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The map label for this gene is dapE [H]

Identifier: 62391666

GI number: 62391666

Start: 2989130

End: 2990455

Strand: Reverse

Name: dapE [H]

Synonym: cg3131

Alternate gene names: 62391666

Gene position: 2990455-2989130 (Counterclockwise)

Preceding gene: 62391668

Following gene: 62391664

Centisome position: 91.1

GC content: 53.62

Gene sequence:

>1326_bases
ATGACGCTTTACGACGAAACCCTCACCCTCCTTCAGGAACTTATCCGCAACGCCTGCGTGAATGATCTAACCCCAGATTC
AGGTCAGGAAATTAGAAACGCGGAAAGCCTAGAACGTTTCTTTGAAGGAACCCCCAACGTTAAAATCACCAAGCTGGAAC
CGCATCCGGGCCGGACCTCAATTATCGTGACTGTTCCAGGCAGCGATCCAGATGCTGAGCCTTTAACACTGCTTGGACAT
ACTGATGTTGTGCCTGTTGATCTGCCTAAATGGACTAAAGATCCATTCGGTGCGGAGATTTCGGATGGACAGATTTGGGG
TAGAGGGTCCGTCGATATGCTCTTTATTACCGCAACCCAAGCGGCCGTCACCCGTCAAGTAGCCCGTGAAGGCGGCCTGC
GTGGCACGCTGACATTCGTTGGCGTTGCTGATGAGGAAGCCCGCGGCGGACTCGGAGCGAAGTGGCTTTCCGAAGAACAC
CAAAACCTCTTCAGCTGGAAAAACTGCCTCTCCGAATCCGGTGGATCGCACCTTCCAGTCCACGACGGCAGCGACGCAGT
AGTAATTAACGTTGGAGAAAAAGGTGCAGCTCAACGTCGTATTCACGTCAATGGCGATGCTGGTCATGGTTCCATTCCTT
TCGACCGTGACAGCGCTATTGTCAAGATCGGTGAAGTCGCCCGCCGAATCGCTGCCGCCGATCTGAAGGTAGCCAAGGAC
GATATCTGGCAAGGCTTCGTCCAAGCGCACCGTTTCGACCCAGAAACGGAGCAGGCGCTTCTTAGCGGGACCTCCCCTGA
GGCCTACGCAGAGTTCGGCGGACTCTCCCGCTTCGCCCACGCGGTGTCTCATCTCACGATCGCCCAAACTGTGGTTCGTG
CAGGTCAAGCCATCAATGTATTGCCATCGCATGCGTACTTGGAACTGGATATCCGTACCCTTCCAGGCCAAACCAATGAC
TATGTTGATGACACCCTGCGTGCTGCTCTGGGCGATCTTGCCGATGAAGTAGAAATCGAACACCTCATCTCTGAAGAAGC
AACGGTGAGCCCAACTGATTCCAGGTTGTATAACACCTTGGAAAAAGTTCTTGGTGATTTCTTCCCCGATGCGCCTGTGG
TCCCAATTATTTCCTCTGGTGGCTCTGACCTGCGCTTTGGTCGTCGACTAGGCGGTGTTGGTTATGGTTTTGCAGTTCAT
GCACGTGAACGAACTTTGGCGGAAGCAATGGGGCAACTTCACTCCCATGACGAGGCGCTGTACCTGGAAGATCTTGAACT
GACTGTTCGGGGTTATGACTCCGTCGTGCGTGAATTCCTAGGCTAA

Upstream 100 bases:

>100_bases
ACGATACGGTCTAAAACTCCAGGGAAAACAGACAGAATCCAGCGTCAGTTAGCCGGAAATTCGATACAGTGGCGATGAAC
GCGATATTAGAAAGAAAAAG

Downstream 100 bases:

>100_bases
AAACATGAAGCAGGAGTCTTTTCAATTGAACGGGTTCTGAAACTAAGCACCGTTTGAAGCGCCACAACTGCAAGAACGAC
GCCTGCCAACAAGGGCATTC

Product: acetylornithine deacetylase-like protein

Products: NA

Alternate protein names: SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTLYDETLTLLQELIRNACVNDLTPDSGQEIRNAESLERFFEGTPNVKITKLEPHPGRTSIIVTVPGSDPDAEPLTLLGH
TDVVPVDLPKWTKDPFGAEISDGQIWGRGSVDMLFITATQAAVTRQVAREGGLRGTLTFVGVADEEARGGLGAKWLSEEH
QNLFSWKNCLSESGGSHLPVHDGSDAVVINVGEKGAAQRRIHVNGDAGHGSIPFDRDSAIVKIGEVARRIAAADLKVAKD
DIWQGFVQAHRFDPETEQALLSGTSPEAYAEFGGLSRFAHAVSHLTIAQTVVRAGQAINVLPSHAYLELDIRTLPGQTND
YVDDTLRAALGDLADEVEIEHLISEEATVSPTDSRLYNTLEKVLGDFFPDAPVVPIISSGGSDLRFGRRLGGVGYGFAVH
ARERTLAEAMGQLHSHDEALYLEDLELTVRGYDSVVREFLG

Sequences:

>Translated_441_residues
MTLYDETLTLLQELIRNACVNDLTPDSGQEIRNAESLERFFEGTPNVKITKLEPHPGRTSIIVTVPGSDPDAEPLTLLGH
TDVVPVDLPKWTKDPFGAEISDGQIWGRGSVDMLFITATQAAVTRQVAREGGLRGTLTFVGVADEEARGGLGAKWLSEEH
QNLFSWKNCLSESGGSHLPVHDGSDAVVINVGEKGAAQRRIHVNGDAGHGSIPFDRDSAIVKIGEVARRIAAADLKVAKD
DIWQGFVQAHRFDPETEQALLSGTSPEAYAEFGGLSRFAHAVSHLTIAQTVVRAGQAINVLPSHAYLELDIRTLPGQTND
YVDDTLRAALGDLADEVEIEHLISEEATVSPTDSRLYNTLEKVLGDFFPDAPVVPIISSGGSDLRFGRRLGGVGYGFAVH
ARERTLAEAMGQLHSHDEALYLEDLELTVRGYDSVVREFLG
>Mature_440_residues
TLYDETLTLLQELIRNACVNDLTPDSGQEIRNAESLERFFEGTPNVKITKLEPHPGRTSIIVTVPGSDPDAEPLTLLGHT
DVVPVDLPKWTKDPFGAEISDGQIWGRGSVDMLFITATQAAVTRQVAREGGLRGTLTFVGVADEEARGGLGAKWLSEEHQ
NLFSWKNCLSESGGSHLPVHDGSDAVVINVGEKGAAQRRIHVNGDAGHGSIPFDRDSAIVKIGEVARRIAAADLKVAKDD
IWQGFVQAHRFDPETEQALLSGTSPEAYAEFGGLSRFAHAVSHLTIAQTVVRAGQAINVLPSHAYLELDIRTLPGQTNDY
VDDTLRAALGDLADEVEIEHLISEEATVSPTDSRLYNTLEKVLGDFFPDAPVVPIISSGGSDLRFGRRLGGVGYGFAVHA
RERTLAEAMGQLHSHDEALYLEDLELTVRGYDSVVREFLG

Specific function: Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bact

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. DapE subfamily [H]

Homologues:

Organism=Homo sapiens, GI269846968, Length=392, Percent_Identity=25.2551020408163, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI4501901, Length=439, Percent_Identity=24.373576309795, Blast_Score=87, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17538640, Length=292, Percent_Identity=27.0547945205479, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71982710, Length=278, Percent_Identity=26.6187050359712, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71982082, Length=400, Percent_Identity=25.5, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322289, Length=213, Percent_Identity=30.0469483568075, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24649206, Length=427, Percent_Identity=24.3559718969555, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24649210, Length=389, Percent_Identity=23.6503856041131, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR005941
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 47773; Mature: 47642

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLYDETLTLLQELIRNACVNDLTPDSGQEIRNAESLERFFEGTPNVKITKLEPHPGRTS
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCHHHHHHHHCCCCCEEEEEECCCCCCEE
IIVTVPGSDPDAEPLTLLGHTDVVPVDLPKWTKDPFGAEISDGQIWGRGSVDMLFITATQ
EEEEECCCCCCCCCEEEECCCCEEECCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEEHH
AAVTRQVAREGGLRGTLTFVGVADEEARGGLGAKWLSEEHQNLFSWKNCLSESGGSHLPV
HHHHHHHHHHCCCEEEEEEEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
HDGSDAVVINVGEKGAAQRRIHVNGDAGHGSIPFDRDSAIVKIGEVARRIAAADLKVAKD
CCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DIWQGFVQAHRFDPETEQALLSGTSPEAYAEFGGLSRFAHAVSHLTIAQTVVRAGQAINV
HHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEE
LPSHAYLELDIRTLPGQTNDYVDDTLRAALGDLADEVEIEHLISEEATVSPTDSRLYNTL
CCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
EKVLGDFFPDAPVVPIISSGGSDLRFGRRLGGVGYGFAVHARERTLAEAMGQLHSHDEAL
HHHHHHHCCCCCCCEEECCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCEE
YLEDLELTVRGYDSVVREFLG
EEECEEEEECCHHHHHHHHCC
>Mature Secondary Structure 
TLYDETLTLLQELIRNACVNDLTPDSGQEIRNAESLERFFEGTPNVKITKLEPHPGRTS
CCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCHHHHHHHHCCCCCEEEEEECCCCCCEE
IIVTVPGSDPDAEPLTLLGHTDVVPVDLPKWTKDPFGAEISDGQIWGRGSVDMLFITATQ
EEEEECCCCCCCCCEEEECCCCEEECCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEEHH
AAVTRQVAREGGLRGTLTFVGVADEEARGGLGAKWLSEEHQNLFSWKNCLSESGGSHLPV
HHHHHHHHHHCCCEEEEEEEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
HDGSDAVVINVGEKGAAQRRIHVNGDAGHGSIPFDRDSAIVKIGEVARRIAAADLKVAKD
CCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DIWQGFVQAHRFDPETEQALLSGTSPEAYAEFGGLSRFAHAVSHLTIAQTVVRAGQAINV
HHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEE
LPSHAYLELDIRTLPGQTNDYVDDTLRAALGDLADEVEIEHLISEEATVSPTDSRLYNTL
CCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
EKVLGDFFPDAPVVPIISSGGSDLRFGRRLGGVGYGFAVHARERTLAEAMGQLHSHDEAL
HHHHHHHCCCCCCCEEECCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCEE
YLEDLELTVRGYDSVVREFLG
EEECEEEEECCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]