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The map label for this gene is folK [H]

Identifier: 62391529

GI number: 62391529

Start: 2838172

End: 2838651

Strand: Reverse

Name: folK [H]

Synonym: cg2979

Alternate gene names: 62391529

Gene position: 2838651-2838172 (Counterclockwise)

Preceding gene: 62391530

Following gene: 62391528

Centisome position: 86.47

GC content: 53.54

Gene sequence:

>480_bases
ATGCATGCAGTTTTGTCCATCGGTTCCAACATGGATGATCGCTACGCGCTGCTCAACACAGTGATCGAGGAATTCAAAGA
TGAGATCGTGGCGCAGTCTGCGATCTACTCAACCCCACCGTGGGGCATTGAGGATCAGGATGAATTCCTCAACGCAGTGC
TCGTTGTTGAGGTTGAAGAAACCCCCATCGAGTTGCTGCGCCGTGGCCAAAAACTCGAAGAAGCCGCCGAGCGGGTCCGC
GTCCGCAAATGGGGGCCACGCACCCTCGATGTGGATATCGTGCAGATCATTAAAGATGGGGAAGAGATCCTTTCTGAGGA
TCCCGAACTGACCTTGCCACACCCTTGGGCTTGGCAGCGTGCCTTCGTGTTGATCCCTTGGTTGGAAGCAGAACCTGATG
CCGTCCTGCACGGCACGACCATTGCAGAACATGTGGATAATCTTGATCCCACAGACATTGAAGGTGTCACCAAGATTTAA

Upstream 100 bases:

>100_bases
TCCATAAGCCCAAAGCACCGATCCCACGTACTTTTGCTGACGTCGCGGTGGTTGCCCGACGTTCCAGGAAATCCATGGCT
GCTGGAAGGAGCAACGCCTA

Downstream 100 bases:

>100_bases
GGAGTCGTGGCTTTCATGCAGAAAACGTCAGCGGGTTGGTTGATCGCAACGGGAGGTTTCCTCGCCGCTGTGTCCGCCAT
TTTGACGTGGCGTTTTTATG

Product: 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MHAVLSIGSNMDDRYALLNTVIEEFKDEIVAQSAIYSTPPWGIEDQDEFLNAVLVVEVEETPIELLRRGQKLEEAAERVR
VRKWGPRTLDVDIVQIIKDGEEILSEDPELTLPHPWAWQRAFVLIPWLEAEPDAVLHGTTIAEHVDNLDPTDIEGVTKI

Sequences:

>Translated_159_residues
MHAVLSIGSNMDDRYALLNTVIEEFKDEIVAQSAIYSTPPWGIEDQDEFLNAVLVVEVEETPIELLRRGQKLEEAAERVR
VRKWGPRTLDVDIVQIIKDGEEILSEDPELTLPHPWAWQRAFVLIPWLEAEPDAVLHGTTIAEHVDNLDPTDIEGVTKI
>Mature_159_residues
MHAVLSIGSNMDDRYALLNTVIEEFKDEIVAQSAIYSTPPWGIEDQDEFLNAVLVVEVEETPIELLRRGQKLEEAAERVR
VRKWGPRTLDVDIVQIIKDGEEILSEDPELTLPHPWAWQRAFVLIPWLEAEPDAVLHGTTIAEHVDNLDPTDIEGVTKI

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=36.6906474820144, Blast_Score=84, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324073, Length=152, Percent_Identity=36.1842105263158, Blast_Score=89, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18045; Mature: 18045

Theoretical pI: Translated: 4.06; Mature: 4.06

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAVLSIGSNMDDRYALLNTVIEEFKDEIVAQSAIYSTPPWGIEDQDEFLNAVLVVEVEE
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCEEEEEEECC
TPIELLRRGQKLEEAAERVRVRKWGPRTLDVDIVQIIKDGEEILSEDPELTLPHPWAWQR
CHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCHHHHHCCCCCCCCCCCCCCCC
AFVLIPWLEAEPDAVLHGTTIAEHVDNLDPTDIEGVTKI
EEEEEEECCCCCCCEEECCHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MHAVLSIGSNMDDRYALLNTVIEEFKDEIVAQSAIYSTPPWGIEDQDEFLNAVLVVEVEE
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCEEEEEEECC
TPIELLRRGQKLEEAAERVRVRKWGPRTLDVDIVQIIKDGEEILSEDPELTLPHPWAWQR
CHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCHHHHHCCCCCCCCCCCCCCCC
AFVLIPWLEAEPDAVLHGTTIAEHVDNLDPTDIEGVTKI
EEEEEEECCCCCCCEEECCHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]