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The map label for this gene is ispD [H]

Identifier: 62391498

GI number: 62391498

Start: 2801685

End: 2802455

Strand: Reverse

Name: ispD [H]

Synonym: cg2945

Alternate gene names: 62391498

Gene position: 2802455-2801685 (Counterclockwise)

Preceding gene: 62391499

Following gene: 62391497

Centisome position: 85.37

GC content: 59.27

Gene sequence:

>771_bases
ATGTCGTCTACACGAATCCCCGTCATCGCACTCCTCGCGGCGGCGGGGCGCGGAACCCGCCTCGGCGGACCCATCCCCAA
AGCATTCGTCACGTTGCGTGAACGCACACTTTTAGAGCGCTCGCTCCAAGCCATGCTCACCTCCGAAAGCGTCGACGAAA
TCATCATCCTCGTCAGCCCCGACATGGAAACCTACGCCCGCGATTTGCTGCGCAAACGCGGTCTTTTGAACGACCCCGAA
GGGGTACGCGTACGGCTCGTGCACGGCGGCGGGGAGCGCGCGGACTCGGTCTGGGCAGGCCTTCAGGCAATTTCGCTTGA
CGACGCCACCCCCGATGCAATTGTCTTAATCCACGACAGCGCCCGAGCGCTCACACCACCCGGCATGATTGCGCGCGTGG
TGCGCAAAGTCCACGAAGGCGCCACCGCAGTCATCCCAGTACTGCCAGTATCGGACACCATCAAACGAGTGTCCCCTGAT
GGCGGAGTAGTTGTCGACACACCCAACCGTGCAGAACTTCGCGCCGTCCAAACCCCACAAGGCTTCCTGCTGTCCGAACT
TGTTGCAGCGAATGAGAAATTCTTCGCCGACCCCAACCCAGGCTTCATCCCAACCGATGACGCCAGCTTGATGGAATGGT
ACGGCGCAGATGTAGTCTGCGTACAAGGCGACCCAATGGCGTTTAAAGTAACAACCCCCATTGATATGATGCTGGCACAA
CGCATCACCGACGAAGCCGAACCCACAATATTTGAGGTACCAGGTGACTAA

Upstream 100 bases:

>100_bases
GCTCGGCGACGAGGAAGAGAAGAAGGACGCATTCGACGACTTCGACGATTCCGACGTGGATCTTGACGATCTGAGCTTCG
ACGACGAAGATTAGACGCCC

Downstream 100 bases:

>100_bases
CCCAATCATCCCCCGCGTAGGAATCGCCACAGACGCCCACCAAATCGAAGCGGGAAAACCCTGCTGGATCGCCTGCCTCC
TCTTTGAAGGCGTCGACGGC

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MSSTRIPVIALLAAAGRGTRLGGPIPKAFVTLRERTLLERSLQAMLTSESVDEIIILVSPDMETYARDLLRKRGLLNDPE
GVRVRLVHGGGERADSVWAGLQAISLDDATPDAIVLIHDSARALTPPGMIARVVRKVHEGATAVIPVLPVSDTIKRVSPD
GGVVVDTPNRAELRAVQTPQGFLLSELVAANEKFFADPNPGFIPTDDASLMEWYGADVVCVQGDPMAFKVTTPIDMMLAQ
RITDEAEPTIFEVPGD

Sequences:

>Translated_256_residues
MSSTRIPVIALLAAAGRGTRLGGPIPKAFVTLRERTLLERSLQAMLTSESVDEIIILVSPDMETYARDLLRKRGLLNDPE
GVRVRLVHGGGERADSVWAGLQAISLDDATPDAIVLIHDSARALTPPGMIARVVRKVHEGATAVIPVLPVSDTIKRVSPD
GGVVVDTPNRAELRAVQTPQGFLLSELVAANEKFFADPNPGFIPTDDASLMEWYGADVVCVQGDPMAFKVTTPIDMMLAQ
RITDEAEPTIFEVPGD
>Mature_255_residues
SSTRIPVIALLAAAGRGTRLGGPIPKAFVTLRERTLLERSLQAMLTSESVDEIIILVSPDMETYARDLLRKRGLLNDPEG
VRVRLVHGGGERADSVWAGLQAISLDDATPDAIVLIHDSARALTPPGMIARVVRKVHEGATAVIPVLPVSDTIKRVSPDG
GVVVDTPNRAELRAVQTPQGFLLSELVAANEKFFADPNPGFIPTDDASLMEWYGADVVCVQGDPMAFKVTTPIDMMLAQR
ITDEAEPTIFEVPGD

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=245, Percent_Identity=28.1632653061224, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1789104, Length=240, Percent_Identity=34.1666666666667, Blast_Score=108, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 27525; Mature: 27394

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTRIPVIALLAAAGRGTRLGGPIPKAFVTLRERTLLERSLQAMLTSESVDEIIILVSP
CCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
DMETYARDLLRKRGLLNDPEGVRVRLVHGGGERADSVWAGLQAISLDDATPDAIVLIHDS
CHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHCCEEEECCCCCCCEEEEEECC
ARALTPPGMIARVVRKVHEGATAVIPVLPVSDTIKRVSPDGGVVVDTPNRAELRAVQTPQ
CCCCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHCCCCCCEEEECCCCCEEEEECCCC
GFLLSELVAANEKFFADPNPGFIPTDDASLMEWYGADVVCVQGDPMAFKVTTPIDMMLAQ
CHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHCCCCEEEECCCCEEEEECCCHHHHHHH
RITDEAEPTIFEVPGD
HHCCCCCCEEEECCCC
>Mature Secondary Structure 
SSTRIPVIALLAAAGRGTRLGGPIPKAFVTLRERTLLERSLQAMLTSESVDEIIILVSP
CCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
DMETYARDLLRKRGLLNDPEGVRVRLVHGGGERADSVWAGLQAISLDDATPDAIVLIHDS
CHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHCCEEEECCCCCCCEEEEEECC
ARALTPPGMIARVVRKVHEGATAVIPVLPVSDTIKRVSPDGGVVVDTPNRAELRAVQTPQ
CCCCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHCCCCCCEEEECCCCCEEEEECCCC
GFLLSELVAANEKFFADPNPGFIPTDDASLMEWYGADVVCVQGDPMAFKVTTPIDMMLAQ
CHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHCCCCEEEECCCCEEEEECCCHHHHHHH
RITDEAEPTIFEVPGD
HHCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA