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The map label for this gene is lmrB [H]

Identifier: 62391522

GI number: 62391522

Start: 2830918

End: 2832363

Strand: Reverse

Name: lmrB [H]

Synonym: cg2971

Alternate gene names: 62391522

Gene position: 2832363-2830918 (Counterclockwise)

Preceding gene: 62391523

Following gene: 62391515

Centisome position: 86.28

GC content: 52.7

Gene sequence:

>1446_bases
ATGGATTCCCAAATTAATACTCAGACCTCTCCGGCAGCTGCGAAGCTGCCTAGGGAGGTCGTTGTTGTTCTTTCGATCCT
CGTGGTTTCCGCGATGATCATGATTCTTAATGAAACCATTCTGTCGGTTGCGTTGCCTTCCATCATGGAAGATTTCTCCG
TGCCTGAAACTACTGCACAGTGGTTGACCACTGGCTTTATGTTGACGATGGCAGTGGTGATTCCAACTACTGGTTATCTG
CTTGATCGTTTTTCCACTAAGACGATCTTTGTTACTGCGTTGTTGTTCTTTACGGTTGGTACGTTGACTGCGGCGTTGGC
TCCAACGTTTGCGGTGCTGCTTGGTGCTCGTATCGTTCAGGCGGTTGGTACTGCGCTGGTGATGCCTTTGCTGATGACGG
TTACGTTGACGGTGGTTCCTGCGGAGCGTCGTGGTTCGATGATGGGCATTATTTCCATCGTGATTTCTGTTGCGCCGGCG
CTTGGTCCTACGTTGTCTGGTGTCATTCTTAACTCTTTGACCTGGCACTGGTTGTTTTGGATGATGCTTCCGATCGTTGT
TATCGCTTTGGTAATTGGTTTCTTCTTGATCAAAAATATCGGCGAAACCAAGATCACCCCACTGGATGTTCTGTCTGTCA
TCCTTTCGGTGTTTGCCTTCGGTGGTTTGGTGTACGGCTTCAGTTCCTTCGGAGCAATCCTGGAGGGCGAAGGCACCGTA
GGTATCTTCGCGATCGTCGTTGGCGCCATCGCACTCCTCATCTTTGCTTTGCGACAGCACCAACTCGGCAAGCAAGACAA
AGCACTGATGGATCTCCGAGCCTTCAAGGTGAGGAACTTCAGCTTCTCCTTGACCACCATCCTTTTGGCGTTCGGCGCGA
TGCTCGGAACCGTCATGGTTTTGCCAATCTACCTGCAGACTTCCCTCGGAGTTACTGCTTTGGTGACCGGTTTGGTTGTT
ATGCCCGGCGGCCTCCTCCAGGGTCTGATCAGCCCATTCATCGGACGTTTCTACGACAAGGTCGGTCCACGTCCGCTGCT
GATTCCCGGAGCAATTGCGCTGGCTATCGCGGCATCCTCGATGACTTTCCTCAATGAGAATTCACCCGTGTGGATGGTCG
TGGTCATGCACGTTGTGTTCAGCATCGGCATGTGTTTGATGATGACCCCTCTCATGACCACCGCTCTCGGCGCCCTTCCG
AAGCACCTCTATGGTCACGGCTCCGCAATTTTGAACACGTTCCAACAGCTCGCAGGCGCAGCCGGAACAGCGATCATGAT
TGCAGCACTTTCCTTCGGCACTTCCATTGCAGCGTCTTCGGGATCTGCGCATGCTGAAGCTGTTGCCGCTGGTACCAAGG
TTGCGTTCATCGCAGGCGCAATCATCGCGGTGATCGCTTTGGTTGTTTCCCTCTTCGTCACTCGCGTCGAGGAAGAAGCT
CACTAA

Upstream 100 bases:

>100_bases
TTGTGGCACTCTTTAGTAGTTTTTTCTCATAGCTCAGTTTCGCAACTTTAGAGAACTCTAGAAACTGAGCTTCATGCTGT
GAAAGGCCTTTTCTCCATTC

Downstream 100 bases:

>100_bases
ATACCAAAAAATGGGGCAGAAGGTCATTGACTTTCTGCCCCATTTTTTTGCTTCTCGACGCCTCCCGCCGCCACCTCACC
TTAAGCGTGCTCAGCGCTCC

Product: lincomycin resistance protein LMRB

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MDSQINTQTSPAAAKLPREVVVVLSILVVSAMIMILNETILSVALPSIMEDFSVPETTAQWLTTGFMLTMAVVIPTTGYL
LDRFSTKTIFVTALLFFTVGTLTAALAPTFAVLLGARIVQAVGTALVMPLLMTVTLTVVPAERRGSMMGIISIVISVAPA
LGPTLSGVILNSLTWHWLFWMMLPIVVIALVIGFFLIKNIGETKITPLDVLSVILSVFAFGGLVYGFSSFGAILEGEGTV
GIFAIVVGAIALLIFALRQHQLGKQDKALMDLRAFKVRNFSFSLTTILLAFGAMLGTVMVLPIYLQTSLGVTALVTGLVV
MPGGLLQGLISPFIGRFYDKVGPRPLLIPGAIALAIAASSMTFLNENSPVWMVVVMHVVFSIGMCLMMTPLMTTALGALP
KHLYGHGSAILNTFQQLAGAAGTAIMIAALSFGTSIAASSGSAHAEAVAAGTKVAFIAGAIIAVIALVVSLFVTRVEEEA
H

Sequences:

>Translated_481_residues
MDSQINTQTSPAAAKLPREVVVVLSILVVSAMIMILNETILSVALPSIMEDFSVPETTAQWLTTGFMLTMAVVIPTTGYL
LDRFSTKTIFVTALLFFTVGTLTAALAPTFAVLLGARIVQAVGTALVMPLLMTVTLTVVPAERRGSMMGIISIVISVAPA
LGPTLSGVILNSLTWHWLFWMMLPIVVIALVIGFFLIKNIGETKITPLDVLSVILSVFAFGGLVYGFSSFGAILEGEGTV
GIFAIVVGAIALLIFALRQHQLGKQDKALMDLRAFKVRNFSFSLTTILLAFGAMLGTVMVLPIYLQTSLGVTALVTGLVV
MPGGLLQGLISPFIGRFYDKVGPRPLLIPGAIALAIAASSMTFLNENSPVWMVVVMHVVFSIGMCLMMTPLMTTALGALP
KHLYGHGSAILNTFQQLAGAAGTAIMIAALSFGTSIAASSGSAHAEAVAAGTKVAFIAGAIIAVIALVVSLFVTRVEEEA
H
>Mature_481_residues
MDSQINTQTSPAAAKLPREVVVVLSILVVSAMIMILNETILSVALPSIMEDFSVPETTAQWLTTGFMLTMAVVIPTTGYL
LDRFSTKTIFVTALLFFTVGTLTAALAPTFAVLLGARIVQAVGTALVMPLLMTVTLTVVPAERRGSMMGIISIVISVAPA
LGPTLSGVILNSLTWHWLFWMMLPIVVIALVIGFFLIKNIGETKITPLDVLSVILSVFAFGGLVYGFSSFGAILEGEGTV
GIFAIVVGAIALLIFALRQHQLGKQDKALMDLRAFKVRNFSFSLTTILLAFGAMLGTVMVLPIYLQTSLGVTALVTGLVV
MPGGLLQGLISPFIGRFYDKVGPRPLLIPGAIALAIAASSMTFLNENSPVWMVVVMHVVFSIGMCLMMTPLMTTALGALP
KHLYGHGSAILNTFQQLAGAAGTAIMIAALSFGTSIAASSGSAHAEAVAAGTKVAFIAGAIIAVIALVVSLFVTRVEEEA
H

Specific function: Proton-dependent transporter. May mediate the efflux of lincomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=403, Percent_Identity=26.7990074441687, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87081983, Length=414, Percent_Identity=26.8115942028986, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789042, Length=413, Percent_Identity=27.1186440677966, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790195, Length=402, Percent_Identity=27.6119402985075, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788392, Length=476, Percent_Identity=25.6302521008403, Blast_Score=115, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6325455, Length=286, Percent_Identity=25.8741258741259, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321663, Length=125, Percent_Identity=32, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322958, Length=206, Percent_Identity=27.6699029126214, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323735, Length=166, Percent_Identity=28.3132530120482, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50572; Mature: 50572

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSQINTQTSPAAAKLPREVVVVLSILVVSAMIMILNETILSVALPSIMEDFSVPETTAQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
WLTTGFMLTMAVVIPTTGYLLDRFSTKTIFVTALLFFTVGTLTAALAPTFAVLLGARIVQ
HHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGTALVMPLLMTVTLTVVPAERRGSMMGIISIVISVAPALGPTLSGVILNSLTWHWLFW
HHHHHHHHHHHHHHHHHEEEHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
MMLPIVVIALVIGFFLIKNIGETKITPLDVLSVILSVFAFGGLVYGFSSFGAILEGEGTV
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCH
GIFAIVVGAIALLIFALRQHQLGKQDKALMDLRAFKVRNFSFSLTTILLAFGAMLGTVMV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LPIYLQTSLGVTALVTGLVVMPGGLLQGLISPFIGRFYDKVGPRPLLIPGAIALAIAASS
HHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHH
MTFLNENSPVWMVVVMHVVFSIGMCLMMTPLMTTALGALPKHLYGHGSAILNTFQQLAGA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
AGTAIMIAALSFGTSIAASSGSAHAEAVAAGTKVAFIAGAIIAVIALVVSLFVTRVEEEA
CCHHHHHHHHHHCCHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
H
C
>Mature Secondary Structure
MDSQINTQTSPAAAKLPREVVVVLSILVVSAMIMILNETILSVALPSIMEDFSVPETTAQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
WLTTGFMLTMAVVIPTTGYLLDRFSTKTIFVTALLFFTVGTLTAALAPTFAVLLGARIVQ
HHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGTALVMPLLMTVTLTVVPAERRGSMMGIISIVISVAPALGPTLSGVILNSLTWHWLFW
HHHHHHHHHHHHHHHHHEEEHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
MMLPIVVIALVIGFFLIKNIGETKITPLDVLSVILSVFAFGGLVYGFSSFGAILEGEGTV
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCH
GIFAIVVGAIALLIFALRQHQLGKQDKALMDLRAFKVRNFSFSLTTILLAFGAMLGTVMV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LPIYLQTSLGVTALVTGLVVMPGGLLQGLISPFIGRFYDKVGPRPLLIPGAIALAIAASS
HHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHH
MTFLNENSPVWMVVVMHVVFSIGMCLMMTPLMTTALGALPKHLYGHGSAILNTFQQLAGA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
AGTAIMIAALSFGTSIAASSGSAHAEAVAAGTKVAFIAGAIIAVIALVVSLFVTRVEEEA
CCHHHHHHHHHHCCHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]