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The map label for this gene is cgtS11 [H]

Identifier: 62391774

GI number: 62391774

Start: 3109897

End: 3111360

Strand: Reverse

Name: cgtS11 [H]

Synonym: cg3248

Alternate gene names: 62391774

Gene position: 3111360-3109897 (Counterclockwise)

Preceding gene: 62391776

Following gene: 62391773

Centisome position: 94.78

GC content: 53.83

Gene sequence:

>1464_bases
ATGGGAAGGCCGTCAGTAATTACTTCCGGGGCTGCCTCGGTGGTGGTCTCTGGGGTTGCTTCAGGTTCCGCCGGGGTACA
AGCGGTGAGCATGATGGAAGCAGCGAGGATAGTAGGTAATGTACGACGCATGCAGTCAAGCCTAGATCGTGTGTCGGAAA
CCGGACGCAATGAGCTCGATGTTGAAACCCTTGTGAAGAAGGGGAATCAACCGGGCGCGATGAGCTATCGCAACAGTATC
CACATTTTGACAGCCTCGCTGCTGGTCGTGGGGTTGGGAGCTTCCGCCCGCCTGACGCTGCCGATGTTTGCGCTGTCGTG
CGTGCTGTTGTTTGTGTGGGGTTTTCTGTACTTCTATGGATCAACCAAACGCGTAGATTTGAGCCACGGCATGCAGCTGG
GCTGGCTGTTTGTGCTGACGCTGGTGTGGATTTTTATGGTGCCGATCGTGCCCGTGTCCATTTATCTGCTGTTCCCGCTG
TTTTTCCTCTATCTACAGGTGATGCCTGACGTGAGAGGCATTATTGCGATTTTGGGTGCGACAGCGATTGCGATTGCCAG
CCAGTATTCCGTGGGGTTGACCTTTGGTGGTGTGATGGGTCCGGTGGTCTCTGCGATCGTGACCGTGGCTATTGATTACG
CGTTCCGCACGTTGTGGCGGGTGAATAATGAAAAGCAGGAATTGATTGATCAGTTGATTGAAACTCGCTCCCAGCTGGCG
GTGACGGAACGAAATGCGGGTATTGCTGCGGAACGTCAACGTATTGCGCATGAAATTCATGACACGGTCGCCCAGGGACT
CTCCTCCATTCAAATGCTGCTGCATGTCTCTGAACAGGAGATTCTCGTTGCTGAGATGGAAGAGAAGCCAAAGGAGGCGA
TCGTGAAGAAGATGCGCCTTGCCCGACAAACAGCCTCCGACAATCTCAGTGAGGCTCGCGCGATGATTGCGGCGTTGCAA
CCGGCAGCGCTGTCTAAAACCTCCTTGGAAGCAGCACTTCACCGCGTCACAGAACCGTTGTTGGGTATTAATTTTGTGAT
TTCTGTCGACGGTGATGTTCGCCAACTGCCCATGAAAACTGAAGCCACCCTTCTGCGAATTGCTCAAGGTGCGATCGGAA
ATGTGGCGAAACATTCAGAGGCGAAAAACTGCCACGTGACACTAACCTACGAAGACACAGAAGTACGCCTTGATGTGGTT
GATGACGGTGTGGGTTTTGAGCCTTCGGAAGTGTCCAGTACCCCCGCTGGCCTTGGCCATATCGGCTTAACCGCATTGCA
GCAGCGTGCGATGGAATTGCACGGCGAAGTTATAGTGGAATCTGCATATGGGCAGGGTACTGCGGTATCTGCAGCATTGC
CGGTGGAGCCACCAGAGGGGTTTGTCGGGGCGCCGGTTTTGGCAGATTCGGACTCAAGTGCTACAGGCGAGGTTGAACTA
AGTTCTCCAACTGACGATGAGTAA

Upstream 100 bases:

>100_bases
GTAACCCGTGACGCGCTGGCCGTTGGTATCGGCGACCCAGTCGGTGCCCAGGTAGGGGCATGCGGTTTGTGCGGTGCGTT
CGACCGCGGGCATCGCGTCG

Downstream 100 bases:

>100_bases
GGCTAGACTAAAGTACGATTCATCTGCTCATCGATACTCTTGAAGGCGCATTTTCATTCGAAACGAAGTGCGCCATTGGG
AAGGACCTAGTTCAAACAAT

Product: two component sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MGRPSVITSGAASVVVSGVASGSAGVQAVSMMEAARIVGNVRRMQSSLDRVSETGRNELDVETLVKKGNQPGAMSYRNSI
HILTASLLVVGLGASARLTLPMFALSCVLLFVWGFLYFYGSTKRVDLSHGMQLGWLFVLTLVWIFMVPIVPVSIYLLFPL
FFLYLQVMPDVRGIIAILGATAIAIASQYSVGLTFGGVMGPVVSAIVTVAIDYAFRTLWRVNNEKQELIDQLIETRSQLA
VTERNAGIAAERQRIAHEIHDTVAQGLSSIQMLLHVSEQEILVAEMEEKPKEAIVKKMRLARQTASDNLSEARAMIAALQ
PAALSKTSLEAALHRVTEPLLGINFVISVDGDVRQLPMKTEATLLRIAQGAIGNVAKHSEAKNCHVTLTYEDTEVRLDVV
DDGVGFEPSEVSSTPAGLGHIGLTALQQRAMELHGEVIVESAYGQGTAVSAALPVEPPEGFVGAPVLADSDSSATGEVEL
SSPTDDE

Sequences:

>Translated_487_residues
MGRPSVITSGAASVVVSGVASGSAGVQAVSMMEAARIVGNVRRMQSSLDRVSETGRNELDVETLVKKGNQPGAMSYRNSI
HILTASLLVVGLGASARLTLPMFALSCVLLFVWGFLYFYGSTKRVDLSHGMQLGWLFVLTLVWIFMVPIVPVSIYLLFPL
FFLYLQVMPDVRGIIAILGATAIAIASQYSVGLTFGGVMGPVVSAIVTVAIDYAFRTLWRVNNEKQELIDQLIETRSQLA
VTERNAGIAAERQRIAHEIHDTVAQGLSSIQMLLHVSEQEILVAEMEEKPKEAIVKKMRLARQTASDNLSEARAMIAALQ
PAALSKTSLEAALHRVTEPLLGINFVISVDGDVRQLPMKTEATLLRIAQGAIGNVAKHSEAKNCHVTLTYEDTEVRLDVV
DDGVGFEPSEVSSTPAGLGHIGLTALQQRAMELHGEVIVESAYGQGTAVSAALPVEPPEGFVGAPVLADSDSSATGEVEL
SSPTDDE
>Mature_486_residues
GRPSVITSGAASVVVSGVASGSAGVQAVSMMEAARIVGNVRRMQSSLDRVSETGRNELDVETLVKKGNQPGAMSYRNSIH
ILTASLLVVGLGASARLTLPMFALSCVLLFVWGFLYFYGSTKRVDLSHGMQLGWLFVLTLVWIFMVPIVPVSIYLLFPLF
FLYLQVMPDVRGIIAILGATAIAIASQYSVGLTFGGVMGPVVSAIVTVAIDYAFRTLWRVNNEKQELIDQLIETRSQLAV
TERNAGIAAERQRIAHEIHDTVAQGLSSIQMLLHVSEQEILVAEMEEKPKEAIVKKMRLARQTASDNLSEARAMIAALQP
AALSKTSLEAALHRVTEPLLGINFVISVDGDVRQLPMKTEATLLRIAQGAIGNVAKHSEAKNCHVTLTYEDTEVRLDVVD
DGVGFEPSEVSSTPAGLGHIGLTALQQRAMELHGEVIVESAYGQGTAVSAALPVEPPEGFVGAPVLADSDSSATGEVELS
SPTDDE

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=238, Percent_Identity=26.4705882352941, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR017202 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52119; Mature: 51988

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRPSVITSGAASVVVSGVASGSAGVQAVSMMEAARIVGNVRRMQSSLDRVSETGRNELD
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VETLVKKGNQPGAMSYRNSIHILTASLLVVGLGASARLTLPMFALSCVLLFVWGFLYFYG
HHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
STKRVDLSHGMQLGWLFVLTLVWIFMVPIVPVSIYLLFPLFFLYLQVMPDVRGIIAILGA
CCCEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
TAIAIASQYSVGLTFGGVMGPVVSAIVTVAIDYAFRTLWRVNNEKQELIDQLIETRSQLA
HHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHE
VTERNAGIAAERQRIAHEIHDTVAQGLSSIQMLLHVSEQEILVAEMEEKPKEAIVKKMRL
EHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHH
ARQTASDNLSEARAMIAALQPAALSKTSLEAALHRVTEPLLGINFVISVDGDVRQLPMKT
HHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHCCCHH
EATLLRIAQGAIGNVAKHSEAKNCHVTLTYEDTEVRLDVVDDGVGFEPSEVSSTPAGLGH
HHHHHHHHHHHHCCHHHCCCCCCCEEEEEEECCEEEEEEEECCCCCCCCCCCCCCCCCHH
IGLTALQQRAMELHGEVIVESAYGQGTAVSAALPVEPPEGFVGAPVLADSDSSATGEVEL
HHHHHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCEEECCCCCCCCEEEE
SSPTDDE
CCCCCCC
>Mature Secondary Structure 
GRPSVITSGAASVVVSGVASGSAGVQAVSMMEAARIVGNVRRMQSSLDRVSETGRNELD
CCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VETLVKKGNQPGAMSYRNSIHILTASLLVVGLGASARLTLPMFALSCVLLFVWGFLYFYG
HHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
STKRVDLSHGMQLGWLFVLTLVWIFMVPIVPVSIYLLFPLFFLYLQVMPDVRGIIAILGA
CCCEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
TAIAIASQYSVGLTFGGVMGPVVSAIVTVAIDYAFRTLWRVNNEKQELIDQLIETRSQLA
HHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHE
VTERNAGIAAERQRIAHEIHDTVAQGLSSIQMLLHVSEQEILVAEMEEKPKEAIVKKMRL
EHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHH
ARQTASDNLSEARAMIAALQPAALSKTSLEAALHRVTEPLLGINFVISVDGDVRQLPMKT
HHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHCCCHH
EATLLRIAQGAIGNVAKHSEAKNCHVTLTYEDTEVRLDVVDDGVGFEPSEVSSTPAGLGH
HHHHHHHHHHHHCCHHHCCCCCCCEEEEEEECCEEEEEEEECCCCCCCCCCCCCCCCCHH
IGLTALQQRAMELHGEVIVESAYGQGTAVSAALPVEPPEGFVGAPVLADSDSSATGEVEL
HHHHHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCEEECCCCCCCCEEEE
SSPTDDE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]