACTCGGCCGGCATG
GGCCTGATGCCAGGCGGTATCTTCCGCGCGCTGTACCCGTGCGAACTGCATGGCGTGAGCGTGGATGATTCCATCGCCAG
CATCGAGCGCATTTTCAAGAATGACGCCGAGCCCAAGGACATTGCTGCAATCATCATCGAACCGGTACAGGGCGAGGGTG
GTTTCTATGTGGCGCCGAAGGCCTTCATGCTGCGTCTGCGCGAGCTGTGCGACAAGCACGGCATTCTGCTGATCGCTGAC
GAAGTGCAGACCGGCGCTGGCCGTACCGGCACGTTCTTCGCGATGGAGCAGATGGGCGTTGCGGCTGACCTGACTACTTT
CGCCAAGTCCATCGCAGGCGGCTTCCCGCTGGCGGGCGTGTGCGGCAAGGCTGAATACATGGACGCCATCGCACCTGGCG
GTCTGGGCGGCACGTATGCCGGTAGCCCGGTGGCCTGCGCTGCGGCACTGGCGGTGCTGGACATCTTCGAAGAAGAGCAC
TTGCTGGAGCGCTGCAAGGCGGTTGGCGAGCAGTTGGTGACCTCGCTCAAGGCGATGCAGGCCAAGTACCCGGTTATCGG
TGAAGTGCGTGCGCTCGGTGCGATGATCGCTGTCGAGCTGTTCGAAGACGGCGACTCGCACAAGCCTAACGCCGCTGCAG
TGGCTCAGGTGGTTGCCAAGGCGCGTGACAAGGGTCTGATTCTGTTGTCCTGCGGTACTTACGGCAACGTGTTGCGCGTG
CTGGTGCCGTTGACCGCCGAAGACGAATTGCTCAAACGCGGCCTGGCCATTCTTGACGAATGCTTTGCTGAAATCGCGTA
A

Upstream 100 bases:

>100_bases
CCTGAAGGCTGCAGCAGTCGATCATCGTATGCTGCCGCAGTTGATCCGGTCCGCTTGATCCTTGACCCACGCCGACCGAT
GAGCGGCGAATGAGGAATAC

Downstream 100 bases:

>100_bases
AAAGTGTGAAGTCATGAATTGATTAATTTATGACCAAACAGACAAAAAAAGCCCGTTTCGACGGGTTTTTTTTGCTTTGG
AGCGGGGTATTTCGCTGTTT

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSKTNESLMQRRHAAVPRGVGQIHPIFAASAKNATVTDVEGREFIDFAGGIAVLNTGHLHPKIIAAVQEQLTKLSHTCFQ
VLAYEPYVELCEKINAKVPGDFDKKTLLVTTGSEAVENAVKIARAATGRAGVIAFTGAYHGRTMMTLGLTGKVVPYSAGM
GLMPGGIFRALYPCELHGVSVDDSIASIERIFKNDAEPKDIAAIIIEPVQGEGGFYVAPKAFMLRLRELCDKHGILLIAD
EVQTGAGRTGTFFAMEQMGVAADLTTFAKSIAGGFPLAGVCGKAEYMDAIAPGGLGGTYAGSPVACAAALAVLDIFEEEH
LLERCKAVGEQLVTSLKAMQAKYPVIGEVRALGAMIAVELFEDGDSHKPNAAAVAQVVAKARDKGLILLSCGTYGNVLRV
LVPLTAEDELLKRGLAILDECFAEIA

Sequences:

>Translated_426_residues
MSKTNESLMQRRHAAVPRGVGQIHPIFAASAKNATVTDVEGREFIDFAGGIAVLNTGHLHPKIIAAVQEQLTKLSHTCFQ
VLAYEPYVELCEKINAKVPGDFDKKTLLVTTGSEAVENAVKIARAATGRAGVIAFTGAYHGRTMMTLGLTGKVVPYSAGM
GLMPGGIFRALYPCELHGVSVDDSIASIERIFKNDAEPKDIAAIIIEPVQGEGGFYVAPKAFMLRLRELCDKHGILLIAD
EVQTGAGRTGTFFAMEQMGVAADLTTFAKSIAGGFPLAGVCGKAEYMDAIAPGGLGGTYAGSPVACAAALAVLDIFEEEH
LLERCKAVGEQLVTSLKAMQAKYPVIGEVRALGAMIAVELFEDGDSHKPNAAAVAQVVAKARDKGLILLSCGTYGNVLRV
LVPLTAEDELLKRGLAILDECFAEIA
>Mature_425_residues
SKTNESLMQRRHAAVPRGVGQIHPIFAASAKNATVTDVEGREFIDFAGGIAVLNTGHLHPKIIAAVQEQLTKLSHTCFQV
LAYEPYVELCEKINAKVPGDFDKKTLLVTTGSEAVENAVKIARAATGRAGVIAFTGAYHGRTMMTLGLTGKVVPYSAGMG
LMPGGIFRALYPCELHGVSVDDSIASIERIFKNDAEPKDIAAIIIEPVQGEGGFYVAPKAFMLRLRELCDKHGILLIADE
VQTGAGRTGTFFAMEQMGVAADLTTFAKSIAGGFPLAGVCGKAEYMDAIAPGGLGGTYAGSPVACAAALAVLDIFEEEHL
LERCKAVGEQLVTSLKAMQAKYPVIGEVRALGAMIAVELFEDGDSHKPNAAAVAQVVAKARDKGLILLSCGTYGNVLRVL
VPLTAEDELLKRGLAILDECFAEIA

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=433, Percent_Identity=30.0230946882217, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI13994255, Length=407, Percent_Identity=32.1867321867322, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI37574042, Length=418, Percent_Identity=30.3827751196172, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI226442709, Length=386, Percent_Identity=31.0880829015544, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI226442705, Length=418, Percent_Identity=29.6650717703349, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI24119277, Length=415, Percent_Identity=27.2289156626506, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI284507298, Length=323, Percent_Identity=30.030959752322, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI188536080, Length=402, Percent_Identity=27.1144278606965, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI38679950, Length=402, Percent_Identity=27.1144278606965, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI38679946, Length=402, Percent_Identity=27.1144278606965, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI1789016, Length=422, Percent_Identity=73.9336492890995, Blast_Score=654, Evalue=0.0,
Organism=Escherichia coli, GI1787560, Length=421, Percent_Identity=55.1068883610451, Blast_Score=457, Evalue=1e-130,
Organism=Escherichia coli, GI1789759, Length=424, Percent_Identity=33.4905660377358, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1788044, Length=399, Percent_Identity=35.0877192982456, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI145693181, Length=385, Percent_Identity=32.7272727272727, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1786991, Length=418, Percent_Identity=29.9043062200957, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1786349, Length=386, Percent_Identity=31.6062176165803, Blast_Score=134, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI32564660, Length=400, Percent_Identity=34.75, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI71992977, Length=442, Percent_Identity=27.3755656108597, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI25144271, Length=422, Percent_Identity=29.1469194312796, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI25144274, Length=245, Percent_Identity=30.6122448979592, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17541228, Length=427, Percent_Identity=24.3559718969555, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6323470, Length=412, Percent_Identity=30.5825242718447, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324432, Length=397, Percent_Identity=31.2342569269521, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321456, Length=349, Percent_Identity=26.647564469914, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324386, Length=375, Percent_Identity=22.9333333333333, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI161085790, Length=451, Percent_Identity=32.3725055432373, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI28574759, Length=433, Percent_Identity=32.5635103926097, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI21357415, Length=416, Percent_Identity=29.8076923076923, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21356575, Length=453, Percent_Identity=27.1523178807947, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI281366494, Length=368, Percent_Identity=25, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24667139, Length=368, Percent_Identity=25, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24667143, Length=368, Percent_Identity=25, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 44990; Mature: 44858

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTNESLMQRRHAAVPRGVGQIHPIFAASAKNATVTDVEGREFIDFAGGIAVLNTGHLH
CCCCHHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEECCCCCHHHHHCCCEEEEECCCCC
PKIIAAVQEQLTKLSHTCFQVLAYEPYVELCEKINAKVPGDFDKKTLLVTTGSEAVENAV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHH
KIARAATGRAGVIAFTGAYHGRTMMTLGLTGKVVPYSAGMGLMPGGIFRALYPCELHGVS
HHHHHCCCCCCEEEEECCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHHHCCCEECCCC
VDDSIASIERIFKNDAEPKDIAAIIIEPVQGEGGFYVAPKAFMLRLRELCDKHGILLIAD
CCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHCCEEEEEE
EVQTGAGRTGTFFAMEQMGVAADLTTFAKSIAGGFPLAGVCGKAEYMDAIAPGGLGGTYA
CCCCCCCCCCCEEHHHHCCCHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHCCCCCCCCCC
GSPVACAAALAVLDIFEEEHLLERCKAVGEQLVTSLKAMQAKYPVIGEVRALGAMIAVEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
FEDGDSHKPNAAAVAQVVAKARDKGLILLSCGTYGNVLRVLVPLTAEDELLKRGLAILDE
HCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
CFAEIA
HHHHCC
>Mature Secondary Structure 
SKTNESLMQRRHAAVPRGVGQIHPIFAASAKNATVTDVEGREFIDFAGGIAVLNTGHLH
CCCHHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEECCCCCHHHHHCCCEEEEECCCCC
PKIIAAVQEQLTKLSHTCFQVLAYEPYVELCEKINAKVPGDFDKKTLLVTTGSEAVENAV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHH
KIARAATGRAGVIAFTGAYHGRTMMTLGLTGKVVPYSAGMGLMPGGIFRALYPCELHGVS
HHHHHCCCCCCEEEEECCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHHHCCCEECCCC
VDDSIASIERIFKNDAEPKDIAAIIIEPVQGEGGFYVAPKAFMLRLRELCDKHGILLIAD
CCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHCCEEEEEE
EVQTGAGRTGTFFAMEQMGVAADLTTFAKSIAGGFPLAGVCGKAEYMDAIAPGGLGGTYA
CCCCCCCCCCCEEHHHHCCCHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHCCCCCCCCCC
GSPVACAAALAVLDIFEEEHLLERCKAVGEQLVTSLKAMQAKYPVIGEVRALGAMIAVEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
FEDGDSHKPNAAAVAQVVAKARDKGLILLSCGTYGNVLRVLVPLTAEDELLKRGLAILDE
HCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
CFAEIA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]