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The map label for this gene is groEL [H]

Identifier: 62391553

GI number: 62391553

Start: 2862202

End: 2863848

Strand: Reverse

Name: groEL [H]

Synonym: cg3011

Alternate gene names: 62391553

Gene position: 2863848-2862202 (Counterclockwise)

Preceding gene: 62391554

Following gene: 62391552

Centisome position: 87.24

GC content: 57.92

Gene sequence:

>1647_bases
ATGGCAAAGATCATCGCCTTTGATGAGGAAGCACGTCGTGGCCTAGAAAAGGGACTGAACACCCTGGCTGACGCTGTTAA
GGTTACTTTGGGACCAAAGGGCCGTAACGTCGTTTTGGAAAAGGCTTGGGGTGCCCCAACCATTACCAACGATGGTGTCA
CCATCGCACGTGAGATCGAGCTTGAGGATCCTTACGAGAAGATCGGCGCAGAGCTGGTCAAGGAAGTCGCTAAGAAGACT
GATGACGTCGCGGGCGATGGCACCACCACCGCTACCGTATTGGCACAGGCTCTGGTTCGGGAAGGCCTGCGCAACGTTGC
TGCTGGCTCTAACCCAATGGGCATCAAGCGTGGCATCGAGAAGGCTGTTGCTCAGGTAACTGAGAAGCTGCTCGAGGCTG
CGAAGGAAGTTGAGACCGAGGAGCAGATCGCTGCTACCGCTGGTATCTCCGCAGCTGACCCAGCTATCGGCGCACAGATT
GCTAAGGCAATGTACGCAGTTGGCGGTGGCAAGCTGAACAAGGATTCCGTCATCACTGTTGAAGAGTCCAACACTTTCGG
TGTTGAGCTCGAGGTTACTGAGGGTATGCGCTTTGATAAGGGCTACATCTCCGGTTACTTCGCAACTGACATGGAGCGCC
TCGAGGCTGTTCTGGAAGATCCTTACATCCTGCTGGTTTCCGGCAAGATCTCCAACATCAAGGACCTGCTCCCACTGCTG
GAGAAGGTCATGCAGTCCGGCAAGCCTTTGCTGATCATCTCTGAGGACGTCGAGGGCGAGGCTCTGTCCACCCTGGTTGT
CAACAAGATCCGTGGCACCTTCAAGTCTGTTGCTGTTAAGGCTCCGGGCTTCGGCGACCGTCGTAAGGCTCAGCTGCAGG
ACATTGCTGTTCTGACCGGTGGCCAGGTCATTTCTGAAGAGGTTGGCCTCTCCCTTGAGACCGCTGATCTGCCACTTCTA
GGCCAGGCACGCAAGGTTGTTGTCACCAAGGATGACACCACCATCGTTGACGGCGCAGGTTCTGAGGCTCAGATCGAAGG
CCGCGTCAACCAGATCCGCGTTGAGATCGAGAACTCCGATTCCGACTACGACCGTGAGAAGCTCAACGAGCGTCTGGCTA
AGCTTGCCGGCGGCGTTGCAGTGCTTAAGGTGGGCGCAGCTACCGAGGTTGAGCTCAAGGAGCGCAAGCACCGCATTGAG
GATGCTGTCCGTAACGCTAAGGCAGCTGTTGAAGAGGGCATCGTTGCCGGCGGTGGCGTTGCGCTGCTGCAGGCTGCTCA
CGTCCTGGACAACGATCTTGAGCTTTCCGGCGACGAGGCAACCGGCGTTCGCATCGTCCGCGAGGCTCTGACTGCTCCTC
TGAAGCAGATCGCTGCTAACGCTGGCCTCGAGCCAGGCGTTGTTGCTGACAAGGTTTCCCAGCTCCCACAGGGCGAGGGC
CTCAACGCTGCAAACGGCGAGTACGTCGACCTCATGGCTGCGGGCATCAACGACCCAGTTAAGGTCACCCGCTCCGCACT
CCAGAACGCTGCATCCATTGCAGCTCTGTTCCTGACCACTGAGGCTGTCGTTGCTGACAAGCCACAGCCTGCAGGCGCAG
CTGGCATGCCAGGTGCAGACGAGATGGGCGGCATGGGCGGCTTCTAA

Upstream 100 bases:

>100_bases
TGGGTGAGGTTGGTCCACACTCACTAACCGTGCCGTCGCGGGCGCCTACCGGGCAGAAGACGTGAGTGTCGTCCTACAAA
TATTTCAGGAGCACAAACAC

Downstream 100 bases:

>100_bases
GCCCCTCATTCGCGCACCTCAATTGCCCTCCCGCACGCTTTGCGGGAGGGCTTTTGCGTGTCAAAAGATATTGCTTTTCG
ACGTCTCCCCACACCTTCGG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MAKIIAFDEEARRGLEKGLNTLADAVKVTLGPKGRNVVLEKAWGAPTITNDGVTIAREIELEDPYEKIGAELVKEVAKKT
DDVAGDGTTTATVLAQALVREGLRNVAAGSNPMGIKRGIEKAVAQVTEKLLEAAKEVETEEQIAATAGISAADPAIGAQI
AKAMYAVGGGKLNKDSVITVEESNTFGVELEVTEGMRFDKGYISGYFATDMERLEAVLEDPYILLVSGKISNIKDLLPLL
EKVMQSGKPLLIISEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLQDIAVLTGGQVISEEVGLSLETADLPLL
GQARKVVVTKDDTTIVDGAGSEAQIEGRVNQIRVEIENSDSDYDREKLNERLAKLAGGVAVLKVGAATEVELKERKHRIE
DAVRNAKAAVEEGIVAGGGVALLQAAHVLDNDLELSGDEATGVRIVREALTAPLKQIAANAGLEPGVVADKVSQLPQGEG
LNAANGEYVDLMAAGINDPVKVTRSALQNAASIAALFLTTEAVVADKPQPAGAAGMPGADEMGGMGGF

Sequences:

>Translated_548_residues
MAKIIAFDEEARRGLEKGLNTLADAVKVTLGPKGRNVVLEKAWGAPTITNDGVTIAREIELEDPYEKIGAELVKEVAKKT
DDVAGDGTTTATVLAQALVREGLRNVAAGSNPMGIKRGIEKAVAQVTEKLLEAAKEVETEEQIAATAGISAADPAIGAQI
AKAMYAVGGGKLNKDSVITVEESNTFGVELEVTEGMRFDKGYISGYFATDMERLEAVLEDPYILLVSGKISNIKDLLPLL
EKVMQSGKPLLIISEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLQDIAVLTGGQVISEEVGLSLETADLPLL
GQARKVVVTKDDTTIVDGAGSEAQIEGRVNQIRVEIENSDSDYDREKLNERLAKLAGGVAVLKVGAATEVELKERKHRIE
DAVRNAKAAVEEGIVAGGGVALLQAAHVLDNDLELSGDEATGVRIVREALTAPLKQIAANAGLEPGVVADKVSQLPQGEG
LNAANGEYVDLMAAGINDPVKVTRSALQNAASIAALFLTTEAVVADKPQPAGAAGMPGADEMGGMGGF
>Mature_547_residues
AKIIAFDEEARRGLEKGLNTLADAVKVTLGPKGRNVVLEKAWGAPTITNDGVTIAREIELEDPYEKIGAELVKEVAKKTD
DVAGDGTTTATVLAQALVREGLRNVAAGSNPMGIKRGIEKAVAQVTEKLLEAAKEVETEEQIAATAGISAADPAIGAQIA
KAMYAVGGGKLNKDSVITVEESNTFGVELEVTEGMRFDKGYISGYFATDMERLEAVLEDPYILLVSGKISNIKDLLPLLE
KVMQSGKPLLIISEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLQDIAVLTGGQVISEEVGLSLETADLPLLG
QARKVVVTKDDTTIVDGAGSEAQIEGRVNQIRVEIENSDSDYDREKLNERLAKLAGGVAVLKVGAATEVELKERKHRIED
AVRNAKAAVEEGIVAGGGVALLQAAHVLDNDLELSGDEATGVRIVREALTAPLKQIAANAGLEPGVVADKVSQLPQGEGL
NAANGEYVDLMAAGINDPVKVTRSALQNAASIAALFLTTEAVVADKPQPAGAAGMPGADEMGGMGGF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=46.9811320754717, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=46.9811320754717, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI302058290, Length=532, Percent_Identity=24.6240601503759, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI38455427, Length=121, Percent_Identity=32.2314049586777, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI63162572, Length=536, Percent_Identity=22.3880597014925, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=58.7901701323251, Blast_Score=575, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI17555558, Length=531, Percent_Identity=47.2693032015066, Blast_Score=462, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI193210679, Length=208, Percent_Identity=50.9615384615385, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17564182, Length=555, Percent_Identity=22.7027027027027, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=529, Percent_Identity=49.7164461247637, Blast_Score=473, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6322524, Length=152, Percent_Identity=31.5789473684211, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320058, Length=184, Percent_Identity=28.804347826087, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24641193, Length=530, Percent_Identity=47.3584905660377, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24641191, Length=530, Percent_Identity=47.3584905660377, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45550936, Length=530, Percent_Identity=45.6603773584906, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45550132, Length=530, Percent_Identity=45.6603773584906, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45550935, Length=530, Percent_Identity=45.6603773584906, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI17864606, Length=528, Percent_Identity=40.1515151515151, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24584129, Length=537, Percent_Identity=34.8230912476723, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI19921262, Length=537, Percent_Identity=34.8230912476723, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24645179, Length=119, Percent_Identity=34.453781512605, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57355; Mature: 57224

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIIAFDEEARRGLEKGLNTLADAVKVTLGPKGRNVVLEKAWGAPTITNDGVTIAREIE
CCEEEECCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCEEEEEEEC
LEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGSNPMGIKRGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KAVAQVTEKLLEAAKEVETEEQIAATAGISAADPAIGAQIAKAMYAVGGGKLNKDSVITV
HHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEE
EESNTFGVELEVTEGMRFDKGYISGYFATDMERLEAVLEDPYILLVSGKISNIKDLLPLL
ECCCCEEEEEEECCCCEECCCHHCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHH
EKVMQSGKPLLIISEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLQDIAVLTG
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHEECC
GQVISEEVGLSLETADLPLLGQARKVVVTKDDTTIVDGAGSEAQIEGRVNQIRVEIENSD
CHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCEEEECCCCCCEECCCEEEEEEEEECCC
SDYDREKLNERLAKLAGGVAVLKVGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGV
CCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ALLQAAHVLDNDLELSGDEATGVRIVREALTAPLKQIAANAGLEPGVVADKVSQLPQGEG
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
LNAANGEYVDLMAAGINDPVKVTRSALQNAASIAALFLTTEAVVADKPQPAGAAGMPGAD
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
EMGGMGGF
HCCCCCCC
>Mature Secondary Structure 
AKIIAFDEEARRGLEKGLNTLADAVKVTLGPKGRNVVLEKAWGAPTITNDGVTIAREIE
CEEEECCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCEEEEEEEC
LEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGSNPMGIKRGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KAVAQVTEKLLEAAKEVETEEQIAATAGISAADPAIGAQIAKAMYAVGGGKLNKDSVITV
HHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEE
EESNTFGVELEVTEGMRFDKGYISGYFATDMERLEAVLEDPYILLVSGKISNIKDLLPLL
ECCCCEEEEEEECCCCEECCCHHCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHH
EKVMQSGKPLLIISEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLQDIAVLTG
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHEECC
GQVISEEVGLSLETADLPLLGQARKVVVTKDDTTIVDGAGSEAQIEGRVNQIRVEIENSD
CHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCEEEECCCCCCEECCCEEEEEEEEECCC
SDYDREKLNERLAKLAGGVAVLKVGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGV
CCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ALLQAAHVLDNDLELSGDEATGVRIVREALTAPLKQIAANAGLEPGVVADKVSQLPQGEG
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
LNAANGEYVDLMAAGINDPVKVTRSALQNAASIAALFLTTEAVVADKPQPAGAAGMPGAD
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
EMGGMGGF
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA