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The map label for this gene is adhA [H]

Identifier: 62391642

GI number: 62391642

Start: 2969050

End: 2970087

Strand: Reverse

Name: adhA [H]

Synonym: cg3107

Alternate gene names: 62391642

Gene position: 2970087-2969050 (Counterclockwise)

Preceding gene: 62391643

Following gene: 62391641

Centisome position: 90.48

GC content: 55.88

Gene sequence:

>1038_bases
ATGACCACTGCTGCACCCCAAGAATTTACCGCTGCTGTTGTTGAAAAATTCGGTCATGACGTGACCGTGAAGGATATTGA
CCTTCCAAAGCCAGGGCCACACCAGGCATTGGTGAAGGTACTCACCTCCGGCATCTGCCACACCGACCTCCACGCCTTGG
AGGGCGATTGGCCAGTAAAGCCGGAACCACCATTCGTACCAGGACACGAAGGTGTAGGTGAAGTTGTTGAGCTCGGACCA
GGTGAACACGATGTGAAGGTCGGCGATATTGTCGGCAATGCGTGGCTCTGGTCAGCGTGTGGCACCTGCGAATACTGCAT
CACCGGCAGGGAAACTCAGTGCAACGAAGCTGAGTATGGTGGCTACACCCAAAATGGATCCTTCGGCCAGTACATGCTGG
TGGATACCCGTTACGCCGCTCGCATCCCAGACGGCGTGGACTACCTCGAAGCAGCACCAATTCTGTGTGCAGGCGTGACT
GTCTACAAGGCACTCAAAGTCTCTGAAACCCGCCCGGGCCAATTCATGGTGATCTCCGGTGTCGGCGGACTTGGCCACAT
CGCAGTCCAATACGCAGCGGCGATGGGCATGCGTGTCATTGCGGTAGATATTGCCGATGACAAGCTGGAACTTGCCCGTA
AGCACGGTGCGGAATTTACCGTGAATGCGCGTAATGAAGATTCAGGCGAAGCTGTACAGAAGTACACCAACGGTGGCGCA
CACGGCGTGCTTGTGACTGCAGTTCACGAGGCAGCATTCGGCCAGGCACTGGATATGGCTCGACGTGCAGGAACAATTGT
GTTCAACGGTCTGCCACCGGGAGAGTTCCCAGCATCCGTGTTCAACATCGTATTCAAGGGCCTGACCATCCGTGGATCCC
TCGTGGGAACCCGCCAAGACTTGGCCGAAGCGCTCGATTTCTTTGCACGCGGACTAATCAAGCCAACCGTGAGTGAGTGC
TCCCTCGATGAGGTCAATGGTGTGCTTGACCGCATGCGAAACGGCAAGATCGATGGTCGTGTGGCGATTCGTTTCTAA

Upstream 100 bases:

>100_bases
TTGCAAGGATTGTAATTTAAGGCACATCTATGTCGGTGTGAAATTACATGTGCCAGAAGAGCAATTTGCCAAGTAATCCA
AGCGAGAAGGAGTGAGTTTT

Downstream 100 bases:

>100_bases
CGGATTGTGTTGAAACTGCTCTGAAGCTACTTTGAGGCGGTTGCTGCAGAGCGGTTTGGCTGAAAATGTGACGAACTTTG
GCTGAGCTTTCGTCGCTTTT

Product: Zn-dependent alcohol dehydrogenase

Products: NA

Alternate protein names: ADH [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTTAAPQEFTAAVVEKFGHDVTVKDIDLPKPGPHQALVKVLTSGICHTDLHALEGDWPVKPEPPFVPGHEGVGEVVELGP
GEHDVKVGDIVGNAWLWSACGTCEYCITGRETQCNEAEYGGYTQNGSFGQYMLVDTRYAARIPDGVDYLEAAPILCAGVT
VYKALKVSETRPGQFMVISGVGGLGHIAVQYAAAMGMRVIAVDIADDKLELARKHGAEFTVNARNEDSGEAVQKYTNGGA
HGVLVTAVHEAAFGQALDMARRAGTIVFNGLPPGEFPASVFNIVFKGLTIRGSLVGTRQDLAEALDFFARGLIKPTVSEC
SLDEVNGVLDRMRNGKIDGRVAIRF

Sequences:

>Translated_345_residues
MTTAAPQEFTAAVVEKFGHDVTVKDIDLPKPGPHQALVKVLTSGICHTDLHALEGDWPVKPEPPFVPGHEGVGEVVELGP
GEHDVKVGDIVGNAWLWSACGTCEYCITGRETQCNEAEYGGYTQNGSFGQYMLVDTRYAARIPDGVDYLEAAPILCAGVT
VYKALKVSETRPGQFMVISGVGGLGHIAVQYAAAMGMRVIAVDIADDKLELARKHGAEFTVNARNEDSGEAVQKYTNGGA
HGVLVTAVHEAAFGQALDMARRAGTIVFNGLPPGEFPASVFNIVFKGLTIRGSLVGTRQDLAEALDFFARGLIKPTVSEC
SLDEVNGVLDRMRNGKIDGRVAIRF
>Mature_344_residues
TTAAPQEFTAAVVEKFGHDVTVKDIDLPKPGPHQALVKVLTSGICHTDLHALEGDWPVKPEPPFVPGHEGVGEVVELGPG
EHDVKVGDIVGNAWLWSACGTCEYCITGRETQCNEAEYGGYTQNGSFGQYMLVDTRYAARIPDGVDYLEAAPILCAGVTV
YKALKVSETRPGQFMVISGVGGLGHIAVQYAAAMGMRVIAVDIADDKLELARKHGAEFTVNARNEDSGEAVQKYTNGGAH
GVLVTAVHEAAFGQALDMARRAGTIVFNGLPPGEFPASVFNIVFKGLTIRGSLVGTRQDLAEALDFFARGLIKPTVSECS
LDEVNGVLDRMRNGKIDGRVAIRF

Specific function: Active with primary alcohols, including methanol [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=360, Percent_Identity=27.5, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI34577061, Length=360, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4501929, Length=314, Percent_Identity=28.343949044586, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI262073058, Length=333, Percent_Identity=26.4264264264264, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI71743840, Length=333, Percent_Identity=26.4264264264264, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI71565152, Length=317, Percent_Identity=25.5520504731861, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI71565154, Length=257, Percent_Identity=26.0700389105058, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4501939, Length=368, Percent_Identity=24.1847826086957, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI156523966, Length=368, Percent_Identity=24.1847826086957, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI22538446, Length=321, Percent_Identity=25.2336448598131, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI22538444, Length=321, Percent_Identity=25.2336448598131, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI156627571, Length=280, Percent_Identity=25.7142857142857, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI194239674, Length=336, Percent_Identity=23.2142857142857, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI13236495, Length=336, Percent_Identity=23.2142857142857, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87081918, Length=339, Percent_Identity=44.5427728613569, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1786518, Length=330, Percent_Identity=33.3333333333333, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI87082401, Length=337, Percent_Identity=28.486646884273, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790045, Length=337, Percent_Identity=30.2670623145401, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788073, Length=264, Percent_Identity=29.5454545454545, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI226510992, Length=300, Percent_Identity=30.6666666666667, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI87082125, Length=262, Percent_Identity=28.6259541984733, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1788075, Length=309, Percent_Identity=29.7734627831715, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790718, Length=308, Percent_Identity=27.5974025974026, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787863, Length=307, Percent_Identity=27.6872964169381, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786552, Length=370, Percent_Identity=30, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788407, Length=198, Percent_Identity=30.3030303030303, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790485, Length=304, Percent_Identity=28.2894736842105, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=343, Percent_Identity=38.7755102040816, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI71988145, Length=347, Percent_Identity=35.7348703170029, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI17562582, Length=350, Percent_Identity=39.1428571428571, Blast_Score=223, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI17562878, Length=218, Percent_Identity=31.1926605504587, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=215, Percent_Identity=30.6976744186047, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI25146526, Length=264, Percent_Identity=26.1363636363636, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507255, Length=247, Percent_Identity=26.3157894736842, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71997431, Length=266, Percent_Identity=25.9398496240602, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323729, Length=345, Percent_Identity=44.9275362318841, Blast_Score=291, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6323961, Length=341, Percent_Identity=45.4545454545455, Blast_Score=285, Evalue=5e-78,
Organism=Saccharomyces cerevisiae, GI6324486, Length=323, Percent_Identity=47.0588235294118, Blast_Score=278, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6319621, Length=342, Percent_Identity=44.7368421052632, Blast_Score=278, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6319949, Length=330, Percent_Identity=30, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6323980, Length=327, Percent_Identity=28.1345565749235, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6319520, Length=313, Percent_Identity=25.5591054313099, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322619, Length=329, Percent_Identity=27.6595744680851, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=328, Percent_Identity=27.1341463414634, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=269, Percent_Identity=28.6245353159851, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=215, Percent_Identity=27.906976744186, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17737895, Length=364, Percent_Identity=23.9010989010989, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17137530, Length=304, Percent_Identity=25.6578947368421, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17737897, Length=224, Percent_Identity=25.8928571428571, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36812; Mature: 36681

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAAPQEFTAAVVEKFGHDVTVKDIDLPKPGPHQALVKVLTSGICHTDLHALEGDWPVK
CCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCC
PEPPFVPGHEGVGEVVELGPGEHDVKVGDIVGNAWLWSACGTCEYCITGRETQCNEAEYG
CCCCCCCCCCCCCHHHCCCCCCCCEEEHHEECCCHHHHCCCCEEEEECCCCCCCCCCCCC
GYTQNGSFGQYMLVDTRYAARIPDGVDYLEAAPILCAGVTVYKALKVSETRPGQFMVISG
CCCCCCCCCEEEEEECHHHHCCCCCCHHHHHCHHHHHHHHHHHHHCCCCCCCCCEEEEEC
VGGLGHIAVQYAAAMGMRVIAVDIADDKLELARKHGAEFTVNARNEDSGEAVQKYTNGGA
CCCHHHHHHHHHHHCCEEEEEEEECCHHHHHHHHCCCEEEEECCCCCCHHHHHHHCCCCC
HGVLVTAVHEAAFGQALDMARRAGTIVFNGLPPGEFPASVFNIVFKGLTIRGSLVGTRQD
CEEEEEEHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCHHH
LAEALDFFARGLIKPTVSECSLDEVNGVLDRMRNGKIDGRVAIRF
HHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure 
TTAAPQEFTAAVVEKFGHDVTVKDIDLPKPGPHQALVKVLTSGICHTDLHALEGDWPVK
CCCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCC
PEPPFVPGHEGVGEVVELGPGEHDVKVGDIVGNAWLWSACGTCEYCITGRETQCNEAEYG
CCCCCCCCCCCCCHHHCCCCCCCCEEEHHEECCCHHHHCCCCEEEEECCCCCCCCCCCCC
GYTQNGSFGQYMLVDTRYAARIPDGVDYLEAAPILCAGVTVYKALKVSETRPGQFMVISG
CCCCCCCCCEEEEEECHHHHCCCCCCHHHHHCHHHHHHHHHHHHHCCCCCCCCCEEEEEC
VGGLGHIAVQYAAAMGMRVIAVDIADDKLELARKHGAEFTVNARNEDSGEAVQKYTNGGA
CCCHHHHHHHHHHHCCEEEEEEEECCHHHHHHHHCCCEEEEECCCCCCHHHHHHHCCCCC
HGVLVTAVHEAAFGQALDMARRAGTIVFNGLPPGEFPASVFNIVFKGLTIRGSLVGTRQD
CEEEEEEHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCHHH
LAEALDFFARGLIKPTVSECSLDEVNGVLDRMRNGKIDGRVAIRF
HHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8049268 [H]